Single mutations change CYP2F3 from a dehydrogenase of 3-methylindole to an oxygenase

Biochemistry

Volumn 47, Issue 37, 2008, Pages 9756-9770

  Kartha, Jaya S ^a,c   Skordos, Konstantine W ^a,d   Sun, Hao ^a,e   Hall, Clifton ^a   Easterwood, LaHoma M ^a,f   Reilly, Christopher A ^a   Johnson, Eric F ^b   Yost, Garold S ^a  

^a UNIVERSITY OF UTAH   (United States)

^b SCRIPPS RESEARCH INSTITUTE   (United States)

^c XENOBIOTIC LABORATORIES INC   (United States)

^d GLAXOSMITHKLINE   (United States)

^e PFIZER INC   (United States)

^f CellzDirect Inc   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ARSENIC COMPOUNDS; BIOCHEMISTRY; CHLORINE COMPOUNDS; DEHYDROGENATION; DEUTERIUM; ENZYMES; FOOD ADDITIVES; HYDROCARBONS; HYDROGEN; INTERACTIVE COMPUTER SYSTEMS; ISOTOPES; MECHANISMS; NONMETALS; OXYGENATION; OXYGENATORS;

CYTOCHROME P-450; DOUBLE MUTANTS; HOMOLOGY MODELING; HYDROGEN ATOM ABSTRACTION; ISOTOPE EFFECT; METHYL GROUPS; MOLECULAR MECHANISMS; OXYGENASE; PARENT COMPOUNDS; SUBSTRATE RECOGNITION SITES;

STIMULATED RAMAN SCATTERING;

CYTOCHROME P450; CYTOCHROME P450 2F3; DEUTERIUM; HYDROGEN; ISOLEUCINE; METHYL GROUP; OXIDOREDUCTASE; OXYGENASE; SERINE; SKATOLE; UNCLASSIFIED DRUG;

AMINO ACID SUBSTITUTION; ARTICLE; CATALYSIS; DEHYDROGENATION; ENZYME ACTIVITY; GENE MUTATION; ISOTOPE ANALYSIS; METABOLISM; MOLECULAR MECHANICS; MOLECULAR MODEL; MOLECULAR RECOGNITION; NONHUMAN; OXYGENATION; PRIORITY JOURNAL;

AMINO ACID SEQUENCE; CYTOCHROME P-450 CYP2E1; CYTOCHROME P-450 ENZYME SYSTEM; DEUTERIUM; HYDROGEN; KINETICS; MASS SPECTROMETRY; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTATION; OXIDOREDUCTASES; OXYGENASES; SEQUENCE ALIGNMENT; SKATOLE; SUBSTRATE SPECIFICITY;

EID: 51849095469     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi8005658     Document Type: Article

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