Chronic RU486 treatment reduces age-related alterations of mouse hippocampal function

Neurobiology of Aging

Volumn 17, Issue 1, 1996, Pages 9-14

  Talmi, Mustapha ^a,b,c   Carlier, Edmond ^b   Bengelloun, Wahil ^c   Soumireu Mourat, Bernard ^a  

^a CNRS   (France)

^b AIX MARSEILLE UNIVERSITY   (France)

^c MOHAMMED V UNIVERSITY   (Morocco)

Author keywords

Aging; Electrophysiology; Glucocorticoids; Hippocampus; RU486

Indexed keywords

GLUCOCORTICOID RECEPTOR; MIFEPRISTONE;

ADOLESCENT; AGED; AGING; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; HIPPOCAMPUS; MALE; MOUSE; NEUROPHYSIOLOGY; NONHUMAN; PRIORITY JOURNAL; RECEPTOR BLOCKING; SUBCUTANEOUS DRUG ADMINISTRATION;

EID: 0030068493     PISSN: 01974580     EISSN: None     Source Type: Journal    
DOI: 10.1016/0197-4580(95)00094-1     Document Type: Article

References (40)

1. Applegate, M. D.; Landfield, P. W. Synaptic vesicle redistribution during hippocampal frequency potentiation and depression in young and aged rats. J. Neurosci. 8:1096-1111; 1988.
2. Barnes, C. A. The physiology of the senescent hippocampus. In Seifert, W., ed. Neurobiology of the hippocampus. London: Academic Press; 1983:87-108.
3. Barnes, C. A.; Rao, G, Foster, T. C.; McNaughton, B. L. Region-specific age effects on AMPA sensitivity: Electrophysiological evidence for loss of synaptic contacts in hippocampal field CA1. Hippocampus 2:457-468; 1992.
4. Carlier, E.; Soumireu-Mourat, B. Effect of central administration of glucocorticoids on hippocampal evoked activity in mice. C.R. Acad. Sci. 299:877-882; 1984.
5. De Kloet, E. R. Brain corticosteroid receptor balance and homeostatic control. In: Ganon, W. F.; Martini, L., eds. Frontiers in neuroendocrinology. New York: Raven Press; 1991:95-164.
6. De Kloet, E. R.; Voorhuis, T. A. M. Neuropeptides, steroid hormones, stress and reproduction. J. Controlled Release 21:105-116; 1992.
7. De Kosky, S.; Scheff, S.; Cotman, C. Elevated corticosterone levels: A possible cause of reduced axon sprouting in aged animals. Neuroendocrinology 38:33-38; 1984.
8. Eldridge, J. C.; Fleenor, D. G.; Kerr, D. S.; Landfield, P. W. Impaired upregulation of type II corticosteroid receptors in hippocampus of aged rats. Brain Res. 478:248-256; 1988.
9. Gould, E.; Woolley, G. S.; McEwen, B. S. Short-term glucocorticoid manipulations affect neuronal morphology and survival in the adult dentate gyrus. Neurosci. 37:367-375; 1990.
10. Hall, E. D. Steroids and neuronal destruction or stabilization. In: Chadwick, D., Widdows, K., eds. Steroid and neuronal activity. Chichester: Wiley; 1990:206-219.
11. Joels, M.; De Kloet, E. R. Effect of glucocorticoid and norepinephrine on the excitability in the hippocampus. Science 245:1502-1505; 1989.
12. Joels, M.; De Kloet, E. R. Effect of corticosteroid hormones on electrical activity in rat hippocampus. J. Steroid. Biochem. Mol. Biol. 40:83-86; 1991.
13. Kerr, D. S.; Campbell, L. W.; Hao, S. Y.; Landfield, P. W. Corticosteroid modulation of hippocampal potentials: Increased effect with aging. Science 245:1505-1507; 1989.
14. Kerr, D. S.; Campbell, L. W.; Applegate, M. D.; Brodish, A.; Landfield, P. W. Chronic stress-induced acceleration of electrophysiologic and morphometric biomarkers of hippocampal aging. J. Neurosci. (11) 316-324; 1991.
15. Landfield, P. W.; McGaugh, J. L.; Lynch, G. Impaired synaptic potentiation process in the hippocampus of aged memory-deficient rats. Brain Res. 150:85-101; 1978.
16. Landfield, P. W.; Waymire, J.; Lynch, G. Hippocampal aging and adrenocorticoids: Quantitative correlations. Science 202:1098-1102; 1981.
17. Landfield, P. W.; Baskin, R.; Pitler, T. Brain aging correlates: Retardation by hormonal-pharmacological treatments. Science 214:581-584; 1981.
