Gait and behavior in an IL1β-mediated model of rat knee arthritis and effects of an IL1 antagonist

Journal of Orthopaedic Research

Volumn 29, Issue 5, 2011, Pages 694-703

  Allen, Kyle D ^a,b   Adams Jr , Samuel B ^a   Mata, Brian A ^a   Shamji, Mohammed F ^b,c   Gouze, Elvire ^d   Jing, Liufang ^b   Nettles, Dana L ^b   Latt, L Daniel ^a   Setton, Lori A ^a,b  

^a DUKE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b Duke University   (United States)

^c UNIVERSITY OF OTTAWA   (Canada)

^d INSERM   (France)

Author keywords

animal model; arthritis; interleukin 1; joint dysfunction; pain

Indexed keywords

COMPLEMENTARY DNA; INTERLEUKIN 1 RECEPTOR BLOCKING AGENT; INTERLEUKIN 1BETA;

ALLODYNIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BEHAVIOR; BODY WEIGHT; CARTILAGE DEGENERATION; CONTROLLED STUDY; CYTOKINE PRODUCTION; FIBROBLAST; GAIT; GENE OVEREXPRESSION; HISTOPATHOLOGY; JOINT CAVITY; JOINT SWELLING; KNEE; KNEE ARTHRITIS; KNEE PAIN; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; VELOCITY;

ANIMALS; ARTHRITIS; BEHAVIOR, ANIMAL; DISEASE MODELS, ANIMAL; GAIT; HINDLIMB; HUMANS; INJECTIONS, INTRA-ARTICULAR; INTERLEUKIN 1 RECEPTOR ANTAGONIST PROTEIN; INTERLEUKIN-1BETA; JOINTS; PAIN; RATS; RATS, WISTAR;

EID: 79952787834     PISSN: 07360266     EISSN: 1554527X     Source Type: Journal    
DOI: 10.1002/jor.21309     Document Type: Article

References (49)

