Role of p63/p73 in epithelial remodeling and their response to steroid treatment in nasal polyposis

Journal of Allergy and Clinical Immunology

Volumn 127, Issue 3, 2011, Pages 765-772.e2

  Li, Chun Wei ^a   Shi, Li ^b   Zhang, Ke Ke ^b   Li, Tian Ying ^c   Lin, Zhi Bin ^c   Lim, Mei Kee ^d   McKeon, Frank ^d,e   Xian, Wa ^f   Wang, De Yun ^a  

^a NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^b SHANDONG UNIVERSITY   (China)

^c SUN YAT SEN UNIVERSITY   (China)

^d GENOME INSTITUTE OF SINGAPORE   (Singapore)

^e HARVARD MEDICAL SCHOOL   (United States)

^f INSTITUTE OF MEDICAL BIOLOGY   (Singapore)

Author keywords

epithelial remodeling; glucocorticosteroids; Nasal polyposis; p63; p73

Indexed keywords

MESSENGER RNA; PREDNISONE; PROTEIN P63; PROTEIN P73;

ADOLESCENT; ADULT; AGED; ARTICLE; CELL COUNT; CONTROLLED STUDY; FEMALE; GENE EXPRESSION REGULATION; HUMAN; HUMAN TISSUE; HYPERPLASIA; IMMUNOHISTOCHEMISTRY; MAJOR CLINICAL STUDY; MALE; NASAL BIOPSY; NOSE MUCOSA; NOSE POLYP; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN EXPRESSION; QUANTITATIVE ANALYSIS; STEROID THERAPY; TRANSACTIVATION; TREATMENT RESPONSE; TURBINATE; UPREGULATION;

EID: 79952310717     PISSN: 00916749     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jaci.2010.12.011     Document Type: Article

References (47)

