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Volumn 7, Issue 2, 2011, Pages

Gene expression noise in spatial patterning: Hunchback promoter structure affects noise amplitude and distribution in Drosophila segmentation

Author keywords

[No Author keywords available]

Indexed keywords

DYNAMICS; GENE EXPRESSION REGULATION; PROTEINS; STOCHASTIC MODELS; STOCHASTIC SYSTEMS; TRANSCRIPTION;

EID: 79952469264     PISSN: 1553734X     EISSN: 15537358     Source Type: Journal    
DOI: 10.1371/journal.pcbi.1001069     Document Type: Article
Times cited : (55)

References (72)
  • 1
    • 0037075022 scopus 로고    scopus 로고
    • Establishment of developmental precision and proportions in the early Drosophila embryo
    • Houchmandzadeh B, Wieschaus E, Leibler S, (2002) Establishment of developmental precision and proportions in the early Drosophila embryo. Nature 415: 798-802.
    • (2002) Nature , vol.415 , pp. 798-802
    • Houchmandzadeh, B.1    Wieschaus, E.2    Leibler, S.3
  • 2
    • 27644547453 scopus 로고    scopus 로고
    • Bicoid determines sharp and precise target gene expression on the Drosophila embryo
    • Crauk O, Dostatni N, (2005) Bicoid determines sharp and precise target gene expression on the Drosophila embryo. Curr Biol 15: 1888-1898.
    • (2005) Curr Biol , vol.15 , pp. 1888-1898
    • Crauk, O.1    Dostatni, N.2
  • 3
    • 33750995578 scopus 로고    scopus 로고
    • Analysis of pattern precision shows that Drosophila segmentation develops substantial independence from gradients of maternal gene products
    • Holloway DM, Harrison LG, Kosman D, Vanario-Alonso CE, Spirov AV, (2006) Analysis of pattern precision shows that Drosophila segmentation develops substantial independence from gradients of maternal gene products. Dev Dynam 235: 2949-2960.
    • (2006) Dev Dynam , vol.235 , pp. 2949-2960
    • Holloway, D.M.1    Harrison, L.G.2    Kosman, D.3    Vanario-Alonso, C.E.4    Spirov, A.V.5
  • 4
    • 34447099234 scopus 로고    scopus 로고
    • Probing the limits to positional information
    • Gregor T, Tank DW, Wieschaus EF, Bialek W, (2007) Probing the limits to positional information. Cell 130: 153-164.
    • (2007) Cell , vol.130 , pp. 153-164
    • Gregor, T.1    Tank, D.W.2    Wieschaus, E.F.3    Bialek, W.4
  • 5
    • 53249149490 scopus 로고    scopus 로고
    • Probing intrinsic properties of a robust morphogen gradient in Drosophila
    • He F, Wen Y, Lin X, Lu LJ, Jiao R, et al. (2008) Probing intrinsic properties of a robust morphogen gradient in Drosophila. Dev Cell 15: 558-567.
    • (2008) Dev Cell , vol.15 , pp. 558-567
    • He, F.1    Wen, Y.2    Lin, X.3    Lu, L.J.4    Jiao, R.5
  • 6
    • 0023679744 scopus 로고
    • The bicoid protein determines position in the Drosophila embryo in a concentration-dependent manner
    • Driever W, Nüsslein-Volhard C, (1988) The bicoid protein determines position in the Drosophila embryo in a concentration-dependent manner. Cell 54: 95-104.
    • (1988) Cell , vol.54 , pp. 95-104
    • Driever, W.1    Nüsslein-Volhard, C.2
  • 7
    • 0023677769 scopus 로고
    • A gradient of bicoid protein in Drosophila embryos
    • Driever W, Nüsslein-Volhard C, (1988) A gradient of bicoid protein in Drosophila embryos. Cell 54: 83-93.
    • (1988) Cell , vol.54 , pp. 83-93
    • Driever, W.1    Nüsslein-Volhard, C.2
  • 8
    • 0004279072 scopus 로고    scopus 로고
    • Oxford (UK), Oxford University Press, 2nd Ed
    • Wolpert L, (2002) Principles of development. 2nd ed Oxford (UK) Oxford University Press.
