Site-specific regulation of corticosteroid and serotonin receptor subtype gene expression in the rat hippocampus following 3,4-methylenedioxymethamphetamine: Role of corticosterone and serotonin

Neuroscience

Volumn 78, Issue 1, 1997, Pages 111-121

  Yau, J L W ^a   Noble, J ^a   Seckl, J R ^a  

^a UNIVERSITY OF EDINBURGH   (United Kingdom)

Author keywords

5 HT receptor; gene expression; glucocorticoid receptor; hippocampus; MDMA; mineralocorticoid receptor

Indexed keywords

3,4 METHYLENEDIOXYMETHAMPHETAMINE; CORTICOSTEROID RECEPTOR; MESSENGER RNA; RECEPTOR SUBTYPE; SEROTONIN RECEPTOR;

ADRENALECTOMY; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN REGION; CONTROLLED STUDY; CORTICOSTERONE BLOOD LEVEL; GENE EXPRESSION; HIPPOCAMPUS; IN SITU HYBRIDIZATION; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; SUBCUTANEOUS DRUG ADMINISTRATION;

ANIMALS; CORTICOSTERONE; GENE EXPRESSION; HIPPOCAMPUS; IN SITU HYBRIDIZATION; MALE; N-METHYL-3,4-METHYLENEDIOXYAMPHETAMINE; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, MINERALOCORTICOID; RECEPTORS, SEROTONIN; RECEPTORS, STEROID; RNA, MESSENGER; SEROTONIN; SEROTONIN AGENTS;

EID: 0030969296     PISSN: 03064522     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0306-4522(96)00497-6     Document Type: Article

References (62)

