Lipophilic thiamine treatment in long-standing insulin-dependent diabetes mellitus

Acta Diabetologica

Volumn 36, Issue 1-2, 1999, Pages 73-76

  Valerio, G ^a   Franzese, A ^b   Poggi, V ^c   Patrini, C ^d   Laforenza, U ^d   Tenore, A ^a  

^a Department of Pediatrics ^*  (Italy)

^b UNIVERSITY OF NAPLES FEDERICO II   (Italy)

^c Pausilipon Hospital   (Italy)

^d UNIVERSITY OF PAVIA   (Italy)

Author keywords

Lipophilic thiamine; Thiamine; Type 1 diabetes

Indexed keywords

ANTIDIABETIC AGENT; BENTIAMINE; C PEPTIDE; DIAGNOSTIC AGENT; DRUG DERIVATIVE; GLUCAGON; GLYCOSYLATED HEMOGLOBIN; INSULIN; PLACEBO; THIAMINE; THIAMINE PHOSPHATE;

ADOLESCENT; ARTICLE; BLOOD; CHILD; CLINICAL TRIAL; COMPARATIVE STUDY; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; HUMAN; INSULIN DEPENDENT DIABETES MELLITUS; METABOLISM; ONSET AGE; PRESCHOOL CHILD; RANDOMIZED CONTROLLED TRIAL; REFERENCE VALUE; TIME;

ADOLESCENT; AGE OF ONSET; C-PEPTIDE; CHILD; CHILD, PRESCHOOL; DIABETES MELLITUS, TYPE 1; DOUBLE-BLIND METHOD; GLUCAGON; HEMOGLOBIN A, GLYCOSYLATED; HUMANS; HYPOGLYCEMIC AGENTS; INSULIN; PLACEBOS; REFERENCE VALUES; THIAMINE; THIAMINE MONOPHOSPHATE; TIME FACTORS;

EID: 0033139349     PISSN: 09405429     EISSN: None     Source Type: Journal    
DOI: 10.1007/s005920050148     Document Type: Article

References (21)

1. Rathanaswami R, Sundaresan R (1991) Effects of thiamine deficiency on the biosynthesis of insulin in rats. Biochem Int 24:1057-1062
2. Rathanaswami R, Pourany A, Sundaresan R (1991) Effects of thiamine deficiency on the secretion of insulin and the metabolism of glucose in isolated rat pancreatic islets. Biochem Int 25:577-583
3. Rogers LE, Porter FS, Sidbury JB (1969) Thiamine-responsive megaloblastic anemia. J Pediatr 74:494-504
4. Viana MB, Carvalho RI (1978) Thiamine-responsive megaloblastic anemia, sensorineural deafness, and diabetes mellitus: a new syndrome? J Pediatr 93:235-238
5. Haworth C, Evans DJK, Mitra J, Wickramasinhe SN (1982) Thiamine responsive anaemia: a study of two further cases. Br J Haematol 50:549-561
6. Mandel H, Berant M, Hazani A, Naven Y (1984) Thiamine dependent beriberi in the "thiamine-responsive anaemia syndrome". N Engl J Med 311:836-838
7. Abboud MR, Alexander D, Najar SS (1985) Diabetes mellitus, thiamine dependent megaloblastic anemia and sensorineural deafness associated with deficient α-ketoglutarate dehydrogenase activity. J Pediatr 107:537-541
8. Tenconi F, Bertoncelli M, Gatti F, Rosso C (1983) A novel vitamin B1 derivative: benzoyl-oxymethyl-thiamine (BT831). Boll Chim Farm 122:27-44
9. Poggi V, Rindi G, Patrini C, De Vizia B, Longo G, Andria G (1989) Studies on thiamine metabolism in thiamine-responsive megaloblastic anaemia. Eur J Pediatr 148:307-311
10. Rindi G, Casirola D, Poggi V, De Vizia B, Patrini C, Laforenza U (1992) Thiamine transport by erythrocytes and ghosts in thiamine responsive megaloblastic anaemia. J Inherit Metab Dis 15:231-242
11. Rindi G, Patrini C, Laforenza U, Mandel H, Berant M, Viana MB, Poggi V, Zarra ANF (1994) Further studies on erythrocytes thiamin transport and phosphorylation in seven patients with thiamin-responsive megaloblastic anaemia. J Inherit Metab Dis 17:667-677
12. Mandel H, Berant M, Vardi P, Laforenza U, Patrini C, Rindi G (1994) The diabetes in thiamine responsive megaloblastic anemia syndrome: a model for the role of thiamine in glucose transport and insulin biosynthesis. VI International Congress "Inborn Errors of Metabolism". Milan (Italy), May 27-31 (abstr)
13. Marshall WA, Tanner JM (1969) Variations in the pattern of pubertal changes in girls. Arch Dis Child 44:291-303
14. Marshall WA, Tanner JM (1970) Variations in the pattern of pubertal changes in boys. Arch Dis Child 45:12-23
15. Bettendorff L, Grandfils C, De Rycker C, Schoffeniels, E (1986) Determination of thiamine and its phosphate esters in human blood serum at femtomole levels. J Chromatr 382:297-302
16. Funk C (1922) The vitamins. Williams & Wilkins, Baltimore, p 388
17. Valerio G, Franzese A, Poggi V, Tenore A (1998) Long term follow-up in two patients with the thiamine responsive megaloblastic anemia syndrome. Diabetes Care 91:38-41
18. Haugen HN (1964) The blood concentration of thiamine in diabetes. Scand J Clin Lab Investig 16:260-266
19. Hobara R, Ozawa K, Okazaki M, Yasuhara H (1981) Relationship between thiamine and glucose levels in diabetes mellitus. Jpn J Pharmacol 31:1098-1100
20. Kodentsova VM, Vrezhesinskaia OA, Sokol'nikov AA, Kharitonchik LA, Spirichev VB (1993) Metabolism of B group vitamins in patients with insulin-dependent and non-insulin dependent forms of diabetes mellitus. Vopr Med Khim 39:26-29
21. Cook JS, Hoffman RP, Stene MA, Hansen JR (1993) Effects of maturational stage of insulin sensitivity during puberty. J Clin Endocrinol Metab 77:725-730