    • (2002) Principles of Development
    • Wolpert, L.1
  • 9
    • 0842303319 scopus 로고    scopus 로고
    • Seeing is believing: The bicoid morphogen gradient matures
    • Ephrussi A, St Johnston D, (2004) Seeing is believing: The bicoid morphogen gradient matures. Cell 116: 143-152.
    • (2004) Cell , vol.116 , pp. 143-152
    • Ephrussi, A.1    St Johnston, D.2
  • 11
    • 59649094362 scopus 로고    scopus 로고
    • A ten percent solution
    • Reinitz J, (2007) A ten percent solution. Nature 448: 418-419.
    • (2007) Nature , vol.448 , pp. 418-419
    • Reinitz, J.1
  • 12
    • 0042536457 scopus 로고    scopus 로고
    • Making the body plan: precision in the genetic hierarchy of Drosophila embryo segmentation
    • Spirov AV, Holloway DM, (2003) Making the body plan: precision in the genetic hierarchy of Drosophila embryo segmentation. In Silico Biol 3: 89-100.
    • (2003) In Silico Biol , vol.3 , pp. 89-100
    • Spirov, A.V.1    Holloway, D.M.2
  • 13
    • 17844376743 scopus 로고    scopus 로고
    • Dynamics of Drosophila embryonic patterning network perturbed in space and time using microfluidics
    • Lucchetta EM, Lee JH, Fu LA, Patel NH, Ismagilov RF, (2005) Dynamics of Drosophila embryonic patterning network perturbed in space and time using microfluidics. Nature 434: 1134-1138.
    • (2005) Nature , vol.434 , pp. 1134-1138
    • Lucchetta, E.M.1    Lee, J.H.2    Fu, L.A.3    Patel, N.H.4    Ismagilov, R.F.5
  • 14
    • 56649097257 scopus 로고    scopus 로고
    • A precise Bicoid gradient is nonessential during cycles 11-13 for precise patterning in the Drosophila blastoderm
    • Lucchetta EM, Vincent ME, Ismagilov RF, (2008) A precise Bicoid gradient is nonessential during cycles 11-13 for precise patterning in the Drosophila blastoderm. PLoS ONE 3: e3651.
    • (2008) PLoS ONE , vol.3
    • Lucchetta, E.M.1    Vincent, M.E.2    Ismagilov, R.F.3
  • 16
    • 0000359208 scopus 로고
    • Kinetic proofreading: a new mechanism for reducing errors in biosynthetic processes requiring high specificity
    • Hopfield JJ, (1974) Kinetic proofreading: a new mechanism for reducing errors in biosynthetic processes requiring high specificity. Proc Nat Acad Sci USA 71: 4135-4139.
    • (1974) Proc Nat Acad Sci USA , vol.71 , pp. 4135-4139
    • Hopfield, J.J.1
  • 17
    • 0030890691 scopus 로고    scopus 로고
    • Drosophila embryonic pattern repair: how embryos respond to bicoid dosage alteration
    • Namba R, Pazdera TM, Cerrone RL, Minden JS, (1997) Drosophila embryonic pattern repair: how embryos respond to bicoid dosage alteration. Development 124: 1393-1403.
    • (1997) Development , vol.124 , pp. 1393-1403
    • Namba, R.1    Pazdera, T.M.2    Cerrone, R.L.3    Minden, J.S.4
  • 18
    • 33244485265 scopus 로고    scopus 로고
    • The interpretation of morphogen gradients
    • Ashe HL, Briscoe J, (2006) The interpretation of morphogen gradients. Development 133: 385-394.
    • (2006) Development , vol.133 , pp. 385-394
    • Ashe, H.L.1    Briscoe, J.2
  • 19
    • 0034691214 scopus 로고    scopus 로고
    • Stochastic focusing: fluctuation-enhanced sensitivity of intracellular regulation
    • Paulsson J, Berg OG, Ehrenberg M, (2000) Stochastic focusing: fluctuation-enhanced sensitivity of intracellular regulation. Proc Nat Acad Sci USA 97: 7148-7153.
    • (2000) Proc Nat Acad Sci USA , vol.97 , pp. 7148-7153
    • Paulsson, J.1    Berg, O.G.2    Ehrenberg, M.3
  • 21
    • 0037078982 scopus 로고    scopus 로고
    • Control, exploitation and tolerance of intracellular noise
    • Rao CV, Wolf DM, Arkin AP, (2002) Control, exploitation and tolerance of intracellular noise. Nature 420: 231-237.
