PTEN status is related to cell proliferation and self-renewal independent of CD133 phenotype in the glioma-initiating cells

Molecular and Cellular Biochemistry

Volumn 349, Issue 1-2, 2011, Pages 149-157

  Cheng, Ru Bin ^a,b   Ma, Rui Juan ^a   Wang, Zhao Kai ^a   Yang, Shan Jun ^a   Lin, Xiang Zhi ^a   Rong, Hui ^a   Ma, Yong ^a  

^a Key Laboratory of Marine Genetic Resources of Fujian Province   (China)

^b XIAMEN UNIVERSITY   (China)

Author keywords

CD133; Glioma initiating cell; Proliferation and self renewal; PTEN

Indexed keywords

CD133 ANTIGEN; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PROTEIN KINASE B;

AGGRESSION; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL PROLIFERATION; COMPARATIVE STUDY; CONTROLLED STUDY; GENE OVEREXPRESSION; GLIOMA CELL; MALE; MOUSE; NONHUMAN; PHENOTYPE; PROTEIN DEFICIENCY; RECEPTOR DOWN REGULATION; TUMOR SPHEROID;

ANTIGENS, CD; BRAIN NEOPLASMS; CELL CULTURE TECHNIQUES; CELL PROLIFERATION; DOWN-REGULATION; GLIOMA; GLYCOPROTEINS; HUMANS; NEOPLASTIC STEM CELLS; ONCOGENE PROTEIN V-AKT; PEPTIDES; PHOSPHORYLATION; PTEN PHOSPHOHYDROLASE; TUMOR BURDEN; TUMOR CELLS, CULTURED;

EID: 79952283135     PISSN: 03008177     EISSN: 15734919     Source Type: Journal    
DOI: 10.1007/s11010-010-0669-1     Document Type: Article

References (56)

