-
1
-
-
33645693409
-
A synthetic triterpenoid, CDDO-Me, inhibits IkappaBalpha kinase and enhances apoptosis induced by TNF and chemotherapeutic agents through down-regulation of expression of nuclear factor kappaB-regulated gene products in human leukemic cells
-
Shishodia S, Sethi G, Konopleva M et al. A synthetic triterpenoid, CDDO-Me, inhibits IkappaBalpha kinase and enhances apoptosis induced by TNF and chemotherapeutic agents through down-regulation of expression of nuclear factor kappaB-regulated gene products in human leukemic cells. Clin Cancer Res 2006; 12: 1828-38.
-
(2006)
Clin Cancer Res
, vol.12
, pp. 1828-1838
-
-
Shishodia, S.1
Sethi, G.2
Konopleva, M.3
-
2
-
-
0033214236
-
Cleavage of the death domain kinase RIP by caspase-8 prompts TNF-induced apoptosis
-
Lin Y, Devin A, Rodriguez Y et al. Cleavage of the death domain kinase RIP by caspase-8 prompts TNF-induced apoptosis. Genes Dev 1999; 13: 2514-26.
-
(1999)
Genes Dev
, vol.13
, pp. 2514-2526
-
-
Lin, Y.1
Devin, A.2
Rodriguez, Y.3
-
3
-
-
34547896623
-
Elevated NF-kappaB responses and FLIP levels in leukemic but not normal lymphocytes: reduction by salicylate allows TNF-induced apoptosis
-
Rae C, Langa S, Tucker SJ et al. Elevated NF-kappaB responses and FLIP levels in leukemic but not normal lymphocytes: reduction by salicylate allows TNF-induced apoptosis. Proc Natl Acad Sci USA 2007; 104: 12790-5.
-
(2007)
Proc Natl Acad Sci USA
, vol.104
, pp. 12790-12795
-
-
Rae, C.1
Langa, S.2
Tucker, S.J.3
-
4
-
-
4444376712
-
Signaling to NF-kappaB
-
Hayden MS, Ghosh S. Signaling to NF-kappaB. Genes Dev 2004; 18: 2195-224.
-
(2004)
Genes Dev
, vol.18
, pp. 2195-2224
-
-
Hayden, M.S.1
Ghosh, S.2
-
5
-
-
0036203419
-
The phosphorylation status of nuclear NF-kappa B determines its association with CBP/p300 or HDAC-1
-
Zhong H, May MJ, Jimi E et al. The phosphorylation status of nuclear NF-kappa B determines its association with CBP/p300 or HDAC-1. Mol Cell 2002; 9: 625-36.
-
(2002)
Mol Cell
, vol.9
, pp. 625-636
-
-
Zhong, H.1
May, M.J.2
Jimi, E.3
-
6
-
-
0037011056
-
Acetylation of RelA at discrete sites regulates distinct nuclear functions of NF-kappaB
-
Chen LF, Mu Y, Greene WC. Acetylation of RelA at discrete sites regulates distinct nuclear functions of NF-kappaB. EMBO J 2002; 21: 6539-48.
-
(2002)
EMBO J
, vol.21
, pp. 6539-6548
-
-
Chen, L.F.1
Mu, Y.2
Greene, W.C.3
-
7
-
-
0032508414
-
NF-kappaB antiapoptosis: induction of TRAF1 and TRAF2 and c-IAP1 and c-IAP2 to suppress caspase-8 activation
-
Wang CY, Mayo MW, Korneluk RG et al. NF-kappaB antiapoptosis: induction of TRAF1 and TRAF2 and c-IAP1 and c-IAP2 to suppress caspase-8 activation. Science (New York, NY) 1998; 281: 1680-3.
-
(1998)
Science (New York, NY)
, vol.281
, pp. 1680-1683
-
-
Wang, C.Y.1
Mayo, M.W.2
Korneluk, R.G.3
-
8
-
-
0034743199
-
NF-kappaB signals induce the expression of c-FLIP
-
Micheau O, Lens S, Gaide O et al. NF-kappaB signals induce the expression of c-FLIP. Mol Cell Biol 2001; 21: 5299-305.
-
(2001)
Mol Cell Biol
, vol.21
, pp. 5299-5305
-
-
Micheau, O.1
Lens, S.2
Gaide, O.3
-
9
-
-
22144432216
-
Mitochondrial reactive oxygen species regulate the temporal activation of nuclear factor kappaB to modulate tumour necrosis factor-induced apoptosis: evidence from mitochondria-targeted antioxidants
-
Hughes G, Murphy MP, Ledgerwood EC. Mitochondrial reactive oxygen species regulate the temporal activation of nuclear factor kappaB to modulate tumour necrosis factor-induced apoptosis: evidence from mitochondria-targeted antioxidants. Biochem J 2005; 389: 83-9.
