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Volumn 6, Issue 3, 2011, Pages

Residual beta cell function in newly diagnosed type 1 diabetes after treatment with atorvastatin: The randomized DIATOR trial

Author keywords

[No Author keywords available]

Indexed keywords

ATORVASTATIN; AUTOANTIBODY; C PEPTIDE; C REACTIVE PROTEIN; CHOLESTEROL; PLACEBO; GLYCOSYLATED HEMOGLOBIN; HEPTANOIC ACID DERIVATIVE; LIPID; PYRROLE DERIVATIVE;

EID: 79952581919     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0017554     Document Type: Article
Times cited : (19)

References (36)
  • 1
    • 0023709376 scopus 로고
    • Cyclosporin-induced remission of IDDM after early intervention. Association of 1 yr of cyclosporin treatment with enhanced insulin secretion. The Canadian-European Randomized Control Trial Group
    • The Canandian/European Randomized Control Trial Group
    • The Canandian/European Randomized Control Trial Group (1988) Cyclosporin-induced remission of IDDM after early intervention. Association of 1 yr of cyclosporin treatment with enhanced insulin secretion. The Canadian-European Randomized Control Trial Group. Diabetes 37: 1574-1582.
    • (1988) Diabetes , vol.37 , pp. 1574-1582
  • 2
    • 62749168302 scopus 로고    scopus 로고
    • Advances in Type 1 diabetes therapeutics: immunomodulation and beta-cell salvage
    • Waldron-Lynch F, Herold KC, (2009) Advances in Type 1 diabetes therapeutics: immunomodulation and beta-cell salvage. Endocrinol Metab Clin North Am 38: 303-17, viii.
    • (2009) Endocrinol Metab Clin North Am , vol.38
    • Waldron-Lynch, F.1    Herold, K.C.2
  • 3
    • 35748945752 scopus 로고    scopus 로고
    • Atorvastatin inhibits T cell activation through 3-hydroxy-3-methylglutaryl coenzyme A reductase without decreasing cholesterol synthesis
    • Blank N, Schiller M, Krienke S, Busse F, Schatz B, et al. (2007) Atorvastatin inhibits T cell activation through 3-hydroxy-3-methylglutaryl coenzyme A reductase without decreasing cholesterol synthesis. J Immunol 179: 3613-3621.
    • (2007) J Immunol , vol.179 , pp. 3613-3621
    • Blank, N.1    Schiller, M.2    Krienke, S.3    Busse, F.4    Schatz, B.5
  • 4
    • 58349116856 scopus 로고    scopus 로고
    • Comparative effects of 10-mg versus 80-mg Atorvastatin on high-sensitivity C-reactive protein in patients with stable coronary artery disease: results of the CAP (Comparative Atorvastatin Pleiotropic effects) study
    • Bonnet J, McPherson R, Tedgui A, Simoneau D, Nozza A, et al. (2008) Comparative effects of 10-mg versus 80-mg Atorvastatin on high-sensitivity C-reactive protein in patients with stable coronary artery disease: results of the CAP (Comparative Atorvastatin Pleiotropic effects) study. Clin Ther 30: 2298-2313.
    • (2008) Clin Ther , vol.30 , pp. 2298-2313
    • Bonnet, J.1    McPherson, R.2    Tedgui, A.3    Simoneau, D.4    Nozza, A.5
  • 5
    • 0034948339 scopus 로고    scopus 로고
    • Statins selectively inhibit leukocyte function antigen-1 by binding to a novel regulatory integrin site
    • Weitz-Schmidt G, Welzenbach K, Brinkmann V, Karnata T, Kallen J, et al. (2001) Statins selectively inhibit leukocyte function antigen-1 by binding to a novel regulatory integrin site. Nat Med 7: 687-692.
