Lithospermic acid B protects beta-cells from cytokine-induced apoptosis by alleviating apoptotic pathways and activating anti-apoptotic pathways of Nrf2-HO-1 and Sirt1

Toxicology and Applied Pharmacology

Volumn 252, Issue 1, 2011, Pages 47-54

  Lee, Byung Wan ^a   Chun, Sung Wan ^a   Kim, Soo Hyun ^a   Lee, Yongho ^a   Kang, Eun Seok ^a   Cha, Bong Soo ^a   Lee, Hyun Chul ^a  

^a Yonsei University College of Medicine   (South Korea)

Author keywords

Cytokine; Diabetes; Islet; Magnesium lithospermate B; Nrf2 HO 1; Sirt1

Indexed keywords

CASPASE 3; GAMMA INTERFERON; HEME OXYGENASE 1; INTERLEUKIN 1BETA; LITHOSPERMIC ACID; LITHOSPERMIC ACID B; SIRTUIN 1; STRESS ACTIVATED PROTEIN KINASE; SYNAPTOPHYSIN; TRANSCRIPTION FACTOR NRF2; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL PROTECTION; CONTROLLED STUDY; ENZYME ACTIVITY; GLUCOSE TOLERANCE; IN VITRO STUDY; IN VIVO STUDY; MALE; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; OTSUKA LONG EVANS TOKUSHIMA FATTY RAT; PANCREAS ISLET BETA CELL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; RAT;

ANIMALS; APOPTOSIS; BENZOFURANS; CELLS, CULTURED; CYTOKINES; DEPSIDES; DIABETES MELLITUS, TYPE 2; HEME OXYGENASE (DECYCLIZING); INSULIN-SECRETING CELLS; MALE; NF-E2-RELATED FACTOR 2; PROTECTIVE AGENTS; RANDOM ALLOCATION; RATS; RATS, INBRED OLETF; RATS, LONG-EVANS; SIGNAL TRANSDUCTION; SIRTUIN 1;

ANIMALIA; RATTUS;

EID: 79952617737     PISSN: 0041008X     EISSN: 10960333     Source Type: Journal    
DOI: 10.1016/j.taap.2011.01.018     Document Type: Article

References (27)

