Synthesis, anticonvulsant and toxicity screening of thiazolyl-thiadiazole derivatives

Medicinal Chemistry Research

Volumn 20, Issue 2, 2011, Pages 261-268

  Siddiqui, Nadeem ^a   Ahsan, Waquar ^a  

^a HAMDARD UNIVERSITY   (India)

Author keywords

Anticonvulsant activity; Hepatotoxicity; Neurotoxicity; Thiadiazole; Thiazole

Indexed keywords

ANTICONVULSIVE AGENT; CARBAMAZEPINE; ETHOSUXIMIDE; N (2 METHOXYPHENYL) N' (4 PHENYL 1,3 THIAZOL 2 YL) 1,3,4 THIADIAZOLE 2,5 DIAMINE; N (2 METHOXYPHENYL) N' [4 (4 NITROPHENYL) 1,3 THIAZOL 2 YL] 1,3,4 THIADIAZOLE 2,5 DIAMINE; N (2 METHYLPHENYL) N' 4 (PHENYL 1,3 THIAZOL 2 YL) 1,3,4 THIADIAZOLE 2,5 DIAMINE; N (2 METHYLPHENYL) N' [4 (4 NITROPHENYL) 1,3 THIAZOL 2 YL] 1,3,4 THIADIAZOLE 2,5 DIAMINE; N (4 METHOXYPHENYL) N' (4 PHENYL 1,3 THIAZOL 2 YL) 1,3,4 THIADIAZOLE 2,5 DIAMINE; N (4 METHOXYPHENYL) N' [4 (4 NITROPHENYL) 1,3 THIAZOL 2 YL] 1,3,4 THIADIAZOLE 2,5 DIAMINE; N (4 METHYLPHENYL) N' (4 PHENYL 1,3 THIAZOL 2 YL) 1,3,4 THIADIAZOLE 2,5 DIAMINE; N (4 METHYLPHENYL) N' [4 (4 NITROPHENYL) 1,3 THIAZOL 2 YL] 1,3,4 THIADIAZOLE 2,5 DIAMINE; N [4 (4 BROMOPHENYL)THIAZOL 2 YL] N' (2 METHOXYPHENYL) [1,3,4]THIADIAZOLE 2,5 DIAMINE; N [4 (4 BROMOPHENYL)THIAZOL 2 YL] N' (2 METHYLPHENYL) [1,3,4]THIADIAZOLE 2,5 DIAMINE; N [4 (4 BROMOPHENYL)THIAZOL 2 YL] N' (4 METHOXYPHENYL) [1,3,4]THIADIAZOLE 2,5 DIAMINE; N [4 (4 BROMOPHENYL)THIAZOL 2 YL] N' (4 METHYLPHENYL) [1,3,4]THIADIAZOLE 2,5 DIAMINE; N [4 (4 BROMOPHENYL)THIAZOL 2 YL] N' PHENYL[1,3,4]THIADIAZOLE 2,5 DIAMINE; N [4 (4 CHLOROPHENYL)THIAZOL 2 YL] N' (2 METHOXYPHENYL) [1,3,4]THIADIAZOLE 2,5 DIAMINE; N [4 (4 CHLOROPHENYL)THIAZOL 2 YL] N' (2 METHYLPHENYL) [1,3,4]THIADIAZOLE 2,5 DIAMINE; N [4 (4 CHLOROPHENYL)THIAZOL 2 YL] N' (4 METHYLPHENYL) [1,3,4]THIADIAZOLE 2,5 DIAMINE; N [4 (4 CHLOROPHENYL)THIAZOL 2 YL] N' (4 METHYOXPHENYL) [1,3,4]THIADIAZOLE 2,5 DIAMINE; N [4 (4 CHLOROPHENYL)THIAZOL 2 YL] N' PHENYL[1,3,4]THIADIAZOLE 2,5 DIAMINE; N [4 (4 NITROPHENYL)THIAZOL 2 YL] N' PHENYL[1,3,4]THIADIAZOLE 2,5 DIAMINE; N PHENYL N' (4 PHENYL 1,3 THIAZOL 2 YL) [1,3,4]THIADIAZOLE 2,5 DIAMINE; PENTETRAZOLE; PHENOBARBITAL; PHENYTOIN; THIADIAZOLE DERIVATIVE; THIAZOLYLTHIADIAZOLE DERIVATIVE; UNCLASSIFIED DRUG; VALPROIC ACID;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTICONVULSANT ACTIVITY; ARTICLE; DRUG SCREENING; DRUG SYNTHESIS; ELECTRIC SHOCK; IN VIVO STUDY; MALE; MOUSE; NEUROTOXICITY; NONHUMAN; PHYSICAL CHEMISTRY; SEIZURE; SUBSTITUTION REACTION; TOXICITY TESTING;

EID: 79952701822     PISSN: 10542523     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00044-010-9313-6     Document Type: Article

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