Oral administration of ginsenoside Rh1 inhibits the development of atopic dermatitis-like skin lesions induced by oxazolone in hairless mice

International Immunopharmacology

Volumn 11, Issue 4, 2011, Pages 511-518

  Zheng, Hua ^a   Jeong, Yunju ^a   Song, Jeongmin ^a   Ji, Geun Eog ^a,b  

^a Seoul National University   (South Korea)

^b Bifido Co   (South Korea)

Author keywords

Atopic dermatitis; Cytokine; Ginsenoside; Hairless mice; Oxazolone

Indexed keywords

GAMMA INTERFERON; GINSENOSIDE RH1; IMMUNOGLOBULIN E; INTERLEUKIN 4; INTERLEUKIN 6; OXAZOLONE; PREDNISOLONE; SAPONIN; TRANSCRIPTION FACTOR FOXP3; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ATOPIC DERMATITIS; CONTROLLED STUDY; DRUG MEGADOSE; DRUG STRUCTURE; DRY SKIN; EAR WEIGHT; EROSION; FEMALE; GENE EXPRESSION; HISTOPATHOLOGY; IMMUNOGLOBULIN BLOOD LEVEL; INFLAMMATORY INFILTRATE; MAST CELL DEGRANULATION; MOUSE; NONHUMAN; ORGAN WEIGHT; OTITIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; SKIN BLEEDING; SPLEEN WEIGHT;

ADMINISTRATION, ORAL; ANIMALS; DERMATITIS, ATOPIC; DISEASE MODELS, ANIMAL; FORKHEAD TRANSCRIPTION FACTORS; GINSENOSIDES; IMMUNOGLOBULIN E; IMMUNOLOGIC FACTORS; INTERFERON-GAMMA; INTERLEUKIN-6; LYMPH NODES; MICE; MICE, HAIRLESS; MOLECULAR STRUCTURE; OXAZOLONE; SKIN;

EID: 79952737043     PISSN: 15675769     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.intimp.2010.12.022     Document Type: Article

References (47)