1. Butler A.E., Janson J., Bonner-Weir S., Ritzel R., Rizza R.A., Butler P.C. Beta-cell deficit and increased beta-cell apoptosis in humans with type 2 diabetes. Diabetes 2003, 52:102-110.
2. Cnop M., Welsh N., Jonas J.C., Jorns A., Lenzen S., Eizirik D.L. Mechanisms of pancreatic beta-cell death in type 1 and type 2 diabetes: many differences, few similarities. Diabetes 2005, 54(Suppl 2):S97-S107.
3. Eizirik D.L., Mandrup-Poulsen T. A choice of death-the signal-transduction of immune-mediated beta-cell apoptosis. Diabetologia 2001, 44:2115-2133.
4. Hambrock A., de Oliveira Franz C.B., Hiller S., Grenz A., Ackermann S., Schulze D.U., Drews G., Osswald H. Resveratrol binds to the sulfonylurea receptor (SUR) and induces apoptosis in a SUR subtype-specific manner. J. Biol. Chem. 2007, 282:3347-3356.
5. Hur K.Y., Seo H.J., Kang E.S., Kim S.H., Song S., Kim E.H., Lim S., Choi C., Heo J.H., Hwang K.C., Ahn C.W., Cha B.S., Jung M., Lee H.C. Therapeutic effect of magnesium lithospermate B on neointimal formation after balloon-induced vascular injury. Eur. J. Pharmacol. 2008, 586:226-233.
6. Hur K.Y., Kim S.H., Choi M.A., Williams D.R., Lee Y.H., Kang S.W., Yadav U.C., Srivastava S.K., Jung M., Cho J.W., Kim S.G., Kang E.S., Lee E.J., Lee H.C. Protective effects of magnesium lithospermate B against diabetic atherosclerosis via Nrf2-ARE-NQO1 transcriptional pathway. Atherosclerosis 2010, 211:69-76.
7. Itoh K., Chiba T., Takahashi S., Ishii T., Igarashi K., Katoh Y., Oyake T., Hayashi N., Satoh K., Hatayama I., Yamamoto M., Nabeshima Y. An Nrf2/small Maf heterodimer mediates the induction of phase II detoxifying enzyme genes through antioxidant response elements. Biochem. Biophys. Res. Commun. 1997, 236:313-322.
8. Itoh K., Tong K.I., Yamamoto M. Molecular mechanism activating Nrf2-Keap1 pathway in regulation of adaptive response to electrophiles. Free Radic. Biol. Med. 2004, 36:1208-1213.
9. Kajimoto Y., Kaneto H. Role of oxidative stress in pancreatic beta-cell dysfunction. Ann. NY Acad. Sci. 2004, 1011:168-176.
10. Kang K.W., Lee S.J., Park J.W., Kim S.G. Phosphatidylinositol 3-kinase regulates nuclear translocation of NF-E2-related factor 2 through actin rearrangement in response to oxidative stress. Mol. Pharmacol. 2002, 62:1001-1010.
11. Kang E.S., Lee G.T., Kim B.S., Kim C.H., Seo G.H., Han S.J., Hur K.Y., Ahn C.W., Ha H., Jung M., Ahn Y.S., Cha B.S., Lee H.C. Lithospermic acid B ameliorates the development of diabetic nephropathy in OLETF rats. Eur. J. Pharmacol. 2008, 579:418-425.
12. Kim M.K., Jung H.S., Yoon C.S., Ko J.H., Jun H.J., Kim T.K., Kwon M.J., Lee S.H., Ko K.S., Rhee B.D., Park J.H. The effect of glucose fluctuation on apoptosis and function of INS-1 pancreatic beta cells. Korean Diabetes J 2010, 34:47-54.
13. Lee G.T., Ha H., Jung M., Li H., Hong S.W., Cha B.S., Lee H.C., Cho Y.D. Delayed treatment with lithospermate B attenuates experimental diabetic renal injury. J. Am. Soc. Nephrol. 2003, 14:709-720.
14. Lee B.W., Kwon S.J., Chae H.Y., Kang J.G., Kim C.S., Lee S.J., Yoo H.J., Kim J.H., Park K.S., Ihm S.H. Dose-related cytoprotective effect of alpha-lipoic acid on hydrogen peroxide-induced oxidative stress to pancreatic beta cells. Free Radic. Res. 2009, 43:68-77.
15. Lee J.H., Song M.Y., Song E.K., Kim E.K., Moon W.S., Han M.K., Park J.W., Kwon K.B., Park B.H. Overexpression of SIRT1 protects pancreatic beta-cells against cytokine toxicity by suppressing the nuclear factor-kappaB signaling pathway. Diabetes 2009, 58:344-351.
16. Liu X., Chen R., Shang Y., Jiao B., Huang C. Lithospermic acid as a novel xanthine oxidase inhibitor has anti-inflammatory and hypouricemic effects in rats. Chem. Biol. Interact. 2008, 176:137-142.
17. Papa S., Bubici C., Zazzeroni F., Pham C.G., Kuntzen C., Knabb J.R., Dean K., Franzoso G. The NF-kappaB-mediated control of the JNK cascade in the antagonism of programmed cell death in health and disease. Cell Death Differ. 2006, 13:712-729.
18. Robertson R.P., Harmon J.S. Diabetes, glucose toxicity, and oxidative stress: a case of double jeopardy for the pancreatic islet beta cell. Free Radic. Biol. Med. 2006, 41:177-184.
19. Schroeder M., Zagoory-Sharon O., Shbiro L., Marco A., Hyun J., Moran T.H., Bi S., Weller A. Development of obesity in the Otsuka Long-Evans Tokushima Fatty rat. Am. J. Physiol. Regul. Integr. Comp. Physiol. 2009, 297:R1749-R1760.
20. Soung D.Y., Rhee S.H., Kim J.S., Lee J.Y., Yang H.S., Choi J.S., Yokozawa T., Han Y.N., Chung H.Y. Peroxynitrite scavenging activity of lithospermate B from Salvia miltiorrhiza. J. Pharm. Pharmacol. 2003, 55:1427-1432.
21. Surh Y.J., Kundu J.K., Li M.H., Na H.K., Cha Y.N. Role of Nrf2-mediated heme oxygenase-1 upregulation in adaptive survival response to nitrosative stress. Arch. Pharm. Res. 2009, 32:1163-1176.
22. Tanaka Y., Gleason C.E., Tran P.O., Harmon J.S., Robertson R.P. Prevention of glucose toxicity in HIT-T15 cells and Zucker diabetic fatty rats by antioxidants. Proc. Natl Acad. Sci. USA 1999, 96:10857-10862.
23. Targonsky E.D., Dai F., Koshkin V., Karaman G.T., Gyulkhandanyan A.V., Zhang Y., Chan C.B., Wheeler M.B. alpha-Lipoic acid regulates AMP-activated protein kinase and inhibits insulin secretion from beta cells. Diabetologia 2006, 49:1587-1598.
24. Thomas H.E., McKenzie M.D., Angstetra E., Campbell P.D., Kay T.W. Beta cell apoptosis in diabetes. Apoptosis 2009, 14:1389-1404.
25. Wu X.J., Wang Y.P., Wang W., Sun W.K., Xu Y.M., Xuan L.J. Free radical scavenging and inhibition of lipid peroxidation by magnesium lithospermate B. Acta Pharmacol. Sin. 2000, 21:855-858.
26. Yang S.R., Wright J., Bauter M., Seweryniak K., Kode A., Rahman I. Sirtuin regulates cigarette smoke-induced proinflammatory mediator release via RelA/p65 NF-kappaB in macrophages in vitro and in rat lungs in vivo: implications for chronic inflammation and aging. Am. J. Physiol. Lung Cell. Mol. Physiol. 2007, 292:L567-L576.
27. Zhang D.D. Mechanistic studies of the Nrf2-Keap1 signaling pathway. Drug Metab. Rev. 2006, 38:769-789.