Comparative pulmonary toxicity assessment of pristine and functionalized multi-walled carbon nanotubes intratracheally instilled in rats: Morphohistochemical evaluations

Histology and Histopathology

Volumn 26, Issue 3, 2011, Pages 357-367

  Roda, E ^a   Coccini, T ^b   Acerbi, D ^b   Barni, S ^a   Vaccarone, R ^a   Manzo, L ^a,b  

^a UNIVERSITY OF PAVIA   (Italy)

^b IRCCS   (Italy)

Author keywords

IL 6 TGF 1; In vivo; Lung inflammation; Nanomaterials; PCNA; TUNEL

Indexed keywords

CARBON NANOTUBE; COLLAGEN TYPE 1; CYCLINE; INTERLEUKIN 6; TRANSFORMING GROWTH FACTOR BETA1;

ANIMAL; ARTICLE; CHEMICALLY INDUCED DISORDER; CHEMISTRY; COMPARATIVE STUDY; ENDOTRACHEAL INTUBATION; FEMALE; IMMUNOHISTOCHEMISTRY; INHALATIONAL DRUG ADMINISTRATION; LUNG; LUNG DISEASE; LUNG FIBROSIS; MALE; METABOLISM; NICK END LABELING; PARTICLE SIZE; PATHOLOGY; PNEUMONIA; RAT; SPRAGUE DAWLEY RAT;

ADMINISTRATION, INHALATION; ANIMALS; COLLAGEN TYPE I; FEMALE; IMMUNOHISTOCHEMISTRY; IN SITU NICK-END LABELING; INTERLEUKIN-6; INTUBATION, INTRATRACHEAL; LUNG; LUNG DISEASES; MALE; NANOTUBES, CARBON; PARTICLE SIZE; PNEUMONIA; PROLIFERATING CELL NUCLEAR ANTIGEN; PULMONARY FIBROSIS; RATS; RATS, SPRAGUE-DAWLEY; TRANSFORMING GROWTH FACTOR BETA1;

ANIMALIA; RATTUS;

EID: 79952345432     PISSN: 02133911     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (54)

