Defects in Saccharomyces cerevisiae protein phosphatase type I activate the spindle/kinetochore checkpoint

Genes and Development

Volumn 13, Issue 5, 1999, Pages 517-522

  Bloecher, Andrew ^a   Tatchell, Kelly ^a  

^a LOUISIANA STATE UNIV MEDICAL CENTER   (United States)

Author keywords

Checkpoint; Kinetochore; Mitotic spindle; Protein phosphatase I; Yeast

Indexed keywords

PHOSPHOPROTEIN PHOSPHATASE;

ARTICLE; CELL CYCLE; CENTROMERE; ENZYME ACTIVITY; MITOSIS; MITOSIS SPINDLE; NONHUMAN; PRIORITY JOURNAL; SACCHAROMYCES CEREVISIAE;

SACCHAROMYCES CEREVISIAE;

EID: 0033105613     PISSN: 08909369     EISSN: None     Source Type: Journal    
DOI: 10.1101/gad.13.5.517     Document Type: Article

References (37)

1. Axton, J.M., V. Dombradi, P.T.W. Cohen, and D.M. Glover. 1990. One of the protein phosphatase 1 isoenzymes in Drosophila is essential for mitosis. Cell 63: 33-46.
2. Baker, S.H., D.L. Frederick, A. Bloecher, and K. Tatchell. 1997. Alanine scanning mutagenesis of protein phosphatase type 1 in the yeast Saccharomyces cerevisiae. Genetics 145: 615-626.
3. Bradford, M.M. 1976. Rapid and sensitive method for quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem. 72: 248-254.
4. Chen, R.H., J.C. Waters, E.D. Salmon, and A.W. Murray. 1996. Association of spindle assembly checkpoint component XMAD2 with unattached kinetochores. Science 274: 242-246.
5. Doonan, J.H. and N.R. Morris. 1989. The bimG gene of Aspergillus nidulans, required for completion of anaphase, encodes a homolog of mammalian phosphoprotein phosphatase 1. Cell 57: 987-996.
6. Fang, G., H. Yu, and M.W. Kirschner. 1998. The checkpoint protein MAD2 and the mitotic regulator CDC20 form a ternary complex with the anaphase-promoting complex to control anaphase initiation. Genes & Dev. 12: 1871-1883.
7. Fernandez, A., D.L. Brautigan, and N.J.C. Lamb. 1992. Protein phosphatase type 1 in mammalian cell mitosis: Chromosome localization and involvement in mitotic exit. J. Cell Biol. 116: 1421-1430.
8. Gorbsky, G.J. and W.A. Ricketts. 1993. Differential expression of a phosphoepitope at the kinetochores of moving chromosomes. J. Cell Biol. 122: 1311-1321.
9. Hardwick, K.G. 1998. The spindle checkpoint. Trends. Genet. 14: 1-4.
10. Hisamoto, N., K. Sugimoto, and K. Matsumoto. 1994. The Glc7 type 1 protein phosphatase of Saccharomyces cerevisiae is required for cell cycle progression in G2/M. Mol. Cell. Biol 14: 3158-3165.
11. Hoyt, M.A., L. Totis, and B.T. Roberts. 1991. S. cerevisiae genes required for cell cycle arrest in response to loss of microtubule function. Cell 66: 507-517.
12. Hubbard, M.J. and P. Cohen. 1993. On target with a new mechanism for the regulation of protein phosphorylation. Trends Biochem. Sci. 18: 172-177.
13. Ishii, K., K. Kumada, T. Toda, and M. Yanagida. 1996. Requirement for PP1 phosphatase and 20S cyclosome/APC for the onset of anaphase is lessened by the dosage increase of a novel gene sds23+. EMBO J. 15: 6629-6640.
14. Jiang, W., M.Y. Lim, H.J. Yoon, J. Thomer, G.S. Martin, and J. Carbon. 1995. Overexpression of the yeast MCK1 protein kinase suppresses conditional mutations in centromere-binding protein genes CBF2 and CBF5. Mol. Gen. Genet. 246: 360-366.
15. Kahana, J.A., B.J. Schnapp, and P.A. Silver. 1995. Kinetics of spindle pole body separation in budding yeast. Ptoc. Natl. Acad. Sci. 92: 9707-9711.
16. Kaplan, K.B., A.A. Hyman, and P.K. Sorger. 1997. Regulating the yeast kinetochore by ubiquitin-dependent degradation and Skp1p-mediated phosphorylation. Cell 91: 491-500.
