Role of serotonin 5-HT2A and 5-HT2C receptors on brain stimulation reward and the reward-facilitating effect of cocaine

Psychopharmacology

Volumn 213, Issue 2-3, 2011, Pages 337-354

  Katsidoni, Vicky ^a   Apazoglou, Kalliopi ^a   Panagis, George ^a  

^a UNIVERSITY OF CRETE   (Greece)

Author keywords

5 Hydroxytryptamine; Intracranial self stimulation; Medial prefrontal cortex; Mesolimbocortical system; Nucleus accumbens; Psychostimulants; Reward; Ventral tegmental area

Indexed keywords

6 CHLORO 5 METHYL 1 [[2 [(2 METHYL 3 PYRIDYL)OXY] 5 PYRIDYL]CARBAMOYL]INDOLINE; 8,9 DICHLORO 2,3,4,4A TETRAHYDRO 1H PYRAZINO[1,2 A]QUINOXALIN 5(6H) ONE; COCAINE; SEROTONIN 2A AGONIST; SEROTONIN 2A ANTAGONIST; SEROTONIN 2A RECEPTOR; SEROTONIN 2C AGONIST; SEROTONIN 2C ANTAGONIST; SEROTONIN 2C RECEPTOR;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN DEPTH STIMULATION; BRAIN FUNCTION; CONTROLLED STUDY; ELECTROSTIMULATION; FACILITATION; HYPOTHALAMUS; MALE; MESOLIMBIC DOPAMINERGIC SYSTEM; NEUROMODULATION; NONHUMAN; NUCLEUS ACCUMBENS; PREFRONTAL CORTEX; PRIORITY JOURNAL; PROTEIN LOCALIZATION; PROTEIN TARGETING; RAT; SPRAGUE DAWLEY RAT; VENTRAL TEGMENTUM;

ANIMALS; BRAIN; COCAINE; DOPAMINE; ELECTRIC STIMULATION; MALE; RATS; RATS, SPRAGUE-DAWLEY; RECEPTOR, SEROTONIN, 5-HT2A; RECEPTOR, SEROTONIN, 5-HT2C; REINFORCEMENT (PSYCHOLOGY); REWARD; SEROTONIN ANTAGONISTS; SEROTONIN RECEPTOR AGONISTS;

EID: 79952485802     PISSN: 00333158     EISSN: 14322072     Source Type: Journal    
DOI: 10.1007/s00213-010-1887-7     Document Type: Article

References (82)