    • (2001) Nat Med , vol.7 , pp. 687-692
    • Weitz-Schmidt, G.1    Welzenbach, K.2    Brinkmann, V.3    Karnata, T.4    Kallen, J.5
  • 6
    • 0026498992 scopus 로고
    • Elevated levels of circulating adhesion molecules in IDDM patients and in subjects at risk for IDDM
    • Lampeter ER, Kishimoto TK, Rothlein R, Mainolfi EA, Bertrams J, et al. (1992) Elevated levels of circulating adhesion molecules in IDDM patients and in subjects at risk for IDDM. Diabetes 41: 1668-1671.
    • (1992) Diabetes , vol.41 , pp. 1668-1671
    • Lampeter, E.R.1    Kishimoto, T.K.2    Rothlein, R.3    Mainolfi, E.A.4    Bertrams, J.5
  • 7
    • 0028177702 scopus 로고
    • Soluble forms of intercellular adhesion molecule-1 in insulin-dependent diabetes mellitus
    • Roep BO, Heidenthal E, de Vries RR, Kolb H, Martin S, (1994) Soluble forms of intercellular adhesion molecule-1 in insulin-dependent diabetes mellitus. Lancet 343: 1590-1593.
    • (1994) Lancet , vol.343 , pp. 1590-1593
    • Roep, B.O.1    Heidenthal, E.2    de Vries, R.R.3    Kolb, H.4    Martin, S.5
  • 8
    • 0031738502 scopus 로고    scopus 로고
    • Soluble forms of intercellular adhesion molecule-1 inhibit insulitis and onset of autoimmune diabetes
    • Martin S, Heidenthal E, Schulte B, Rothe H, Kolb H, (1998) Soluble forms of intercellular adhesion molecule-1 inhibit insulitis and onset of autoimmune diabetes. Diabetologia 41: 1298-1303.
    • (1998) Diabetologia , vol.41 , pp. 1298-1303
    • Martin, S.1    Heidenthal, E.2    Schulte, B.3    Rothe, H.4    Kolb, H.5
  • 9
    • 2942670131 scopus 로고    scopus 로고
    • Trial of Atorvastatin in Rheumatoid Arthritis (TARA): double-blind, randomised placebo-controlled trial
    • McCarey DW, McInnes IB, Madhok R, Hampson R, Scherbakov O, et al. (2004) Trial of Atorvastatin in Rheumatoid Arthritis (TARA): double-blind, randomised placebo-controlled trial. Lancet 363: 2015-2021.
    • (2004) Lancet , vol.363 , pp. 2015-2021
    • McCarey, D.W.1    McInnes, I.B.2    Madhok, R.3    Hampson, R.4    Scherbakov, O.5
  • 10
    • 44849127754 scopus 로고    scopus 로고
    • Oral high-dose atorvastatin treatment in relapsing-remitting multiple sclerosis
    • Paul F, Waiczies S, Wuerfel J, Bellman-Strobl J, Dorr J, et al. (2008) Oral high-dose atorvastatin treatment in relapsing-remitting multiple sclerosis. PLoS One 3: e1928.
    • (2008) PLoS One , vol.3
    • Paul, F.1    Waiczies, S.2    Wuerfel, J.3    Bellman-Strobl, J.4    Dorr, J.5
  • 11
    • 56549086423 scopus 로고    scopus 로고
    • Combining beta interferon and atorvastatin may increase disease activity in multiple sclerosis
    • Birnbaum G, Cree B, Altafullah I, Zinser M, Reder AT, (2008) Combining beta interferon and atorvastatin may increase disease activity in multiple sclerosis. Neurology 71: 1390-1395.
    • (2008) Neurology , vol.71 , pp. 1390-1395
    • Birnbaum, G.1    Cree, B.2    Altafullah, I.3    Zinser, M.4    Reder, A.T.5
  • 12
    • 67649488058 scopus 로고    scopus 로고
    • Effect of statins on clinical and molecular responses to intramuscular interferon beta-1a
    • Rudick RA, Pace A, Rani MR, Hyde R, Paanzara M, et al. (2009) Effect of statins on clinical and molecular responses to intramuscular interferon beta-1a. Neurology 72: 1989-1993.