1. Ackermann M.R. (2007). Chronic inflammation and wound healing. In: Pathologic basis of veterinary disease. Zachary M.D.M.a.J.F. (ed). Mosby Elsevier. St. Louis, pp 153-191.
2. Barni S., Pontiggia E., Bertone V., Pontiggia P. and Mathè G. (2006). Analysis of cell proliferation and cell death during in situ hyperthermic treatment of neoplastic cells: a case report of human non-Hodgkin lymphoma. Biomed. Pharmacother. 60, 227-232. (Pubitemid 43996936)
3. Bottini M., Bruckner S., Nika K., Bottini N., Bellucci S., Magrini A., Bergamaschi A. and Mustelin T. (2006). Multi-walled carbon nanotubes induce T lymphocyte apoptosis. Toxicol. Lett. 160, 121-126. (Pubitemid 41578955)
4. Chen H.H., Zhao S. and Song J.G. (2003). TGF-B1 suppresses apoptosis via differential regulation of MAP kinase and ceramide production. Cell Death. Differ. 10, 516-527. (Pubitemid 36656641)
5. Coccini T., Roda E., Sarigiannis D.A., Mustarelli P., Quartarone E., Profumo A. and Manzo L. (2010). Effects of water-soluble functionalized multi-walled carbon nanotubes examined by different cytotoxicity methods in human astrocyte D384 and lung A549 cells. Toxicology 269, 41-53.
6. Davoren M., Herzog E., Casey A., Cottineau B., Chambers G., Byrne H.J. and Lyng F.M. (2007). In vitro toxicity evaluation of single walled carbon Nanotubes on human A549 lung cells. Toxicol. In Vitro 21, 438-448. (Pubitemid 46453117)
7. Donaldson K., Aitken R., Tran L., Stone V., Duffin R., Forrest G. and Alexander A. (2006). Carbon nanotubes: A review of their properties in relation to pulmonary toxicology and workplace safety. Toxicol. Sci. 92, 5-22. (Pubitemid 43985785)
8. Donaldson K., Borm P.J., Castranova V. and Gulumian M. (2009). The limits of testing particle-mediated oxidative stress in vitro in predicting diverse pathologies; relevance for testing of nanoparticles. Part. Fibre Toxicol. 27, 6-13.
9. Driscoll K.E., Costa D.L., Hatch G., Henderson R., Oberdorster G., Salem H. and Schlesinger R.B. (2000). Intratracheal instillation as an exposure technique for the avaluation of respiratory tract toxicity: uses and limitations. Toxicol. Sci. 55, 24-35. (Pubitemid 30252432)
10. Elgrabli D., Abella-Gallart S., Robidel F., Rogerieux F., Boczkowski J. and Lacroix G. (2008). Induction of apoptosis and absence of inflammation in rat lung after intratracheal instillation of multiwalled carbon nanotubes. Toxicology 253, 131-136.
11. Fagnoni M., Profumo A., Dondi D., Merli D., Mustarelli, P. and Quartarone E. (2009). Water-miscible liquid multiwalled carbon nanotubes. Adv. Mater. 21, 1761-1765.
12. Fenoglio I., Greco G., Tomatis M., Muller J., Raimundo-Piñero E., Béguin F., Fonseca A., Nagy J.B., Lison D. and Fubini B. (2008). Structural defects play a major role in the acute lung toxicity of multiwall carbon Nanotubes: physicochemical aspects. Chem. Res. Toxicol. 21, 1690-1697.
13. Haider Y., Malizia A.P., Keating D.T., Birch M., Tomlinson A., Martin G., Ferguson M.W., Doran P.P. and Egan J.J. (2007). Host predisposition by endogenous Transforming Growth Factor-beta1 overexpression promotes pulmonary fibrosis following bleomycin injury. J. Inflamm. (Lond) 4, 18.
14. Iijima S. (1991). Helical microtubules of graphitic carbon. Nature 354, 56-58. (Pubitemid 21896780)
15. Kinnula V.L. and Crapo J.D. (2004). Superoxide dismutases in malignant cells and human tumors. Free Radic. Biol. Med. 36, 718-744. (Pubitemid 38264416)
16. Lam C.W., James J.T., McCluskey R. and Hunter R.L. (2004). Pulmonary toxicity of single wall carbon nanotubes in mice 7 and 90 days after intratracheal instillation. Toxicol. Sci. 77, 126-134. (Pubitemid 38128652)
17. Lam C.W., James J.T., McCluskey R., Arepalli S. and Hunter R.L. (2006). A review of carbon nanotube toxicity and assessment of potential occupational and environmental health risks. Crit. Rev. Toxicol. 36, 189-217.
18. Li J.G., Li W.-X., Xu J.-Y., Cai X.-Q., Liu R.-L., Li Y.-J., Zhao Q.-F. and Li Q.-N. (2007). Comparative study of pathological lesionsinduced by multiwalled carbon nanotubes in lungs of mice by intratracheal instillation and inhalation. Environ. Toxicol. 22, 415-421. (Pubitemid 47121922)