1. Abramowski D, Rigo M, Duc D, Hoyer D, Staufenbiel M (1995) Localization of the 5-hydroxytryptamine2C receptor protein in human and rat brain using specific antisera. Neuropharmacology 34:1635-1645
2. Alex KD, Pehek EA (2007) Pharmacologic mechanisms of serotonergic regulation of dopamine neurotransmission. Pharmacol Ther 113:296-320 (Pubitemid 46149046)
3. Benaliouad F, Kapur S, Rompre PP (2007) Blockade of 5-HT2a receptors reduces haloperidol-induced attenuation of reward. Neuropsychopharmacology 32:551-561
4. Boulougouris V, Robbins TW (2010) Enhancement of spatial reversal learning by 5-HT2C receptor antagonism is neuroanatomically specific. J Neurosci 30:930-938
5. Boulougouris V, Glennon JC, Robbins TW (2008) Dissociable effects of selective 5-HT2A and 5-HT2C receptor antagonists on serial spatial reversal learning in rats. Neuropsychopharmacology 33:2007-2019 (Pubitemid 351832598)
6. Bubar MJ, Cunningham KA (2006) Serotonin 5-HT2A and 5-HT2C receptors as potential targets for modulation of psychostimulant use and dependence. Curr Top Med Chem 6:1971-1985 (Pubitemid 44524471)
7. Bubar MJ, Cunningham KA (2007) Distribution of serotonin 5-HT2C receptors in the ventral tegmental area. Neuroscience 146:286-297 (Pubitemid 46654599)
8. Bubar MJ, Cunningham KA (2008) Prospects for serotonin 5-HT2R pharmacotherapy in psychostimulant abuse. Prog Brain Res 172:319-346
9. Burmeister JJ, Lungren EM, Kirschner KF, Neisewander JL (2004) Differential roles of 5-HT receptor subtypes in cue and cocaine reinstatement of cocaine-seeking behavior in rats. Neuropsychopharmacology 29:660-668 (Pubitemid 38402473)
10. Campbell KA, Evans G, Gallistel CR (1985) A microcomputer-based method for physiologically interpretable measurement of the rewarding efficacy of brain stimulation. Physiol Behav 35:395-403 (Pubitemid 16249644)
11. Carlezon WA Jr, Chartoff EH (2007) Intracranial self-stimulation (ICSS) in rodents to study the neurobiology of motivation. Nat Protoc 2:2987-2995
12. Coulombe D, Miliaressis E (1987) Fitting intracranial self-stimulation data with growth models. Behav Neurosci 101:209-214 (Pubitemid 17077263)
13. Cryan JF, Lucki I (2000) Antidepressant-like behavioral effects mediated by 5-hydroxytryptamine(2C) receptors. J Pharmacol Exp Ther 295:1120-1126
14. De Deurwaerdere P, Navailles S, Berg KA, Clarke WP, Spampinato U (2004) Constitutive activity of the serotonin2C receptor inhibits in vivo dopamine release in the rat striatum and nucleus accumbens. J Neurosci 24:3235-3241 (Pubitemid 38451889)
15. Di Chiara G, Bassareo V (2007) Reward system and addiction: what dopamine does and doesn't do. Curr Opin Pharmacol 7:69-76 (Pubitemid 46238042)
16. Di Matteo V, De Blasi A, Di Giulio C, Esposito E (2001) Role of 5-HT(2C) receptors in the control of central dopamine function. Trends Pharmacol Sci 22:229-232 (Pubitemid 32411523)
17. Di Matteo V, Cacchio M, Di Giulio C, Esposito E (2002) Role of serotonin(2C) receptors in the control of brain dopaminergic function. Pharmacol Biochem Behav 71:727-734 (Pubitemid 34219223)
18. Edmonds DE, Gallistel CR (1974) Parametric analysis of brain stimulation reward in the rat: III. Effect of performance variables on the reward summation function. J Comp Physiol Psychol 87:876-883
19. Filip M (2005) Role of serotonin (5-HT)2 receptors in cocaine self-administration and seeking behavior in rats. Pharmacol Rep 57:35-46
20. Filip M, Cunningham KA (2002) Serotonin 5-HT(2C) receptors in nucleus accumbens regulate expression of the hyperlocomotive and discriminative stimulus effects of cocaine. Pharmacol Biochem Behav 71:745-756 (Pubitemid 34219225)
21. Filip M, Cunningham KA (2003) Hyperlocomotive and discriminative stimulus effects of cocaine are under the control of serotonin(2C) (5-HT(2C)) receptors in rat prefrontal cortex. J Pharmacol Exp Ther 306:734-743 (Pubitemid 36886175)