18. 2+ ratios on frequency potentiation in hippocampal slices of young and aged rats. J. Neurophysiol. 56:797-812; 1986.
19. Landfield, P. W. Impaired frequency potentiation as a basis for aging-dependent memory impairment: The role of excess calcium influx. Neurosci. Res. Comm. 13:519-522; 1993.
20. McEwen, B. S.; De Kloet, E. R.; Rostene, W. Adrenal steroid receptors and actions in the nervous system. Physiol. Rev. 66:1121-1188; 1986.
21. Nieman, L. K.; Chrousos, G. P.; Kellner, L.; Spitz, I. M.; Nisula, B. C.; Merriam, G. R.; Bardin, C. W.; Loriaux, D. L. Successful treatment of Cushing's syndrome with the glucocorticoid antagonist RU486. J. Clin. Endocrinol. Metab. 61:536-540; 1985.
22. Nieman, L. K.; Loriaux, D. L. Clinical applications of the glucocorticoid and progestin RU486. In: Agarwal, M. K., ed. Receptor mediated antisteroid action. Berlin: Walterde Gruyter; 1987:77-97.
23. Pfaff, D. W.; Silva, M. T. A.; Weiss, J. M. Telemetered recording of hormone effects in hippocampal neurons. Science 172:394-395; 1971.
24. Philibert, D. RU38486: An original multifaceted anti-hormone in vivo. In: Agarwal, M. K., ed. Adrenal steroid antagonism. New York: De Gruyter; 1984:78-101.
25. Reiheld, C. T.; Teyler, T. J. Effects of corticosterone on the electrophysiology of hippocampal CA1 pyramidal cells in vitro. Brain Res. Bull. 12:349-353; 1984.
26. Reul, J. M. H.; De Kloet, E. R. Two receptor systems for corticosterone in rat brain: Micro-distribution and differential occupation. Endocrinology 117:2505-2511; 1985.
27. Reul, J. M. H.; De Kloet, E. R. Anatomical resolution of 2 types of corticosterone receptor sites in rat brain with in vitro autoradi-ography and computerized image analysis. J. Steroid Biochem. 24:269-272; 1986.
28. Rey, M.; Carlier, E.; Soumireu-Mourat, B. Effects of corticosterone on hippocampal slice electrophysiology in normal and adrenalectomized BALB/c mice. Neuroendocrinology 46:424-429; 1987.
29. Rey, M.; Carlier, E.; Soumireu-Mourat, B. Effects of RU 486 on hippocampal slice electrophysiology in normal and adrenalectomized BALB/c mice. Neuroendocrinology 49:120-124; 1989.
30. Rey, M.; Carlier, E.; Talmi, M.; Soumireu-Mourat, B. In vitro functional differentiation of hippocampal corticosteroid mineralo-and glucocorticoid receptors. C.R. Acad. Sci. 312:247-253; 1991.
31. Sapolsky, R. M.; Krey, L. C.; McEwen, B. S. Corticosterone receptors decline in a site-specific manner in the aged brain. Brain Res. 289:235-240; 1983.
32. Sapolsky, R. M.; Krey, L. C.; McEwen, B. S. Prolonged glucocorticoid exposure reduces hippocampal neuron number: Implications for aging. J. Neurosci. 5:1222-1227; 1985.
33. Sapolsky, R. M.; Krey, L. C.; McEwen, B. S. The neuroendocrinology of stress and aging: The glucocorticoid cascade hypothesis. Endocrinol. Rev. 7:284-304; 1986.
34. Sapolsky, R. M. Glucocorticoids and hippocampal damage. Trends Neurosci. 10:346-349; 1987.
35. Sapolsky, R. M.; Packan, D. R.; Vale, W. W. Glucocorticoid toxicity in the hippocampus: In vitro demonstration. Brain Res. 453: 367-371; 1988.
36. Sapolsky, R. M. Do glucocorticoid concentrations rise with age in the rat. Neurobiol. Aging 13:171-175; 1992.
37. Talmi, M.; Carlier, E.; Soumireu-Mourat, B. Similar effects of aging and corticosterone treatment on mouse hippocampal function. Neurobiol. Aging 14:239-244; 1993.
38. Veldhuiss, H. D.; Van Koppen, C.; Van Ittersum, M.; De Kloet, E. R. Specificity of the adrenal steroid receptor system in rat hippocampus. Endocrinology 110:2044-2051; 1982.
39. Vidal, C.; Jordan, W.; Ziegelgansberger, W. Corticosterone reduces the excitability of hippocampal pyramidal cells in vitro. Brain Res. 383:54-59; 1986.
40. Young, G. A.; Akana, S.; Dallman, M. F. Decreased sensitivity to glucocorticoid fast feedback in chronically stressed rats. Neuroendocrinology 51:536-542; 1990.