Dendritic cells stimulated with outer membrane protein A (OmpA) of Salmonella typhimurium generate effective anti-tumor immunity

Vaccine

Volumn 29, Issue 13, 2011, Pages 2400-2410

  Jang, Min Ja ^a   Kim, Jee Eun ^b   Chung, Yoon Hee ^a   Lee, Won Bok ^a   Shin, Yong Kyoo ^a   Lee, Jun Sik ^c   Kim, Daejin ^a   Park, Yeong Min ^d  

^a Chung Ang University College of Medicine   (South Korea)

^b Sookmyung Women's University   (South Korea)

^c ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

^d Pusan National University School of Medicine   (South Korea)

Author keywords

Anti tumor immunity; Dendritic cells; Outer membrane protein A

Indexed keywords

B7 ANTIGEN; CD86 ANTIGEN; DENDRITIC CELL VACCINE; DNA VACCINE; INTERLEUKIN 10; INTERLEUKIN 12P40; INTERLEUKIN 4; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; OUTER MEMBRANE PROTEIN A; PADRE PEPTIDE; PEPTIDE; PROTEIN E7; TUMOR ANTIGEN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIBODY DEPENDENT CELLULAR CYTOTOXICITY; ANTIGEN EXPRESSION; ANTIGEN PRESENTATION; ANTIGEN SPECIFICITY; ANTINEOPLASTIC ACTIVITY; ARTICLE; BONE MARROW CELL; CANCER IMMUNOTHERAPY; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CELL ACTIVATION; CELL MATURATION; CELL STIMULATION; COMPETITIVE INHIBITION; CONTROLLED STUDY; CYTOKINE PRODUCTION; DENDRITIC CELL; DNA IMMUNIZATION; EFFECTOR CELL; FEMALE; GENE EXPRESSION; MEMORY T LYMPHOCYTE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTECTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SALMONELLA TYPHIMURIUM; SPLEEN CELL; TH1 CELL; TUMOR IMMUNITY;

ANIMALS; ANTIGENS, NEOPLASM; ANTIGENS, SURFACE; BACTERIAL OUTER MEMBRANE PROTEINS; CANCER VACCINES; CD4-POSITIVE T-LYMPHOCYTES; CD8-POSITIVE T-LYMPHOCYTES; CYTOKINES; DENDRITIC CELLS; FEMALE; GENE EXPRESSION PROFILING; MICE; MICE, INBRED C57BL; NEOPLASMS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SALMONELLA TYPHIMURIUM;

EID: 79952362367     PISSN: 0264410X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.vaccine.2011.01.036     Document Type: Article

References (47)

