Effect of the administration of statins in non-cardiac critical disease;Efecto de la administración de las estatinas en la patología crítica no cardiológica

Medicina Intensiva

Volumn 35, Issue 2, 2011, Pages 107-116

  Ruiz Bailen M ^a   Perez Valenzuela J ^b   Ferrezuelo Mata, A ^b   Obra Cuadra, R J ^b  

^a UNIVERSITY OF JAÉN   (Spain)

^b Unidad de Medicina Intensiva   (Spain)

Author keywords

Critically ill patient; Estatinas; Mortalidad; Mortality; Paciente cr ticamente enfermo; Sepsis; Statins

Indexed keywords

HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR;

CARDIOVASCULAR DISEASE; COMORBIDITY; CRITICAL ILLNESS; CRITICALLY ILL PATIENT; DETERIORATION; DRUG EFFICACY; EVIDENCE BASED MEDICINE; HIGH RISK POPULATION; HUMAN; INTENSIVE CARE; MORTALITY; PRIMARY PREVENTION; SECONDARY PREVENTION; SHORT SURVEY;

ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; CARDIOVASCULAR DISEASES; CEREBROVASCULAR DISORDERS; COHORT STUDIES; COMORBIDITY; CRITICAL CARE; CRITICAL ILLNESS; DISEASE MODELS, ANIMAL; DOUBLE-BLIND METHOD; HUMANS; HYDROXYMETHYLGLUTARYL-COA REDUCTASE INHIBITORS; HYPERLIPIDEMIAS; LIVER CIRRHOSIS; MULTICENTER STUDIES AS TOPIC; NEUROPROTECTIVE AGENTS; POSTOPERATIVE COMPLICATIONS; PROSPECTIVE STUDIES; PULMONARY DISEASE, CHRONIC OBSTRUCTIVE; RANDOMIZED CONTROLLED TRIALS AS TOPIC; RETROSPECTIVE STUDIES; SEPSIS; STRESS, PHYSIOLOGICAL;

EID: 79952490569     PISSN: 02105691     EISSN: 15786749     Source Type: Journal    
DOI: 10.1016/j.medin.2010.05.007     Document Type: Short Survey

References (85)