    • (2002) Nature , vol.420 , pp. 231-237
    • Rao, C.V.1    Wolf, D.M.2    Arkin, A.P.3
  • 22
    • 0036111831 scopus 로고    scopus 로고
    • Attenuation of noise in ultrasensitive signaling cascades
    • Thattai M, van Oudenaarden A, (2002) Attenuation of noise in ultrasensitive signaling cascades. Biophys J 82: 2943-2950.
    • (2002) Biophys J , vol.82 , pp. 2943-2950
    • Thattai, M.1    van Oudenaarden, A.2
  • 23
    • 33745287724 scopus 로고    scopus 로고
    • Noise in protein expression scales with natural protein abundance
    • Bar-Even A, Paulsson J, Maheshri N, Carmi M, O'Shea E, et al. (2006) Noise in protein expression scales with natural protein abundance. Nat Genet 38: 636-643.
    • (2006) Nat Genet , vol.38 , pp. 636-643
    • Bar-Even, A.1    Paulsson, J.2    Maheshri, N.3    Carmi, M.4    O'Shea, E.5
  • 24
    • 67749117790 scopus 로고    scopus 로고
    • Partial penetrance facilitates developmental evolution in bacteria
    • Eldar A, Chary VK, Xenopoulos P, Fontes ME, Losón OC, et al. (2009) Partial penetrance facilitates developmental evolution in bacteria. Nature 460: 510-514.
    • (2009) Nature , vol.460 , pp. 510-514
    • Eldar, A.1    Chary, V.K.2    Xenopoulos, P.3    Fontes, M.E.4    Losón, O.C.5
  • 25
    • 38649137978 scopus 로고    scopus 로고
    • Master equation simulation analysis of immunostained Bicoid morphogen gradient
    • Wu YF, Myasnikova E, Reinitz J, (2007) Master equation simulation analysis of immunostained Bicoid morphogen gradient. BMC Sys Biol 1: 52.
    • (2007) BMC Sys Biol , vol.1 , pp. 52
    • Wu, Y.F.1    Myasnikova, E.2    Reinitz, J.3
  • 26
    • 0041324718 scopus 로고    scopus 로고
    • Mesoscopic reaction-diffusion in intracellular signaling
    • Elf J, Dončić A, Ehrenberg M, (2003) Mesoscopic reaction-diffusion in intracellular signaling. Proc SPIE 5110: 114-124.
    • (2003) Proc SPIE , vol.5110 , pp. 114-124
    • Elf, J.1    Dončić, A.2    Ehrenberg, M.3
  • 27
    • 20844432892 scopus 로고    scopus 로고
    • Stochastic reaction-diffusion simulation with MesoRD
    • Hattne J, Fange D, Elf J, (2005) Stochastic reaction-diffusion simulation with MesoRD. Bioinformatics 21: 2923-2924.
    • (2005) Bioinformatics , vol.21 , pp. 2923-2924
    • Hattne, J.1    Fange, D.2    Elf, J.3
  • 28
    • 0017030517 scopus 로고
    • A general method for numerically simulating the stochastic time evolution of coupled chemical reactions
    • Gillespie D, (1976) A general method for numerically simulating the stochastic time evolution of coupled chemical reactions. J Comput Phys 22: 403-434.
    • (1976) J Comput Phys , vol.22 , pp. 403-434
    • Gillespie, D.1
  • 29
    • 0034225547 scopus 로고    scopus 로고
    • The chemical Langevin equation
    • Gillespie DT, (2000) The chemical Langevin equation. J Chem Phys 113: 297-306.
    • (2000) J Chem Phys , vol.113 , pp. 297-306
    • Gillespie, D.T.1
  • 31
    • 0024947426 scopus 로고
    • The products of the Drosophila gap genes hunchback and Krüppel bind to the hunchback promoters
    • Treisman J, Desplan C, (1989) The products of the Drosophila gap genes hunchback and Krüppel bind to the hunchback promoters. Nature 341: 335-337.
    • (1989) Nature , vol.341 , pp. 335-337
    • Treisman, J.1    Desplan, C.2
  • 32
    • 0024569785 scopus 로고
    • The Bicoid protein is a positive regulator of hunchback transcription in the early Drosophila embryo
    • Driever W, Nüsslein-Volhard C, (1989) The Bicoid protein is a positive regulator of hunchback transcription in the early Drosophila embryo. Nature 337: 138-143.