1. Azmitia E. C., McNaughton N., Tsaltas L., Fillenz M. and Gray J. A. (1984) Interactions between hippocampal serotonin and the pituitary-adrenal axis in the septal driving of hippocampal theta-rhythm. Neuroendocrinology 39, 471-475.
2. Boess F. G. and Martin I. L. (1994) Molecular biology of 5-HT receptors. Neuropharmacology 33, 275-317.
3. Brodkin J., Malyala A. and Nash J. F. (1993) Effect of acute monoamine depletion on 3,4-methylenedioxymethamphetamine-induced neurotoxicity. Pharmac. Biochem. Behav. 45, 647-653.
4. Brousseau D., Wieland S., Lucki I. and McGonigle P. (1991) 5-HT depletion alters the levels of 5-HT1A receptor mRNA. Soc. Neurosci. Abstr. 17, 719.
5. Burnet P. W. J., Mefford I. N., Smith C. C., Gold P. W. and Sternberg E. M. (1996) Hippocampal 5-HT(1A) receptor binding site densities, 5-HT(1A) receptor messenger ribonucleic acid abundance and serotonin levels parallel the activity of the hypothalamo-pituitary-adrenal axis. Behav. Brain Res. 73, 365-368.
6. Burnet P. W. J., Michelson D., Smith M. A., Gold P. W. and Sternberg E. M. (1994) The effect of chronic imipramine administration on the densities of 5-HT1A and 5-HT2 receptors and the abundancies of 5-HT receptor and transporter mRNA in the cortex, hippocampus and dorsal raphe of three strains of rat. Brain Res. 638, 311-324.
7. Burnstein K. L., Bellingham D. L., Jewell C., Powell-Oliver F. E. and Cidlowski J. A. (1991) Autoregulation of glucocorticoid receptor gene expression. Steroids 56, 52-58.
8. Castrén M., Trapp T., Berninger B., Castrén E. and Holsboer F. (1995) Transcriptional induction of rat mineralocorticoid receptor gene in neurones by corticosteroids. J. molec. Endocr. 14, 285-293.
9. Chalmers D., Kwak S., Mansour A., Akil H. and Watson S. (1993) Corticosteroids regulate brain hippocampal 5-HT1A receptor mRNA expression. J. Neurosci. 13, 914-923.
10. Chaouloff F. (1995) Regulation of 5-HT receptors by corticosteroids: where do we stand? Fundam. clin. Pharmac. 9, 219-233.
11. Chen H., Zhang L., Rubinow D. R. and Chuang D.-M. (1995) Chronic buspirone treatment differentially regulates 5-HT1A and 5-HT2A receptor mRNA and binding sites in various regions of the rat hippocampus. Molec. Brain Res. 32, 348-353.
12. De Kloet E., Kovács G., Szabö G., Telegdy G., Bohus B. and Versteeg D. (1982) Decreased serotonin turnover in the dorsal hippocampus of the rat brain shortly after adrenalectomy: selective normalization after corticosterone substitution. Brain Res. 239, 659-663.
13. De Kloet E. R. (1991) Brain corticosteroid receptor balance and homeostatic control. Front. Neuroendocr. 12, 95-164.
14. Diamond D. M., Bennett M. C., Fleshner M. and Rose G. M. (1992) Inverted-U relationship between the level of peripheral corticosterone and the magnitude of hippocampal primed burst potentiation. Hippocampus 2, 421-430.
15. Dinan T. (1994) Glucocorticoid s and the genesis of depressive illness: a psychobiological model. Br. J. Psychiat. 164, 356-371.
16. Flügge G. (1995) Dynamics of central nervous 5-HT1A-receptors under psychosocial stress. J. Neurosci. 15, 7132-7140.
17. Fuller R. W. (1996) Serotonin receptors involved in regulation of pituitary-adrenocortical function in rats. Behav. Brain Res. 73, 215-219.
18. Goodwin G. M., Muir W. J., Seckl J. R., Bennie J., Carroll S., Dick H. and Fink G. (1992) The effects of Cortisol infusion upon hormone secretion from the anterior pituitary and subjective mood in depressive illness and in controls. J. Affect. Disord. 26, 73-83.
19. Green A. R., Cross A. J. and Goodwin G. M. (1995) Review of the pharmacology and clinical pharmacology of 3,4-methylenedioxymethamphetamine (MDMA or "Ecstasy"). Psychopharmacology 119, 247-260.
20. Härfstrand A., Fuxe K., Cintra A. and Agnati L. F. (1986) Glucocorticosteroid receptor immunoreactivity in monoaminergic neurons of the rat brain. Proc. natn. Acad. Sci. U.S.A. 83, 9779-9783.