1. Ruiz Bailén M., Rucabado Aguilar L., López Martínez A. Aturdimiento miocárdico neurogénico. Med Intensiva 2006, 30:13-18.
2. Pan W., Pintar T., Anton J., Lee V.V., Vaughn W.K., Collard C.D. Statins are associated with a reduced incidence of perioperative mortality after coronary artery bypass graft surgery. Circulation 2004, 110:II45-II49.
3. Ali I.S., Buth K.J. Preoperative statin use and outcomes following cardiac surgery. Int J Cardiol 2005, 103:12-18.
4. Collard C.D., Body S.C., Shirnan S.K., Wang S., Mangano D.T. Preoperative statin therapy is associated with reduced cardiac mortality after coronary artery bypass graft surgery. J Thorac Cardiovasc Surg 2006, 132:392-400.
5. Chello M., Anselmi A., Spadaccio C., Patti G., Goffredo C., Di Sciascio G., et al. Simvastatin increases neutrophil apoptosis and reduces inflammatory reaction after coronary surgery. Ann Thorac Surg 2007, 83:1374-1380.
6. Liakopoulos O.J., Choi Y.H., Haldenwang P.L., Strauch J., Wittwer T., Dorge H., et al. Impact of preoperative statin therapy on adverse postoperative outcomes in patients undergoing cardiac surgery: a meta-analysis of over 30.000 patients. Eur Heart J 2008, 29:1548-1549.
7. Ouattara A., Benhaoua H., Le Manach Y., Mabrouk-Zerguini N., Itani O., Osman A., et al. Perioperative statin therapy is associated with a significant and dose-dependent reduction of adverse cardiovascular outcomes after coronary artery bypass graft surgery. J Cardiothorac Vasc Anesth 2009, 23:633-638.
8. Ryding A.D., Kumar S., Worthington A.M., Burgess D. Prognostic value of brain natriuretic peptide in noncardiac surgery: a meta-analysis. Anesthesiology 2009, 111:311-319.
9. Mangano D.T. Adverse outcomes after surgery in the year 2001--a continuing odyssey. Anesthesiology 1998, 88:561-564.
10. Poldermans D., Bax J.J., Kertai M.D., Krenning B., Westerhout C.M., Schinkel A.F., et al. Statins are associated with a reduced incidence of perioperative mortality in patients undergoing major noncardiac vascular surgery. Circulation 2003, 107:1848-1851.
11. Kertai M.D., Boersma E., Westerhout C.M., Klein J., van Urk H., Bax J.J., et al. A combination of statins and beta-blockers is independently associated with a reduction in the incidence of perioperative mortality and nonfatal myocardial infarction in patients undergoing abdominal aortic aneurysm surgery. Eur J Vasc Endovasc Surg 2004, 28:343-352.
12. Lindenauer P.K., Pekow P., Wang K., Gutierrez B., Benjamin E.M. Lipidlowering therapy and in-hospital mortality following major noncardiac surgery. JAMA 2004, 291:2092-2099.
13. O'Neil-Callahan K., Katsimaglis G., Tepper M.R., Ryan J., Mosby C., Ioannidis J.P.A., et al. Statins decrease perioperative cardiac complications in patients undergoing noncardiac vascular surgery: the statins for risk reduction in surgery (StaRRS) study. J Am Coll Cardiol 2005, 45:336-342.
14. Winkel T.A., Schouten O., van Kuijk J.P., Verhagen H.J., Bax J.J., Poldermans D. Perioperative asymptomatic cardiac damage after endovascular abdominal aneurysm repair is associated with poor long-term outcome. J Vasc Surg 2009, 50:749-754.
15. Feringa H.H., Bax J.J., Hoeks S., van Waning V.H., Elhendy A., Karagiannis S., et al. A prognostic risk index for long-term mortality in patients with peripheral arterial disease. Arch Intern Med 2007, 167:2482-2489.
16. Corriere M.A., Edwards M.S., Pearce J.D., Andrews J.S., Geary R.L., Hansen K.J. Restenosis after renal artery angioplasty and stenting: Incidence and risk factors. Vasc Surg 2009, 50:813-819.