    • (1989) Nature , vol.337 , pp. 138-143
    • Driever, W.1    Nüsslein-Volhard, C.2
  • 33
    • 0028021851 scopus 로고
    • Synergy between the Hunchback and Bicoid morphogens is required for anterior patterning in Drosophila
    • Simpson-Brose M, Treisman J, Desplan C, (1994) Synergy between the Hunchback and Bicoid morphogens is required for anterior patterning in Drosophila. Cell 78: 855-865.
    • (1994) Cell , vol.78 , pp. 855-865
    • Simpson-Brose, M.1    Treisman, J.2    Desplan, C.3
  • 34
    • 0024323615 scopus 로고
    • Determination of spatial domains of zygotic gene-expression in the Drosophila embryo by the affinity of binding-sites for the Bicoid morphogen
    • Driever W, Thoma G, Nüsslein-Volhard C, (1989) Determination of spatial domains of zygotic gene-expression in the Drosophila embryo by the affinity of binding-sites for the Bicoid morphogen. Nature 340: 363-367.
    • (1989) Nature , vol.340 , pp. 363-367
    • Driever, W.1    Thoma, G.2    Nüsslein-Volhard, C.3
  • 35
    • 50449099063 scopus 로고    scopus 로고
    • The role of input noise in transcriptional regulation
    • Tkacik G, Gregor T, Bialek W, (2008) The role of input noise in transcriptional regulation. PLoS ONE 3: e2774.
    • (2008) PLoS ONE , vol.3
    • Tkacik, G.1    Gregor, T.2    Bialek, W.3
  • 36
    • 70049101507 scopus 로고    scopus 로고
    • Stable, precise, and reproducible patterning of Bicoid and Hunchback molecules in the early Drosophila embryo
    • Okabe-Oho Y, Murakami H, Oho S, Sasai M, (2009) Stable, precise, and reproducible patterning of Bicoid and Hunchback molecules in the early Drosophila embryo. PLoS Comput Biol 5: e1000486.
    • (2009) PLoS Comput Biol , vol.5
    • Okabe-Oho, Y.1    Murakami, H.2    Oho, S.3    Sasai, M.4
  • 37
    • 70349997681 scopus 로고    scopus 로고
    • Statistical lower bounds on protein copy number from fluorescence expression images
    • Zamparo L, Perkins TJ, (2009) Statistical lower bounds on protein copy number from fluorescence expression images. Bioinformatics 25: 2670-2676.
    • (2009) Bioinformatics , vol.25 , pp. 2670-2676
    • Zamparo, L.1    Perkins, T.J.2
  • 38
    • 0032531831 scopus 로고    scopus 로고
    • Cooperative DNA-binding by Bicoid provides a mechanism for threshold-dependent gene activation in the Drosophila embryo
    • Burz DS, Rivera-Pomar R, Jäckle H, Hanes SD, (1998) Cooperative DNA-binding by Bicoid provides a mechanism for threshold-dependent gene activation in the Drosophila embryo. EMBO J 17: 5998-6009.
    • (1998) EMBO J , vol.17 , pp. 5998-6009
    • Burz, D.S.1    Rivera-Pomar, R.2    Jäckle, H.3    Hanes, S.D.4
  • 39
    • 0029917071 scopus 로고    scopus 로고
    • The Drosophila morphogenetic protein Bicoid binds DNA cooperatively
    • Ma XG, Yuan D, Diepold K, Scarborough T, Ma J, (1996) The Drosophila morphogenetic protein Bicoid binds DNA cooperatively. Development 122: 1195-1206.
    • (1996) Development , vol.122 , pp. 1195-1206
    • Ma, X.G.1    Yuan, D.2    Diepold, K.3    Scarborough, T.4    Ma, J.5
  • 40
    • 0035847110 scopus 로고    scopus 로고
    • Isolation of mutations that disrupt cooperative DNA binding by the Drosophila Bicoid protein
    • Burz DS, Hanes SD, (2001) Isolation of mutations that disrupt cooperative DNA binding by the Drosophila Bicoid protein. J Mol Biol 305: 219-230.