22. Filip M, Bubar MJ, Cunningham KA (2004) Contribution of serotonin (5-hydroxytryptamine; 5-HT) 5-HT2 receptor subtypes to the hyperlocomotor effects of cocaine: acute and chronic pharmacological analyses. J Pharmacol Exp Ther 310:1246-1254 (Pubitemid 39108947)
23. Filip M, Frankowska M, Zaniewska M, Golda A, Przegalinski E (2005) The serotonergic system and its role in cocaine addiction. Pharmacol Rep 57:685-700
24. Filip M, Bubar MJ, Cunningham KA (2006) Contribution of serotonin (5-HT) 5-HT2 receptor subtypes to the discriminative stimulus effects of cocaine in rats. Psychopharmacology (Berl) 183:482-489 (Pubitemid 41721150)
25. Fink KB, Gothert M (2007) 5-HT receptor regulation of neurotransmitter release. Pharmacol Rev 59:360-417
26. Flaisher-Grinberg S, Klavir O, Joel D (2008) The role of 5-HT2A and 5-HT2C receptors in the signal attenuation rat model of obsessive-compulsive disorder. Int J Neuropsychopharmacol 11:811-825
27. Fletcher PJ, Grottick AJ, Higgins GA (2002a) Differential effects of the 5-HT(2A) receptor antagonist M100907 and the 5-HT(2C) receptor antagonist SB242084 on cocaine-induced locomotor activity, cocaine self-administration and cocaine-induced reinstatement of responding. Neuropsychopharmacology 27:576-586
28. Fletcher PJ, Korth KM, Robinson SR, Baker GB (2002b) Multiple 5-HT receptors are involved in the effects of acute MDMA treatment: studies on locomotor activity and responding for conditioned reinforcement. Psychopharmacology (Berl) 162:282-291 (Pubitemid 34762287)
29. Fletcher PJ, Chintoh AF, Sinyard J, Higgins GA (2004) Injection of the 5-HT2C receptor agonist Ro60-0175 into the ventral tegmental area reduces cocaine-induced locomotor activity and cocaine self-administration. Neuropsychopharmacology 29:308-318 (Pubitemid 38175149)
30. Fox MA, French HT, Laporte JL, Blackler AR, Murphy DL (2009) The serotonin 5-HT(2A) receptor agonist TCB-2: a behavioral and neurophysiological analysis. Psychopharmacology (in press)
31. Gallo A, Lapointe S, Stip E, Potvin S, Rompre PP (2010) Quetiapine blocks cocaine-induced enhancement of brain stimulation reward. Behav Brain Res 208:163-168
32. Grottick AJ, Fletcher PJ, Higgins GA (2000) Studies to investigate the role of 5-HT(2C) receptors on cocaine- and food-maintained behavior. J Pharmacol Exp Ther 295:1183-1191
33. Grottick AJ, Corrigall WA, Higgins GA (2001) Activation of 5-HT (2C) receptors reduces the locomotor and rewarding effects of nicotine. Psychopharmacology (Berl) 157:292-298 (Pubitemid 32905571)
34. Halliday GM, Tork I (1989) Serotonin-like immunoreactive cells and fibres in the rat ventromedial mesencephalic tegmentum. Brain Res Bull 22:725-735
35. Hayes DJ, Clements R, Greenshaw AJ (2009a) Effects of systemic and intra-nucleus accumbens 5-HT2C receptor compounds on ventral tegmental area self-stimulation thresholds in rats. Psychopharmacology (Berl) 203:579-588
36. Hayes DJ, Mosher TM, Greenshaw AJ (2009b) Differential effects of 5-HT2C receptor activation by WAY 161503 on nicotine-induced place conditioning and locomotor activity in rats. Behav Brain Res 197:323-330
37. Howell LL, Byrd LD (1995) Serotonergic modulation of the behavioral effects of cocaine in the squirrel monkey. J Pharmacol Exp Ther 275:1551-1559 (Pubitemid 26129947)
38. Hoyer D, Pazos A, Probst A, Palacios JM (1986) Serotonin receptors in the human brain. II. Characterization and autoradiographic localization of 5-HT1C and 5-HT2 recognition sites. Brain Res 376:97-107
39. Karila L, Gorelick D, Weinstein A, Noble F, Benyamina A, Coscas S, Blecha L, Lowenstein W, Martinot JL, Reynaud M, Lepine JP (2008) New treatments for cocaine dependence: a focused review. Int J Neuropsychopharmacol 11:425-438 (Pubitemid 351482505)
40. Kornetsky C (1985) Brain-stimulation reward: a model for the neuronal bases for drug-induced euphoria. NIDA Res Monogr 62:30-50
41. Liu S, Cunningham KA (2006) Serotonin2C receptors (5-HT2C R) control expression of cocaine-induced conditioned hyperactivity. Drug Alcohol Depend 81:275-282 (Pubitemid 43152454)