17. Schanzer A., Hevelone N., Owens C.D., Beckman J.A., Belkin M., Conte M.S. Statins are independently associated with reduced mortality in patients undergoing infrainguinal bypass graft surgery for critical limb ischemia. Vasc Surg 2008, 47:774-781.
18. Durazzo A.E., Machado F.S., Ikeoka D.T., De Bernoche C., Monachini M.C., Puech-Leao P., et al. Reduction in cardiovascular events after vascular surgery with atorvastatin: a randomized trial. J Vasc Surg 2004, 39:967-975.
19. Dunkelgrun M., Boersma E., Schouten O., Koopman-van Gemert A.W., van Poorten F., Bax J.J., et al. Bisoprolol and fluvastatin for the reduction of perioperative cardiac mortality and myocardial infarction in intermediate-risk patients undergoing noncardiovascular surgery: a randomized controlled trial (DECREASE-IV). Ann Surg 2009, 249:921-926. Echocardiographic Cardiac Risk Evaluation Applying Stress Echocardiography Study Group.
20. Wu H., Lu D., Jiang H., Xiong Y., Qu C., Li B., et al. Increase in phosphorylation of Akt and its downstream signaling targets and suppression of apoptosis by simvastatin after traumatic brain injury. J Neurosurg 2008, 109:691-698.
21. Pannu R., Christie D.K., Barbosa E., Singh I., Singh A.K. Post-trauma Lipitor treatmentprevents endothelial dysfunction, facilitates neuroprotection, and promotes locomotor recovery following spinal cord injury. J Neurochem 2007, 101:182-200.
22. McGirt M.J., Lynch J.R., Parra A., Sheng H., Pearlstein R.D., Laskowitz D.T., et al. Simvastatin increases endothelial nitric oxide synthase and ameliorates cerebral vasospasm resulting from subarachnoid hemorrhage. Stroke 2002, 33:2950-2956.
23. McGirt M.J., Pradilla G., Legnani F.G., Thai Q.A., Recinos P.F., Tamargo R.J., et al. Systemic administration of simvastatin after the onset of experimental subarachnoid hemorrhage attenuates cerebral vasospasm. Neurosurgery 2006, 58:945-951.
24. McGirt M.J., Garces Ambrossi G.L., Huang J., Tamargo R.J. Simvastatin for the prevention of symptomatic cerebral vasospasm following aneurysmal subarachnoid hemorrhage: a single-institution prospective cohort study. J Neurosurg 2009, 110:968-974.
25. Parra A., Kreiter K.T., Williams S., Sciacca R., Mack W.J., Naidech A.M., et al. Effect of prior statin use on functional outcome and delayed vasospasm after acute aneurismal subarachnoid hemorrhage: a matched controlled cohort study. Neurosurgery 2005, 56:476-484.
26. Lynch J.R., Wang H., McGirt M.J., Floyd J., Friedman A.H., Coon A.L., et al. Simvastatin reduces vasospasm after aneurysmal subarachnoid hemorrhage: results of a pilot randomized clinical trial. Stroke 2005, 36:2024-2026.
27. Chou S.H., Smith E.E., Badjatia N., Nogueira R.G., Sims J.R., Ogilvy C.S., et al. Randomized, double-blind, placebo-controlled pilot study of simvastatin in aneurismal subarachnoid hemorrhage. Stroke 2008, 39:2891-2893.
28. Risselada R., Straatman H., van Kooten F., Dippel D.W., van der Lugt A., Niessen W.J., et al. Withdrawal of statins and risk of subarachnoid hemorrhage. Stroke 2009, 40:2887-2892.
29. Sihgahl A.B., Topcuoglu M.A., Dorer D.J., Ogilvy C.S., Carter B.S., Koroshetz W.J. SSRI and statin use increases the risk for vasospasm after subarachnoid hemorrhage. Neurology 2005, 64:1008-1013.
30. Schwartz G.G., Olsson A.G., Ezekowitz M.D., Ganz P., Oliver M.F., Waters D., et al. Effects of atorvastatin on early recurrent ischemic events in acute coronary syndromes: the MIRACL study: a randomized controlled trial. JAMA 2001, 285:1711-1718. Myocardial Ischemia Reduction with Aggressive Cholesterol Lowering (MIRACL) StudyInvestigators.
31. Amarenco P., Bogousslavsky J., Callahan A., Goldstein L.B., Hennerici M., Rudolph A.E., et al. High-dose atorvastatin after stroke or transient ischemic attack. N Engl J Med 2006, 355:549-559. Stroke Prevention by Aggressive Reduction in Cholesterol Levels (SPARCL) Investigators.
