Oral steroids enhance epithelial repair in nasal polyposis via upregulation of the AP-1 gene network

Thorax

Volumn 64, Issue 4, 2009, Pages 306-312

  Li, C W ^a   Cheung, W ^b   Lin, Z B ^c   Li, T Y ^c   Lim, J T ^a   Wang, D Y ^a  

^a NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c SUN YAT SEN UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

AMPHIREGULIN; CYCLOOXYGENASE 2; EARLY GROWTH RESPONSE FACTOR 1; HEPARIN BINDING EPIDERMAL GROWTH FACTOR; INTERLEUKIN 6; PROTEIN C FOS; PROTEIN C JUN; STEROID; TRANSCRIPTION FACTOR AP 1; GLUCOCORTICOID; MESSENGER RNA; PREDNISONE;

ADULT; ARTICLE; CELL REGENERATION; CLINICAL ARTICLE; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME REGULATION; EPITHELIUM CELL; FEMALE; HUMAN; HUMAN TISSUE; MALE; NOSE POLYP; PRIORITY JOURNAL; PROTEIN EXPRESSION; TISSUE REPAIR; CASE CONTROL STUDY; CHRONIC DISEASE; EXTRACELLULAR SPACE; GENETIC TRANSCRIPTION; GENETICS; IMMUNOHISTOCHEMISTRY; MIDDLE AGED; NOSE MUCOSA; ONCOGENE; ORAL DRUG ADMINISTRATION; POLYMERASE CHAIN REACTION; UPREGULATION;

ADMINISTRATION, ORAL; ADULT; CASE-CONTROL STUDIES; CHRONIC DISEASE; EXTRACELLULAR SPACE; FEMALE; GENES, JUN; GLUCOCORTICOIDS; HUMANS; IMMUNOHISTOCHEMISTRY; MALE; MIDDLE AGED; NASAL MUCOSA; NASAL POLYPS; POLYMERASE CHAIN REACTION; PREDNISONE; RNA, MESSENGER; TRANSCRIPTION FACTOR AP-1; TRANSCRIPTION, GENETIC; UP-REGULATION; YOUNG ADULT;

EID: 64849084659     PISSN: 00406376     EISSN: 14683296     Source Type: Journal    
DOI: 10.1136/thx.2008.106096     Document Type: Article

References (33)