    • (2009) Neurology , vol.72 , pp. 1989-1993
    • Rudick, R.A.1    Pace, A.2    Rani, M.R.3    Hyde, R.4    Paanzara, M.5
  • 13
    • 77954688218 scopus 로고    scopus 로고
    • Atorvastatin combined to interferon to verify the efficacy (ACTIVE) in relapsing-remitting active multiple sclerosis patients: a longitudinal controlled trial of combination therapy
    • Lanzillo R, Orefice G, Quarantelli M, Rinaldi C, Prinster A, et al. (2010) Atorvastatin combined to interferon to verify the efficacy (ACTIVE) in relapsing-remitting active multiple sclerosis patients: a longitudinal controlled trial of combination therapy. Mult Scler 16: 450-454.
    • (2010) Mult Scler , vol.16 , pp. 450-454
    • Lanzillo, R.1    Orefice, G.2    Quarantelli, M.3    Rinaldi, C.4    Prinster, A.5
  • 14
    • 34548858217 scopus 로고    scopus 로고
    • Simvastatin protects against multiple low-dose streptozotocin-induced type 1 diabetes in CD-1 mice and recurrence of disease in nonobese diabetic mice
    • Rydgren T, Vaarala O, Sandler S, (2007) Simvastatin protects against multiple low-dose streptozotocin-induced type 1 diabetes in CD-1 mice and recurrence of disease in nonobese diabetic mice. J Pharmacol Exp Ther 323: 180-185.
    • (2007) J Pharmacol Exp Ther , vol.323 , pp. 180-185
    • Rydgren, T.1    Vaarala, O.2    Sandler, S.3
  • 15
    • 23844485269 scopus 로고    scopus 로고
    • Atorvastatin does not decrease or delay diabetes onset in two different mouse models of type 1 diabetes
    • Palomer X, Calpe-Berdiel L, Verdaguer J, Carillo J, Pastor X, et al. (2005) Atorvastatin does not decrease or delay diabetes onset in two different mouse models of type 1 diabetes. Diabetologia 48: 1671-1673.
    • (2005) Diabetologia , vol.48 , pp. 1671-1673
    • Palomer, X.1    Calpe-Berdiel, L.2    Verdaguer, J.3    Carillo, J.4    Pastor, X.5
  • 16
    • 33745292324 scopus 로고    scopus 로고
    • Atorvastatin fails to prevent the development of autoimmune diabetes despite inhibition of pathogenic beta-cell-specific CD8 T-cells
    • Lozanoska-Ochser B, Barone F, Pitzalis C, Peakman M, (2006) Atorvastatin fails to prevent the development of autoimmune diabetes despite inhibition of pathogenic beta-cell-specific CD8 T-cells. Diabetes 55: 1004-1010.
    • (2006) Diabetes , vol.55 , pp. 1004-1010
    • Lozanoska-Ochser, B.1    Barone, F.2    Pitzalis, C.3    Peakman, M.4
  • 17
    • 43649095009 scopus 로고    scopus 로고
    • Effects of pravastatin in prevention of diabetes and mechanism thereof: experiment with non-obese diabetic mice
    • Zhang S, Yan X, Zhou PC, et al. (2008) [Effects of pravastatin in prevention of diabetes and mechanism thereof: experiment with non-obese diabetic mice]. Zhonghua Yi Xue Za Zhi 88: 568-572.
    • (2008) Zhonghua Yi Xue Za Zhi , vol.88 , pp. 568-572
    • Zhang, S.1    Yan, X.2    Zhou, P.C.3
  • 18
    • 0037184318 scopus 로고    scopus 로고
    • Simvastatin induces activation of the serine-threonine protein kinase AKT and increases survival of isolated human pancreatic islets
    • Contreras JL, Smyth CA, Bilbao G, Young CJ, Thompson JA, Eckhoff DE, (2002) Simvastatin induces activation of the serine-threonine protein kinase AKT and increases survival of isolated human pancreatic islets. Transplantation 74: 1063-1069.