    • (2001) J Mol Biol , vol.305 , pp. 219-230
    • Burz, D.S.1    Hanes, S.D.2
  • 41
    • 34447104600 scopus 로고    scopus 로고
    • Stability and nuclear dynamics of the bicoid morphogen gradient
    • Gregor T, Wieschaus EF, McGregor AP, Bialek W, Tank DW, (2007) Stability and nuclear dynamics of the bicoid morphogen gradient. Cell 130: 141-152.
    • (2007) Cell , vol.130 , pp. 141-152
    • Gregor, T.1    Wieschaus, E.F.2    McGregor, A.P.3    Bialek, W.4    Tank, D.W.5
  • 42
    • 65949084005 scopus 로고    scopus 로고
    • Canalization of gene expression in the Drosophila blastoderm by gap gene cross regulation
    • Manu, Surkova S, Spirov AV, Gursky VV, Janssens H, et al. (2009) Canalization of gene expression in the Drosophila blastoderm by gap gene cross regulation. PLoS Biol 7: e1000049.
    • (2009) PLoS Biol , vol.7
    • Manu1    Surkova, S.2    Spirov, A.V.3    Gursky, V.V.4    Janssens, H.5
  • 43
    • 42549110153 scopus 로고    scopus 로고
    • Exact probabilistic solution of spatial-dependent stochastics and associated spatial potential landscape for the bicoid protein
    • Lepzelter D, Wang J, (2008) Exact probabilistic solution of spatial-dependent stochastics and associated spatial potential landscape for the bicoid protein. Phys Rev E 77: 041917.
    • (2008) Phys Rev E , vol.77 , pp. 041917
    • Lepzelter, D.1    Wang, J.2
  • 44
    • 36549006909 scopus 로고    scopus 로고
    • Modeling the bicoid gradient: diffusion and reversible nuclear trapping of a stable protein
    • Coppey M, Berezhovskii AM, Kim Y, Boettiger AN, Shvartsman SY, (2007) Modeling the bicoid gradient: diffusion and reversible nuclear trapping of a stable protein. Dev Biol 312: 623-630.
    • (2007) Dev Biol , vol.312 , pp. 623-630
    • Coppey, M.1    Berezhovskii, A.M.2    Kim, Y.3    Boettiger, A.N.4    Shvartsman, S.Y.5
  • 45
    • 45449115714 scopus 로고    scopus 로고
    • Nuclear trapping shapes the terminal gradient in the Drosophila embryo
    • Coppey M, Boettiger AN, Berezhovskii AM, Shvartsman SY, (2008) Nuclear trapping shapes the terminal gradient in the Drosophila embryo. Curr Biol 18: 915-919.
    • (2008) Curr Biol , vol.18 , pp. 915-919
    • Coppey, M.1    Boettiger, A.N.2    Berezhovskii, A.M.3    Shvartsman, S.Y.4
  • 46
    • 64549083692 scopus 로고    scopus 로고
    • Formation of the bicoid morphogen gradient: an mRNA gradient dictates the protein gradient
    • Spirov AV, Fahmy K, Schneider M, Frei E, Noll M, et al. (2009) Formation of the bicoid morphogen gradient: an mRNA gradient dictates the protein gradient. Development 136: 605-614.
    • (2009) Development , vol.136 , pp. 605-614
    • Spirov, A.V.1    Fahmy, K.2    Schneider, M.3    Frei, E.4    Noll, M.5
  • 50
    • 0042424655 scopus 로고    scopus 로고
    • Transcriptional regulatory cascades in development: Initial rates, not steady state, determine network kinetics
    • Bolouri H, Davidson E, (2003) Transcriptional regulatory cascades in development: Initial rates, not steady state, determine network kinetics. Proc Nat Acad Sci USA 100: 9371-9376.
    • (2003) Proc Nat Acad Sci USA , vol.100 , pp. 9371-9376
    • Bolouri, H.1    Davidson, E.2
  • 52
    • 77649220197 scopus 로고    scopus 로고
    • Noise can induce bimodality in positive transcriptional feedback loops without bistability
    • To T-L, Maheshri N, (2010) Noise can induce bimodality in positive transcriptional feedback loops without bistability. Science 327: 1142-1145.