1. Cork MJ, Danby SG, Vasilopoulos Y, Hadgraft J, Lane ME, Moustafa M, et al. Epidermal barrier dysfunction in atopic dermatitis. J Invest Dermatol 2009;129: 1892-908.
2. Leung DYM, Bieber T. Atopic dermatitis. Lancet 2003;361:151-60. (Pubitemid 36092023)
3. von Mutius E. The environmental predictors of allergic disease. J Allergy Clin Immunol 2000;105:9-19.
4. Lewis-Jones S. Quality of life and childhood atopic dermatitis: the misery of living with childhood eczema. Int J Clin Pract 2006;60:984-92. (Pubitemid 44082290)
5. Strachan DP. Hay fever, hygiene, and household size. Br Med J 1989;299:1259-60. (Pubitemid 19280051)
6. Emanuel MB. Hay fever, a post industrial revolution epidemic: a history of its growth during the 19th century. Clin Exp Allergy 1988;18:295-304.
7. Akdis M, Akdis C, Weigl L, Disch R, Blaser K. Skin-homing, CLA+ memory T cells are activated in atopic dermatitis and regulate IgE by an IL-13-dominated cytokine pattern: IgG4 counter-regulation by CLA-memory T cells. J Immunol 1997;159: 4611-9. (Pubitemid 127470624)
8. van Reijsen FC, Bruijnzeel-Koomen CAFM, Kalthoff FS, Maggi E, Romagnani S, Westland JKT, et al. Skin-derived aeroallergen-speci.c T-cell clones of Th2 phenotype in patients with atopic dermatitis. J Allergy Clin Immunol 1992;90:184-93.
9. Del Prete G, Maggi E, Parronchi P, Chretien I, Tiri A, Macchia D, et al. IL-4 is an essential factor for the IgE synthesis induced in vitro by human T cell clones and their supernatants. J Immunol 1988;140:4193-8.
10. Punnonen J, Aversa G, Cocks BG, McKenzie AN, Menon S, Zurawski G, et al. Interleukin 13 induces interleukin 4-independent IgG4 and IgE synthesis and CD23 expression by human B cells. Proc Natl Acad Sci USA 1993;90:3730-4. (Pubitemid 23111441)
11. Lopez AL, Sanderson CJ, Gamble JR, Campbell HD, Young IG, Vardas MA. Recombinant human interleukin 5 is a selective activator of human eosinophil function. J Exp Med 1988:167.
12. Kindt TJ, Goldsby RA, Osborne BA. Immunology. 6 ed. New York: W.H. Freeman and Company; 2007.
13. Szegedi A, Baráth S, Nagy G, Szodoray P, Gál M, Sipka S, et al. Regulatory T cells in atopic dermatitis: epidermal dendritic cell clusters may contribute to their local expansion. Br J Dermatol 2009;160:984-93.
14. Wing K, Sakaguchi S. Regulatory T cells exert checks and balances on self tolerance and autoimmunity. Nat Immunol 2010;11:7-13.
15. Kwon H-K, Lee C-G, So J-S, Chae C-S, Hwang J-S, Sahoo A, et al. Generation of regulatory dendritic cells and CD4+Foxp3+ T cells by probiotics administration suppresses immune disorders. Proc Natl Acad Sci 2010;107:2159-64.
16. Matsuda H, Watanabe N, Geba GP, Sperl J, Tsudzuki M, Hiroi J, et al. Development of atopic dermatitis-like skin lesion with IgE hyperproduction in NC/Nga mice. Int Immunol 1997;9:461-6. (Pubitemid 27113270)
17. Aioi A, Tonogaito H, Suto H, Hamada K, Ra C, Ogawa H, et al. Impairment of skin barrier function in NC/Nga Tnd mice as a possible model for atopic dermatitis. Br J Dermatol 2001;144:12-8. (Pubitemid 32154587)
18. Chan LS, Robinson N, Xu L. Expression of Interleukin-4 in the Epidermis of Transgenic Mice Results in a Pruritic Inflammatory Skin Disease: An Experimental Animal Model to Study Atopic Dermatitis. 2001;117:977-83.
19. Konishi H, Tsutsui H, Murakami T, Yumikura-Futatsugi S, Yamanaka K-i, Tanaka M, et al. IL-18 contributes to the spontaneous development of atopic dermatitis-like inflammatory skin lesion independently of IgE/stat6 under specific pathogen-free conditions. Proc Natl Acad Sci USA 2002;99:11340-5. (Pubitemid 34920927)
20. Matsuoka H, Maki N, Yoshida S, Arai M, Wang J, Oikawa Y, et al. A mouse model of the atopic eczema/dermatitis syndrome by repeated application of a crude extract of house-dust mite Dermatophagoides farinae. Allergy 2003;58:139-45. (Pubitemid 36359833)
21. Gao XK, Nakamura N, Fuseda K, Tanaka H, Inagaki N, Nagai H. Establishment of allergic dermatitis in NC/Nga mice as a model for severe atopic dermatitis. Biol Pharm Bull 2004;27:1376-81. (Pubitemid 41701678)
22. Kang JS, Lee K, Han SB, Ahn JM, Lee H, Han MH, et al. Induction of atopic eczema/ dermatitis syndrome-like skin lesions by repeated topical application of a crude extract of Dermatophagoides pteronyssinus in NC/Nga mice. Int Immunopharmacol 2006;6:1616-22. (Pubitemid 44216203)
23. Matsumoto K, Mizukoshi K, Oyobikawa M, Ohshima H, Tagami H. Establishment of an atopic dermatitis-like skin model in a hairless mouse by repeated elicitation of contact hypersensitivity that enables to conduct functional analyses of the stratum corneum with various non-invasive biophysical instruments. Skin Res Technol 2004;10:122-9. (Pubitemid 38559514)