32. Aslanyan S., Weir C.J., McInnes G.T., Reid J.L., Walters M.R., Lees K.R. Statin administration prior to ischaemic stroke onset and survival: exploratory evidence from matched treatment-control study. Eur J Neurol 2005, 12:493-498.
33. Amarenco P., Benavente O., Goldstein L.B., Callahan A., Sillesen H., Hennerici M.G., et al. Results of the Stroke Prevention by Aggressive Reduction in Cholesterol Levels (SPARCL) trial by stroke subtypes. Stroke 2009, 40:1405-1409. Stroke Prevention by Aggressive Reduction in Cholesterol Levels Investigators.
34. Lavallée P.C., Labreuche J., Gongora-Rivera F., Jaramillo A., Brenner D., Klein I.F., et al. Placebo-controlled trial of high-dose atorvastatin in patients with severe cerebral small vessel disease. Stroke 2009, 40:1721-1728. Lacunar-BICHAT Investigators.
35. Meier N., Nedeltchev K., Brekenfeld C., Galimanis A., Fischer U., Findling O., et al. Prior statin use, intracranial hemorrhage, and outcome after intra-arterial thrombolysis for acute ischemic stroke. Stroke 2009, 40:1729-1737.
36. Greisenegger S., Mullner M., Tentschert S., Lang W., Lalouschek W. Effect of preteatment with statins on the severity of acute ischemic cerebrovascular events. J Neurol Sci 2004, 221:1-2.
37. Vergouvwen M.D., de Haan R.J., Vermeulen M., Roos Y.B. Statin treatment and the occurrence of hemorrhagic stroke in patients with a history of cerebrovascular disease. Stroke 2008, 39:497-502.
38. Naval N.S., Abdelhak T.A., Urrunaga N., Zeballos P., Mirski M.A., Carhuapoma J.R. An association of prior statin use with decreased perihematomal edema. Neurocrit Care 2008, 8:13-18.
39. Naval N.S., Abdelhak T.A., Zeballos P., Urrunaga N., Mirski M.A., Carhuapoma J.R. Prior statin use reduces mortality in intracerebral hemorrhage. Neurocrit Care 2008, 8:6-12.
40. Leker R.R., Khoury S.T., Rafaeli G., Shwartz R., Eichel R., Tanne D. Prior use of statins improves outcome in patients with intracerebral hemorrhage: prospective data from the National Acute Stroke Israeli Surveys (NASIS). Stroke 2009, 40:2581-2584. NASIS Investigators.
41. Tapia-Perez H., Sanchez-Aguilar M., Torres-Corzo J.G., Rodriguez-Leyva I., Gonzalez-Aguirre D., Gordillo-Moscoso A., et al. Use of statins for the treatment of spontaneous intracerebral hemorrhage: results of a pilot study. Cen Eur Neurosurg 2009, 70:15-20.
42. Naval N.S., Mirski M.A., Carhuapoma J.R. Impact of statins on validation of ICH mortality prediction models. Neurol Res 2009, 31:425-429.
43. Van der Most P.J., Dolga A.M., Nijholt I.M., Luiten P.G., Eisel U.L. Statins: mechanisms of neuroprotection. Prog Neurobiol 2009, 88:64-75.
44. Blamoun A.I., Batty G.N., DeBari V.A., Rashid A.O., Sheikh M., Khan M.A. Statins may reduce episodes of exacerbation and the requirement for intubation in patients with COPD: evidence from a retrospective cohort study. Int J Clin Pract 2008, 62:1373-1378.
45. De Lucas-Ramos P., Izquierdo-Alonso J.L., Rodríguez-González Moro J.M., Bellón-Cano J.M., Ancochea-Bermúdez J., Calle-Rubio M., et al. Factores de riesgo cardiovascular en la enfermedad pulmonar obstructiva crónica. El estudio ARCE. Arch Bronconeumol 2008, 44:233-238.
46. Frost F.J., Petersen H., Tollestrup K., Skipper B. Influenza and COPD mortality protection as pleiotropic, dose-dependent effects of statins. Chest 2007, 131:1006-1012.
47. Van Gestel Y.R., Hoeks S.E., Sin D.D., Simsek C., Welten G.M., Schouten O., et al. Effect of statin therapy on mortality in patients with peripheral arterial disease and comparison of those with versus without associated chronic obstructive pulmonary disease. Am J Cardiol 2008, 102:192-196.