    • (2002) Transplantation , vol.74 , pp. 1063-1069
    • Contreras, J.L.1    Smyth, C.A.2    Bilbao, G.3    Young, C.J.4    Thompson, J.A.5    Eckhoff, D.E.6
  • 19
    • 73749087527 scopus 로고    scopus 로고
    • Differing effect of statins on insulin sensitivity in non-diabetics: a systematic review and meta-analysis
    • Baker WL, Talati R, White CM, Coleman CI, (2010) Differing effect of statins on insulin sensitivity in non-diabetics: a systematic review and meta-analysis. Diabetes Res Clin Pract 87: 98-107.
    • (2010) Diabetes Res Clin Pract , vol.87 , pp. 98-107
    • Baker, W.L.1    Talati, R.2    White, C.M.3    Coleman, C.I.4
  • 20
    • 0034781727 scopus 로고    scopus 로고
    • Does partial preservation of residual beta-cell function justify immune intervention in recent onset Type I diabetes?
    • Kolb H, Gale EA, (2001) Does partial preservation of residual beta-cell function justify immune intervention in recent onset Type I diabetes? Diabetologia 44: 1349-1353.
    • (2001) Diabetologia , vol.44 , pp. 1349-1353
    • Kolb, H.1    Gale, E.A.2
  • 21
    • 9144268894 scopus 로고    scopus 로고
    • C-peptide is the appropriate outcome measure for type 1 diabetes clinical trials to preserve beta-cell function: report of an ADA workshop, 21-22 October 2001
    • Palmer JP, Fleming GA, Greenbaum CJ, Herold KC, Jansa LD, et al. (2004) C-peptide is the appropriate outcome measure for type 1 diabetes clinical trials to preserve beta-cell function: report of an ADA workshop, 21-22 October 2001. Diabetes 53: 250-264.
    • (2004) Diabetes , vol.53 , pp. 250-264
    • Palmer, J.P.1    Fleming, G.A.2    Greenbaum, C.J.3    Herold, K.C.4    Jansa, L.D.5
  • 22
    • 55249085210 scopus 로고    scopus 로고
    • Mixed-meal tolerance test versus glucagon stimulation test for the assessment of beta-cell function in therapeutic trials in type 1 diabetes
    • Greenbaum CJ, Mandrup-Poulsen T, McGee PF, Batllino T, Haastert B, et al. (2008) Mixed-meal tolerance test versus glucagon stimulation test for the assessment of beta-cell function in therapeutic trials in type 1 diabetes. Diabetes Care 31: 1966-1971.
    • (2008) Diabetes Care , vol.31 , pp. 1966-1971
    • Greenbaum, C.J.1    Mandrup-Poulsen, T.2    McGee, P.F.3    Batllino, T.4    Haastert, B.5
  • 23
    • 0034533147 scopus 로고    scopus 로고
    • Statins as a newly recognized type of immunomodulator
    • Kwak B, Mulhaupt F, Myit S, Mach F, (2000) Statins as a newly recognized type of immunomodulator. Nat Med 6: 1399-1402.
    • (2000) Nat Med , vol.6 , pp. 1399-1402
    • Kwak, B.1    Mulhaupt, F.2    Myit, S.3    Mach, F.4
  • 24
    • 20144379879 scopus 로고    scopus 로고
    • Statins reduce interleukin-6-induced C-reactive protein in human hepatocytes: new evidence for direct antiinflammatory effects of statins
    • Arnaud C, Burger F, Steffens S, Veillard NR, Nguyen TH, et al. (2005) Statins reduce interleukin-6-induced C-reactive protein in human hepatocytes: new evidence for direct antiinflammatory effects of statins. Arterioscler Thromb Vasc Biol 25: 1231-1236.
