Mechanisms involved in the expansion of Tregs during pregnancy: Role of IL-2/STAT5 signalling

Journal of Reproductive Immunology

Volumn 88, Issue 2, 2011, Pages 93-98

  Fainboim, L ^a,b,c   Arruvito, L ^a,b,c  

^a HOSPITAL DE CLÍNICAS JOSÉ DE SAN MARTÍN   (Argentina)

^b Facultad de Ciencias Naturales e Instituto M Lillo   (Argentina)

^c UNIVERSIDAD DE BUENOS AIRES   (Argentina)

Author keywords

Human reproduction; IL 2; Regulatory T cell; STAT 5

Indexed keywords

INTERLEUKIN 2; INTERLEUKIN 6; SEX HORMONE; STAT5 PROTEIN; TRANSCRIPTION FACTOR FOXP3;

ADAPTIVE IMMUNITY; ARTICLE; AUTOIMMUNITY; CD4+ CD25+ T LYMPHOCYTE; CELL DIFFERENTIATION; CELL EXPANSION; CELL INTERACTION; CHRONIC DISEASE; FEMALE; HUMAN; PATHOGENESIS; PREGNANCY; PRIORITY JOURNAL; REGULATORY T LYMPHOCYTE; SIGNAL TRANSDUCTION; T LYMPHOCYTE SUBPOPULATION; VIRUS INFECTION;

ANIMALS; CELL PROLIFERATION; FEMALE; GONADAL STEROID HORMONES; HUMANS; IMMUNE TOLERANCE; INTERLEUKIN-2; PREGNANCY; PREGNANCY COMPLICATIONS; SIGNAL TRANSDUCTION; STAT5 TRANSCRIPTION FACTOR; T-LYMPHOCYTES, REGULATORY;

EID: 79952694178     PISSN: 01650378     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jri.2010.12.007     Document Type: Article

References (54)

