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Volumn 31, Issue 4, 2011, Pages 552-560

A glycyrrhizin-containing preparation reduces hepatic steatosis induced by hepatitis C virus protein and iron in mice

Author keywords

Carnitine palmitoyl transferase; Mitochondria; Oxidative stress; Reactive oxygen species; Transgenic mice

Indexed keywords

HEPATITIS C VIRUS POLYPROTEIN; IRON; NEOMINOPHAGEN C; REACTIVE OXYGEN METABOLITE; SODIUM CHLORIDE; UNCLASSIFIED DRUG; VIRUS PROTEIN;

EID: 79952465186     PISSN: 14783223     EISSN: 14783231     Source Type: Journal    
DOI: 10.1111/j.1478-3231.2011.02469.x     Document Type: Article
Times cited : (39)

References (31)
  • 1
    • 0036829816 scopus 로고    scopus 로고
    • Natural history of chronic hepatitis C
    • Seeff LB. Natural history of chronic hepatitis C. Hepatology 2002; 36: S35-46.
    • (2002) Hepatology , vol.36
    • Seeff, L.1
  • 2
    • 0037179698 scopus 로고    scopus 로고
    • Peginterferon alfa-2a plus ribavirin for chronic hepatitis C virus infection
    • Fried MW, Shiffman ML, Reddy KR, et al. Peginterferon alfa-2a plus ribavirin for chronic hepatitis C virus infection. N Engl J Med 2002; 347: 975-82.
    • (2002) N Engl J Med , vol.347 , pp. 975-982
    • Fried, M.1    Shiffman, M.2    Reddy, K.3
  • 3
    • 33748120825 scopus 로고    scopus 로고
    • Biochemical and histological effects of 26 weeks of glycyrrhizin treatment in chronic hepatitis C
    • J Hepatol
    • Orlent H, Hansen BE, Willems M, et al. Biochemical and histological effects of 26 weeks of glycyrrhizin treatment in chronic hepatitis C: a randomized phase II trial. J Hepatol 2006; 45: 539-46.
    • (2006) a randomized phase II trial , vol.45 , pp. 539-546
    • Orlent, H.1    Hansen, B.2    Willems, M.3
  • 4
    • 0031002861 scopus 로고    scopus 로고
    • The long term efficacy of glycyrrhizin in chronic hepatitis C patients
    • Arase Y, Ikeda K, Murashima N, et al. The long term efficacy of glycyrrhizin in chronic hepatitis C patients. Cancer 1997; 79: 1494-500.
    • (1997) Cancer , vol.79 , pp. 1494-1500
    • Arase, Y.1    Ikeda, K.2    Murashima, N.3
  • 5
    • 0028946727 scopus 로고
    • Iron storage, lipid peroxidation and glutathione turnover in chronic anti-HCV positive hepatitis
    • Farinati F, Cardin R, De Maria N, et al. Iron storage, lipid peroxidation and glutathione turnover in chronic anti-HCV positive hepatitis. J Hepatol 1995; 22: 449-56.
    • (1995) J Hepatol , vol.22 , pp. 449-456
    • Farinati, F.1    Cardin, R.2    De Maria, N.3
  • 6
    • 22844447076 scopus 로고    scopus 로고
    • In situ detection of oxidized n-3 polyunsaturated fatty acids in chronic hepatitis C
    • J Gastroenterol
    • Kitase A, Hino K, Furutani T, et al. In situ detection of oxidized n-3 polyunsaturated fatty acids in chronic hepatitis C: correlation with hepatic steatosis. J Gastroenterol 2005; 40: 617-24.
    • (2005) correlation with hepatic steatosis , vol.40 , pp. 617-624
    • Kitase, A.1    Hino, K.2    Furutani, T.3
  • 7
    • 0033180064 scopus 로고    scopus 로고
    • Hepatocellular mitochondrial alterations in patients with chronic hepatitis C
    • Am J Gastroenterol
    • Barbaro G, Di Lorenzo G, Asti A, et al. Hepatocellular mitochondrial alterations in patients with chronic hepatitis C: ultrastructural and biochemical findings. Am J Gastroenterol 1999; 94: 2198-205.
    • (1999) ultrastructural and biochemical findings , vol.94 , pp. 2198-2205
    • Barbaro, G.1    Di Lorenzo, G.2    Asti, A.3
  • 8
    • 33744512454 scopus 로고    scopus 로고
    • Hepatic iron overload induces hepatocellular carcinoma in transgenic mice expressing the hepatitis C virus polyprotein
    • Furutani T, Hino K, Okuda M, et al. Hepatic iron overload induces hepatocellular carcinoma in transgenic mice expressing the hepatitis C virus polyprotein. Gastroenterology 2006; 130: 2087-98.
    • (2006) Gastroenterology , vol.130 , pp. 2087-2098
    • Furutani, T.1    Hino, K.2    Okuda, M.3
  • 9
    • 34447298339 scopus 로고    scopus 로고
    • ™, a glycyrrhizin-containing preparation, protects liver against carbon tetrachloride-induced oxidative stress in transgenic mice expressing the hepatitis C virus polyprotein