1. Fokkens W, Lund V, Mullol J. European position paper on Rhinosinusitis and Nasal Polyps Group. Rhinology Suppl 2007;20:1-136.
2. Jordana M, Nakano K, Nakano A, et al. Nasal polyposis: a model of chronic airways inflammation. In: Busse WW, Holgate ST, eds. Asthma and rhinitis. 2nd ed. Oxford: Blackwell Scientific Publications, 2000:223-31.
3. Watelet JB, Van Zele T, Gjomarkaj M, et al. Tissue remodelling in upper airways: where is the link with lower airway remodelling? Allergy 2006;61:1249-58.
4. Barnes PJ. Corticosteroid effects on cell signalling. Eur Respir J 2006;27:413-26.
5. Mastruzzo C, Greco LR, Nakano K, et al. Impact of intranasal budesonide on immune inflammatory responses and epithelial remodeling in chronic upper airway inflammation. J Allergy Clin Immunol 2003;112:37-44.
6. Wadsworth SJ, Nijmeh HS, Hall IP. Glucocorticoids increase repair potential in a novel in vitro human airway epithelial wounding model. J Clin Immunol 2006;26:376-87.
7. Reddy SP, Mossman BT. Role and regulation of activator protein-1 in toxicant-induced responses of the lung. Am J Physiol Lung Cell Mol Physiol 2002;283:1161-78.
8. Wang J, Homer RJ, Chen Q, et al. Endogenous and exogenous IL-6 inhibit aeroallergen-induced Th2 inflammation. J Immunol 2000;165:4051-61.
9. Watelet JB, Bachert C, Gevaert P, et al. Wound healing of the nasal and paranasal mucosa: a review. Am J Rhinol 2002;16:77-84.
10. Livak KJ, Schmittgen TD. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods 2001;25:402-8.
11. Wladislavosky-Waserman P, Kern EB, Holley KE, et al. Epithelial damage in nasal polyps. Clin Allergy 1984;14:241-7.
12. Putti TC, To KF, Hsu HC, et al. Expression of epidermal growth factor receptor in head and neck cancers correlates with clinical progression: a multicentre immunohistochemical study in the Asia-Pacific region. Histopathology 2002;41:144-51.
13. Karin M, Liu Z, Zandi E. AP-1 function and regulation. Curr Opin Cell Biol 1997;9:240-6.
14. Grose R. Epithelial migration: open your eyes to c-Jun. Curr Biol 2003;13:678-80.
15. Gallucci RM, Simeonova PP, Matheson JM, et al. Impaired cutaneous wound healing in interleukin-6-deficient and immunosuppressed mice. FASEB J 2000;14:2525-31.
16. Yamaguchi K, Lantowski A, Dannenberg AJ, et al. Histone deacetylase inhibitors suppress the induction of c-Jun and its target genes including COX-2. J Biol Chem 2005;280:32569-77.
17. Li G, Gustafson-Brown C, Hanks SK, et al. c-Jun is essential for organization of the epidermal leading edge. Dev Cell 2003;4:865- 77.
18. Baraniuk JN, Wong G, Ali M, et al. Glucocorticoids decrease c-fos expression in human nasal polyps in vivo. Thorax 1998;53:577-82.
19. Zhou F, Thompson EB. Role of c-jun induction in the glucocorticoid-evoked apoptotic pathway in human leukemic lymphoblasts. Mol Endocrinol 1996;10:306-16.
20. Lee H, Shaw YT, Chiou ST, et al. The effects of glucocorticoid hormone on the expression of c-jun. FEBS Lett 1991;280:134-6.
21. Bolger WE, Joshi AS, Spear S, et al. Gene expression analysis in sinonasal polyposis before and after oral corticosteroids: a preliminary investigation. Otolaryngol Head Neck Surg 2007;137:27-33.
22. Sassone-Corsi P, Sisson JC, Verma IM. Transcriptional autoregulation of the protooncogene fos. Nature 1988;334:314-9.
23. Yang-Yen HF, Chambard JC, Sun YL, et al. Transcriptional interference between c- Jun and the glucocorticoid receptor: mutual inhibition of DNA binding due to direct protein-protein interaction. Cell 1990;62:1205-15.
24. Savla U, Appel HJ, Sporn PH, et al. Prostaglandin E(2) regulates wound closure in airway epithelium. Am J Physiol Lung Cell Mol Physiol 2001;280:421-31.
25. Mullol J, Fernandez-Morata JC, Roca-Ferrer J, et al. Cyclooxygenase 1 and cyclooxygenase 2 expression is abnormally regulated in human nasal polyps. J Allergy Clin Immunol 2002;109:824-30.
26. Dworski RT, Funk CD, Oates JA, et al. Prednisone increases PGH-synthase 2 in atopic humans in vivo. Am J Respir Crit Care Med 1997;155:351- 7.
27. Franchimont N, Durant D, Rydziel S, et al. Platelet-derived growth factor induces interleukin-6 transcription in osteoblasts through the activator protein-1 complex and activating transcription factor-2. J Biol Chem 1999;274:6783-9.
28. Sols-Herruzo JA, Rippe RA, Schrum LW, et al. Interleukin-6 increases rat metalloproteinase-13 gene expression through stimulation of activator protein 1 transcription factor in cultured fibroblasts. J Biol Chem 1999;274:30919-26.
29. Homma T, Kato A, Hashimoto N, et al. Corticosteroid and cytokines synergistically enhance toll-like receptor 2 expression in respiratory epithelial cells. Am J Respir Cell Mol Biol 2004;31:463-9.
30. Johnson AC, Murphy BA, Matelis CM, et al. Activator protein-1 mediates induced but not basal epidermal growth factor receptor gene expression. Mol Med 2000;6:17-27.
31. Levkovitz Y, Baraban JM. A dominant negative inhibitor of the Egr family of transcription regulatory factors suppresses cerebellar granule cell apoptosis by blocking c-Jun activation. J Neurosci 2001;21:5893-901.
32. Warburton G, Nares S, Angelov N, et al. Transcriptional events in a clinical model of oral mucosal tissue injury and repair. Wound Repair Regen 2005;13:19-26.
33. Revest JM, Di Blasi F, Kitchener P, et al. The MAPK pathway and Egr-1 mediate stress-related behavioral effects of glucocorticoids. Nat Neurosci 2005;8:664-72.