1. D Hallahan L Geng S Qu C Scarfone T Giorgio, et al. 2003 Integrin-mediated targeting of drug delivery to irradiated tumor blood vessels Cancer Cell 3 63 74 1:CAS:528:DC%2BD3sXhtFamt7c%3D 10.1016/S1535-6108(02)00238-6 12559176 (Pubitemid 37443891)
2. JE Dick 2008 Stem cell concepts renew cancer research Blood 112 4793 4807 1:CAS:528:DC%2BD1cXhsFWmtr3M 10.1182/blood-2008-08-077941 19064739
3. S Bao Q Wu RE McLendon Y Hao Q Shi, et al. 2006 Glioma stem cells promote radioresistance by preferential activation of the DNA damage response Nature 444 756 760 1:CAS:528:DC%2BD28Xht1OntbzP 10.1038/nature05236 17051156 (Pubitemid 44949604)
4. X Fan LG Salford B Widegren 2007 Glioma stem cells: evidence and limitation Semin Cancer Biol 17 214 218 1:CAS:528:DC%2BD2sXjtVanu7Y%3D 10.1016/j.semcancer.2006.04.002 16750389 (Pubitemid 46413075)
5. MS Lesniak 2006 Targeted therapy for malignant glioma: neural stem cells Expert Rev Neurother 6 1 3 10.1586/14737175.6.1.1 16466305
6. SK Singh C Hawkins ID Clarke JA Squire J Bayani, et al. 2004 Identification of human brain tumour initiating cells Nature 432 396 401 1:CAS:528:DC%2BD2cXpvVCjtbY%3D 10.1038/nature03128 15549107 (Pubitemid 39551674)
7. S Miraglia W Godfrey AH Yin K Atkins R Warnke, et al. 1997 A novel five-transmembrane hematopoietic stem cell antigen: isolation, characterization, and molecular cloning Blood 90 5013 5021 1:CAS:528:DyaK2sXnvFWkt7c%3D 9389721 (Pubitemid 28007218)
8. Y Yu A Flint EL Dvorin J Bischoff 2002 AC133-2, a novel isoform of human AC133 stem cell antigen J Biol Chem 277 20711 20716 1:CAS:528: DC%2BD38XkslWgu7s%3D 10.1074/jbc.M202349200 12042327 (Pubitemid 34967375)
9. SK Singh ID Clarke M Terasaki VE Bonn C Hawkins J Squire PB Dirks 2003 Identification of a cancer stem cell in human brain tumors Cancer Res 63 5821 5828 1:CAS:528:DC%2BD3sXnvVSjtbc%3D 14522905 (Pubitemid 37187480)
10. Q Shu KK Wong JM Su AM Adesina LT Yu, et al. 2008 Direct orthotopic transplantation of fresh surgical specimen preserves CD133+ tumor cells in clinically relevant mouse models of medulloblastoma and glioma Stem Cells 26 1414 1424 10.1634/stemcells.2007-1009 18403755
11. A Wu S Oh SM Wiesner K Ericson L Chen, et al. 2008 Persistence of CD133+ cells in human and mouse glioma cell lines: detailed characterization of GL261 glioma cells with cancer stem cell-like properties Stem Cells Dev 17 173 184 1:CAS:528:DC%2BD1cXhvVyksL4%3D 10.1089/scd.2007.0133 18271701 (Pubitemid 351271617)
12. JX Cheng BL Liu X Zhang 2009 How powerful is CD133 as a cancer stem cell marker in brain tumors? Cancer Treat Rev 35 403 408 1:CAS:528: DC%2BD1MXptlSksrc%3D 10.1016/j.ctrv.2009.03.002 19369008
13. SM Pollard K Yoshikawa ID Clarke D Danovi S Stricker, et al. 2009 Glioma stem cell lines expanded in adherent culture have tumor-specific phenotypes and are suitable for chemical and genetic screens Cell Stem Cell 4 568 580 1:CAS:528:DC%2BD1MXnt1Ggtbg%3D 10.1016/j.stem.2009.03.014 19497285
14. D Beier P Hau M Proescholdt A Lohmeier J Wischhusen, et al. 2007 CD133(+) and CD133(-) glioblastoma-derived cancer stem cells show differential growth characteristics and molecular profiles Cancer Res 67 4010 4015 1:CAS:528:DC%2BD2sXltVyku74%3D 10.1158/0008-5472.CAN-06-4180 17483311 (Pubitemid 46815044)
15. KM Joo SY Kim X Jin SY Song DS Kong, et al. 2008 Clinical and biological implications of CD133-positive and CD133-negative cells in glioblastomas Lab Invest 88 808 815 1:CAS:528:DC%2BD1cXovV2ltL8%3D 10.1038/labinvest.2008.57 18560366
16. J Wang PO Sakariassen O Tsinkalovsky H Immervoll SO Boe, et al. 2008 CD133 negative glioma cells form tumors in nude rats and give rise to CD133 positive cells Int J Cancer 122 761 768 1:CAS:528:DC%2BD1cXhsFShsrg%3D 10.1002/ijc.23130 17955491
17. V Clement V Dutoit D Marino PY Dietrich I Radovanovic 2009 Limits of CD133 as a marker of glioma self-renewing cells Int J Cancer 125 244 248 1:CAS:528:DC%2BD1MXmslCgurc%3D 10.1002/ijc.24352 19350631
18. GA Alexiou S Voulgaris 2010 The role of the PTEN gene in malignant gliomas Neurol Neurochir Pol 44 80 86 20358487
19. EM Duerr B Rollbrocker Y Hayashi N Peters B Meyer-Puttlitz, et al. 1998 PTEN mutations in gliomas and glioneuronal tumors Oncogene 16 2259 2264 1:CAS:528:DyaK1cXjtFegtbw%3D 10.1038/sj.onc.1201756 9619835 (Pubitemid 28220656)