    • ™, a glycyrrhizin-containing preparation, protects liver against carbon tetrachloride-induced oxidative stress in transgenic mice expressing the hepatitis C virus polyprotein. Liver Int 2007; 27: 845-53.
    • (2007) Liver Int , vol.27 , pp. 845-853
    • Hidaka, I.1    Hino, K.2    Korenaga, M.3
  • 10
    • 0033063225 scopus 로고    scopus 로고
    • An infectious molecular clone of a Japanese genotype 1b hepatitis C virus
    • Beard MR, Abell G, Honda M, et al. An infectious molecular clone of a Japanese genotype 1b hepatitis C virus. Hepatology 1999; 30: 316-24.
    • (1999) Hepatology , vol.30 , pp. 316-324
    • Beard, M.1    Abell, G.2    Honda, M.3
  • 11
    • 0036158719 scopus 로고    scopus 로고
    • Steatosis and liver cancer in transgenic mice expressing the structural and nonstructural proteins of hepatitis C virus
    • Lerat H, Honda M, Beard MR, et al. Steatosis and liver cancer in transgenic mice expressing the structural and nonstructural proteins of hepatitis C virus. Gastroenterology 2002; 122: 352-65.
    • (2002) Gastroenterology , vol.122 , pp. 352-365
    • Lerat, H.1    Honda, M.2    Beard, M.3
  • 12
    • 33845261493 scopus 로고
    • A rapid method of total lipid extraction and purification
    • Bligh EG, Dyer WJ. A rapid method of total lipid extraction and purification. Can J Biochem Physiol 1959; 37: 911-7.
    • (1959) Can J Biochem Physiol , vol.37 , pp. 911-917
    • Bligh, E.1    Dyer, W.2
  • 13
    • 71849104860 scopus 로고
    • Protein measurement with the Folin phenol reagent
    • Lowry OH, Rosebrough NJ, Farr AL, Randall RJ. Protein measurement with the Folin phenol reagent. J Biol Chem 1951; 193: 265-75.
    • (1951) J Biol Chem , vol.193 , pp. 265-275
    • Lowry, O.1    Rosebrough, N.2    Farr, A.3    Randall, R.4
  • 14
    • 37349065804 scopus 로고    scopus 로고
    • Hepatitis C virus-induced reactive oxygen species raise hepatic iron level in mice by reducing hepcidin transcription
    • Nishina S, Hino K, Korenaga M, et al. Hepatitis C virus-induced reactive oxygen species raise hepatic iron level in mice by reducing hepcidin transcription. Gastroenterology 2008; 134: 226-38.
    • (2008) Gastroenterology , vol.134 , pp. 226-238
    • Nishina, S.1    Hino, K.2    Korenaga, M.3
  • 15
    • 33747359666 scopus 로고    scopus 로고
    • Alcohol metabolism-mediated oxidative stress down-regulates hepcidin transcription and leads to increased duodenal iron transporter expression
    • Harrison-Findik DD, Schafer D, Klein E, et al. Alcohol metabolism-mediated oxidative stress down-regulates hepcidin transcription and leads to increased duodenal iron transporter expression. J Biol Chem 2006; 281: 22974-82.
    • (2006) J Biol Chem , vol.281 , pp. 22974-22982
    • Harrison-Findik, D.1    Schafer, D.2    Klein, E.3
  • 16
    • 77954367356 scopus 로고    scopus 로고
    • Hepatitis C virus protein and iron overload induce hepatic steatosis through the unfolded protein response in mice
    • Nishina S, Korenaga M, Hino K, et al. Hepatitis C virus protein and iron overload induce hepatic steatosis through the unfolded protein response in mice. Liver Int 2010; 30: 683-92.
    • (2010) Liver Int , vol.30 , pp. 683-692
    • Nishina, S.1    Korenaga, M.2    Hino, K.3
  • 17
    • 0035082455 scopus 로고    scopus 로고
    • Peroxisomal beta-oxidation and steatohepatitis
    • Rao MS, Reddy JK. Peroxisomal beta-oxidation and steatohepatitis. Semin Liver Dis 2001; 21: 43-55.
    • (2001) Semin Liver Dis , vol.21 , pp. 43-55
    • Rao, M.1    Reddy, J.2
  • 18
    • 0034717940 scopus 로고    scopus 로고
    • Fatty acid import into mitochondria
    • Kerner J, Hoppel C. Fatty acid import into mitochondria. Biochim Biophys Acta 2000; 1486: 1-17.
    • (2000) Biochim Biophys Acta , vol.1486 , pp. 1-17
    • Kerner, J.1    Hoppel, C.2
  • 19
    • 27844604269 scopus 로고    scopus 로고
    • Hepatitis C virus core protein inhibits mitochondrial electron transport and increases reactive oxygen species (ROS) production
    • Korenaga M, Wang T, Li Y, et al. Hepatitis C virus core protein inhibits mitochondrial electron transport and increases reactive oxygen species (ROS) production. J Biol Chem 2005; 280: 37481-8.
    • (2005) J Biol Chem , vol.280 , pp. 37481-37488
    • Korenaga, M.1    Wang, T.2    Li, Y.3
  • 22
    • 0037011917 scopus 로고    scopus 로고
