-
1
-
-
68949195832
-
-
Y. Lu, N. Yeung, N. Sieracki, N. M. Marshall, Nature 2009, 460, 855;
-
(2009)
Nature
, vol.460
, pp. 855
-
-
Lu, Y.1
Yeung, N.2
Sieracki, N.3
Marshall, N.M.4
-
2
-
-
0035471138
-
-
Y. Lu, S. M. Berry, T. D. Pfister, Chem. Rev. 2001, 101, 3047;
-
(2001)
Chem. Rev.
, vol.101
, pp. 3047
-
-
Lu, Y.1
Berry, S.M.2
Pfister, T.D.3
-
4
-
-
34250872269
-
-
M. D. Toscano, K. J. Woycechowsky, D. Hilvert, Angew. Chem. 2007, 119, 3274; Angew. Chem. Int. Ed. 2007, 46, 3212.
-
(2007)
Angew. Chem. 2007, 119, 3274; Angew. Chem. Int. Ed.
, vol.46
, pp. 3212
-
-
Toscano, M.D.1
Woycechowsky, K.J.2
Hilvert, D.3
-
6
-
-
21844434930
-
-
I. G. Denisov, T. M. Makris, S. G. Sligar, I. Schlichting, Chem. Rev. 2005, 105, 2253.
-
(2005)
Chem. Rev.
, vol.105
, pp. 2253
-
-
Denisov, I.G.1
Makris, T.M.2
Sligar, S.G.3
Schlichting, I.4
-
8
-
-
79952667925
-
-
SRSs are generally conserved among most CYP450s. Here the SRSs of CYP450 2C8, one of the principal drug-metabolizing CYP450 variants expressed in human liver and able to catalyze substrates of relatively large size, were chosen for the construction.
-
SRSs are generally conserved among most CYP450s. Here the SRSs of CYP450 2C8, one of the principal drug-metabolizing CYP450 variants expressed in human liver and able to catalyze substrates of relatively large size, were chosen for the construction.
-
-
-
-
9
-
-
0029643523
-
-
Y. Bai, T. R. Sosnick, L. Mayne, S. W. Englander, Science 1995, 269, 192;
-
(1995)
Science
, vol.269
, pp. 192
-
-
Bai, Y.1
Sosnick, T.R.2
Mayne, L.3
Englander, S.W.4
-
10
-
-
0038786579
-
-
M. M. Krishna, Y. Lin, J. N. Rumbley, S. W. Englander, J. Mol. Biol. 2003, 331, 29.
-
(2003)
J. Mol. Biol.
, vol.331
, pp. 29
-
-
Krishna, M.M.1
Lin, Y.2
Rumbley, J.N.3
Englander, S.W.4
-
11
-
-
79952681010
-
-
Models of the hybrids were created with the VMD program and energy-minimized with the aid of the NAMD program and then submitted to CASTp with a 1.4 Å probe radius server to identify pockets and cavities in hybrid proteins.
-
Models of the hybrids were created with the VMD program and energy-minimized with the aid of the NAMD program and then submitted to CASTp with a 1.4 Å probe radius server to identify pockets and cavities in hybrid proteins.
-
-
-
-
13
-
-
79952664710
-
-
See the Supporting Information.
-
See the Supporting Information.
-
-
-
-
14
-
-
0034640268
-
-
L. S. Koo, R. A. Tschirret-Guth, W. E. Straub, P. Moenne-Loccoz, T. M. Loehr, P. R. Ortiz de Montellano, J. Biol. Chem. 2000, 275, 14112.
-
(2000)
J. Biol. Chem.
, vol.275
, pp. 14112
-
-
Koo, L.S.1
Tschirret-Guth, R.A.2
Straub, W.E.3
Moenne-Loccoz, P.4
Loehr, T.M.5
Ortiz de Montellano, P.R.6
-
15
-
-
79952649119
-
-
2 and then analyzed by GC-MS.
-
2 and then analyzed by GC-MS.
-
-
-
-
16
-
-
27744433524
-
-
V. E. Kagan, V. A. Tyurin, J. Jiang, Y. Y. Tyurina, V. B. Ritov, A. A. Amoscato, A. N. Osipov, N. A. Belikova, A. A. Kapralov, V. Kini, I. I. Vlasova, Q. Zhao, M. Zou, P. Di, D. A. Svistunenko, I. V. Kurnikov, G. G. Borisenko, Nat. Chem. Biol. 2005, 1, 223.