1. Banchereau J., Briere F., Caux C., Davoust J., Pulendran B., Palucka K., et al. Immunobiology of dendritic cells. Annu Rev Immunol 2000, 18:767-811.
2. Fields R.C., Shimizu K., Mulé J.J. Murine dendritic cells pulsed with whole tumor lysates mediate potent antitumor immune responses in vitro and in vivo. Proc Natl Acad Sci USA 1998, 95(August (16)):9482-9487.
3. Fearon D.T., Locksley R.M. The instructive role of innate immunity in the acquired immune response. Science 1996, 272:50-54.
4. Medzhitov R., Janeway C.A. Innate immunity: the virtues of a nonclonal system of recognition. Cell 1997, 91:295-298.
5. Akira S., Takeda K., Kaisho T. Toll-like receptors: critical proteins linking innate and acquired immunity. Nat Immunol 2001, 2:675-680.
6. Kimbrell D.A., Beutler B. The evolution and genetics of innate immunity. Nat Rev Genet 2001, 2:256-267.
7. Krutzik S.A., Sieling P.A., Modlin R.L. The role of Toll-like receptors in host defense against microbial infection. Curr Opin Immunol 2001, 13:104-108.
8. Medzhitov R., Janeway C.A. Innate immunity: impact on the adaptive immune response. Curr Opin Immunol 1997, 9:4-9.
9. Medzhitov R., Janeway C.A. Decoding the patterns of self and nonself by the innate immune system. Science 2002, 296:298-300.
10. Janeway C.A., Medzhitov R. Innate immune recognition. Annu Rev Immunol 2002, 20:197-216.
11. Matzinger P. The danger model: a renewed sense of self. Science 2002, 96:301-305.
12. Barton G.M., Medzhitov R. Control of adaptive immune responses by Toll-like receptors. Curr Opin Immunol 2002, 14:380-383.
13. Beveridge T.J. Structures of gram-negative cell walls and their derived membrane vesicles. J Bacteriol 1999, 181:4725-4733.
14. Poolman J.T. Bacterial outer membrane protein vaccines. Novel strategies in design and production of vaccines 1996, 73-77. Plenum Press, New York. S. Cohen, A. Shafferman (Eds.).
15. Weiser J.N., Gotschlich E.C. Outer membrane protein A (OmpA) contributes to serum resistance and pathogenicity of Escherichia coli K-1. Infect Immun 1991, 59:2252-2258.
16. Jeannin P., Renno T., Goetsch L., Romero P., Cerottini J.C., Bonnefoy J.Y., et al. OmpA targets dendritic cells, induces their maturation and delivers antigen into the MHC class I presentation pathway. Nat Immunol 2000, 1:502-509.
17. Soulas C., Baussant T., Aubry J.P., Delneste Y., Bonnefoy J.Y., Jeannin P., et al. Outer membrane protein A (OmpA) binds to and activates human macrophages. J Immunol 2000, 165:2335-2340.
18. Lee J.S., Lee J.C., Lee C.M., Jung I.D., Chung H.Y., Park Y.M., et al. Outer membrane protein A of Acinetobacter baumannii induces differentiation of CD4+ T-cells toward a Th1 polarizing phenotype through the activation of dendritic cells. Biochem Pharmacol 2007, 74:86-97.
19. Lee J.S., Jung I.D., Lee C.M., Park J.W., Chun S.H., Jeong S.K., et al. Outer membrane protein a of Salmonella enterica serovar Typhimurium activates dendritic cells and enhances Th1 polarization. BMC Microbiol 2010, 10:263.
20. Xu C., Ren H., Wang S., Peng X. Proteomic analysis of salt-sensitive outer membrane proteins of Vibrio parahaemolyticus. Res Microbiol 2004, 155:835-842.
21. Singh R., Shasany A.K., Aggarwal A., Sinha S., Khanuja S.P., Misra R., et al. Low molecular weight proteins of outer membrane of Salmonella typhimurium are immunogenic in Salmonella induced reactive arthritis revealed by proteomics. Clin Exp Immunol 2007, 148:486-493.
22. Udhayakumar V., Muthukkaruppan V.R. Protective immunity induced by outer membrane proteins of Salmonella typhimurium in mice. Infect Immun 1987, 55:816-821.
23. Singh S.P., Williams Y.U., Miller S., Nikaido H. The C-terminal domain of Salmonella enterica serovar typhimurium OmpA is an immunodominant antigen in mice but appears to be only partially exposed on the bacterial cell surface. Infect Immun 2003, 71:3937-3946.
24. Lin K.Y., Guarnieri F.G., Staveley-O'Carroll K.F., Levitsky H.I., August T., Pardoll D.M., et al. Treatment of established tumors with a novel vaccine that enhances major histocompatibility class II presentation of tumor antigen. Cancer Res 1996, 56:21-26.
25. Choi C.H., Hyun S.H., Lee J.Y., Lee J.S., Lee Y.S., Kim S.A., et al. Acinetobacter baumannii outer membrane protein A targets the nucleus and induces cytotoxicity. Cell Microbiol 2008, 10:309-319.
26. Cheng W.F., Hung C.F., Chai C.Y., Hsu K.F., He L., Ling M., et al. Tumor-specific immunity and antiangiogenesis generated by a DNA vaccine encoding calreticulin linked to a tumor antigen. J Clin Invest 2001, 108:669-678.