-
(2005)
Biochem J
, vol.389
, pp. 83-89
-
-
Hughes, G.1
Murphy, M.P.2
Ledgerwood, E.C.3
-
10
-
-
33749341552
-
TNF receptor superfamily-induced cell death: redox-dependent execution
-
Shen HM, Pervaiz S. TNF receptor superfamily-induced cell death: redox-dependent execution. FASEB J 2006; 20: 1589-98.
-
(2006)
FASEB J
, vol.20
, pp. 1589-1598
-
-
Shen, H.M.1
Pervaiz, S.2
-
11
-
-
13244249801
-
2 production as a mechanism for cell type-specific inhibition of tumor necrosis factor alpha-induced but not interleukin-1beta-induced IkappaB kinase complex/nuclear factor-kappaB activation
-
2 production as a mechanism for cell type-specific inhibition of tumor necrosis factor alpha-induced but not interleukin-1beta-induced IkappaB kinase complex/nuclear factor-kappaB activation. J Biol Chem 2005; 280: 2912-23.
-
(2005)
J Biol Chem
, vol.280
, pp. 2912-2923
-
-
Panopoulos, A.1
Harraz, M.2
Engelhardt, J.F.3
-
12
-
-
33947265925
-
A quantitative study of NF-kappaB activation by H2O2: relevance in inflammation and synergy with TNF-alpha
-
de Oliveira-Marques V, Cyrne L, Marinho HS, Antunes F. A quantitative study of NF-kappaB activation by H2O2: relevance in inflammation and synergy with TNF-alpha. J Immunol 2007; 178: 3893-902.
-
(2007)
J Immunol
, vol.178
, pp. 3893-3902
-
-
de Oliveira-Marques, V.1
Cyrne, L.2
Marinho, H.S.3
Antunes, F.4
-
13
-
-
0035929670
-
Cytokine-induced activation of nuclear factor-kappa B is inhibited by hydrogen peroxide through oxidative inactivation of IkappaB kinase
-
Korn SH, Wouters EF, Vos N et al. Cytokine-induced activation of nuclear factor-kappa B is inhibited by hydrogen peroxide through oxidative inactivation of IkappaB kinase. J Biol Chem 2001; 276: 35693-700.
-
(2001)
J Biol Chem
, vol.276
, pp. 35693-35700
-
-
Korn, S.H.1
Wouters, E.F.2
Vos, N.3
-
14
-
-
68949213938
-
Redox regulation of tumor necrosis factor signaling
-
Han D, Ybanez MD, Ahmadi S et al. Redox regulation of tumor necrosis factor signaling. Antioxid Redox Signal 2009; 11: 2245-63.
-
(2009)
Antioxid Redox Signal
, vol.11
, pp. 2245-2263
-
-
Han, D.1
Ybanez, M.D.2
Ahmadi, S.3
-
15
-
-
33645801376
-
Effects of flavonoids extracted from Scutellaria baicalensis Georgi on hemin-nitrite-H2O2 induced liver injury
-
Zhao Y, Li H, Gao Z et al. Effects of flavonoids extracted from Scutellaria baicalensis Georgi on hemin-nitrite-H2O2 induced liver injury. Eur J Pharmacol 2006; 536: 192-9.
-
(2006)
Eur J Pharmacol
, vol.536
, pp. 192-199
-
-
Zhao, Y.1
Li, H.2
Gao, Z.3
-
16
-
-
0036166889
-
Antiviral Chinese medicinal herbs against respiratory syncytial virus
-
Ma SC, Du J, But PP et al. Antiviral Chinese medicinal herbs against respiratory syncytial virus. J Nat Prod 2002; 79: 205-11.
-
(2002)
J Nat Prod
, vol.79
, pp. 205-211
-
-
Ma, S.C.1
Du, J.2
But, P.P.3
-
17
-
-
0030950634
-
Effects of flavonoids isolated from scutellariae radix on fibrinolytic system induced by trypsin in human umbilical vein endothelial cells
-
Kimura Y, Okuda H, Ogita Z. Effects of flavonoids isolated from scutellariae radix on fibrinolytic system induced by trypsin in human umbilical vein endothelial cells. J Nat Prod 1997; 60: 598-601.
-
(1997)
J Nat Prod
, vol.60
, pp. 598-601
-
-
Kimura, Y.1
Okuda, H.2
Ogita, Z.3
-
18
-
-
0141852335
-
Effects of wogonin, a plant flavone from Scutellaria radix, on skin inflammation: in vivo regulation of inflammation-associated gene expression
-
Chi YS, Lim H, Park H et al. Effects of wogonin, a plant flavone from Scutellaria radix, on skin inflammation: in vivo regulation of inflammation-associated gene expression. Biochem Pharmacol 2003; 66: 1271-8.