    • (2010) Science , vol.327 , pp. 1142-1145
    • To, T.-L.1    Maheshri, N.2
  • 53
    • 34547540506 scopus 로고    scopus 로고
    • Discovering transcriptional regulatory regions in Drosophila by a nonalignment method for phylogenetic footprinting
    • Sosinsky A, Honig B, Mann BS, Califano A, (2007) Discovering transcriptional regulatory regions in Drosophila by a nonalignment method for phylogenetic footprinting. Proc Nat Acad Sci USA 104: 6305-10.
    • (2007) Proc Nat Acad Sci USA , vol.104 , pp. 6305-6310
    • Sosinsky, A.1    Honig, B.2    Mann, B.S.3    Califano, A.4
  • 54
    • 0033026626 scopus 로고    scopus 로고
    • High sequence turnover in the regulatory regions of the developmental gene hunchback in insects
    • Hancock JM, Shaw PJ, Bonneton F, Dover GA, (1999) High sequence turnover in the regulatory regions of the developmental gene hunchback in insects. Mol Biol Evol 16: 253-265.
    • (1999) Mol Biol Evol , vol.16 , pp. 253-265
    • Hancock, J.M.1    Shaw, P.J.2    Bonneton, F.3    Dover, G.A.4
  • 55
    • 0035544649 scopus 로고    scopus 로고
    • Rapid restructuring of bicoid-dependent hunchback promoters within and between Dipteran species: implications for molecular coevolution
    • McGregor AP, Shaw PJ, Hancock JM, Bopp D, Hediger M, et al. (2001) Rapid restructuring of bicoid-dependent hunchback promoters within and between Dipteran species: implications for molecular coevolution. Evol and Dev 3: 397-407.
    • (2001) Evol and Dev , vol.3 , pp. 397-407
    • McGregor, A.P.1    Shaw, P.J.2    Hancock, J.M.3    Bopp, D.4    Hediger, M.5
  • 56
  • 58
    • 33746492940 scopus 로고    scopus 로고
    • Localization of bicoid mRNA in late oocytes is maintained by continual active transport
    • Weil TT, Forrest KM, Gavis ER, (2006) Localization of bicoid mRNA in late oocytes is maintained by continual active transport. Dev Cell 11: 251-262.
    • (2006) Dev Cell , vol.11 , pp. 251-262
    • Weil, T.T.1    Forrest, K.M.2    Gavis, E.R.3
  • 59
    • 51749125934 scopus 로고    scopus 로고
    • Changes in bicoid mRNA anchoring highlight conserved mechanisms during the oocyte-to-embryo transition
    • Weil TT, Parton R, Davis I, Gavis ER, (2008) Changes in bicoid mRNA anchoring highlight conserved mechanisms during the oocyte-to-embryo transition. Curr Biol 18: 1055-1061.
    • (2008) Curr Biol , vol.18 , pp. 1055-1061
    • Weil, T.T.1    Parton, R.2    Davis, I.3    Gavis, E.R.4
  • 60
    • 67749106610 scopus 로고    scopus 로고
    • Synchronous and stochastic patterns of gene activation in the Drosophila embryo
    • Boettiger A, Levine M, (2009) Synchronous and stochastic patterns of gene activation in the Drosophila embryo. Science 325: 471-473.
    • (2009) Science , vol.325 , pp. 471-473
    • Boettiger, A.1    Levine, M.2
  • 61
    • 0347987855 scopus 로고    scopus 로고
    • A self-organizing system of repressor gradients establishes segmental complexity in Drosophila
    • Clyde D, Corado M, Wu X, Pare A, Papatsenko D, et al. (2003) A self-organizing system of repressor gradients establishes segmental complexity in Drosophila. Nature 426: 849-853.
    • (2003) Nature , vol.426 , pp. 849-853
    • Clyde, D.1    Corado, M.2    Wu, X.3    Pare, A.4    Papatsenko, D.5
  • 62
    • 0035449397 scopus 로고    scopus 로고
    • Thoracic patterning by the Drosophila gap gene hunchback
    • Wu XL, Vasisht V, Kosman D, Reinitz J, Small S, (2001) Thoracic patterning by the Drosophila gap gene hunchback. Dev Biol 237: 79-92.
    • (2001) Dev Biol , vol.237 , pp. 79-92
    • Wu, X.L.1    Vasisht, V.2    Kosman, D.3    Reinitz, J.4    Small, S.5
  • 63
    • 45449087493 scopus 로고    scopus 로고
    • Precise registration of gene expression boundaries by a repressive morphogen in Drosophila
    • Yu D, Small S, (2008) Precise registration of gene expression boundaries by a repressive morphogen in Drosophila. Curr Biol 18: 868-876.