20. FB Furnari T Fenton RM Bachoo A Mukasa JM Stommel, et al. 2007 Malignant astrocytic glioma: genetics, biology, and paths to treatment Genes Dev 21 2683 2710 1:CAS:528:DC%2BD2sXhtlSitLrO 10.1101/gad.1596707 17974913 (Pubitemid 350070717)
21. T Maehama JE Dixon 1998 The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate J Biol Chem 273 13375 13378 1:CAS:528:DyaK1cXjvVejsLk%3D 10.1074/jbc.273.22.13375 9593664 (Pubitemid 28268370)
22. A Radu V Neubauer T Akagi H Hanafusa MM Georgescu 2003 PTEN induces cell cycle arrest by decreasing the level and nuclear localization of cyclin D1 Mol Cell Biol 23 6139 6149 1:CAS:528:DC%2BD3sXms1Oht74%3D 10.1128/MCB.23.17.6139- 6149.2003 12917336 (Pubitemid 37013092)
23. B Stiles V Gilman N Khanzenzon R Lesche A Li, et al. 2002 Essential role of AKT-1/protein kinase B alpha in PTEN-controlled tumorigenesis Mol Cell Biol 22 3842 3851 1:CAS:528:DC%2BD38XjslWlt70%3D 10.1128/MCB.22.11.3842-3851.2002 11997518 (Pubitemid 34525225)
24. TH Hu CC Huang PR Lin HW Chang LP Ger, et al. 2003 Expression and prognostic role of tumor suppressor gene PTEN/MMAC1/TEP1 in hepatocellular carcinoma Cancer 97 1929 1940 1:CAS:528:DC%2BD3sXjtlektLc%3D 10.1002/cncr.11266 12673720 (Pubitemid 36397268)
25. S Izumoto T Ohnishi H Kanemura N Arita M Maruno, et al. 2001 PTEN mutations in malignant gliomas and their relation with meningeal gliomatosis J Neurooncol 53 21 26 1:STN:280:DC%2BD3MrntVOjsw%3D%3D 10.1023/A:1011839920176 11678426 (Pubitemid 32936655)
26. R Galli E Binda U Orfanelli B Cipelletti A Gritti, et al. 2004 Isolation and characterization of tumorigenic, stem-like neural precursors from human glioblastoma Cancer Res 64 7011 7021 1:CAS:528:DC%2BD2cXotFalsLs%3D 10.1158/0008-5472.CAN-04-1364 15466194 (Pubitemid 39331011)
27. E Koller S Propp H Murray W Lima B Bhat, et al. 2006 Competition for RISC binding predicts in vitro potency of siRNA Nucleic Acids Res 34 4467 4476 1:CAS:528:DC%2BD28XhtVygu7vI 10.1093/nar/gkl589 16945958 (Pubitemid 44567046)
28. AV Molofsky R Pardal T Iwashita IK Park MF Clarke SJ Morrison 2003 Bmi-1 dependence distinguishes neural stem cell self-renewal from progenitor proliferation Nature 425 962 967 1:CAS:528:DC%2BD3sXosVOht7w%3D 10.1038/nature02060 14574365 (Pubitemid 37376927)
29. BA Reynolds S Weiss 1992 Generation of neurons and astrocytes from isolated cells of the adult mammalian central nervous system Science 255 1707 1710 1:STN:280:DyaK383gsFemsw%3D%3D 10.1126/science.1553558 1553558
30. BA Reynolds S Weiss 1996 Clonal and population analyses demonstrate that an EGF-responsive mammalian embryonic CNS precursor is a stem cell Dev Biol 175 1 13 1:CAS:528:DyaK28Xitlynt7Y%3D 10.1006/dbio.1996.0090 8608856 (Pubitemid 26150042)
31. CA Gilbert MC Daou RP Moser AH Ross 2010 Gamma-secretase inhibitors enhance temozolomide treatment of human gliomas by inhibiting neurosphere repopulation and xenograft recurrence Cancer Res 70 6870 6879 1:CAS:528:DC%2BC3cXhtV2rsLfE 10.1158/0008-5472.CAN-10-1378 20736377
32. I Singec R Knoth RP Meyer J Maciaczyk B Volk, et al. 2006 Defining the actual sensitivity and specificity of the neurosphere assay in stem cell biology Nat Methods 3 801 806 1:CAS:528:DC%2BD28XpvVCmtLg%3D 10.1038/nmeth926 16990812 (Pubitemid 44445827)
33. M Groszer R Erickson DD Scripture-Adams R Lesche A Trumpp, et al. 2001 Negative regulation of neural stem/progenitor cell proliferation by the Pten tumor suppressor gene in vivo Science 294 2186 2189 1:CAS:528: DC%2BD3MXptVOmt74%3D 10.1126/science.1065518 11691952 (Pubitemid 33150679)
34. F Zeppernick R Ahmadi B Campos C Dictus BM Helmke, et al. 2008 Stem cell marker CD133 affects clinical outcome in glioma patients Clin Cancer Res 14 123 129 1:CAS:528:DC%2BD1cXoslCg 10.1158/1078-0432.CCR-07-0932 18172261 (Pubitemid 351377986)
35. G Liu X Yuan Z Zeng P Tunici H Ng, et al. 2006 Analysis of gene expression and chemoresistance of CD133+ cancer stem cells in glioblastoma Mol Cancer 5 67 10.1186/1476-4598-5-67 17140455 (Pubitemid 44942887)
36. D Hambardzumyan M Squatrito EC Holland 2006 Radiation resistance and stem-like cells in brain tumors Cancer Cell 10 454 456 1:CAS:528: DC%2BD28XhtlCnsrbO 10.1016/j.ccr.2006.11.008 17157785 (Pubitemid 44854752)