    • IRE1 couples endoplasmic reticulum load to secretory capacity by processing the XBP-1 mRNA
    • Calfon M, Zeng H, Urano F, et al. IRE1 couples endoplasmic reticulum load to secretory capacity by processing the XBP-1 mRNA. Nature 2002; 415: 92-6.
    • (2002) Nature , vol.415 , pp. 92-96
    • Calfon, M.1    Zeng, H.2    Urano, F.3
  • 23
    • 0035966269 scopus 로고    scopus 로고
    • XBP1 mRNA is induced by ATF6 and spliced by IRE1 in response to ER stress to produce a highly active transcription factor
    • Yoshida H, Matsui T, Yamamoto A, Okada T, Mori K. XBP1 mRNA is induced by ATF6 and spliced by IRE1 in response to ER stress to produce a highly active transcription factor. Cell 2001; 107: 881-91.
    • (2001) Cell , vol.107 , pp. 881-891
    • Yoshida, H.1    Matsui, T.2    Yamamoto, A.3    Okada, T.4    Mori, K.5
  • 24
    • 33749492425 scopus 로고    scopus 로고
    • Endoplasmic reticulum stress signaling in disease
    • Marciniak SJ, Ron D. Endoplasmic reticulum stress signaling in disease. Physiol Rev 2006; 86: 1133-49.
    • (2006) Physiol Rev , vol.86 , pp. 1133-1149
    • Marciniak, S.1    Ron, D.2
  • 25
    • 0036713724 scopus 로고    scopus 로고
    • Distinct roles of activating transcription factor 6 (ATF6) and double-stranded RNA-activated protein kinase-like endoplasmic reticulum kinase (PERK) in transcription during the mammalian unfolded protein response
    • Okada T, Yoshida H, Akazawa R, Negishi M, Mori K. Distinct roles of activating transcription factor 6 (ATF6) and double-stranded RNA-activated protein kinase-like endoplasmic reticulum kinase (PERK) in transcription during the mammalian unfolded protein response. Biochem J 2002; 366: 585-94.
    • (2002) Biochem J , vol.366 , pp. 585-594
    • Okada, T.1    Yoshida, H.2    Akazawa, R.3    Negishi, M.4    Mori, K.5
  • 27
    • 0037714524 scopus 로고    scopus 로고
    • Hepatic steatosis is a risk factor for hepatocellular carcinoma in patients with chronic hepatitis C virus infection
    • Ohata K, Hamasaki K, Toriyama K, et al. Hepatic steatosis is a risk factor for hepatocellular carcinoma in patients with chronic hepatitis C virus infection. Cancer 2003; 97: 3036-43.
    • (2003) Cancer , vol.97 , pp. 3036-3043
    • Ohata, K.1    Hamasaki, K.2    Toriyama, K.3
  • 28
    • 0035893552 scopus 로고    scopus 로고
    • Normalization of elevated hepatic 8-hydroxy-2′-deoxyguanosine levels in chronic hepatitis C patients by phlebotomy and low iron diet
    • Kato J, Kobune M, Nakamura T, et al. Normalization of elevated hepatic 8-hydroxy-2′-deoxyguanosine levels in chronic hepatitis C patients by phlebotomy and low iron diet. Cancer Res 2001; 61: 8697-702.
    • (2001) Cancer Res , vol.61 , pp. 8697-8702
    • Kato, J.1    Kobune, M.2    Nakamura, T.3
  • 29
    • 2442658823 scopus 로고    scopus 로고
    • Hepatic iron concentration does not predict response to standard and pegylated-IFN/ribavirin therapy in patients with chronic hepatitis C
    • Hofer H, Osterreicher C, Jessner W, et al. Hepatic iron concentration does not predict response to standard and pegylated-IFN/ribavirin therapy in patients with chronic hepatitis C. J Hepatol 2004; 40: 1018-22.
    • (2004) J Hepatol , vol.40 , pp. 1018-1022
    • Hofer, H.1    Osterreicher, C.2    Jessner, W.3
  • 30
    • 13944256260 scopus 로고    scopus 로고
    • Relationships between hepatic iron content and virologic response in chronic hepatitis C patients treated with interferon and ribavirin
    • Rulyak SJ, Eng SC, Patel K, et al. Relationships between hepatic iron content and virologic response in chronic hepatitis C patients treated with interferon and ribavirin. Am J Gastroenterol 2005; 100: 332-7.
    • (2005) Am J Gastroenterol , vol.100 , pp. 332-337
    • Rulyak, S.1    Eng, S.2    Patel, K.3
  • 31
    • 3242673323 scopus 로고    scopus 로고
    • Targeting of hepatitis C virus core protein to mitochondria through a novel C-terminal localization motif
    • Schwer B, Ren S, Pietschmann T, et al. Targeting of hepatitis C virus core protein to mitochondria through a novel C-terminal localization motif. J Virol 2004; 78: 7958-68.
    • (2004) J Virol , vol.78 , pp. 7958-7968
    • Schwer, B.1    Ren, S.2    Pietschmann, T.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.