-
(2003)
Biochem Pharmacol
, vol.66
, pp. 1271-1278
-
-
Chi, Y.S.1
Lim, H.2
Park, H.3
-
19
-
-
43049090780
-
Role of p53, PUMA, and Bax in wogonin-induced apoptosis in human cancer cells
-
Lee DH, Kim C, Zhang L et al. Role of p53, PUMA, and Bax in wogonin-induced apoptosis in human cancer cells. Biochem Pharmacol 2008; 75: 2020-33.
-
(2008)
Biochem Pharmacol
, vol.75
, pp. 2020-2033
-
-
Lee, D.H.1
Kim, C.2
Zhang, L.3
-
21
-
-
38349057321
-
Anticancer effects of wogonin in both estrogen receptor-positive and -negative human breast cancer cell lines in vitro and in nude mice xenografts
-
Chung H, Jung YM, Shin DH et al. Anticancer effects of wogonin in both estrogen receptor-positive and -negative human breast cancer cell lines in vitro and in nude mice xenografts. Int J Cancer 2008; 122: 816-22.
-
(2008)
Int J Cancer
, vol.122
, pp. 816-822
-
-
Chung, H.1
Jung, Y.M.2
Shin, D.H.3
-
22
-
-
33845258748
-
Wogonin sensitizes resistant malignant cells to TNFalpha- and TRAIL-induced apoptosis
-
Fas SC, Baumann S, Zhu JY et al. Wogonin sensitizes resistant malignant cells to TNFalpha- and TRAIL-induced apoptosis. Blood 2006; 108: 3700-6.
-
(2006)
Blood
, vol.108
, pp. 3700-3706
-
-
Fas, S.C.1
Baumann, S.2
Zhu, J.Y.3
-
23
-
-
0037081782
-
Wogonin and fisetin induce apoptosis in human promyeloleukemic cells, accompanied by a decrease of reactive oxygen species, and activation of caspase 3 and Ca(2+)-dependent endonuclease
-
Lee WR, Shen SC, Lin HY et al. Wogonin and fisetin induce apoptosis in human promyeloleukemic cells, accompanied by a decrease of reactive oxygen species, and activation of caspase 3 and Ca(2+)-dependent endonuclease. Biochem Pharmacol 2002; 63: 225-36.
-
(2002)
Biochem Pharmacol
, vol.63
, pp. 225-236
-
-
Lee, W.R.1
Shen, S.C.2
Lin, H.Y.3
-
24
-
-
31544470589
-
17-allylamino-17-demethoxygeldanamycin synergistically potentiates tumor necrosis factor-induced lung cancer cell death by blocking the nuclear factor-kappaB pathway
-
Wang X, Ju W, Renouard J et al. 17-allylamino-17-demethoxygeldanamycin synergistically potentiates tumor necrosis factor-induced lung cancer cell death by blocking the nuclear factor-kappaB pathway. Cancer Res 2006; 66: 1089-95.
-
(2006)
Cancer Res
, vol.66
, pp. 1089-1095
-
-
Wang, X.1
Ju, W.2
Renouard, J.3
-
25
-
-
34247512973
-
A critical role of luteolin-induced reactive oxygen species in blockage of tumor necrosis factor-activated nuclear factor-kappaB pathway and sensitization of apoptosis in lung cancer cells
-
Ju W, Wang X, Shi H et al. A critical role of luteolin-induced reactive oxygen species in blockage of tumor necrosis factor-activated nuclear factor-kappaB pathway and sensitization of apoptosis in lung cancer cells. Mol Pharmacol 2007; 71: 1381-8.
-
(2007)
Mol Pharmacol
, vol.71
, pp. 1381-1388
-
-
Ju, W.1
Wang, X.2
Shi, H.3
-
26
-
-
77952355889
-
Oxidants positively or negatively regulate nuclear factor kappaB in a context-dependent manner
-
Loukili N, Rosenblatt-Velin N, Rolli J et al. Oxidants positively or negatively regulate nuclear factor kappaB in a context-dependent manner. J Biol Chem 2010; 285: 15746-52.
-
(2010)
J Biol Chem
, vol.285
, pp. 15746-15752
-
-
Loukili, N.1
Rosenblatt-Velin, N.2
Rolli, J.3
-
27
-
-
72549111131
-
The NF-kappaB activation pathways, emerging molecular targets for cancer prevention and therapy
-
Lin Y, Bai L, Chen W et al. The NF-kappaB activation pathways, emerging molecular targets for cancer prevention and therapy. Expert Opin Ther Tar 2010; 14: 45-55.