1. Aluvihare V.R., Kallikourdis M., et al. Regulatory T cells mediate maternal tolerance to the fetus. Nat. Immunol. 2004, 5(3):266-271.
2. Aoki C.A., Roifman C.M., et al. IL-2 receptor alpha deficiency and features of primary biliary cirrhosis. J. Autoimmun. 2006, 27(1):50-53.
3. + regulatory T cells during the follicular phase of the menstrual cycle: implications for human reproduction. J. Immunol. 2007, 178(4):2572-2578.
4. + cells in women with reproductive failure. J. Reprod. Immunol. 2009, 82(2):158-165.
5. Arruvito L., Sotelo A.I., et al. A physiological role for inducible FOXP3(+) Treg cells. Lessons from women with reproductive failure. Clin. Immunol. 2010, 136(3):432-441.
6. Baek K.H., Lee E.J., et al. Recurrent pregnancy loss: the key potential mechanisms. Trends Mol. Med. 2007, 13(7):310-317.
7. Bluestone J.A., Abbas A.K. Natural versus adaptive regulatory T cells. Nat. Rev. Immunol. 2003, 3(3):253-257.
8. Brix T.H., Kyvik K.O., et al. A population-based study of chronic autoimmune hypothyroidism in Danish twins. J. Clin. Endocrinol. Metab. 2000, 85(2):536-539.
9. + regulatory T cells. J. Immunol. 2007, 178(1):280-290.
10. + CD25(high) T cells in human STAT5b deficiency. J. Immunol. 2006, 177(5):2770-2774.
11. + T regulatory cells. J. Immunol. 2007, 178(7):4022-4026.
12. +CD25 T cells. J. Immunol. 2007, 179(4):2041-2045.
13. Fainboim L., Navarrete C., et al. Precursor and effector phenotypes of activated human T lymphocytes. Nature 1980, 288(5789):391-393.
14. + Tregs by limiting STAT-5 phosphorylation in patients chronically infected with HCV. J. Clin. Invest. 2009, 119(3):551-564.
15. Heikkinen J., Mottonen M., et al. Phenotypic characterization of regulatory T cells in the human decidua. Clin. Exp. Immunol. 2004, 136(2):373-378.
16. +CD25high T cells gives rise to homogeneous regulatory T-cell lines upon in vitro expansion. Blood 2006, 108(13):4260-4267.
17. +CD25 bright regulatory T cells and CTLA-4 expression in peripheral and decidual lymphocytes are down-regulated in human miscarriage. Clin. Immunol. 2009, 133(3):402-410.
18. Kahn D.A., Baltimore D. Pregnancy induces a fetal antigen-specific maternal T regulatory cell response that contributes to tolerance. Proc. Natl. Acad. Sci. U.S.A. 2010, 107(20):9299-9304.
19. Kallikourdis M., Betz A.G. Periodic accumulation of regulatory T cells in the uterus: preparation for the implantation of a semi-allogeneic fetus?. PLoS One 2007, 2(4):e382.
20. Kishimoto T. Interleukin-6 and its receptor in autoimmunity. J. Autoimmun. 1992, 5(Suppl. A):123-132.
21. Long S.A., Cerosaletti K., et al. Defects in IL-2R signaling contribute to diminished maintenance of FOXP3 expression in CD4(+)CD25(+) regulatory T-cells of type 1 diabetic subjects. Diabetes 2010, 59(2):407-415.
22. Longhi M.P., Wright K., et al. Interleukin-6 is crucial for recall of influenza-specific memory CD4 T cells. PLoS Pathog. 2008, 4(2):e1000006.
23. Malek T.R. The biology of interleukin-2. Annu. Rev. Immunol. 2008, 26:453-479.
24. + regulatory T cells. J. Exp. Med. 2005, 201(7):1061-1067.
25. + T cells expressing the FoxP3 transcription factor. Immunity 2009, 30(6):899-911.
26. + Tregs in human second trimester pregnancy is induced by progesterone and 17beta-estradiol. J. Immunol. 2009, 183(1):759-769.
27. + regulatory T cells and T helper 1, T helper 2, and T helper 17 cells in human early pregnancy decidua. Biol. Reprod. 2010, 82(4):698-705.
28. Murray P.J. The JAK-STAT signaling pathway: input and output integration. J. Immunol. 2007, 178(5):2623-2629.
29. Ochanuna Z., Geiger-Maor A., et al. Inhibition of effector function but not T cell activation and increase in FoxP3 expression in T cells differentiated in the presence of PP14. PLoS One 2010, 5(9):e12868.
30. + T cell IFN-gamma expression, and NK cells: a physiological role for testosterone and/or its metabolites. Am. J. Physiol. Endocrinol. Metab. 2006, 290(5):E856-E863.
31. + T cell-mediated suppression by dendritic cells. Science 2003, 299(5609):1033-1036.
32. + regulatory T cell compartment. J. Immunol. 2004, 173(4):2227-2230.
33. Polanczyk M.J., Hopke C., et al. Estrogen-mediated immunomodulation involves reduced activation of effector T cells, potentiation of Treg cells, and enhanced expression of the PD-1 costimulatory pathway. J. Neurosci. Res. 2006, 84(2):370-378.
34. Rai R., Regan L. Recurrent miscarriage. Lancet 2006, 368(9535):601-611.
35. + T regulatory cell pool and induces tolerance to paternal alloantigens in mice. Biol. Reprod. 2009, 80(5):1036-1045.
36. + regulatory T cells in early pregnancy subjects and spontaneous abortion cases. Mol. Hum. Reprod. 2004, 10(5):347-353.
37. Schumacher A., Wafula P.O., et al. Mechanisms of action of regulatory T cells specific for paternal antigens during pregnancy. Obstet. Gynecol. 2007, 110(5):1137-1145.
38. + regulatory T-cell subset. Immunology 2004, 112(1):38-43.
39. Steinborn A., Haensch G.M., et al. Distinct subsets of regulatory T cells during pregnancy: is the imbalance of these subsets involved in the pathogenesis of preeclampsia?. Clin. Immunol. 2008, 129(3):401-412.
40. Strieder T.G., Drexhage H.A., et al. A reduced IL2R (CD25) expression level in first and second degree female relatives of autoimmune thyroid disease patients. A sign of a poor capability to preserve tolerance?. Autoimmunity 2006, 39(2):93-98.
41. Tai P., Wang J., et al. Induction of regulatory T cells by physiological level estrogen. J. Cell Physiol. 2008, 214(2):456-464.
42. Thuere C., Zenclussen M.L., et al. Kinetics of regulatory T cells during murine pregnancy. Am. J. Reprod. Immunol. 2007, 58(6):514-523.
43. +CD25bright regulatory T cells from the peripheral blood to the decidua in human pregnancy. J. Immunol. 2008, 180(8):5737-5745.
44. Tilburgs T., Scherjon S.A., et al. Fetal-maternal HLA-C mismatch is associated with decidual T cell activation and induction of functional T regulatory cells. J. Reprod. Immunol. 2009, 82(2):148-157.
45. + T cell regulatory functions. J. Immunol. 2007, 178(1):271-279.
46. Wilcox A.J., Weinberg C.R., et al. Incidence of early loss of pregnancy. N. Engl. J. Med. 1988, 319(4):189-194.
47. Yao Z., Kanno Y., et al. Nonredundant roles for Stat5a/b in directly regulating Foxp3. Blood 2007, 109(10):4368-4375.
48. + T regulatory cells prevents fetal rejection in a murine abortion model. Am. J. Pathol. 2005, 166(3):811-822.
49. + regulatory T cells. Nat. Med. 2005, 11(11):1238-1243.
50. Zhao J.X., Zeng Y.Y., et al. Fetal alloantigen is responsible for the expansion of the CD4(+)CD25(+) regulatory T cell pool during pregnancy. J. Reprod. Immunol. 2007, 75(2):71-81.
51. + regulatory T cells and for expansion of these cells. J. Immunol. 2007, 178(4):2018-2027.
52. + regulatory T cells induced by IL-2 and TGF-beta are resistant to Th17 conversion by IL-6. J. Immunol. 2008, 180(11):7112-7116.
53. Zinaman M.J., Clegg E.D., et al. Estimates of human fertility and pregnancy loss. Fertil. Steril. 1996, 65(3):503-509.
54. + regulatory T cells through a STAT-dependent mechanism and induces the expansion of these cells in vivo. Blood 2006, 108(5):1571-1579.