1. S.T. Holgate Epithelial damage and response Clin Exp Allergy 30 2000 37 41 (Pubitemid 30341376)
2. C.W. Li, W. Cheung, Z.B. Lin, T.Y. Li, J.T. Lim, and D.Y. Wang Oral steroids enhance epithelial repair in nasal polyposis via upregulation of the AP-1 gene network Thorax 64 2009 306 312
3. R.M. Gallucci, P.P. Simeonova, J.M. Matheson, C. Kommineni, J.L. Guriel, and T. Sugawara Impaired cutaneous wound healing in interleukin-6-deficient and immunosuppressed mice FASEB J 14 2000 2525 2531
4. A. Yang, M. Kaghad, D. Caput, and F. McKeon On the shoulders of giants: p63, p73 and the rise of p53 Trends Genet 18 2002 90 95 (Pubitemid 34127808)
5. E. Candi, D. Dinsdale, A. Rufini, P. Salomoni, R.A. Knight, and M. Mueller TAp63 and DeltaNp63 in cancer and epidermal development Cell Cycle 6 2007 274 285
6. B.Y. Wang, J. Gil, D. Kaufman, L. Gan, D.S. Kohtz, and D.E. Burstein P63 in pulmonary epithelium, pulmonary squamous neoplasms, and other pulmonary tumors Hum Pathol 33 2002 921 926
7. L. Faridoni-Laurens, J. Bosq, F. Janot, M. Vayssade, M.L. Le Bihan, and M. Kaghad P73 expression in basal layers of head and neck squamous epithelium: a role in differentiation and carcinogenesis in concert with p53 and p63? Oncogene 20 2001 5302 5312 (Pubitemid 32844062)
8. K. Tomkova, M. Tomka, and V. Zajac Contribution of p53, p63, and p73 to the developmental diseases and cancer Neoplasma 55 2008 177 181
9. S. Ramadan, A. Terrinoni, M.V. Catani, A.E. Sayan, R.A. Knight, and M. Mueller p73 induces apoptosis by different mechanisms Biochem Biophys Res Commun 331 2005 713 717 (Pubitemid 40615502)
10. J.R. Rock, M.W. Onaitis, E.L. Rawlins, Y. Lu, C.P. Clark, and Y. Xue Basal cells as stem cells of the mouse trachea and human airway epithelium Proc Natl Acad Sci U S A 106 2009 12771 12775
11. A. Yang, R. Schweitzer, D. Sun, M. Kaghad, N. Walker, and R.T. Bronson p63 is essential for regenerative proliferation in limb, craniofacial and epithelial development Nature 398 1999 714 718 (Pubitemid 29197650)
12. Y. Lee, A. Miron, R. Drapkin, M.R. Nucci, F. Medeiros, and A. Saleemuddin A candidate precursor to serous carcinoma that originates in the distal fallopian tube J Pathol 211 2007 26 35 (Pubitemid 46092026)
13. W. Fokkens, V. Lund, J. Mullol European Position Paper on Rhinosinusitis and Nasal Polyps group European position paper on rhinosinusitis and nasal polyps 2007 Rhinol Suppl 20 2007 1 136
14. A. Yang, M. Kaghad, Y. Wang, E. Gillett, M.D. Fleming, and V. Dötsch p63, a p53 homolog at 3q27-29, encodes multiple products with transactivating, death-inducing, and dominant-negative activities Mol Cell 2 1998 305 316 (Pubitemid 128379271)
15. K.J. Livak, and T.D. Schmittgen Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method Methods 25 2001 402 408 (Pubitemid 34164012)
16. C.A. Perez, and J.A. Pietenpol Transcriptional programs regulated by p63 in normal epithelium and tumors Cell Cycle 6 2007 246 254
17. G. Wu, S. Nomoto, M.O. Hoque, T. Dracheva, M. Osada, and C.C. Lee DeltaNp63alpha and TAp63alpha regulate transcription of genes with distinct biological functions in cancer and development Cancer Res 63 2003 2351 2357 (Pubitemid 36605166)
18. C.E. Barbieri, L.J. Tang, K.A. Brown, and J.A. Pietenpol Loss of p63 leads to increased cell migration and up-regulation of genes involved in invasion and metastasis Cancer Res 66 2006 7589 7597 (Pubitemid 44289215)
19. E. Candi, A. Rufini, A. Terrinoni, A. Giamboi-Miraglia, A.M. Lena, and R. Mantovani DeltaNp63 regulates thymic development through enhanced expression of FgfR2 and Jag2 Proc Natl Acad Sci U S A 104 2007 11999 12004 (Pubitemid 47185619)
20. M.D. Westfall, D.J. Mays, J.C. Sniezek, and J.A. Pietenpol The Delta Np63 alpha phosphoprotein binds the p21 and 14-3-3 sigma promoters in vivo and has transcriptional repressor activity that is reduced by Hay-Wells syndrome-derived mutations Mol cell Biol 23 2003 2264 2276 (Pubitemid 36351010)
21. C.O. Leong, N. Vidnovic, M.P. DeYoung, D. Sgroi, and L.W. Ellisen The p63/p73 network mediates chemosensitivity to cisplatin in a biologically defined subset of primary breast cancers J Clin Invest 117 2007 1370 1380 (Pubitemid 46718425)
22. S. Kurata, T. Okuyama, M. Osada, T. Watanabe, Y. Tomimori, and S. Sato p51/p63 controls subunit alpha3 of the major epidermis integrin anchoring the stem cells to the niche J Biol Chem 279 2004 50069 50077 (Pubitemid 39577818)
23. P. Ghioni, F. Bolognese, P.H. Duijf, H. Van Bokhoven, R. Mantovani, and L. Guerrini Complex transcriptional effects of p63 isoforms: identification of novel activation and repression domains Mol Cell Biol 22 2002 8659 8668 (Pubitemid 35397180)
24. G. Liu, and X. Chen The ferredoxin reductase gene is regulated by the p53 family and sensitizes cells to oxidative stress-induced apoptosis Oncogene 21 2002 7195 7204 (Pubitemid 35305606)
25. B.C. Nguyen, K. Lefort, A. Mandinova, D. Antonini, V. Devgan, and G. Della Gatta Cross-regulation between Notch and p63 in keratinocyte commitment to differentiation Genes Dev 20 2006 1028 1042