48. Imamura M., Okunishi K., Ohtsu H., Nakagome K., Harada H., Tanaka R., et al. Pravastatin attenuates allergic airway inflammation by suppressing antigen sensitisation, interleukin 17 production and antigen presentation in the lung. Thorax 2009, 64:44-49.
49. Takahashi S., Nakamura H., Seki M., Shiraishi Y., Yamamoto M., Furuuchi M., et al. Reversal of elastase-induced pulmonary emphysema and promotion of alveolar epithelial cell proliferation by simvastatin in mice. Am J Physiol Lung Cell Mol Physiol 2008, 294:L882-L890.
50. Lee J.H., Lee D.S., Kim E.K., Choe K.H., Oh Y.M., Shim T.S., et al. Simvastatin inhibits cigarette smoking-induced emphysema and pulmonary hypertension in rat lungs. Am J Respir Crit Care Med 2005, 172:987-993.
51. Acute lung injury and the acute respiratory distress syndrome in Ireland: a prospective audit of epidemiology and management. Crit Care 2008, 12:R30. Irish Critical Care Trials Group.
52. Kor D.J., Iscimen R., Yilmaz M., Brown M.J., Brown D.R., Gajic O. Statin administration did not influence the progression of lung injury or associated organ failures in a cohort of patients with acute lung injury. Intensive Care Med 2009, 35:1039-1046.
53. Glynn R.J., Danielson E., Fonseca F.A., Genest J., Gotto A.M., Kastelein J.J., et al. A randomized trial of rosuvastatin in the prevention of venous thromboembolism. N Engl J Med 2009, 360:1851-1861.
54. Abraldes J.G., Albillos A., Bañares R., Turnes J., González R., García-Pagán J.C., et al. Simvastatin lowers portal pressure in patients with cirrhosis and portal hypertension: a randomized controlled trial. Gastroenterology 2009, 136:1651-1658.
55. Slotta J.E., Laschke M.W., Wang Y., Schilling M.K., Menger M.D., Thorlacius H. Inhibition of 3-hydroxy-3-methyl-glutaryl-coenzyme A reductase reduces leukocyte recruitment and hepatocyte apoptosis in endotoxin-induced liver injury. J Investig Med 2009, 57:645-649.
56. Sun H.Y., Singh N. Antimicrobial and imnunomodulatory atributes of statins: Relevance in solid-organ transplant recipients. CID 2009, 48:745-754.
57. Navaneethan S.D., Nigwekar S.U., Perkovic V., Johnson D.W., Craig J.C., Strippoli G.F. HMG CoA reductase inhibitors (statins) for dialysis patients. Cochrane Database Syst Rev 2009, 3:CD004289.
58. Fellström B.C., Jardine A.G., Schmieder R.E., Holdaas H., Bannister K., Beutler J., et al. Rosuvastatin and cardiovascular events in patients undergoinghemodialysis. N Engl J Med 2009, 360:1395-1407. AURORA Study Group.
59. Jerwood S., Cohen J. Unexpected antimicrobial effect of statins. J Antimicrob Chemother 2008, 61:362-364.
60. Felson D.S. Pandemic influeza: A potencial role for statins in treatment andprophylaxis. CID 2006, 34:199-205.
61. Liu Z., Guo Z., Wang G., Zhang D., He H., Li G., et al. Evaluation of the efficacy and safety of a statin/caffeine combination against H5N1, H3N2 and H1N1 virus infection in BALB/c mice. Eur J Pharm Sci 2009, 38:215-223.
62. Winkler F., Angele B., Pfister H.W., Koedel U. Simvastatin attenuates leukocyte recruitment in experimental bacterial meningitis. Int Immunopharmacol 2009, 9:371-374.
63. Hackam D., Mamadani M., Li P., Redelmeier D.A. Statins and Sepsis in patients with cardiovascular disease: a ppulation-based cohort analysis. Lancet 2006, 367:413-418.
64. Almog Y., Shefer A., Novack V., Maimon N., Barski L., Eizinger M., et al. Prior statin therapy is associated with a decreased rate of severe sepsis. Circulation 2004, 110:880-885.