-
(2010)
Expert Opin Ther Tar
, vol.14
, pp. 45-55
-
-
Lin, Y.1
Bai, L.2
Chen, W.3
-
28
-
-
0036016874
-
Wogonin and fisetin induction of apoptosis through activation of caspase 3 cascade and alternative expression of p21 protein in hepatocellular carcinoma cells SK-HEP-1
-
Chen YC, Shen SC, Lee WR et al. Wogonin and fisetin induction of apoptosis through activation of caspase 3 cascade and alternative expression of p21 protein in hepatocellular carcinoma cells SK-HEP-1. Arch Toxicol 2002; 76: 351-9.
-
(2002)
Arch Toxicol
, vol.76
, pp. 351-359
-
-
Chen, Y.C.1
Shen, S.C.2
Lee, W.R.3
-
29
-
-
33750331488
-
Wogonin suppresses TNF-alpha-induced MMP-9 expression by blocking the NF-kappaB activation via MAPK signaling pathways in human aortic smooth muscle cells
-
Lee SO, Jeong YJ, Yu MH et al. Wogonin suppresses TNF-alpha-induced MMP-9 expression by blocking the NF-kappaB activation via MAPK signaling pathways in human aortic smooth muscle cells. Biochem Biophys Res Commun 2006; 351: 118-25.
-
(2006)
Biochem Biophys Res Commun
, vol.351
, pp. 118-125
-
-
Lee, S.O.1
Jeong, Y.J.2
Yu, M.H.3
-
30
-
-
54549104761
-
Wogonin inhibits microglial cell migration via suppression of nuclear factor-kappa B activity
-
Piao HZ, Choi IY, Park JS et al. Wogonin inhibits microglial cell migration via suppression of nuclear factor-kappa B activity. Int Immunopharmacol 2008; 8(12): 1658-62.
-
(2008)
Int Immunopharmacol
, vol.8
, Issue.12
, pp. 1658-1662
-
-
Piao, H.Z.1
Choi, I.Y.2
Park, J.S.3
-
31
-
-
0038166129
-
Effects of baicalin, baicalein, and wogonin on interleukin-6 and interleukin-8 expression, and nuclear factor-kappab binding activities induced by interleukin-1beta in human retinal pigment epithelial cell line
-
Nakamura N, Hayasaka S, Zhang XY et al. Effects of baicalin, baicalein, and wogonin on interleukin-6 and interleukin-8 expression, and nuclear factor-kappab binding activities induced by interleukin-1beta in human retinal pigment epithelial cell line. Exp Eye Res 2003; 77(2): 195-202.
-
(2003)
Exp Eye Res
, vol.77
, Issue.2
, pp. 195-202
-
-
Nakamura, N.1
Hayasaka, S.2
Zhang, X.Y.3
-
32
-
-
6444223595
-
Insufficient p65 phosphorylation at S536 specifically contributes to the lack of NF-kappaB activation and transformation in resistant JB6 cells
-
Hu J, Nakano H, Sakurai H et al. Insufficient p65 phosphorylation at S536 specifically contributes to the lack of NF-kappaB activation and transformation in resistant JB6 cells. Carcinogenesis 2004; 25(10): 1991-2003.
-
(2004)
Carcinogenesis
, vol.25
, Issue.10
, pp. 1991-2003
-
-
Hu, J.1
Nakano, H.2
Sakurai, H.3
-
33
-
-
4544224979
-
Inhibition of NF-kappaB in cancer cells converts inflammation-induced tumor growth mediated by TNFalpha to TRAIL-mediated tumor regression
-
Luo JL, Maeda S, Hsu LC et al. Inhibition of NF-kappaB in cancer cells converts inflammation-induced tumor growth mediated by TNFalpha to TRAIL-mediated tumor regression. Cancer Cell 2004; 6(3): 297-305.
-
(2004)
Cancer Cell
, vol.6
, Issue.3
, pp. 297-305
-
-
Luo, J.L.1
Maeda, S.2
Hsu, L.C.3
-
34
-
-
55149097289
-
Tumor necrosis factor and cancer, buddies or foes?
-
Wang X, Lin Y. Tumor necrosis factor and cancer, buddies or foes? Acta Pharmacol Sin 2008; 29(11): 1275-88.
-
(2008)
Acta Pharmacol Sin
, vol.29
, Issue.11
, pp. 1275-1288
-
-
Wang, X.1
Lin, Y.2
-
35
-
-
4644324186
-
NF-kappaB functions as a tumour promoter in inflammation-associated cancer
-
Pikarsky E, Porat RM, Stein I et al. NF-kappaB functions as a tumour promoter in inflammation-associated cancer. Nature 2004; 431(7007): 461-6.
-
(2004)
Nature
, vol.431
, Issue.7007
, pp. 461-466
-
-
Pikarsky, E.1
Porat, R.M.2
Stein, I.3
|