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Bioorganic and Medicinal Chemistry Letters

Volumn 21, Issue 6, 2011, Pages 1773-1776

Structure-activity relationship studies on 1-(5-carboxyindol-1-yl)-propan- 2-one inhibitors of human cytosolic phospholipase A2α: Variation of the activated ketone moiety

(3) Kaptur, Martina a Elfringhoff, Alwine Schulze a Lehr, Matthias a

a UNIVERSITY OF MÜNSTER (Germany)

Author keywords

Carbamate; Cytosolic phospholipase A 2 ; Electrophilic ketone; Indole; Inhibitor

Indexed keywords

1 (5 CARBOXYINDOL 1 YL)PROPAN 2 ONE; 2,4 THIAZOLIDINEDIONE DERIVATIVE; 4 FLUOROPHENYLCARBAMATE DERIVATIVE; AMIDE; AMINE; ARACHIDONIC ACID DERIVATIVE; BENZHYDRYLINDOLE DERIVATIVE; CARBANILIC ACID DERIVATIVE; CARBOXYLIC ACID DERIVATIVE; ENZYME INHIBITOR; INDOLE 5 CARBOXYLIC ACID DERIVATIVE; INDOLE DERIVATIVE; KETONE DERIVATIVE; O PHENYL CARBAMATE; PHOSPHOLIPASE A2; PHOSPHOLIPASE A2 ALPHA; PHOSPHOLIPASE A2 ALPHA INHIBITOR; PROPAN 2 ONE DERIVATIVE; UNCLASSIFIED DRUG; UREA DERIVATIVE;

ARTICLE; CHEMICAL REACTION; CYTOSOL; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; DRUG TARGETING; ELECTROPHILICITY; ENZYME INHIBITION; HUMAN; IC 50; STRUCTURE ACTIVITY RELATION; THROMBOCYTE;

CYTOSOL; HUMANS; KETONES; PHOSPHOLIPASES A2; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 79952359635 PISSN: 0960894X EISSN: None Source Type: Journal
DOI: 10.1016/j.bmcl.2011.01.085 Document Type: Article

Times cited : (6)

References (28)

1
- 33750964517
- Y. Kita, T. Ohto, N. Uozumi, and T. Shimizu Biochim. Biophys. Acta 1761 2006 1317
- (2006) Biochim. Biophys. Acta , vol.1761 , pp. 1317
- Kita, Y.¹ Ohto, T.² Uozumi, N.³ Shimizu, T.⁴

2
- 33748316787
- M. Ghosh, D.E. Tucker, S.A. Burchett, and C.C. Leslie Prog. Lipid. Res. 45 2006 487
- (2006) Prog. Lipid. Res. , vol.45 , pp. 487
- Ghosh, M.¹ Tucker, D.E.² Burchett, S.A.³ Leslie, C.C.⁴

3
- 0034739477
- A. Sapirstein, and J.V. Bonventre Biochim. Biophys. Acta 1488 2000 139
- (2000) Biochim. Biophys. Acta , vol.1488 , pp. 139
- Sapirstein, A.¹ Bonventre, J.V.²

4
- 1342324060
- J. Bonventre Trends Immunol. 25 2004 116
- (2004) Trends Immunol. , vol.25 , pp. 116
- Bonventre, J.¹

5
- 0029066595
- S. Connolly, and D.H. Robinson Expert Opin. Ther. Patents 5 1995 673
- (1995) Expert Opin. Ther. Patents , vol.5 , pp. 673
- Connolly, S.¹ Robinson, D.H.²

6
- 3543121136
- J.D. Clark, and S. Tam Expert Opin. Ther. Patents 14 2004 937
- (2004) Expert Opin. Ther. Patents , vol.14 , pp. 937
- Clark, J.D.¹ Tam, S.²

7
- 33744477349
- M. Lehr Anti-Inflamm. Anti-Allergy Agents Med. Chem. 5 2006 149
- (2006) Anti-Inflamm. Anti-Allergy Agents Med. Chem. , vol.5 , pp. 149
- Lehr, M.¹

8
- 73649118166
- V. Magrioti, and G. Kokotos Expert Opin. Ther. Patents 20 2010 1
- (2010) Expert Opin. Ther. Patents , vol.20 , pp. 1
- Magrioti, V.¹ Kokotos, G.²