17. Lechner, J. and J. Carbon. 1991. A 240 kd multisubunit protein complex, CBF3, is a major component of the budding yeast centromere. Cell 64: 717-725.
18. Li, R. and A.W. Murray. 1991. Feedback control of mitosis in budding yeast. Cell 66: 519-531.
19. Li, Y. and R. Benezra. 1996. Identification of a human mitotic checkpoint gene: hsMAD2. Science 274: 246-248.
20. MacKelvie, S.H., P.D. Andrews, and M.J.R. Stark. 1995. The Saccharomyces cerevisiae gene SDS22 encodes a potential regulator of the mitotic function of yeast type 1 protein phosphatase. Mol. Cell. Biol. 15: 3777-3785.
21. Osborne, M.A., G. Schlenstedt, T. Jinks, and P.A. Silver. 1994. Nuf2, a spindle pole body-associated protein required for nuclear division in yeast. J. Cell Biol. 125: 853-866.
22. Pangilinan, F. and F. Spencer. 1996. Abnormal kinetochore structure activates the spindle assembly checkpoint in budding yeast. Mol. Biol. Cell 7: 1195-1208.
23. Perier, F. and J. Carbon. 1992. A colony color assay for Saccharomyces cerevisiae mutants defective in kinetochore structure and function. Genetics 132: 39-51.
24. Rudner, A.D. and A.W. Murray. 1996. The spindle assembly checkpoint. Curr. Opin. Cell Biol. 8: 773-780.
25. Sassoon, I., F.F. Severin, P.A. Andrews, M. Taba, K.B. Kaplan, A.J. Ashford, M.J.R. Stark, P.K. Sorger, and A.A. Hyman. 1999. Regulation of yeast Saccharomyces cerevisiae kinetochores by the type 1 phosphatase Glc7p. Genes & Dev. (this issue).
26. Sikorski, R.S. and P. Hieter. 1989. A system of shuttle vectors and yeast host strains designed for efficient manipulation of DNA in Saccharomyces cerevisiae. Genetics 122: 19-27.
27. Stark, M.J.R. 1996. Yeast protein serine/threonine phsophatases: Multiple roles and diverse regulation. Yeast 12: 1647-1675.
28. Straight, A.F. 1997. Cell cycle: Checkpoint proteins and kinetochores. Curr. Biol. 7: 613-616.
29. Straight, A.F., W.F. Marshall, J.W. Sedat, and A.W. Murray. 1997. Mitosis in living budding yeast: Anaphase A but no metaphase plate. Science 277: 574-578.
30. Stuart, J.S., D.L. Frederick, C.M. Vamer, and K. Tatchell. 1994. The mutant type 1 protein phosphatase encoded by glc7-1 from Saccharomyces cerevisiae fails to interact productively with the GAC1-encoded regulatory subunit. Mol. Cell. Biol. 14: 896-905.
31. Surana, U., A. Amon, C. Dowzer, J. McGrew, B. Byers, and K. Nasmyth. 1993. Destruction of the CDC28/CLB mitotic kinase is not required for the metaphase to anaphase transition in budding yeast. EMBO J. 12: 1969-1978.
32. Taylor, S.S. and F. McKeon. 1997. Kinetochore localization of murine Bub1 is required for normal mitotic timing and checkpoint response to spindle damage. Cell 89: 727-735.
33. Tournebize, R., S.S. Andersen, F. Verde, M. Doree, E. Karsenti, and A.A. Hyman. 1997. Distinct roles of PP1 and PP2A-like phosphatases in control of microtubule dynamics during mitosis. EMBO J. 16: 5537-5549.
34. Tu, J. and M. Carlson. 1995. REG1 binds to protein phosphatase type 1 and regulates glucose repression in Saccharomyces cerevisiae. EMBO J. 14: 5939-5946.
35. Waddle, J.A., T.S. Karpova, R.H. Waterston, and J.A. Cooper. 1996. Movement of cortical actin patches in yeast. J. Cell Biol. 132: 861-870.
36. Wang, Y. and D.J. Burke. 1995. Checkpoint genes required to delay cell division in response to nocodazole respond to impaired kinetochore function in the yeast Saccharomyces cerevisiae. Mol. Cell. Biol. 15: 6838-6844.
37. Yeh, E., R.V. Skibbens, J.W. Cheng, E.D. Salmon, and K. Bloom. 1995. Spindle dynamics and cell cycle regulation of dynein in the budding yeast, Saccharomyces cerevisae. J. Cell Biol. 130: 687-700.