24. Lee JH, Jung K-M, Bae I-H, Cho S, Seo D-B, Lee S-J, et al. Anti-inflammatory and barrier protecting effect of Lithospermum erythrorhizon extracts in chronic oxazolone-induced murine atopic dermatitis. J Dermatol Sci 2009;56:64-6.
25. Man M-Q, Hatano Y, Lee SH, Man M, Chang S, Feingold KR, et al. Characterization of a hapten-induced, murine model with multiple features of atopic dermatitis: structural, immunologic, and biochemical changes following single versus multiple oxazolone challenges. J Invest Dermatol 2007;128:79-86. (Pubitemid 350249387)
26. Kim T-H, Jung J-A, Kim G-D, Jang A-H, Cho J-J, Park YS, et al. The histone deacetylase inhibitor, trichostatin A, inhibits the development of 2, 4-dinitro-fluorobenzene-induced dermatitis in NC/Nga mice. Int Immunopharmacol 2010;10:1310-5.
27. Park E-K, Choo M-K, Han MJ, Kim D-H. Ginsenoside Rh1 possesses antiallergic and anti-inflammatory activities; 2004.
28. Kim M, Kwon B, Park M, Ji G. Isolation of ginsenoside Rh1 and compound K from fermented ginseng and efficacy assessment on systemic anaphylactic shock. Food Sci Biotechnol 2008 17:000.
29. Jung J-S, Kim D-H, Kim H-S. Ginsenoside Rh1 suppresses inducible nitric oxide synthase gene expression in IFN-[gamma]-stimulated microglia via modulation of JAK/STAT and ERK signaling pathways. Biochem Biophys Res Commun 2010;397: 323-8.
30. Park YC, Lee CH, Kang HS, Kim KW, Chung HT, Kim HD. Ginsenoside-Rh1 and Rh2 inhibit the induction of nitric oxide synthesis in murine peritoneal macrophages. IUBMB Life 1996;40:751-7. (Pubitemid 26396032)
31. Mark B, Donald YML. Recent insights into atopic dermatitis and implications for management of infectious complications. J Allergy Clin Immunol 2010;125:4-13.
32. Leung DYM, Boguniewicz M, Howell MD, Nomura I, Hamid QA. New insights into atopic dermatitis. J Clin Investig 2004;113:651-7. (Pubitemid 38544154)
33. Joo SS, Won TJ, Nam SY, Kim YB, Lee YC, Park SY, et al. Therapeutic advantages of medicinal herbs fermented with Lactobacillus plantarum, in topical application and its activities on atopic dermatitis. Phytother Res 2009;23:913-9.
34. Oshio T, Sasaki Y, Funakoshi-Tago M, Aizu-Yokota E, Sonoda Y, Matsuoka H, et al. Dermatophagoides farinae extract induces severe atopic dermatitis in NC/Nga mice, which is effectively suppressed by the administration of tacrolimus ointment. Int Immunopharmacol 2009;9:403-11.
35. Jiang J, Yamaguchi T, Funakushi N, Kuhara T, Fan P-s, Ueki R. Oral administration of Yokukansan inhibits the development of atopic dermatitis-like lesions in isolated NC/Nga mice. J Dermatol Sci 2009;56:37-42.
36. Leung DYM. Atopic dermatitis: the skin as a window into the pathogenesis of chronic allergic diseases. J Allergy Clin Immunol 1995;96:302-19.
37. Renz H, Jujo K, Bradley KL, Domenico J, Gelfand EW, Leung DYM. Enhanced IL-4 production and IL-4 receptor expression in atopic dermatitis and their modulation by interferon-gamma. J Investig Dermatol 1992;99:403-8.
38. Reinhold U, Pawelec G, Wehrmann W, Herold M, Wernet P, Kreysel HW. Immunoglobulin E and immunoglobulin G subclass distribution in vivo and relationship to in vitro generation of interferon-gamma and neopterin in patients with severe atopic dermatitis. Int Arch Allergy Immunol 1988;87:120-6. (Pubitemid 18265989)
39. Byung Hun Kim•Jae Youl C. Regulatory effect of ginsenosides Rh1 on monocytic U937 cell adhesion. J Ginseng Res 2009;33:324-9.
40. Yong-Wook Shin E-AB, Sung-Soo Kim, Young-Chul Lee, Boo-Young Lee, Dong- Hyun Kim. The effects of ginsenoside Re and its metabolite, ginsenoside Rh1, on 12-o-tetradecanoylphorbol 13-acetate- and oxazolone-induced mouse dermatitis models. Planta Med 2006;72:376-8.
41. Da Silva JAP, Jacobs JWG, Kirwan JR, Boers M, Saag KG, Inês LBS, et al. Safety of low dose glucocorticoid treatment in rheumatoid arthritis: published evidence and prospective trial data. Ann Rheum Dis 2006;65:285-93. (Pubitemid 43268214)
42. Ishihara K., Hirano T. IL-6 in autoimmune disease and chronic inflammatory proliferative disease. Cytokine & Growth Factor Reviews. 13:357-68.
43. Gabay C. Interleukin-6 and chronic inflammation. Arthritis Res Ther 2006;8:S3.
44. Yun M-Y, Yang J-H, Kim D-K, Cheong K-J, Song H-H, Kim D-H, et al. Therapeutic effects of Baicalein on atopic dermatitis-like skin lesions of NC/Nga mice induced by Dermatophagoides pteronyssinus. Int Immunopharmacol 2010;10:1142-8.
45. Ziegler SF. FOXP3: of mice and men. Annu Rev Immunol 2006;24:209-26.
46. Weaver CT, Hatton RD. Interplay between the TH17 and TReg cell lineages: a (co-) evolutionary perspective. Nat Rev Immunol 2009;9:883-9.
47. Samanta A, Li B, Song X, Bembas K, Zhang G, Katsumata M, et al. TGF-β and IL-6 signals modulate chromatin binding and promoter occupancy by acetylated FOXP3. Proc Natl Acad Sci 2008;105:14023-7.