9
- 0034704801
- K. Seno, T. Okuno, K. Nishi, Y. Murakami, F. Watanabe, T. Matsuura, M. Wada, Y. Fujii, M. Yamada, T. Ogawa, T. Okada, H. Hashizume, M. Kii, S. Hara, S. Hagishita, S. Nakamoto, K. Yamada, Y. Chikazawa, M. Ueno, I. Teshirogi, T. Ono, and M. Ohtani J. Med. Chem. 43 2000 1041
- (2000) J. Med. Chem. , vol.43 , pp. 1041
- Seno, K.¹ Okuno, T.² Nishi, K.³ Murakami, Y.⁴ Watanabe, F.⁵ Matsuura, T.⁶ Wada, M.⁷ Fujii, Y.⁸ Yamada, M.⁹ Ogawa, T.¹⁰ Okada, T.¹¹ Hashizume, H.¹² Kii, M.¹³ Hara, S.¹⁴ Hagishita, S.¹⁵ Nakamoto, S.¹⁶ Yamada, K.¹⁷ Chikazawa, Y.¹⁸ Ueno, M.¹⁹ Teshirogi, I.²⁰ Ono, T.²¹ Ohtani, M.²² more..

10
- 0035952312
- K. Seno, T. Okuno, K. Nishi, Y. Murakami, K. Yamada, S. Nakamoto, and T. Ono Bioorg. Med. Chem. Lett. 11 2001 587
- (2001) Bioorg. Med. Chem. Lett. , vol.11 , pp. 587
- Seno, K.¹ Okuno, T.² Nishi, K.³ Murakami, Y.⁴ Yamada, K.⁵ Nakamoto, S.⁶ Ono, T.⁷

11
- 30444460888
- J.C. McKew, M.A. Foley, P. Thakker, M.L. Behnke, F.E. Lovering, F.W. Sum, S. Tam, K. Wu, M.W. Shen, W. Zhang, M. Gonzalez, S. Liu, A. Mahadevan, H. Sard, S.P. Khor, and J.D. Clark J. Med. Chem. 49 2006 135
- (2006) J. Med. Chem. , vol.49 , pp. 135
- McKew, J.C.¹ Foley, M.A.² Thakker, P.³ Behnke, M.L.⁴ Lovering, F.E.⁵ Sum, F.W.⁶ Tam, S.⁷ Wu, K.⁸ Shen, M.W.⁹ Zhang, W.¹⁰ Gonzalez, M.¹¹ Liu, S.¹² Mahadevan, A.¹³ Sard, H.¹⁴ Khor, S.P.¹⁵ Clark, J.D.¹⁶

12
- 0037075831
- S. Connolly, C. Bennion, S. Botterell, P.J. Croshaw, C. Hallam, K. Hardy, P. Hartopp, C.G. Jackson, S.J. King, L. Lawrence, A. Mete, D. Murray, D.H. Robinson, G.M. Smith, L. Stein, I. Walters, E. Wells, and W.J. Withnall J. Med. Chem. 45 2002 1348
- (2002) J. Med. Chem. , vol.45 , pp. 1348
- Connolly, S.¹ Bennion, C.² Botterell, S.³ Croshaw, P.J.⁴ Hallam, C.⁵ Hardy, K.⁶ Hartopp, P.⁷ Jackson, C.G.⁸ King, S.J.⁹ Lawrence, L.¹⁰ Mete, A.¹¹ Murray, D.¹² Robinson, D.H.¹³ Smith, G.M.¹⁴ Stein, L.¹⁵ Walters, I.¹⁶ Wells, E.¹⁷ Withnall, W.J.¹⁸

13
- 33646146486
- J. Ludwig, S. Bovens, C. Brauch, A. Schulze Elfringhoff, and M. Lehr J. Med. Chem. 49 2006 2611
- (2006) J. Med. Chem. , vol.49 , pp. 2611
- Ludwig, J.¹ Bovens, S.² Brauch, C.³ Schulze Elfringhoff, A.⁴ Lehr, M.⁵

14
- 33947111963
- M. Hess, A. Schulze Elfringhoff, and M. Lehr Bioorg. Med. Chem. 15 2007 2883
- (2007) Bioorg. Med. Chem. , vol.15 , pp. 2883
- Hess, M.¹ Schulze Elfringhoff, A.² Lehr, M.³

15
- 63149125026
- S. Bovens, M. Kaptur, A. Schulze Elfringhoff, and M. Lehr Bioorg. Med. Chem. Lett. 19 2009 2107
- (2009) Bioorg. Med. Chem. Lett. , vol.19 , pp. 2107
- Bovens, S.¹ Kaptur, M.² Schulze Elfringhoff, A.³ Lehr, M.⁴

