Synthesis and animal imaging of 99mTc-hydrazinonicotinamide-folate as a new folate receptor-targeted tumor imaging agent

Acta Academiae Medicinae Sinicae

Volumn 28, Issue 6, 2006, Pages 786-789

  Liu, Li Qin ^a   Wang, Shi Zhen ^a   Li, Fang ^a   Teng, Bao ^a   Wang, Ke Zhan ^a   Qiu, Fei Chan ^a  

^a PEKING UNION MEDICAL COLLEGE HOSPITAL   (China)

Author keywords

Biodistribution; Folate derivatives; Folate receptor; Imaging; Isotope labeling

Indexed keywords

FOLATE RECEPTOR; LIGAND; RADIOPHARMACEUTICAL AGENT; TECHNETIUM HYDRAZINONICOTINAMIDEFOLATE TC 99M; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CANCER DIAGNOSIS; CONTROLLED STUDY; DIAGNOSTIC VALUE; DRUG DISTRIBUTION; DRUG PURITY; DRUG STABILITY; DRUG SYNTHESIS; DRUG UPTAKE; GAMMA SCINTIGRAPHY; ISOTOPE LABELING; MALIGNANT NEOPLASTIC DISEASE; MASS SPECTROMETRY; MOUSE; NONHUMAN; PROTON NUCLEAR MAGNETIC RESONANCE; TUMOR XENOGRAFT; WHOLE BODY IMAGING;

ANIMALS; FEMALE; MICE; MICE, INBRED BALB C; MICE, INBRED ICR; NEOPLASMS, EXPERIMENTAL; ORGANOTECHNETIUM COMPOUNDS; RADIOPHARMACEUTICALS; TISSUE DISTRIBUTION;

EID: 33846413546     PISSN: 1000503X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (7)

1. Ross JF, Chaudhuri PK, Ratnam M. Differential regulation of folate receptor isoforms in normal malignant tissues in vivo and in established cell lines. Cancer, 1994, 73(9):2432-2443.
2. 111In-DTPA Folate as a receptor-targeted diagnostic agent for ovarian cancer: initial clinical results. J Nucl Med, 2003, 44 (5): 700-707.
3. 99mTc-HYNIC-folate: a novel receptor-based targeted radiopharmaceutical for tumor imaging. J Nucl Med, 1999, 40(9):1563-1569.
4. Luo J, Smith MD, Lantrip DA, et al. Efficient syntheses of pyrofolic acid and pteroyl azide, reagents for the production of carboxyl-differentiated derivatives of folic acid. J Am Chem Soc, 1997, 119(42):10004-10013.
5. 99mTc-protein conjugates. Bioconjugate Chem, 1991, 2(5): 334-336.
6. Abrams MJ, Juweid M, tenKate CI, et al. Technetium-99m-human polyclonal IgG radiolabeled via the hydrazino nicotinamide derivative for imaging focal sites of infection in rats. J Nucl Med, 1990, 31(12):2022-2028.
7. 99mTc. Bioconjugate Chem, 1997, 8 (2): 146-154.