Lithospermic acid as a novel xanthine oxidase inhibitor has anti-inflammatory and hypouricemic effects in rats

Chemico-Biological Interactions

Volumn 176, Issue 2-3, 2008, Pages 137-142

  Liu, Xiaoyu ^a   Chen, Ruohua ^b   Shang, Yanjun ^a   Jiao, Binghua ^a   Huang, Caiguo ^a  

^a SECOND MILITARY MEDICAL UNIVERSITY   (China)

^b SECOND MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

Competitive inhibitor; Gouty arthritis; Lithospermic acid; Neutrophilis; Superoxide scavenging; Xanthine oxidase

Indexed keywords

ALLOPURINOL; FORMYLMETHIONYLLEUCYLPHENYLALANINE; INDOMETACIN; LITHOSPERMIC ACID; PHENAZINE METHOSULFATE; PHORBOL 13 ACETATE 12 MYRISTATE; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE; SUPEROXIDE; URATE; URIC ACID; XANTHINE; XANTHINE OXIDASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CELL STIMULATION; COMPETITIVE INHIBITION; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME INHIBITION; GOUT; HUMAN; HUMAN CELL; IC 50; MALE; NEUTROPHIL; NONHUMAN; PAW EDEMA; RAT;

ALLOPURINOL; ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; ARTHRITIS, GOUTY; BENZOFURANS; DEPSIDES; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME INHIBITORS; HUMANS; HYPERURICEMIA; INFLAMMATION; MALE; MOLECULAR CONFORMATION; N-FORMYLMETHIONINE LEUCYL-PHENYLALANINE; NEUTROPHILS; OXONIC ACID; RATS; RATS, WISTAR; REACTIVE OXYGEN SPECIES; TETRADECANOYLPHORBOL ACETATE; URIC ACID; XANTHINE OXIDASE;

RATTUS; SALVIA;

EID: 55249094053     PISSN: 00092797     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cbi.2008.07.003     Document Type: Article

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