Benzothiazole incorporated barbituric acid derivatives: Synthesis and anticonvulsant screening

Archiv der Pharmazie

Volumn 342, Issue 8, 2009, Pages 462-468

  Siddiqui, Nadeem ^a   Ahsan, Waquar ^a  

^a HAMDARD UNIVERSITY   (India)

Author keywords

Anticonvulsants; Barbituric acid; Benzothiazole; Pyrimidinetriones

Indexed keywords

1 (2 METHOXYPHENYL) 3 (6 NITRO 1,3 BENZOTHIAZOL 2 YL)HEXAHYDRO 2,4,6 PYRIMIDINETRIONE; 1 (2 METHYLPHENYL) 3 (6 NITRO 1,3 BENZOTHIAZOL 2 YL)HEXAHYDRO 2,4,6 PYRIMIDINETRIONE; 1 (4 METHOXYPHENYL) 3 (6 NITRO 1,3 BENZOTHIAZOL 2 YL)HEXAHYDRO 2,4,6 PYRIMIDINETRIONE; 1 (4 METHYLPHENYL) 3 (6 NITRO 1,3 BENZOTHIAZOL 2 YL)HEXAHYDRO 2,4,6 PYRIMIDINETRIONE; 1 (6 BROMO 1,3 BENZOTHIAZOL 2 YL) 3 (2 METHOXYPHENYL)HEXAHYDRO 2,4,6 PYRIMIDINETRIONE; 1 (6 BROMO 1,3 BENZOTHIAZOL 2 YL) 3 (2 METHYLPHENYL)HEXAHYDRO 2,4,6 PYRIMIDINETRIONE; 1 (6 BROMO 1,3 BENZOTHIAZOL 2 YL) 3 (4 METHOXYPHENYL)HEXAHYDRO 2,4,6 PYRIMIDINETRIONE; 1 (6 BROMO 1,3 BENZOTHIAZOL 2 YL) 3 (4 METHYLPHENYL)HEXAHYDRO 2,4,6 PYRIMIDINETRIONE; 1 (6 BROMO 1,3 BENZOTHIAZOL 2 YL) 3 PHENYLHEXAHYDRO 2,4,6 PYRIMIDINETRIONE; 1 (6 CHLORO 1,3 BENZOTHIAZOL 2 YL) 3 (2 METHOXYPHENY)HEXAHYDRO 2,4,6 PYRIMIDINETRIONE; 1 (6 CHLORO 1,3 BENZOTHIAZOL 2 YL) 3 (2 METHYLPHENYL)HEXAHYDRO 2,4,6 PYRIMIDINETRIONE; 1 (6 CHLORO 1,3 BENZOTHIAZOL 2 YL) 3 (4 METHOXYPHENY)HEXAHYDRO 2,4,6 PYRIMIDINETRIONE; 1 (6 CHLORO 1,3 BENZOTHIAZOL 2 YL) 3 (4 METHYLPHENYL)HEXAHYDRO 2,4,6 PYRIMIDINETRIONE; 1 (6 CHLORO 1,3 BENZOTHIAZOL 2 YL) 3 PHENYLHEXAHYDRO 2,4,6 PYRIMIDINETRIONE; 1 (6 FLUORO 1,3 BENZOTHIAZOL 2 YL) 3 (2 METHOXYPHENYL)HEXAHYDRO 2,4,6 PYRIMIDINETRIONE; 1 (6 FLUORO 1,3 BENZOTHIAZOL 2 YL) 3 (2 METHYLPHENYL)HEXAHYDRO 2,4,6 PYRIMIDINETRIONE; 1 (6 FLUORO 1,3 BENZOTHIAZOL 2 YL) 3 (4 METHOXYPHENYL)HEXAHYDRO 2,4,6 PYRIMIDINETRIONE; 1 (6 FLUORO 1,3 BENZOTHIAZOL 2 YL) 3 (4 METHYLPHENYL)HEXAHYDRO 2,4,6 PYRIMIDINETRIONE; 1 (6 FLUORO 1,3 BENZOTHIAZOL 2 YL) 3 PHENYLHEXAHYDRO 2,4,6 PYRIMIDINETRIONE; 1 (6 NITRO 1,3 BENZOTHIAZOL 2 YL) 3 PHENYLHEXAHYDRO 2,4,6 PYRIMIDINETRIONE; ANILINE DERIVATIVE; ANTICONVULSIVE AGENT; BARBITURIC ACID DERIVATIVE; BENZOTHIAZOLE DERIVATIVE; CARBAMAZEPINE; ETHOSUXIMIDE; PENTETRAZOLE; PHENOBARBITAL; PHENYTOIN; UNCLASSIFIED DRUG; VALPROIC ACID;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTICONVULSANT ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG POTENCY; DRUG SAFETY; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; ELECTRIC SHOCK; LIPOPHILICITY; MOTOR DYSFUNCTION; MOUSE; NONHUMAN; PHARMACOPHORE; PRIORITY JOURNAL; SEIZURE; STRUCTURE ANALYSIS;