26. K. Ortt, E. Raveh, U. Gat, and S. Sinha A chromatin immunoprecipitation screen in mouse keratinocytes reveals Runx1 as a direct transcriptional target of DeltaNp63 J Cell Biochem 104 2008 1204 1219 (Pubitemid 351961695)
27. M. Osada, H.L. Park, Y. Nagakawa, S. Begum, K. Yamashita, and G. Wu A novel response element confers p63- and p73-specific activation of the WNT4 promoter Biochem Biophys Res Commun 339 2006 1120 1128 (Pubitemid 41790580)
28. W. Yan, and X. Chen GPX2, a direct target of p63, inhibits oxidative stress-induced apoptosis in a p53-dependent manner J Biol Chem 281 2006 7856 7862 (Pubitemid 43847401)
29. Y. Sasaki, Y. Naishiro, Y. Oshima, K. Imai, Y. Nakamura, and T. Tokino Identification of pigment epithelium-derived factor as a direct target of the p53 family member genes Oncogene 24 2005 5131 5136 (Pubitemid 41129091)
30. S.J. Wilson, A. Wallin, G. Della-Cioppa, T. Sandström, and S.T. Holgate Effects of budesonide and formoterol on NF-kappaB, adhesion molecules, and cytokines in asthma Am J Respir Crit Care Med 164 2001 1047 1052 (Pubitemid 32971657)
31. R.A. Romano, K. Ortt, B. Birkaya, K. Smalley, and S. Sinha An active role of the DeltaN isoform of p63 in regulating basal keratin genes K5 and K14 and directing epidermal cell fate PLoS One 4 2009 e5623
32. A. Laitinen, A. Altraja, M. Kämpe, M. Linden, I. Virtanen, and L.A. Laitinen Tenascin is increased in airway basement membrane of asthmatics and decreased by an inhaled steroid Am J Respir Crit Care Med 156 1997 951 958 (Pubitemid 27396441)
33. T. Aoki, Y. Matsumoto, K. Hirata, K. Ochiai, M. Okada, and K. Ichikawa Expression profiling of genes related to asthma exacerbations Clin Exp Allergy 39 2009 213 221
34. L. Liu, L. Hakansson, P. Ridefelt, R.C. Garcia, and P. Venge Priming of eosinophil migration across lung epithelial cell monolayers and upregulation of CD11b/CD18 are elicited by extracellular Ca2+ Am J Respir Cell Mol Biol 28 2003 713 721 (Pubitemid 36677175)
35. K.L. Veraldi, B.T. Gibson, H. Yasuoka, M.M. Myerburg, E.A. Kelly, and S. Balzar Role of insulin-like growth factor binding protein-3 in allergic airway remodeling Am J Respir Crit Care Med 180 2009 611 617
36. A.M. Dittrich, H.A. Meyer, M. Krokowski, D. Quarcoo, B. Ahrens, and S.M. Kube Glutathione peroxidase-2 protects from allergen-induced airway inflammation in mice Eur Respir J 35 2010 1148 1154
37. A.E. Tilley, B.G. Harvey, A. Heguy, N.R. Hackett, R. Wang, and T.P. O'Connor Down-regulation of the notch pathway in human airway epithelium in association with smoking and chronic obstructive pulmonary disease Am J Respir Crit Care Med 179 2009 457 466
38. C. Taillé, S. Grootenboer-Mignot, C. Boursier, L. Michel, M.P. Debray, and J. Fagart Identification of periplakin as a new target for autoreactivity in idiopathic pulmonary fibrosis Am J Respir Crit Care Med 2010 [Epub ahead of print]
39. C.H. Woo, J.H. Lim, and J.H. Kim VCAM-1 upregulation via PKCdelta-p38 kinase-linked cascade mediates the TNF-alpha-induced leukocyte adhesion and emigration in the lung airway epithelium Am J Physiol Lung Cell Mol Physiol 288 2005 307 316
40. G. Pelosi, F. Pasini, C. Olsen Stenholm, U. Pastorino, P. Maisonneuve, and A. Sonzogni p63 immunoreactivity in lung cancer: yet another player in the development of squamous cell carcinomas? J Pathol 198 2002 100 109 (Pubitemid 34966213)
41. K. Nylander, P.J. Coates, and P.A. Hall Characterization of the expression pattern of p63 alpha and delta Np63 alpha in benign and malignant oral epithelial lesions Int J Cancer 87 2000 368 372 (Pubitemid 30451647)
42. K.M. Liefer, M.I. Koster, X.J. Wang, A. Yang, F. McKeon, and D.R. Roop Down-regulation of p63 is required for epidermal UV-B-induced apoptosis Cancer Res 60 2000 4016 4020 (Pubitemid 30636575)
43. M.P. DeYoung, C.M. Johannessen, C.O. Leong, W. Faquin, J.W. Rocco, and L.W. Ellisen Tumor-specific p73 up-regulation mediates p63 dependence in squamous cell carcinoma Cancer Res 66 2006 9362 9368 (Pubitemid 44623630)
44. E.D. Bateman, S.S. Hurd, P.J. Barnes, J. Bousquet, J.M. Drazen, and M. FitzGerald Global strategy for asthma management and prevention: GINA executive summary Eur Respir J 31 2008 143 178
45. S.Y. Leung, P. Eynott, P. Nath, and K.F. Chung Effects of ciclesonide and fluticasone propionate on allergen-induced airway inflammation and remodeling features J Allergy Clin Immunol 115 2005 989 996 (Pubitemid 40616213)
46. J.L. Cascallana, A. Bravo, E. Donet, H. Leis, M.F. Lara, and J.M. Paramio Ectoderm-targeted overexpression of the glucocorticoid receptor induces hypohidrotic ectodermal dysplasia Endocrinology 146 2005 2629 2638 (Pubitemid 40695565)
47. A. Chatterjee, X. Chang, T. Sen, R. Ravi, A. Bedi, and D. Sidransky Regulation of p53 family member isoform DeltaNp63alpha by the nuclear factor-kappaB targeting kinase IkappaB kinase beta Cancer Res 70 2010 1419 1429