    • (2005) Arterioscler Thromb Vasc Biol , vol.25 , pp. 1231-1236
    • Arnaud, C.1    Burger, F.2    Steffens, S.3    Veillard, N.R.4    Nguyen, T.H.5
  • 25
    • 62649086172 scopus 로고    scopus 로고
    • The pleiotropic effects of statins on endothelial function, vascular inflammation, immunomodulation and thrombogenesis
    • Blum A, Shamburek R, (2009) The pleiotropic effects of statins on endothelial function, vascular inflammation, immunomodulation and thrombogenesis. Atherosclerosis 203: 325-330.
    • (2009) Atherosclerosis , vol.203 , pp. 325-330
    • Blum, A.1    Shamburek, R.2
  • 26
    • 61349091828 scopus 로고    scopus 로고
    • Statins inhibit C-reactive protein-induced chemokine secretion, ICAM-1 upregulation and chemotaxis in adherent human monocytes
    • Montecucco F, Burger F, Pelli G, Poku NK, Berlier C, et al. (2009) Statins inhibit C-reactive protein-induced chemokine secretion, ICAM-1 upregulation and chemotaxis in adherent human monocytes. Rheumatology (Oxford) 48: 233-242.
    • (2009) Rheumatology (Oxford) , vol.48 , pp. 233-242
    • Montecucco, F.1    Burger, F.2    Pelli, G.3    Poku, N.K.4    Berlier, C.5
  • 27
    • 77954497611 scopus 로고    scopus 로고
    • Simvastatin induces Foxp3+ T regulatory cells by modulation of transforming growth factor-beta signal transduction
    • Kim YC, Kim KK, Shevach EM, (2010) Simvastatin induces Foxp3+ T regulatory cells by modulation of transforming growth factor-beta signal transduction. Immunology 130: 484-493.
    • (2010) Immunology , vol.130 , pp. 484-493
    • Kim, Y.C.1    Kim, K.K.2    Shevach, E.M.3
  • 28
    • 0037038402 scopus 로고    scopus 로고
    • The HMG-CoA reductase inhibitor, atorvastatin, promotes a Th2 bias and reverses paralysis in central nervous system autoimmune disease
    • Youssef S, Stuve O, Patarroyo JC, Ruiz PJ, Radosevich JL, et al. (2002) The HMG-CoA reductase inhibitor, atorvastatin, promotes a Th2 bias and reverses paralysis in central nervous system autoimmune disease. Nature 420: 78-84.
    • (2002) Nature , vol.420 , pp. 78-84
    • Youssef, S.1    Stuve, O.2    Patarroyo, J.C.3    Ruiz, P.J.4    Radosevich, J.L.5
  • 29
    • 0344013648 scopus 로고    scopus 로고
    • Inhibition of hydroxymethylglutaryl-coenzyme a reductase reduces Th1 development and promotes Th2 development
    • Hakamada-Taguchi R, Uehara Y, Kuribayashi K, Numabe A, Saito K, Negoro H, et al. (2003) Inhibition of hydroxymethylglutaryl-coenzyme a reductase reduces Th1 development and promotes Th2 development. Circ Res 93: 948-956.
    • (2003) Circ Res , vol.93 , pp. 948-956
    • Hakamada-Taguchi, R.1    Uehara, Y.2    Kuribayashi, K.3    Numabe, A.4    Saito, K.5    Negoro, H.6
  • 30
    • 33344475402 scopus 로고    scopus 로고
    • Isoprenoids determine Th1/Th2 fate in pathogenic T cells, providing a mechanism of modulation of autoimmunity by atorvastatin
    • Dunn SE, Youssef S, Goldstein MJ, Prod'homme T, Weber MS, et al. (2006) Isoprenoids determine Th1/Th2 fate in pathogenic T cells, providing a mechanism of modulation of autoimmunity by atorvastatin. J Exp Med 203: 401-412.