42. Liu S, Bubar MJ, Lanfranco MF, Hillman GR, Cunningham KA (2007) Serotonin2C receptor localization in GABA neurons of the rat medial prefrontal cortex: implications for understanding the neurobiology of addiction. Neuroscience 146:1677-1688 (Pubitemid 46783202)
43. Lopez-Gimenez JF, Mengod G, Palacios JM, Vilaro MT (1997) Selective visualization of rat brain 5-HT2A receptors by autoradiography with [3H]MDL 100,907. Naunyn Schmiedebergs Arch Pharmacol 356:446-454 (Pubitemid 27402083)
44. Maldonado-Irizarry CS, Stellar JR, Kelley AE (1994) Effects of cocaine and GBR-12909 on brain stimulation reward. Pharmacol Biochem Behav 48:915-920 (Pubitemid 24259821)
45. Markou A, Koob GF (1991) Postcocaine anhedonia. An animal model of cocaine withdrawal. Neuropsychopharmacology 4:17-26
46. Matthews K, Baldo BA, Markou A, Lown O, Overstreet DH, Koob GF (1996) Rewarding electrical brain stimulation: similar thresholds for Flinders Sensitive Line Hypercholinergic and Flinders Resistant Line Hypocholinergic rats. Physiol Behav 59:1155-1162 (Pubitemid 26198195)
47. McCreary AC, Cunningham KA (1999) Effects of the 5-HT2C/2B antagonist SB 206553 on hyperactivity induced by cocaine. Neuropsychopharmacology 20:556-564 (Pubitemid 29189260)
48. McMahon LR, Cunningham KA (2001) Role of 5-HT(2a) and 5-HT (2B/2C) receptors in the behavioral interactions between serotonin and catecholamine reuptake inhibitors. Neuropsychopharmacology 24:319-329 (Pubitemid 32144815)
49. Miliaressis E, Rompre PP (1987) Effects of concomitant motor reactions on the measurement of rewarding efficacy of brain stimulation. Behav Neurosci 101:827-831 (Pubitemid 18009679)
50. Miliaressis E, Rompre PP, Laviolette P, Philippe L, Coulombe D (1986) The curve-shift paradigm in self-stimulation. Physiol Behav 37:85-91 (Pubitemid 16121802)
51. Morissette MC, Boye SM (2008) Electrolytic lesions of the habenula attenuate brain stimulation reward. Behav Brain Res 187:17-26
52. Muller CP, Huston JP (2006) Determining the region-specific contributions of 5-HT receptors to the psychostimulant effects of cocaine. Trends Pharmacol Sci 27:105-112 (Pubitemid 43184032)
53. Muller CP, Carey RJ, Huston JP, De Souza Silva MA (2007) Serotonin and psychostimulant addiction: focus on 5-HT1A-receptors. Prog Neurobiol 81:133-178 (Pubitemid 46282275)
54. Navailles S, De Deurwaerdere P, Porras G, Spampinato U (2004) In vivo evidence that 5-HT2C receptor antagonist but not agonist modulates cocaine-induced dopamine outflow in the rat nucleus accumbens and striatum. Neuropsychopharmacology 29:319-326
55. Navailles S, Moison D, Cunningham KA, Spampinato U (2008) Differential regulation of the mesoaccumbens dopamine circuit by serotonin2C receptors in the ventral tegmental area and the nucleus accumbens: an in vivo microdialysis study with cocaine. Neuropsychopharmacology 33:237-246 (Pubitemid 350243355)
56. Neisewander JL, Acosta JI (2007) Stimulation of 5-HT2C receptors attenuates cue and cocaine-primed reinstatement of cocaine-seeking behavior in rats. Behav Pharmacol 18:791-800 (Pubitemid 350076436)
57. Nocjar C, Roth BL, Pehek EA (2002) Localization of 5-HT(2A) receptors on dopamine cells in subnuclei of the midbrain A10 cell group. Neuroscience 111:163-176 (Pubitemid 34310459)
58. Olds J, Milner P (1954) Positive reinforcement produced by electrical stimulation of septal area and other regions of rat brain. J Comp Physiol Psychol 47:419-427
59. Panagis G, Spyraki C (1996) Neuropharmacological evidence for the role of dopamine in ventral pallidum self-stimulation. Psychopharmacology (Berl) 123:280-288 (Pubitemid 26074234)
60. Panagis G, Kastellakis A, Spyraki C, Nomikos G (2000) Effects of methyllycaconitine (MLA), an alpha 7 nicotinic receptor antagonist, on nicotine- and cocaine-induced potentiation of brain stimulation reward. Psychopharmacology (Berl) 149:388-396
61. Paterson NE, Myers C, Markou A (2000) Effects of repeated withdrawal from continuous amphetamine administration on brain reward function in rats. Psychopharmacology (Berl) 152:440-446