19. Li Z., Salmen R., Hulderman T., Kisin E., Shvedova A., Luster M.I. and Simeonova P.P. (2005). Pulmonary exposure to carbon Nanotubes induces vascular toxicity. Toxicologist 84 (S-1), 213 (abs. 1045).
20. Li Z., Hulderman T., Salmen R., Chapman R., Leonard S.S., Young S.H., Shvedova A., Luster M.I. and Simeonova P.P. (2007). Cardiovascular effects of pulmonary exposure to single-wall carbon Nanotubes. Environ. Health Perspect. 115, 377-382. (Pubitemid 46554435)
21. Madl A.K. and Pinkerton K.E. (2009). Health effects of inhaled engineered and incidental nanoparticles. Crit. Rev. Toxicol. 39, 629-58.
22. Magnan A., Mege J.L., Escallier J.C., Brisse J., Capo C., Reynaud M., Thomas P., Meric B., Garbe L., Badier M., Viard L., Bongrand P., Giudicelli R., Metras D., Fuentes P., Vervloet D. and Noirclerc M. (1996). Balance between alveolar macrophage IL-6 and TGF-beta in lung -transplant recipients. Marseille and Montréal lung transplantation group. Am. J. Respir. Crit. Care Med. 153, 1431-1436.
23. Mangum J., Turpin E., Antao-Menez A., Cesta M., Bermudez E. and Bonner J. (2006). Single-walled carbon nanotube (SWCNT)-induced interstitial fibrosis in the lungs of rats is associated with increase levels of PDGF mRNA and the formation of unique intercellular carbon structures that bridge alveolar macrophages in situ. Part. Fibre Toxicol. 3, 1-13.
24. Maynard A.D. (2007). Nanotechnology: the next big thing, or much ado about nothing? Ann. Occup. Hyg. 51, 1-12. (Pubitemid 46096390)
25. Maynard A.D., Baron P.A., Foley M., Shvedova A.A., Kisin E.R. and Castranova V. (2004). Exposure to carbon nanotube material: aerosol release during the handling of unrefined single-walled carbon nanotube material. J. Toxicol. Environ. Health Part A 67, 87-107. (Pubitemid 38117533)
26. Maynard A.D., Aitken R.J., Butz T., Colvin V., Donaldson K., Oberdörster G. et al. (2006). Safe handling of nanotechnology. Nature 444, 267-269. (Pubitemid 44764087)
27. McDonald J. and Mitchell L. (2008). To the Editor. Toxicol. Sci. 101, 181-182.
28. Mitchell L.A., Gao J., Vander Wal R., Gigliotti A., Burchiel S.W. and McDonald J.D. (2007). Pulmonary and systemic immune response to inhaled multiwalled carbon nanotubes. Toxicol. Sci. 28, 28.
29. Monteiro-Riviere N.A., Inman A.O., Wang Y.Y. and Nemanich R.J. (2005). Surfactant effects on carbon nanotube interactions with human keratinocytes. Nanomedicine 1, 293-299. (Pubitemid 43963644)
30. Muller J., Huaux F., Moreau N., Misson P., Heilier J.F., Delos M., Arras M., Fonseca A., Nagy J. and Lison D. (2005). Respiratory toxicity of multiwalled carbon nanotubes. Toxicol. Appl. Pharmacol. 207, 221-231. (Pubitemid 41207915)
31. Muller J., Huaux F., Fonseca A., Nagy J., Moreau N., Delos M., Raymundo-Piñeiro L., Béguin F., Kirsch-Volders M., Fenoglio I., Fubini B. and Lison D. (2008a). Structural defects play a major role in the acute lung toxicity of multiwall carbon nanotubes: toxicological aspects. Chem Res Toxicol 21, 1698-1705.
32. Muller J., Decordier I., Hoet P.H., Lombaert N., Thomassen L., Huaux F., Lison D. and Kirsch-Volders M. (2008b). Clastogenic and aneugenic effects of multi-walled carbon Nanotubes in epithelial cells. Carcinogenesis 29, 427-433. (Pubitemid 351359684)
33. Nanoscale Science (2004). The National Nanotechnology Initiative Strategic Plan. Washington DC: National Science and Technology Council. Available: http://www.nano.gov/NNI Strategic-Plan-2004.pdf [accessed 19 December 2005].
34. Nemmar A., Vanbilloen H, Hoylaerts M.F., Hoet P.H., Verbruggen A. and Nemery B. (2001). Passage of intratracheally instilled ultrafine particles from the lung into the systemic circulation in hamster. Am. J. Respir. Crit. Care Med. 164, 1665-1668. (Pubitemid 33124156)
35. Nemmar A., Hoet P.H., Vanquickenborne B., Dinsdale D., Thomeer M., Hoylaerts M.F. Vanbilloen H., Mortelmans L. and Nemery B. (2002). Passage of inhaled particles into the blood circulation in humans. Circulation 105, 411-414. (Pubitemid 34141694)
36. Nemmar A., Al-Maskari S., Ali B.H. and Al-Amri I.S. (2007). Cardiovascular and lung inflammatory effects induced by sistemically administered diesel exhaust particles in rats. Am. J. Physiol. Lung Cell Mol. Physiol. 292, L664-L670. (Pubitemid 46376984)