    • (2006) J Exp Med , vol.203 , pp. 401-412
    • Dunn, S.E.1    Youssef, S.2    Goldstein, M.J.3    Prod'homme, T.4    Weber, M.S.5
  • 31
    • 77953185420 scopus 로고    scopus 로고
    • Statin-induced Kruppel-like factor 2 expression in human and mouse T cells reduces inflammatory and pathogenic responses
    • Bu DX, Tarrio M, Grabie N, Zhang Y, Yamazaki H, et al. (2010) Statin-induced Kruppel-like factor 2 expression in human and mouse T cells reduces inflammatory and pathogenic responses. J Clin Invest 120: 1961-1970.
    • (2010) J Clin Invest , vol.120 , pp. 1961-1970
    • Bu, D.X.1    Tarrio, M.2    Grabie, N.3    Zhang, Y.4    Yamazaki, H.5
  • 32
    • 77953381883 scopus 로고    scopus 로고
    • Effects of atorvastatin on the regeneration of pancreatic {beta}-cells after streptozotocin treatment in the neonatal rodent
    • Marchand KC, Arany EJ, Hill DJ, (2010) Effects of atorvastatin on the regeneration of pancreatic {beta}-cells after streptozotocin treatment in the neonatal rodent. Am J Physiol Endocrinol Metabol 299: E92-E100.
    • (2010) Am J Physiol Endocrinol Metabol , vol.299
    • Marchand, K.C.1    Arany, E.J.2    Hill, D.J.3
  • 33
    • 0032055459 scopus 로고    scopus 로고
    • Effect of intensive therapy on residual beta-cell function in patients with type 1 diabetes in the diabetes control and complications trial. A randomized, controlled trial
    • The Diabetes Control and Complications Trial Research Group
    • The Diabetes Control and Complications Trial Research Group (1998) Effect of intensive therapy on residual beta-cell function in patients with type 1 diabetes in the diabetes control and complications trial. A randomized, controlled trial. Ann Intern Med 128: 517-523.
    • (1998) Ann Intern Med , vol.128 , pp. 517-523
  • 34
    • 59449102051 scopus 로고    scopus 로고
    • Anti-inflammatory effect of lifestyle changes in the Finnish Diabetes Prevention Study
    • Herder C, Peltonen M, Koenig W, Sutfels K, Lindstrom J, et al. (2009) Anti-inflammatory effect of lifestyle changes in the Finnish Diabetes Prevention Study. Diabetologia 52: 433-442.
    • (2009) Diabetologia , vol.52 , pp. 433-442
    • Herder, C.1    Peltonen, M.2    Koenig, W.3    Sutfels, K.4    Lindstrom, J.5
  • 35
    • 33646401824 scopus 로고    scopus 로고
    • Chemokines as risk factors for type 2 diabetes: results from the MONICA/KORA Augsburg study, 1984-2002
    • Herder C, Baumert J, Thorand B, Koenig W, de Jager W, et al. (2006) Chemokines as risk factors for type 2 diabetes: results from the MONICA/KORA Augsburg study, 1984-2002. Diabetologia 49: 921-929.
    • (2006) Diabetologia , vol.49 , pp. 921-929
    • Herder, C.1    Baumert, J.2    Thorand, B.3    Koenig, W.4    de Jager, W.5
  • 36
    • 0242516070 scopus 로고    scopus 로고
    • An association of autoantibody status and serum cytokine levels in type 1 diabetes
    • Hanifi-Moghaddam P, Schloot NC, Kappler S, Seissler J, Kolb H, (2003) An association of autoantibody status and serum cytokine levels in type 1 diabetes. Diabetes 52: 1137-1142.
    • (2003) Diabetes , vol.52 , pp. 1137-1142
    • Hanifi-Moghaddam, P.1    Schloot, N.C.2    Kappler, S.3    Seissler, J.4    Kolb, H.5


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