62. Paxinos G, Watson C (2007) The rat brain in stereotaxic coordinates, 6th edn. Elsevier, Amsterdam
63. Pierce RC, Kumaresan V (2006) The mesolimbic dopamine system: the final common pathway for the reinforcing effect of drugs of abuse? Neurosci Biobehav Rev 30:215-238
64. Platt DM, Rowlett JK, Spealman RD (2002) Behavioral effects of cocaine and dopaminergic strategies for preclinical medication development. Psychopharmacology (Berl) 163:265-282
65. Pompeiano M, Palacios JM, Mengod G (1994) Distribution of the serotonin 5-HT2 receptor family mRNAs: comparison between 5-HT2A and 5-HT2C receptors. Brain Res Mol Brain Res 23:163-178
66. Ranaldi R, Bauco P, Wise RA (1997) Synergistic effects of cocaine and dizocilpine (MK-801) on brain stimulation reward. Brain Res 760:231-237 (Pubitemid 27304157)
67. Robinson ES, Dalley JW, Theobald DE, Glennon JC, Pezze MA, Murphy ER, Robbins TW (2008) Opposing roles for 5-HT2A and 5-HT2C receptors in the nucleus accumbens on inhibitory response control in the 5-choice serial reaction time task. Neuropsychopharmacology 33:2398-2406
68. Rocha BA, Goulding EH, O'Dell LE, Mead AN, Coufal NG, Parsons LH, Tecott LH (2002) Enhanced locomotor, reinforcing, and neurochemical effects of cocaine in serotonin 5-hydroxytryptamine 2C receptor mutant mice. J Neurosci 22:10039-10045 (Pubitemid 35332889)
69. Romeas T, Morissette MC, Mnie-Filali O, Pineyro G, Boye SM (2009) Simultaneous anhedonia and exaggerated locomotor activation in an animal model of depression. Psychopharmacology (Berl) 205:293-303
70. Sharma A, Punhani T, Fone KC (1997) Distribution of the 5-hydroxytryptamine2C receptor protein in adult rat brain and spinal cord determined using a receptor-directed antibody: effect of 5,7- dihydroxytryptamine. Synapse 27:45-56 (Pubitemid 27327601)
71. Shioda K, Nisijima K, Yoshino T, Kuboshima K, Iwamura T, Yui K, Kato S (2008) Risperidone attenuates and reverses hyperthermia induced by 3,4-methylenedioxymethamphetamine (MDMA) in rats. Neurotoxicology 29:1030-1036
72. Singh J, Desiraju T, Raju TR (1996) Comparison of intracranial self-stimulation evoked from lateral hypothalamus and ventral tegmentum: analysis based on stimulation parameters and behavioural response characteristics. Brain Res Bull 41:399-408 (Pubitemid 26427634)
73. Slattery DA, Markou A, Cryan JF (2007) Evaluation of reward processes in an animal model of depression. Psychopharmacology (Berl) 190:555-568 (Pubitemid 46204472)
74. Thomas MJ, Kalivas PW, Shaham Y (2008) Neuroplasticity in the mesolimbic dopamine system and cocaine addiction. Br J Pharmacol 154:327-342 (Pubitemid 351670603)
75. Tomkins DM, Joharchi N, Tampakeras M, Martin JR, Wichmann J, Higgins GA (2002) An investigation of the role of 5-HT(2C) receptors in modifying ethanol self-administration behaviour. Pharmacol Biochem Behav 71:735-744 (Pubitemid 34219224)
76. Vlachou S, Nomikos GG, Panagis G (2003) WIN 55, 212-2 decreases the reinforcing actions of cocaine through CB1 cannabinoid receptor stimulation. Behav Brain Res 141:215-222 (Pubitemid 36542969)
77. Vlachou S, Stamatopoulou F, Nomikos GG, Panagis G (2008) Enhancement of endocannabinoid neurotransmission through CB1 cannabinoid receptors counteracts the reinforcing and psychostimulant effects of cocaine. Int J Neuropsychopharmacol 11:905-923
78. Willins DL, Meltzer HY (1998) Serotonin 5-HT2C agonists selectively inhibit morphine-induced dopamine efflux in the nucleus accumbens. Brain Res 781:291-299 (Pubitemid 28082874)
79. Wise RA (1996) Addictive drugs and brain stimulation reward. Annu Rev Neurosci 19:319-340
80. Wise RA (1998) Drug-activation of brain reward pathways. Drug Alcohol Depend 51:13-22
81. Xi ZX, Gardner EL (2008) Hypothesis-driven medication discovery for the treatment of psychostimulant addiction. Curr Drug Abuse Rev 1:303-327
82. Zaniewska M, McCreary AC, Filip M (2009) Interactions of serotonin (5-HT)2 receptor-targeting ligands and nicotine: locomotor activity studies in rats. Synapse 63:653-661