1. Birchfield PC,. 2001. Osteoarthritis overview. Geriatr Nurs 22: 124-130; quiz 130-121.
2. Buckwalter JA, Stanish WD, Rosier RN, et al. 2001. The increasing need for nonoperative treatment of patients with osteoarthritis. Clin Orthop Relat Res 36-45. (Pubitemid 32246986)
3. Hootman JM, Helmick CG,. 2006. Projections of US prevalence of arthritis and associated activity limitations. Arthritis Rheum 54: 226-229. (Pubitemid 43122205)
4. Attur MG, Patel IR, Patel RN, et al. 1998. Autocrine production of IL-1 beta by human osteoarthritis-affected cartilage and differential regulation of endogenous nitric oxide, IL-6, prostaglandin E2, and IL-8. Proc Assoc Am Physicians 110: 65-72. (Pubitemid 28051639)
5. Buckwalter JA, Lotz M, Stoltz JF,. 2007. Osteoarthritis, inflammation, and degradation: a continuum. Amsterdam; Washington, DC: IOS Press.
6. Dinarello CA,. 1998. Interleukin-1 beta, interleukin-18, and the interleukin-1 beta converting enzyme. Ann NY Acad Sci 856: 1-11. (Pubitemid 28517331)
7. Joosten LA, Helsen MM, Saxne T, et al. 1999. IL-1 alpha beta blockade prevents cartilage and bone destruction in murine type II collagen-induced arthritis, whereas TNF-alpha blockade only ameliorates joint inflammation. J Immunol 163: 5049-5055. (Pubitemid 29501273)
8. Myers SL, Brandt KD, Ehlich JW, et al. 1990. Synovial inflammation in patients with early osteoarthritis of the knee. J Rheumatol 17: 1662-1669.
9. Pelletier JP, McCollum R, DiBattista J, et al. 1993. Regulation of human normal and osteoarthritic chondrocyte interleukin-1 receptor by antirheumatic drugs. Arthritis Rheum 36: 1517-1527. (Pubitemid 23327750)
10. Pelletier JP, Mineau F, Fernandes JC, et al. 1998. Diacerhein and rhein reduce the interleukin 1beta stimulated inducible nitric oxide synthesis level and activity while stimulating cyclooxygenase-2 synthesis in human osteoarthritic chondrocytes. J Rheumatol 25: 2417-2424. (Pubitemid 28551861)
11. Smith MD, Triantafillou S, Parker A, et al. 1997. Synovial membrane inflammation and cytokine production in patients with early osteoarthritis. J Rheumatol 24: 365-371. (Pubitemid 27104104)
12. van de Loo FA, Joosten LA, van Lent PL, et al. 1995. Role of interleukin-1, tumor necrosis factor alpha, and interleukin-6 in cartilage proteoglycan metabolism and destruction. Effect of in situ blocking in murine antigen- and zymosan-induced arthritis. Arthritis Rheum 38: 164-172.
13. Dinarello CA,. 1991. Interleukin-1 and interleukin-1 antagonism. Blood 77: 1627-1652.
14. Granowitz EV, Porat R, Mier JW, et al. 1992. Pharmacokinetics, safety and immunomodulatory effects of human recombinant interleukin-1 receptor antagonist in healthy humans. Cytokine 4: 353-360.
15. Caron JP, Fernandes JC, Martel-Pelletier J, et al. 1996. Chondroprotective effect of intraarticular injections of interleukin-1 receptor antagonist in experimental osteoarthritis. Suppression of collagenase-1 expression. Arthritis Rheum 39: 1535-1544. (Pubitemid 26314988)
16. Gouze E, Pawliuk R, Gouze JN, et al. 2003. Lentiviral-mediated gene delivery to synovium: potent intra-articular expression with amplification by inflammation. Mol Ther 7: 460-466. (Pubitemid 36553414)
17. Frisbie DD, Kawcak CE, Werpy NM, et al. 2007. Clinical, biochemical, and histologic effects of intra-articular administration of autologous conditioned serum in horses with experimentally induced osteoarthritis. Am J Vet Res 68: 290-296. (Pubitemid 46487515)
18. Nixon AJ, Haupt JL, Frisbie DD, et al. 2005. Gene-mediated restoration of cartilage matrix by combination insulin-like growth factor-I/interleukin-1 receptor antagonist therapy. Gene Ther 12: 177-186. (Pubitemid 40185921)
19. Wehling P, Moser C, Frisbie D, et al. 2007. Autologous conditioned serum in the treatment of orthopedic diseases: the orthokine therapy. BioDrugs 21: 323-332. (Pubitemid 47529471)
20. Oligino T, Ghivizzani S, Wolfe D, et al. 1999. Intra-articular delivery of a herpes simplex virus IL-1Ra gene vector reduces inflammation in a rabbit model of arthritis. Gene Ther 6: 1713-1720. (Pubitemid 29485946)
21. Pelletier JP, Caron JP, Evans C, et al. 1997. In vivo suppression of early experimental osteoarthritis by interleukin-1 receptor antagonist using gene therapy. Arthritis Rheum 40: 1012-1019. (Pubitemid 27242287)
22. Goupille P, Mulleman D, Chevalier X,. 2007. Is interleukin-1 a good target for therapeutic intervention in intervertebral disc degeneration: lessons from the osteoarthritic experience. Arthritis Res Ther 9: 110.
23. Chevalier X, Giraudeau B, Conrozier T, et al. 2005. Safety study of intraarticular injection of interleukin 1 receptor antagonist in patients with painful knee osteoarthritis: a multicenter study. J Rheumatol 32: 1317-1323. (Pubitemid 40995389)
24. Chevalier X, Goupille P, Beaulieu AD, et al. 2009. Intraarticular injection of anakinra in osteoarthritis of the knee: a multicenter, randomized, double-blind, placebo-controlled study. Arthritis Rheum 61: 344-352.