16
- 76449106208
- L. Forster, J. Ludwig, M. Kaptur, S. Bovens, A. Schulze Elfringhoff, A. Holtfrerich, and M. Lehr Bioorg. Med. Chem. 18 2010 945
- (2010) Bioorg. Med. Chem. , vol.18 , pp. 945
- Forster, L.¹ Ludwig, J.² Kaptur, M.³ Bovens, S.⁴ Schulze Elfringhoff, A.⁵ Holtfrerich, A.⁶ Lehr, M.⁷

17
- 77954755968
- A. Drews, S. Bovens, K. Roebrock, C. Sunderkötter, D. Reinhardt, M. Schäfers, A. van der Velde, A. Schulze Elfringhoff, J. Fabian, and M. Lehr J. Med. Chem. 53 2010 5165
- (2010) J. Med. Chem. , vol.53 , pp. 5165
- Drews, A.¹ Bovens, S.² Roebrock, K.³ Sunderkötter, C.⁴ Reinhardt, D.⁵ Schäfers, M.⁶ Van Der Velde, A.⁷ Schulze Elfringhoff, A.⁸ Fabian, J.⁹ Lehr, M.¹⁰

18
- 78649861774
- S. Bovens, A. Schulze Elfringhoff, M. Kaptur, D. Reinhardt, M. Schäfers, and M. Lehr J. Med. Chem. 53 2010 8298
- (2010) J. Med. Chem. , vol.53 , pp. 8298
- Bovens, S.¹ Schulze Elfringhoff, A.² Kaptur, M.³ Reinhardt, D.⁴ Schäfers, M.⁵ Lehr, M.⁶

19
- 33947091537
- G.C. Levy, and G.L. Nelson J. Am. Chem. Soc. 94 1972 4897
- (1972) J. Am. Chem. Soc. , vol.94 , pp. 4897
- Levy, G.C.¹ Nelson, G.L.²

20
- 33847803561
- G.E. Hawkes, K. Herwig, and J.D. Roberts J. Org. Chem. 39 1974 1017
- (1974) J. Org. Chem. , vol.39 , pp. 1017
- Hawkes, G.E.¹ Herwig, K.² Roberts, J.D.³

21
- 0003520774
- John Wiley & Sons New York
- R.M. Silverstein, and F.X. Webster Spectrometric Identification of Organic Compounds 1998 John Wiley & Sons New York
- (1998) Spectrometric Identification of Organic Compounds
- Silverstein, R.M.¹ Webster, F.X.²

22
- 0242571912
- M. Kitamura, M. Yoshida, T. Kikuchi, and K. Narasaka Synthesis 2003 2415
- (2003) Synthesis , pp. 2415
- Kitamura, M.¹ Yoshida, M.² Kikuchi, T.³ Narasaka, K.⁴

23
- 79952361341
- PCT WO2004069797
- Lehr, M.; Ludwig, J. PCT WO2004069797, 2004.
- (2004)
- Lehr, M.¹ Ludwig, J.²

24
- 33845634008
- J. Fabian, and M. Lehr J. Pharm. Biomed. Anal. 43 2007 601
- (2007) J. Pharm. Biomed. Anal. , vol.43 , pp. 601
- Fabian, J.¹ Lehr, M.²

25
- 79952362356
- note
- 2α activity was calculated by comparing the arachidonic acid formed by the enzyme in absence and presence of a test compound.

26
- 1642361749
- M. Schmitt, and M. Lehr J. Pharm. Biomed. Anal. 35 2004 135
- (2004) J. Pharm. Biomed. Anal. , vol.35 , pp. 135
- Schmitt, M.¹ Lehr, M.²

27
- 12444260741
- G. Tarzia, A. Duranti, A. Tontini, G. Piersanti, M. Mor, S. Rivara, P.V. Plazzi, C. Park, S. Kathuria, and D. Piomelli J. Med. Chem. 46 2003 2352
- (2003) J. Med. Chem. , vol.46 , pp. 2352
- Tarzia, G.¹ Duranti, A.² Tontini, A.³ Piersanti, G.⁴ Mor, M.⁵ Rivara, S.⁶ Plazzi, P.V.⁷ Park, C.⁸ Kathuria, S.⁹ Piomelli, D.¹⁰

28
- 37349122437
- A. Lodola, M. Mor, S. Rivara, C. Christov, G. Tarzia, D. Piomelli, and A.J. Mulholland Chem. Commun. 14 2008 214
- (2008) Chem. Commun. , vol.14 , pp. 214
- Lodola, A.¹ Mor, M.² Rivara, S.³ Christov, C.⁴ Tarzia, G.⁵ Piomelli, D.⁶ Mulholland, A.J.⁷

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