    • (2008) Curr Biol , vol.18 , pp. 868-876
    • Yu, D.1    Small, S.2
  • 64
    • 20844455677 scopus 로고    scopus 로고
    • Spontaneous separation of bi-stable biochemical systems in spatial domains of opposite phases
    • Elf J, Ehrenberg M, (2004) Spontaneous separation of bi-stable biochemical systems in spatial domains of opposite phases. Syst Biol 2: 230-236.
    • (2004) Syst Biol , vol.2 , pp. 230-236
    • Elf, J.1    Ehrenberg, M.2
  • 65
    • 22844442948 scopus 로고    scopus 로고
    • A high- throughput method for quantifying gene expression data from early Drosophila embryos
    • Janssens H, Kosman D, Vanario-Alonso CE, Jaeger J, Samsonova M, et al. (2005) A high- throughput method for quantifying gene expression data from early Drosophila embryos. Dev Genes Evol 215: 374-381.
    • (2005) Dev Genes Evol , vol.215 , pp. 374-381
    • Janssens, H.1    Kosman, D.2    Vanario-Alonso, C.E.3    Jaeger, J.4    Samsonova, M.5
  • 67
    • 21344474605 scopus 로고    scopus 로고
    • Removal of background signal from in situ data on the expression of segmentation genes in Drosophila
    • Myasnikova E, Samsonova M, Kosman D, Reinitz J, (2005) Removal of background signal from in situ data on the expression of segmentation genes in Drosophila. Dev Genes Evol 215: 320-326.
    • (2005) Dev Genes Evol , vol.215 , pp. 320-326
    • Myasnikova, E.1    Samsonova, M.2    Kosman, D.3    Reinitz, J.4
  • 68
    • 0042933938 scopus 로고    scopus 로고
    • Evolutionary techniques for image processing a large dataset of early Drosophila gene expression
    • Spirov AV, Holloway DM, (2003) Evolutionary techniques for image processing a large dataset of early Drosophila gene expression. EURASIP J on Appl Signal Processing 2003 no. 8: 824-833.
    • (2003) EURASIP J on Appl Signal Processing 2003 , vol.8 , pp. 824-833
    • Spirov, A.V.1    Holloway, D.M.2
  • 70
    • 64549089704 scopus 로고    scopus 로고
    • Singular spectrum analysis of gene expression profiles of early Drosophila embryo: exponential-in-distance patterns
    • Alexandrov T, Golyandina N, Spirov AV, (2008) Singular spectrum analysis of gene expression profiles of early Drosophila embryo: exponential-in-distance patterns. Res Lett Signal Processing 2008: 825758.
    • (2008) Res Lett Signal Processing , vol.2008 , pp. 825758
    • Alexandrov, T.1    Golyandina, N.2    Spirov, A.V.3
  • 71
    • 79952461158 scopus 로고    scopus 로고
    • Dependence of accuracy of ESPRIT estimates on signal eigenvalues: the case of a noisy sum of two real exponentials
    • Alexandrov T, Golyandina N, Timofeyev A, (2009) Dependence of accuracy of ESPRIT estimates on signal eigenvalues: the case of a noisy sum of two real exponentials. Proc Appl Math Mech 8: 10761-10762.
    • (2009) Proc Appl Math Mech , vol.8 , pp. 10761-10762
    • Alexandrov, T.1    Golyandina, N.2    Timofeyev, A.3
  • 72
    • 84926203634 scopus 로고    scopus 로고
    • 2D-extension of Singular Spectrum Analysis: algorithm and elements of theory
    • In: Olshevsky V, Tyrtyshnikov E, editors, Singapore, World Scientific Publishing
    • Golyandina N, Usevich K, (2010) 2D-extension of Singular Spectrum Analysis: algorithm and elements of theory. In: Olshevsky V, Tyrtyshnikov E, editors. Matrix Methods: Theory, Algorithms, ApplicationsSingapore World Scientific Publishing pp. 450-474.
    • (2010) Matrix Methods: Theory, Algorithms, Applications , pp. 450-474
    • Golyandina, N.1    Usevich, K.2


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