4-hydroxy-2-nonenal upregulates and phosphorylates cytosolic phospholipase A2 in cultured Ra2 microglial cells via MAPK pathways

Neuropathology

Volumn 31, Issue 2, 2011, Pages 122-128

  Shibata, Noriyuki ^a   Kato, Yoichiro ^a   Inose, Yuri ^b   Hiroi, Atsuko ^a   Yamamoto, Tomoko ^a   Morikawa, Shunichi ^c   Sawada, Makoto ^d   Kobayashi, Makio ^a  

^a Departments of Pathology   (Japan)

^b Neurology ^*  (Japan)

^c TOKYO WOMEN'S MEDICAL UNIVERSITY   (Japan)

^d NAGOYA UNIVERSITY   (Japan)

Author keywords

4 hydroxy 2 nonenal; Amyotrophic lateral sclerosis; Microglia; Oxidative stress; Phospholipase A2

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; 4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; 4 HYDROXYNONENAL; ACETYLCYSTEINE; AMINO ACID; CYTOSOLIC PHOSPHOLIPASE A2; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE P38;

AMYOTROPHIC LATERAL SCLEROSIS; ANIMAL CELL; ARTICLE; CONTROLLED STUDY; CYTOPLASM; ENZYME PHOSPHORYLATION; IMMUNOBLOTTING; IMMUNOCYTOCHEMISTRY; IN VITRO STUDY; MICROGLIA; NONHUMAN; OPTICAL DENSITY; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; SIGNAL TRANSDUCTION; UPREGULATION; WESTERN BLOTTING;

ALDEHYDES; ANIMALS; BLOTTING, WESTERN; CELL LINE; CYTOSOL; ENZYME ACTIVATION; GROUP IV PHOSPHOLIPASES A2; IMMUNOHISTOCHEMISTRY; LIPID PEROXIDATION; MICE; MICROGLIA; MITOGEN-ACTIVATED PROTEIN KINASES; OXIDATIVE STRESS; PHOSPHORYLATION; SIGNAL TRANSDUCTION; UP-REGULATION;

EID: 79952731286     PISSN: 09196544     EISSN: 14401789     Source Type: Journal    
DOI: 10.1111/j.1440-1789.2010.01139.x     Document Type: Article

References (36)