65. Matthew E., Falagas M.E., Makris G., Matthaiou D.K., Rafailidis P.I. Statins for infection and sepsis: a systematic review of the clinical. J Antimicrob Chemother 2008, 61:774-785.
66. Kopterides P., Falagas M.E. Statins for sepsis: a critical and updated review. Clin Microbiol Infect 2009, 15:325-334.
67. Dobesh P.P., Klepser D.G., McGuire T.R., Morgan C.W., Olsen K.M. Reduction in mortality associated with statin therapy in patients with severe sepsis. Pharmacotherapy 2009, 29:621-630.
68. Van de Garde E.M., Hak E., Souverein P.C., Hoes A.W., van den Bosch J.M., Leufkens H.G. Statin treatment and reduced risk of pneumonia in patients with diabetes. Thorax 2006, 61:957-961.
69. Chalmers J.D., Singanayagam A., Murray M.P., Hill A.T. Prior statin use is associated with improved outcomes in community-acquired pneumonia. Am J Med 2008, 121:1002-1007.
70. Mortensen E.M., Restrepo M.I., Anzueto A., Pugh J. The effect of prior statin use on 30-day mortality for patients hospitalized with community-adquired pneumonia. Respir Res 2005, 25:82.
71. Novack V., Eisinger M., Frenkel A., Terblanche M., Adhikari N.K., Douvdevani A., et al. The effects of statin therapy on inflammatory cytokines in patients with bacterial infections: a randomized double-blind placebo controlled clinical trial. Intensive Care Med 2009, 35:1255-1260.
72. Kämäräinen A., Virkkunen I., Silfvast T., Tenhunen J. Statins for post resuscitation syndrome. Med Hypotheses 2009, 73:97-99.
73. Lee C.C., Lee R.P., Subeq Y.M., Lee C.J., Chen T.M., Hsu B.G. Fluvastatin attenuates severe hemorrhagic shock-induced organ damage in rats. Resuscitation 2009, 80:372-378.
74. Almeida J.L., Sampietre S.N., Mendonca Coelho A.M., Trindade Molan N.A., Machado M.C., Monteiro da Cunha J.E., et al. Statin pretreatment in experimental acute pancreatitis. JOP 2008, 9:431-439.
75. Schmidt H., Hennen R., Keller A., Russ M., Müller-Werdan U., Werdan K., et al. Association of statin therapy and increased survival in patients with multiple organ dysfunction syndrome. Intensive Care Med 2006, 32:1248-1251.
76. Carrillo-Esper R., Rivera-Buendia S., Carrillo-Córdova J.R., Carrillo-Córdova L.D. Estatinas, ¿alternativa terapéutica en sepsis?. Gac Med Mex 2007, 143:499-503.
77. Emanueli C., Monopoli A., Kraenkel N., Meloni M., Gadau S., Campesi I., et al. Nitropravastatin stimulates reparative neovascularisation and improves recovery from limb Ischaemia in type-1 diabetic mice. Br J Pharmacol 2007, 150:873-882.
78. McGown C.C., Brookes Z.L.S. Beneficial effects of statins on the microcirdulation during sepsis: the role of nitric oxide. Br J Anaesth 2007, 98:163-175.
79. Gao F., Linhartiva L., Johnston A.Mc.D., Thickett D.R. Statins and sepsis. Br J Anaesth 2008, 100:288-298.
80. Majumdar S.R., McAlister F.A., Eurich D.T., Padwal R.S., Marrie T.J. Statins and outcomes in patients admitted to hospital with community acquired pneumonia: population based prospective cohort study. BMJ 2006, 333:999.
81. Tleyjeh I.M., Kashour T., Hakim F.A., Zimmerman V.A., Erwin P.J., Sutton A.J., et al. Statins for the prevention and treatment of infections: a systematic review and meta-analysis. Arch Intern Med 2009, 169:1658-1667.
82. Leibivici L. Non-antibiotic treatment for bacterial infections: how to vadilate change findings. Clin Microbiol Infect 2009, 15:298-301.
83. Ruiz Bailén M. Administración de estatinas durante la fase aguda del síndrome coronario agudo. Med Intensiva 2010, 34:56-63.
84. Ruiz Bailén M. Efecto de la retirada de estatinas durante el ingreso en Medicina Intensiva. Med Intensiva 2010, 34:268-272.
85. Brookes Z.L.S., McGown C.C., Reilly C.S. Statins for al: the new premed?. Br J Anaesth 2009, 103:99-107.