25. Fairbank JC, Couper J, Davies JB, et al. 1980. The Oswestry low back pain disability questionnaire. Physiotherapy 66: 271-273. (Pubitemid 11234479)
26. Bellamy N, Gilbert JR, Brooks PM, et al. 1988. A survey of current prescribing practices of antiinflammatory and urate lowering drugs in gouty arthritis in the province of Ontario. J Rheumatol 15: 1841-1847. (Pubitemid 19037657)
27. Bove SE, Laemont KD, Brooker RM, et al. 2006. Surgically induced osteoarthritis in the rat results in the development of both osteoarthritis-like joint pain and secondary hyperalgesia. Osteoarthritis Cartilage 14: 1041-1048. (Pubitemid 44309423)
28. Kohara A, Nagakura Y, Kiso T, et al. 2007. Antinociceptive profile of a selective metabotropic glutamate receptor 1 antagonist YM-230888 in chronic pain rodent models. Eur J Pharmacol 571: 8-16. (Pubitemid 47284045)
29. McDougall JJ, Watkins L, Li Z,. 2006. Vasoactive intestinal peptide (VIP) is a modulator of joint pain in a rat model of osteoarthritis. Pain 123: 98-105. (Pubitemid 43816762)
30. Ferreira-Gomes J, Adaes S, Castro-Lopes JM,. 2008. Assessment of movement-evoked pain in osteoarthritis by the knee-bend and CatWalk tests: a clinically relevant study. J Pain 9: 945-954.
31. Clarke KA, Heitmeyer SA, Smith AG, et al. 1997. Gait analysis in a rat model of osteoarthrosis. Physiol Behav 62: 951-954. (Pubitemid 27425222)
32. Berryman ER, Harris RL, Moalli M, et al. 2009. Digigait quantitation of gait dynamics in rat rheumatoid arthritis model. J Musculoskelet Neuronal Interact 9: 89-98.
33. Yu LP Jr, Smith GN Jr, Brandt KD, et al. 1992. Reduction of the severity of canine osteoarthritis by prophylactic treatment with oral doxycycline. Arthritis Rheum 35: 1150-1159.
34. Madore E, Huneault L, Moreau M, et al. 2007. Comparison of trot kinetics between dogs with stifle or hip arthrosis. Vet Comp Orthop Traumatol 20: 102-107. (Pubitemid 46847770)
35. Brandt KD, Myers SL, Burr D, et al. 1991. Osteoarthritic changes in canine articular cartilage, subchondral bone, and synovium fifty-four months after transection of the anterior cruciate ligament. Arthritis Rheum 34: 1560-1570.
36. Ghosh P, Read R, Armstrong S, et al. 1993. The effects of intraarticular administration of hyaluronan in a model of early osteoarthritis in sheep. I. Gait analysis and radiological and morphological studies. Semin Arthritis Rheum 22: 18-30. (Pubitemid 23176280)
37. Cake M, Read R, Edwards S, et al. 2008. Changes in gait after bilateral meniscectomy in sheep: effect of two hyaluronan preparations. J Orthop Sci 13: 514-523.
38. Ghivizzani SC, Kang R, Georgescu HI, et al. 1997. Constitutive intra-articular expression of human IL-1 beta following gene transfer to rabbit synovium produces all major pathologies of human rheumatoid arthritis. J Immunol 159: 3604-3612. (Pubitemid 127482120)
39. Hedrick T,. 2009. DLTdataviewer. In Chapel Hill, NC: Self-published at
40. Chaplan SR, Bach FW, Pogrel JW, et al. 1994. Quantitative assessment of tactile allodynia in the rat paw. J Neurosci Methods 53: 55-63. (Pubitemid 24238751)
41. Pritzker KP, Gay S, Jimenez SA, et al. 2006. Osteoarthritis cartilage histopathology: grading and staging. Osteoarthritis Cartilage 14: 13-29. (Pubitemid 43034086)
42. Krenn V, Morawietz L, Burmester GR, et al. 2006. Synovitis score: discrimination between chronic low-grade and high-grade synovitis. Histopathology 49: 358-364. (Pubitemid 44401542)
43. Janusz MJ, Bendele AM, Brown KK, et al. 2002. Induction of osteoarthritis in the rat by surgical tear of the meniscus: inhibition of joint damage by a matrix metalloproteinase inhibitor. Osteoarthritis Cartilage 10: 785-791. (Pubitemid 35153719)
44. Chang A, Hurwitz D, Dunlop D, et al. 2007. The relationship between toe-out angle during gait and progression of medial tibiofemoral osteoarthritis. Ann Rheum Dis 66: 1271-1275. (Pubitemid 47492467)
45. Jenkyn TR, Hunt MA, Jones IC, et al. 2008. Toe-out gait in patients with knee osteoarthritis partially transforms external knee adduction moment into flexion moment during early stance phase of gait: a tri-planar kinetic mechanism. J Biomech 41: 276-283.
46. Varejao AS, Cabrita AM, Geuna S, et al. 2003. Toe out angle: a functional index for the evaluation of sciatic nerve recovery in the rat model. Exp Neurol 183: 695-699. (Pubitemid 37205111)
47. Betre H, Liu W, Zalutsky MR, et al. 2006. A thermally responsive biopolymer for intra-articular drug delivery. J Control Release 115: 175-182. (Pubitemid 44537500)
48. Shamji MF, Betre H, Kraus VB, et al. 2007. Development and characterization of a fusion protein between thermally responsive elastin-like polypeptide and interleukin-1 receptor antagonist: sustained release of a local antiinflammatory therapeutic. Arthritis Rheum 56: 3650-3661. (Pubitemid 350100699)
49. Allen KD, Adams SB, Setton LA,. Evaluating intra-articular drug delivery for the treatment of osteoarthritis in a rat model. Tissue Eng Part B Rev 16: 81-92.