21. Herman J., Patel P., Akil H. and Watson S. (1989) Localization and regulation of glucocorticoid and mineralocorticoid receptor messenger RNAs in the hippocampal formation of the rat. Molec. Endocr. 3, 1886-1894.
22. Herman J. P., Watson S. J., Chao H. M., Coirini H. and McEwen B. S. (1993) Diurnal regulation of glucocorticoid receptor and mineralocorticoid receptor mRNAs in rat hippocampus. Molec. Cell. Neurosci. 4, 181-190.
23. Holmes M. C., French K. L. and Seckl J. R. (1995) Modulation of serotonin and corticosteroid receptor gene expression in the rat hippocampus with circadian rhythm and stress. Molec. Brain Res. 28, 186-192.
24. Holmes M. C., Yau J. L. W., French K. L. and Seckl J. R. (1995) The effect of adrenalectomy on 5-HT and corticosteroid receptor subtype mRNA expression in rat anterior hippocampus and dorsal raphe nucleus. Neuroscience 64, 327-337.
25. Joels M. and de Kloet E. R. (1992) Control of neuronal excitability by corticosteroid hormones. Trends Neurosci. 15, 25-30.
26. Johnson M., Stone D. M., Bush L. G., Hanson G. R. and Gibb J. W. (1989) Glucocorticoids and 3,4-methylenedioxymethamphetamine(MDMA)-induced neurotoxicity. Eur. J. Pharmac. 161, 181-188.
27. Kennett G. A., Bailey F., Piper D. C. and Blackburn T. P. (1995) Effect of SB 200646A, a 5HT(2C)/5HT(2B) receptor antagonist, in two conflict models of anxiety. Psychopharmacology 118, 178-182.
28. KokotosLeonardi E. T. and Azmitia E. C. (1994) MDMA(Ecstasy) inhibition of MAO type A and type B: comparisons with fenfluramine and fluoxetine (Prozac). Neuropsychopharmacology 10, 231-238.
29. Krystal J. H., Price L. H., Opsahl C., Ricaurte G. A. and Heninger G. R. (1992) Chronic 3,4-methylenedioxymethamphetamine (MDMA) use: effects on mood and neuropsychological function. Am. J. Drug Alcohol Abuse 18, 331-341.
30. Kuroda Y., Watanabe Y., Albeck D. S., Hastings N. B. and McEwen B. S. (1994) Effects of adrenalectomy and type I and typell glucocorticoid receptor activation on 5-HT1a and 5-HT2 receptor binding and 5-HT transporter mRNA expression in rat brain. Brain Res. 648, 157-161.
31. Lyon R. A., Glennon R. A. and Titeler M. (1986) 3,4-Methylenedioxymethamphetamine (MDMA): stereoselective interactions at brain 5-HT1 and 5-HT2 receptors. Psychopharmacology 88, 525-526.
32. McEwen B. S. (1987) Glucocorticoid-biogenic amine interactions in relation to mood and behaviour. Biochem. Pharmac. 36, 1755-1763.
33. McEwen B. S., DeKloet E. R. and Rostene W. (1986) Adrenal steroid receptors and action in the nervous system. Physiol. Rev. 66, 1121-1188.
34. McGarvey C., Kelly J., ODonnell J. M. and Leonard B. E. (1995) Neuroendocrine and behavioural effects of the serotonin releasers 3,4-methylenedioxymethamphetamine and fenfluramine in rats. J. Serotonin Res. 1, 257-265.
35. McGuire P. K., Cope H. and Fahy T. A. (1994) Diversity of psychopathology associated with use of 3,4-methylenedioxymethamphetamine ("Ecstasy"). Br. J. Psychiat. 165, 391-395.
36. McKenna D. J. and Perouka S. J. (1990) Neurochemistry and neurotoxicity of 3,4-methylenedioxymethamphetamine (MDMA, "Ecstasy"). J. Neurochem. 54, 14-22.
37. McKittrick C. R., Blanchard D. C., Blanchard R. J., McEwen B. S. and Sakai R. R. (1995) Serotonin receptor binding in a colony model of chronic social stress. Biol. Psychiat. 37, 383-393.
38. Meijer O. C. and De Kloet E. R. (1994) Corticosterone suppresses the expression of 5-HT1a receptor mRNA in the rat dentate gyrus. Eur. J. Pharmac. 266, 255-261.
39. Meltzer H. Y. (1990) Role of serotonin in depression. Ann. N. Y. Acad. Sci. 600, 486-500.
40. Mendelson S. D. and McEwen B. S. (1992) Autoradiographic analyses of the effects of adrenalectomy and corticosterone on 5-HT1a and 5-HT1b receptors in the dorsal hippocampus and cortex of the rat. Neuroendocrinology 55, 444-450.
41. Mitchell J. B., Rowe W., Boksa P. and Meaney M. (1990) Serotonin regulates type II corticosteroid receptor binding in hippocampal cell cultures. J. Neurosci. 10, 1745-1752.
42. Murphy D. L. (1990) Neuropsychiatrie disorders and the multiple human brain 5HT receptor subtypes and subsystems. Neuropharmacology 3, 457-471.