37. Nemmar A., Al-Salam S., Dhanasekaran S., Sudhadevi M. and Ali B.H. (2009). Pulmonary exposure to diesel exhaust particles promotes cerebral microvessel thrombosis: protective effect of a cysteine prodrug 1-2-oxothiazolidine-4-carboxylic acid. Toxicology 263, 84-92.
38. Oberdörster G., Sharp Z., Atudorei V., Elder A., Gelein R., Kreyling W. and Cox C. (2004). Translocation of inhaled ultrafine particles to the brain. Inhal. Toxicol. 16, 437-445. (Pubitemid 38685135)
39. Park M., Lankveld D., van Loveren H. and de Jong WH. (2009). The status of in vitro toxicity studies in the risk assessment of nanomaterials. Nanomedicine 4, 669-685.
40. Parra E.R., Teodoro W.R., Velosa A.P., de Oliveira C.C., Yoshinari N.H. and Capelozzi V.L. (2006). Interstitial and vascular type V collagen morphologic disorganization in usual interstitial pneumonia. J Histochem. Cytochem. 12, 1315-1325. (Pubitemid 44788817)
41. Ravichandran P., Perijakaruppan A., Sadanandan B., Ramesh V., Hall J.C., Jejelowo O. and Ramesh G.T. (2009). Induction of apoptosis in rat lung epithelial cells by multiwalled carbon nanotubes. J. Biochem. Mol. Toxicol. 23, 333-44.
42. Sadowska A.M., Verbraecken J., Darquennes K. and De Backer W.A. (2006). Role of N-acetylcysteine in the management of COPD. Int. J. Chron. Obstruct. Pulmon. Dis. 1, 425-434.
43. Salvemini D., Muscoli C., Riley D. P. and Cuzzocrea S. (2002). Superoxide dismutase mimetics. Pulm. Pharmacol. Ther. 15, 439-447. (Pubitemid 35333889)
44. Savolainen K. (2009). Safety of engineered nanomaterials and emerging nanotechnologies - do we know enough to allow us to make reliable judgments?. Hum. Exp. Toxicol. 28, 323-324.
45. Sayes C.M., Liang F., Hudson J.L., Mendez J., Guo W., Beach J.M., Moore V.C., Doyle C.D., West J. L., Billups W. E., Ausman K. D. and Colvin V.L. (2006). Functionalization density dependence of single-walled carbon nanotubes cytotoxicity in vitro. Toxicol. Lett. 161, 135-142. (Pubitemid 41790286)
46. Shvedova A.A., Kisin E.R., Mercer R., Murray A.R., Johnson V.J., Potapovich A.I., Tyurina Y.Y., Gorelik O., Arepalli S., Schwegler-Berry D., Hubbs A.F., Antonini J., Evans D.E., Ku B.K., Ramsey D., Maynard A., Kagan V.E., Castranova V. and Baron P. (2005). Unusual inflammatory and fibrogenic pulmonary response to single-walled carbon nanotubes in mice. Am. J. Physiol. Lung. Cell. Mol. Physiol. 289, L698-L708. (Pubitemid 41504399)
47. Shvedova A.A., Kisin E.R., Porter D., Schulte P., Kagan V.E., Fadeel B. and Castranova V. (2009). Mechanisms of pulmonary toxicity and medical applications of carbon naotubes: Two faces of Janus? Pharmacol. Therapeut. 121, 192-204.
48. Sriram K., Porter D., Tsuruoka S., Endo M., Jefferson A., Wolfarth W., Rogers G.M., Castranova V. and Luster M.I. (2007). Neuro-inflammatory responses following exposure to engineered nanomaterials. Toxicologist A1390.
49. Stone V., Johnston H. and Schins R.P. (2009). Development of in vitro systems for nanotoxicology: methodological considerations. Crit. Rev. Toxicol. 39, 613-626.
50. Tong H., McGee J.K., Saxena R.K., Kodavanti U.P., Devlin R.B. and Gilmour M.I. (2009). Influence of acid functionalization on the cardiopulmonary toxicity of carbon nanotubes and carbon black particles in mice. Toxicol. Appl. Pharmacol. 239, 224-232.
51. Wang X., Jia G., Wang H., Nie H., Yan L., Deng X.Y. and Wang S. (2009). Diameter effects on cytotoxicity of multiwalled carbon nanotubes. J. Nanosci. Nanotechnol. 9, 3025-33.
52. Warheit D.B., Laurence B.R., Reed K.L., Roach D.H., Reynolds G.A.M. and Webb T.R. (2004). Comparative pulmonary toxicity assessment of single-wall carbon Nanotubes in rats. Toxicol. Sci. 77, 117-125. (Pubitemid 38128651)
53. Weibel E.R. (1979). Stereological methods. Vol. 1: Practical methods for biological morphometry. Academic Press Inc. London.
54. Zhang L.W., Zeng L., Barron A.R. and Monteiro-Riviere N.A. (2007). Biological interactions of functionalized single-wall carbon nanotubes in human epidermal keratinocytes. Int. J. Toxicol. 26, 103-113. (Pubitemid 46514921)