ANILINE COMPOUNDS; ANIMALS; ANTICONVULSANTS; BARBITURATES; BENZOTHIAZOLES; BINDING SITES; DRUG EVALUATION, PRECLINICAL; ELECTROSHOCK; MICE; MOTOR ACTIVITY; PENTYLENETETRAZOLE; SEIZURES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 68249132797     PISSN: 03656233     EISSN: 15214184     Source Type: Journal    
DOI: 10.1002/ardp.200900002     Document Type: Article

References (20)

1. S. R. Benbadis., W. O. Tatum, J. Clin. Neurophysiol. 2003, 20, 42-44.
2. J. R. Dimmock, S. N. Pandey, J. W. Quail, U. Pugazhenthi, et al., Eur. J. Med. Chem. 1995, 30, 303-314.
3. A. Agarwal, S. Lata, K. K. Saxena, V. K. Srivastava, A. Kumar, Eur. J. Med. Chem. 2006, 41, 1223-1229.
4. Archana, V. K. Srivastava, A. Kumar, Bioorg. Med. Chem. 2004, 12, 1257-1264.
5. I. Chulak, V. Sutorius, V. Sekerka, Chem. Pap. 1990, 44, 131-138.
6. M. Lacova, J. Chavancova, O. Hyblova, S. Varkonda, Chem. Pap. 1991, 45, 411-418.
7. T. Papenfuhs, Ger. Offen. De 1987, 3, 528-532.
8. N. Siddiqui, S. N. Pandeya, A. P. Sen, G. S. Singh, Pharmakeftiki 1992, 4, 121-125.
9. N. Siddiqui, S. N. Pandeya, S. A. Khan, J. P. Stables, Bioorg. Med. Chem. Lett. 2007, 17, 255-259.
10. N. Siddiqui, A. Rana, S. A. Khan, Bioorg. Med. Chem. Lett. 2007, 17, 4178-4182.
11. A. Rana, N. Siddiqui, S. A .Khan, S. E. Haque, M. A. Bhat, Eur. J. Med. Chem. 2008, 43, 1114-1122.
12. R. Thirumurugan, D. Sriram, A. Saxena, J. P. Stables, P. Yogeeswari, Bioorg. Med. Chem. 2006, 14, 3106-3112.
13. P. T. Flaherty, T. D. Greenwood, A. L. Manheim, J. F. Wolfe, J. Med. Chem. 1996, 39, 1509-1513.
14. U. Huseyin, V. D. Kim, C. Silvia, S. Santi, et al., J. Med. Chem. 1998, 41, 1138-1145.
15. E. J. Lien, R. C. H. Liuo, H. G. Shinoucla, J. Pharm. Sci. 1979, 68, 463-465.
16. Anticonvulsant Screening Project, Antiepileptic Drug Development Program; National Institute of Health, DHEW Publ (NIH) (US) 1978; pp. 78-1093.
17. C. Krall, J. K. Penny, B. G. White, H. G. Kupferberg, Epilepsia 1978, 19, 409-428.
18. G. N. Kelekci, S. Yabanoglu, E. Kupeli, U. Salgin, A. A. Bilgin, Bioorg. Med. Chem. 2007, 15, 5775-5786.
19. J. T. Litchfield, F. Wilcoxon, J. Pharmacol. Exp. Ther. 1949, 96, 99-113.
20. S. G. Kucukguzel, S. Rollas, Il Farmaco 2005, 57, 583-587.