1. 2 enzymes. Prostaglandins Other Lipid Mediat 2002; 68-69: 3-58.
2. 2 in oxidative and inflammatory responses in neurodegenerative diseases. J Neurochem 2007; 103: 1-16.
3. 2. Annu Rev Pharmacol Toxicol 1999; 39: 175-189.
4. 2. J Biol Chem 1999; 274: 5163-5169.
5. 2 and transactivation of cyclooxygenase-2. J Neurochem 1999; 73: 1641-1649.
6. Paris D, Town T, Mullan M. Novel strategies for apposing murine microglial activation. Neurosci Lett 2000; 278: 5-8.
7. Goodall EF, Morison KE. Amyotrophic lateral sclerosis (motor neuron disease): proposed mechanisms and pathways to treatment. Expert Rev Mol Med 2006; 8: 1-22.
8. Rothstein JD. Current hypotheses for the underlying biology of amyotrophic lateral sclerosis. Ann Neurol 2009; 65 (Suppl): S3-S9.
9. Almer G, Guégan C, Teismann P etal. Increased expression of the proinflammatory enzyme cyclooxygenase-2 in amyotrophic lateral sclerosis. Ann Neurol 2001; 49: 176-185.
10. Klivenyl P, Kiaei M, Gardian G, Calingasan NY, Beal MF. Additive neuroprotective effects of creatine and cyclooxygenase 2 inhibitors in a transgenic mouse model of amyotrophic lateral sclerosis. J Neurochem 2004; 88: 576-582.
11. Shibata N, Nagai R, Uchida K etal. Morphological evidence for lipid peroxidation and protein glycoxidation in spinal cords from sporadic amyotrophic lateral sclerosis patients. Brain Res 2001; 917: 97-104.
12. 2 in the spinal cord of patients with sporadic amyotrophic lateral sclerosis. Acta Neuropathol 2010; 119: 345-354.
13. 2 with COX-2 and the effect of non-steroidal anti-inflammatory drugs in a transgenic mouse model of amyotrophic lateral sclerosis. J Neurochem 2005; 93: 403-411.
14. Barber SC, Mead RJ, Shaw PJ. Oxidative stress in ALS: a mechanism of neurodegeneration and a therapeutic target. Biochim Biophys Acta 2006; 1762: 1051-1067.
15. Kasarskis EJ, Tandon L, Lovell MA, Ehmann WD. Alminium, calcium, and iron in the spinal cord of patients with sporadic amyotrophic lateral sclerosis using laser microprobe mass spectroscopy: a preliminary study. J Neurol Sci 1995; 130: 203-208.
16. Jeong SY, Rathore KI, Schulz K, Ponka P, Arosio P, David S. Dysregulation of iron homeostasis in the CNS contributes to disease progression in a mouse model of amyotrophic lateral sclerosis. J Neurosci 2009; 29: 610-619.
17. 2. Free Radic Biol Med 2003; 34: 1531-1543.
18. 2. Cell Death Differ 2004; 11: 974-984.
19. 2 mediate amyloid-β peptide-induced mitochondrial dysfunction. J Neurosci 2006; 26: 11111-11119.
20. 2 level and arachidonic acid release via nitric oxide in APP-transfected PC12 cells. Acta Biochim Pol 2007; 43: 611-623.
21. 2. Biochim Biophys Acta 2008; 1778: 2512-2519.
22. 1-42 in microglia. Glia 2009; 57: 1727-1740.
23. Ito S, Sawada M, Haneda M etal. Amyloid-β peptides induce cell proliferation and macrophage colony-stimulating factor expression via the PI3-kinase/Akt pathway in cultured Ra2 microglial cells. FEBS Lett 2005; 579: 1995-2000.
24. Sapan CV, Lundblad RL, Price NC. Colorimetric protein assay techniques. Biotechnol Appl Biochem 1999; 29: 99-108.
25. Uchida K. 4-Hydroxy-2-nonenal: a product and mediator of oxidative stress. Prog Lipid Res 2003; 42: 318-343.
26. Kumagai T, Matsukawa N, Kaneko Y, Kusumi Y, Mitsumata M, Uchida K. A lipid peroxidation-derived inflammatory mediator. Identification of 4-hydroxy-2-nonenal as a potential inducer of cyclooxygenase-2 in macrophages. J Biol Chem 2004; 279: 48389-48396.
27. Lee SJ, Kim CE, Yun MR etal. 4-Hyxroxynonenal enhances MMP-9 production in murine macrophages via 5-lipoxygenase-mediated activation of ERK and p38 MAPK. Toxicol Appl Pharmacol 2010; 242: 191-198.
28. Iles KE, Liu R-M. Mechanisms of glutamate cysteine ligase (GCL) induction by 4-hydroxynonenal. Free Radic Biol Med 2005; 38: 547-556.
29. Kim C-Y, Lee C, Park GH, Jang J-H. Neuroprotective effect of epigallocatechin-3-gallate against β-amyloid-induced oxidative stress and nitrosative cell death via augmentation of antioxidant defense capacity. Arch Pharm Res 2009; 32: 869-881.
30. Palomba L, Cerioni L, Cantoni O. Arachidonic acid: a key molecule for astrocyte survival to peroxynitrite. Glia 2009; 57: 1672-1679.
31. Fukaya T, Gondaira T, Kashiyae Y etal. Arachidonic acid preserves hippocampal neuron membrane fluidity in senescent rats. Neurobiol Aging 2007; 28: 1179-1186.
32. Lazarewicz JW, Wroblewski JT, Costa E. N-Methyl-D-aspartate-sensitive glutamate receptors induce calcium-mediated arachidonic acid release in primary cultures of cerebellar granule cells. J Neurochem 1990; 55: 1875-1881.
33. 2: a necessary step in long-term potentiation? Proc Natl Acad Sci USA 1991; 88: 1893-1897.
34. Miller B, Sarantis M, Traynelis SF, Attwell D. Potentiation of NMDA receptor currents by arachidonic acid. Nature 1992; 355: 722-725.
35. Stella N, Tence M, Glowinski J, Premont J. Glutamate-evoked release of arachidonic acid from mouse brain astrocytes. J Neurosci 1994; 14: 568-575.
36. 2, cyclooxygenase, and lipoxygenase. Glia 2004; 48: 102-111.