27. Chen C.H., Wang T.L., Hung C.F., Yang Y., Young R.A., Pardoll D.M., et al. Enhancement of DNA vaccine potency by linkage of antigen gene to an HSP70 gene. Cancer Res 2000, 60:1035-1042.
28. Kim D., Hoory T., Wu T.C., Hung C.F. Enhancing DNA vaccine potency by combining a strategy to prolong dendritic cell life and intracellular targeting strategies with a strategy to boost CD4+ T cell. Hum Gene Ther 2007, 18:1129-1139.
29. Fischer K., Mackensen A. The flow cytometric PKH-26 assay for the determination of T-cell mediated cytotoxic activity. Methods 2003, 31(2):135-142.
30. Schütz C., Fischer K., Völkl S., Hoves S., Halbritter D., Mackensen A., et al. A new flow cytometric assay for the simultaneous analysis of antigen-specific elimination of T cells in heterogeneous T cell populations. J Immunol Methods 2009, 344(2):98-108.
31. Lee J.S., Kim J.W., Choi C.H., Lee W.K., Chung H.Y., Lee J.C. Anti-tumor activity of Acinetobacter baumannii outer membrane protein A on dendritic cell-based immunotherapy against murine melanoma. J Microbiol 2008, 46:221-227.
32. Castellino F., Germain R.N. Cooperation between CD4+ and CD8+ T cells: when, where, and how. Annu Rev Immunol 2006, 24:519-540.
33. *0201-binding residues. J Immunol 1996, 157:2539-2548.
34. Salgaller M.L., Marincola F.M., Cormier J.N., Rosenberg S.A. Immunization against epitopes in the human melanoma antigen gp100 following patient immunization with synthetic peptides. Cancer Res 1996, 56:4749-4757.
35. Jaffee E.M., Hruban R.H., Biedrzycki B., Laheru D., Schepers K., Sauter P.R., et al. Novel allogeneic granulocyte-macrophage colony-stimulating factor-secreting tumor vaccine for pancreatic cancer: a phase I trial of safety and immune activation. J Clin Oncol 2001, 19:145-156.
36. Asea A., Kraeft S.K., Kurt-Jones E.A., Stevenson M.A., Chen L.B., Finberg R.W., et al. HSP70 stimulates cytokine production through a CD14-dependant pathway, demonstrating its dual role as a chaperone and cytokine. Nat Med 2000, 6:435-442.
37. Mohamadzadeh M., Berard F., Essert G., Chalouni C., Pulendran B., Davoust J., et al. Interleukin-15 skews monocyte differentiation into dendritic cells with features of Langerhans cells. J Exp Med 2001, 194:1013-1020.
38. Zhao M., Yang M., Li X.M., Jiang P., Baranov E., Li S., et al. Tumor-targeting bacterial therapy with amino acid auxotrophs of GFP-expressing Salmonella typhimurium. Proc Natl Acad Sci USA 2005, 102:755-760.
39. Zhao M., Geller J., Ma H., Yang M., Penman S., Hoffman R.M. Monotherapy with a tumor-targeting mutant of Salmonella typhimurium cures orthotopic metastatic mouse models of human prostate cancer. Proc Natl Acad Sci USA 2007, 104:10170-10174.
40. Zhao M., Yang M., Ma H., Li X., Tan X., Li S., et al. Targeted therapy with a Salmonella typhimurium leucine-arginine auxotroph cures orthotopic human breast tumors in nude mice. Cancer Res 2006, 66:7647-7652.
41. Lee J.S., Choi C.H., Kim J.W., Lee J.C. Acinetobacter baumannii outer membrane protein A induces dendritic cell death through mitochondrial targeting. J Microbiol 2010, 48:387-392.
42. Santini S.M., Lapenta C., Logozzi M., Parlato S., Spada M., Di Pucchio T., et al. Type I interferon as a powerful adjuvant for monocyte-derived dendritic cell development and activity in vitro and in Hu-PBL-SCID mice. J Exp Med 2000, 191:1777-1788.
43. Boyle J.S., Koniaras C., Lew A.M. Influence of cellular location of expressed antigen on the efficacy of DNA vaccination: cytotoxic T lymphocyte and antibody responses are suboptimal when antigen is cytoplasmic after intramuscular DNA immunization. Int Immunol. 1997, 9:1897-1906.
44. Rescigno M., Martino M., Sutherland C.L., Gold M.R., Ricciardi-Castagnoli P. Dendritic cell survival and maturation are regulated by different signaling pathways. J Exp Med 1998, 188:2175-2180.
45. Banchereau J., Palucka A.K. Dendritic cells as therapeutic vaccines against cancer. Nat Rev Immunol 2005, 5:296-306.
46. Godefroy S., Corvaia N., Schmitt D., Bonnefoy J.Y., Jeannin P., Staquet M.J., et al. Outer membrane protein A (OmpA) activates human epidermal Langerhans cells. Eur J Cell Biol 2003, 82:193-200.
47. Kim D., Monie A., He L., Tsai Y.C., Hung C.F., Wu T.C. Role of IL-2 secreted by PADRE-specific CD4+ T cells in enhancing E7-specific CD8+ T-cell immune responses. Gene Ther 2008, 15:677-687.