-
(2005)
Nat. Chem. Biol.
, vol.1
, pp. 223
-
-
Kagan, V.E.1
Tyurin, V.A.2
Jiang, J.3
Tyurina, Y.Y.4
Ritov, V.B.5
Amoscato, A.A.6
Osipov, A.N.7
Belikova, N.A.8
Kapralov, A.A.9
Kini, V.10
Vlasova, I.I.11
Zhao, Q.12
Zou, M.13
Di, P.14
Svistunenko, D.A.15
Kurnikov, I.V.16
Borisenko, G.G.17
-
17
-
-
68149136523
-
-
T. Ying, Z. H. Wang, Y. W. Lin, J. Xie, X. Tan, Z. X. Huang, Chem. Commun. 2009, 4512.
-
(2009)
Chem. Commun.
, pp. 4512
-
-
Ying, T.1
Wang, Z.H.2
Lin, Y.W.3
Xie, J.4
Tan, X.5
Huang, Z.X.6
-
18
-
-
79952656114
-
-
All tests were carried out in Pi buffer (100 mM, pH 6.0) with a stopped-flow apparatus thermostatted at 25°C.
-
All tests were carried out in Pi buffer (100 mM, pH 6.0) with a stopped-flow apparatus thermostatted at 25°C.
-
-
-
-
19
-
-
33645892004
-
-
T. M. Makris, K. von Koenig, I. Schlichting, S. G. Sligar, J. Inorg. Biochem. 2006, 100, 507.
-
(2006)
J. Inorg. Biochem.
, vol.100
, pp. 507
-
-
Makris, T.M.1
von Koenig, K.2
Schlichting, I.3
Sligar, S.G.4
-
21
-
-
4644275807
-
-
B. Meunier, S. P. de Visser, S. Shaik, Chem. Rev. 2004, 104, 3947;
-
(2004)
Chem. Rev.
, vol.104
, pp. 3947
-
-
Meunier, B.1
de Visser, S.P.2
Shaik, S.3
-
22
-
-
84892305135
-
-
3rd ed. (Ed.: P. R. Ortiz de Montellano), Kluwer Academic/Plenum, New York
-
T. M. Makris, I. Denisov, I. Schlichting, S. G. Sligar in Cytochrome P450: Structure, Mechanism, and Biochemistry, 3rd ed. (Ed.: P. R. Ortiz de Montellano), Kluwer Academic/Plenum, New York, 2005, pp. 149-182.
-
(2005)
Cytochrome P450: Structure, Mechanism, and Biochemistry
, pp. 149-182
-
-
Makris, T.M.1
Denisov, I.2
Schlichting, I.3
Sligar, S.G.4
-
23
-
-
0034642204
-
-
P. A. Loughran, L. J. Roman, A. E. Aitken, R. T. Miller, B. S. Masters, Biochemistry 2000, 39, 15110;
-
(2000)
Biochemistry
, vol.39
, pp. 15110
-
-
Loughran, P.A.1
Roman, L.J.2
Aitken, A.E.3
Miller, R.T.4
Masters, B.S.5
-
24
-
-
2942711686
-
-
O. Kerdpin, D. J. Elliot, S. L. Boye, D. J. Birkett, K. Yoovathaworn, J. O. Miners, Biochemistry 2004, 43, 7834;
-
(2004)
Biochemistry
, vol.43
, pp. 7834
-
-
Kerdpin, O.1
Elliot, D.J.2
Boye, S.L.3
Birkett, D.J.4
Yoovathaworn, K.5
Miners, J.O.6
-
25
-
-
51849095469
-
-
J. S. Kartha, K. W. Skordos, H. Sun, C. Hall, L. M. Easterwood, C. A. Reilly, E. F. Johnson, G. S. Yost, Biochemistry 2008, 47, 9756.
-
(2008)
Biochemistry
, vol.47
, pp. 9756
-
-
Kartha, J.S.1
Skordos, K.W.2
Sun, H.3
Hall, C.4
Easterwood, L.M.5
Reilly, C.A.6
Johnson, E.F.7
Yost, G.S.8
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