43. Nash J. F., Meltzer H. Y. and Gudelsky G. A. (1988) Elevation of serum prolactin and corticosterone concentrations in the rat after the administration of 3,4-methylenedioxymethamphetamine. J. Pharmac. exp. Ther. 245, 873-879.
44. Novotney S. and Lowy M. T. (1995) Short-term and long-term effects of p-chloroamphetamine on hippocampal serotonin and corticosteroid receptor levels. Brain Res. 684, 19-25.
45. O'Hearn E., Battaglia G., DeSouza E. B., Kuhar M. J. and Molliver M. E. (1988) Methylenedioxyamphetamine (MDA) and methylenedioxymethamphetamine (MDMA) cause selective ablation of serotonergic axon terminals in forebrain: immunocytochemical evidence for neurotoxicity. J. Neurosci. 8, 2788-2803.
46. Oitzl M. S. and de Kloet E. R. (1992) Selective corticosteroid antagonists modulate specific aspects of spatial orientation learning. Behav. Neurosci. 106, 62-71.
47. Olsson T., Mohammed A. H., Donaldson L. F., Henriksson B. G. and Seckl J. R. (1994) Glucocorticoid receptor and NGFI-A gene expression are induced in the hippocampus after environmental enrichment in adult rats. Molec. Brain Res. 23, 349-353.
48. Pavlides C., Watanabe Y. and McEwen B. S. (1993) Effects of glucocorticoids on hippocampal long-term potentiation. Hippocampus 3, 183-192.
49. Reul J. M. H. M., Pearce P. T., Funder J. W. and Krozowski Z. S. (1989) Type I and type II corticosteroid receptor gene expression in the rat: effect of adrenalectomy and dexamethasone administration. Molec. Endocr. 3, 1680-1689.
50. Reul J. M. H. M., Stec I., Söder M. and Holsboer F. (1993) Chronic treatment of rats with the antidepressant amitriptyline attenuates the activity of the hypothalamic-pituitary-adrenocortical system. Endocrinology 133, 312-320.
51. Ricaurte G. A., Finnegan K. T., Irwin I. and Langston J. W. (1990) Aminergic metabolites in cerebrospinal fluid of humans previously exposed to MDMA: preliminary observations. Ann. N. Y. Acad. Sci. 600, 699-708.
52. Sakai N. and Tanaka C. (1993) Inhibitory modulation of long-term potentiation via the 5-HT1A receptor in slices of the rat hippocampal dentate gyrus. Brain Res. 613, 326-330.
53. Schmidt C. J. (1987) Neurotoxicity of the psychedelic amphetamine, methylenedioxymethamphetamine. J. Pharmac. exp. Ther. 240, 1-7.
54. Seckl J. R. and Fink G. (1992) Antidepressants increase glucocorticoid and mineralocorticoid receptor mRNA expression in the rat hippocampus in vivo. Neuroendocrinology 55, 621-626.
55. Seckl J. R. and Olsson T. (1995) Glucocorticoids and the age-impaired hippocampus: cause or effect? J. Endocr. 145, 201-211.
56. Siegel R. A., Weidenfeld J., Chen M., Feldman S., Melamed E. and Chowers I. (1983) Hippocampal cell nuclear binding of corticosterone following 5,7-dihydroxytryptamine. Molec. Cell Endocr. 31, 253-259.
57. Sik A., Yinen A., Penttonen M. and Buzsaki G. (1994) Inhibitory CAl-CA3-Hilar region feedback in the hippocampus. Science 265, 1722-1724.
58. Stone D. M., Merchant K. M., Hanson G. R. and Gibb J. W. (1987) Immediate and long-term effects of 3,4-methylenedioxymethamphetamine on serotonin pathways in brain of rat. Neuropharmacology 26, 1677-1683.
59. Teyler T. J. and Discenna P. (1984) The topological anatomy of the hippocampus: a clue to its function. Brain Res. Bull. 12, 711-719.
60. Yau J. L. W., Kelly P. A. T., Sharkey J. and Seckl J. R. (1994) Chronic 3,4-methylenedioxymethamphetamine (MDMA) administration decreases glucocorticoid and mineralocorticoid receptor but increases 5-HT1C receptor gene expression in the rat hippocampus. Neuroscience 61, 31-40.
61. Yau J. L. W., Olsson T., Morris R. G. M., Meaney M. J. and Seckl J. R. (1995) Glucocorticoids, hippocampal corticosteroid receptor gene expression and antidepressant treatment: relationship with spatial learning in young and aged rats. Neuroscience 66, 571-581.
62. Zhong P. and Ciaranello R. D. (1995) Transcriptional regulation of hippocampal 5-HT1a receptors by corticosteroid hormones. Molec. Brain Res. 29, 23-34.