37. SG Piccirillo BA Reynolds N Zanetti G Lamorte E Binda, et al. 2006 Bone morphogenetic proteins inhibit the tumorigenic potential of human brain tumour-initiating cells Nature 444 761 765 1:CAS:528:DC%2BD28Xht1Ontb3J 10.1038/nature05349 17151667 (Pubitemid 44949605)
38. PA Clark DM Treisman J Ebben JS Kuo 2007 Developmental signaling pathways in brain tumor-derived stem-like cells Dev Dyn 236 3297 3308 1:CAS:528:DC%2BD1cXot1yisg%3D%3D 10.1002/dvdy.21381 18000980 (Pubitemid 350276387)
39. JL Lasky LM Liau 2006 Targeting stem cells in brain tumors Technol Cancer Res Treat 5 251 260 1:CAS:528:DC%2BD28XntFaktb4%3D 16700621 (Pubitemid 43946258)
40. J Rebetz D Tian A Persson B Widegren LG Salford, et al. 2008 Glial progenitor-like phenotype in low-grade glioma and enhanced CD133-expression and neuronal lineage differentiation potential in high-grade glioma PLoS One 3 e1936 10.1371/journal.pone.0001936 18398462 (Pubitemid 351984112)
41. QS Tong LD Zheng ST Tang QL Ruan Y Liu, et al. 2008 Expression and clinical significance of stem cell marker CD133 in human neuroblastoma World J Pediatr 4 58 62 10.1007/s12519-008-0012-z 18402255 (Pubitemid 351234092)
42. DS Kong MH Kim WY Park YL Suh JI Lee, et al. 2008 The progression of gliomas is associated with cancer stem cell phenotype Oncol Rep 19 639 643 1:CAS:528:DC%2BD1cXjs1elsr8%3D 18288395 (Pubitemid 351330429)
43. A Murat E Migliavacca T Gorlia WL Lambiv T Shay, et al. 2008 Stem cell-related "self-renewal" signature and high epidermal growth factor receptor expression associated with resistance to concomitant chemoradiotherapy in glioblastoma J Clin Oncol 26 3015 3024 1:CAS:528:DC%2BD1cXoslOqsLs%3D 10.1200/JCO.2007.15.7164 18565887
44. M Keniry R Parsons 2008 The role of PTEN signaling perturbations in cancer and in targeted therapy Oncogene 27 5477 5485 1:CAS:528: DC%2BD1cXhtFWiur%2FK 10.1038/onc.2008.248 18794882
45. DA Altomare S Tanno A De Rienzo AJ Klein-Szanto S Tanno, et al. 2002 Frequent activation of AKT2 kinase in human pancreatic carcinomas J Cell Biochem 87 470 476 10.1002/jcb.10287 14735903
46. DH Lee MJ Szczepanski YJ Lee 2009 Magnolol induces apoptosis via inhibiting the EGFR/PI3K/Akt signaling pathway in human prostate cancer cells J Cell Biochem 106 1113 1122 1:CAS:528:DC%2BD1MXkslCktbo%3D 10.1002/jcb.22098 19229860
47. D Hambardzumyan OJ Becher MK Rosenblum PP Pandolfi K Manova-Todorova EC Holland 2008 PI3K pathway regulates survival of cancer stem cells residing in the perivascular niche following radiation in medulloblastoma in vivo Genes Dev 22 436 448 1:CAS:528:DC%2BD1cXivVaitrw%3D 10.1101/gad.1627008 18281460 (Pubitemid 351272752)
48. CE Eyler WC Foo KM LaFiura RE McLendon AB Hjelmeland JN Rich 2008 Brain cancer stem cells display preferential sensitivity to Akt inhibition Stem Cells 26 3027 3036 1:CAS:528:DC%2BD1MXhtFSktrY%3D 10.1634/stemcells.2007-1073 18802038
49. P Chugh B Bradel-Tretheway CM Monteiro-Filho V Planelles SB Maggirwar S Dewhurst B Kim 2008 Akt inhibitors as an HIV-1 infected macrophage-specific anti-viral therapy Retrovirology 5 11 10.1186/1742-4690-5-11 18237430 (Pubitemid 351372533)
50. AM Martelli PL Tazzari G Tabellini R Bortul AM Billi, et al. 2003 A new selective AKT pharmacological inhibitor reduces resistance to chemotherapeutic drugs, TRAIL, all-trans-retinoic acid, and ionizing radiation of human leukemia cells Leukemia 17 1794 1805 1:CAS:528:DC%2BD3sXntFCiurw%3D 10.1038/sj.leu. 2403044 12970779 (Pubitemid 37185255)
51. M Mandal S Kim MN Younes SA Jasser AK El-Naggar GB Mills JN Myers 2005 The Akt inhibitor KP372-1 suppresses Akt activity and cell proliferation and induces apoptosis in thyroid cancer cells Br J Cancer 92 1899 1905 1:CAS:528:DC%2BD2MXkt1Sgsrk%3D 10.1038/sj.bjc.6602595 15870708 (Pubitemid 40826139)
52. M Groszer R Erickson DD Scripture-Adams JD Dougherty J Le Belle, et al. 2006 PTEN negatively regulates neural stem cell self-renewal by modulating G0-G1 cell cycle entry Proc Natl Acad Sci USA 103 111 116 1:CAS:528: DC%2BD28Xms12isg%3D%3D 10.1073/pnas.0509939103 16373498 (Pubitemid 43076113)
53. X Fan W Matsui L Khaki D Stearns J Chun YM Li CG Eberhart 2006 Notch pathway inhibition depletes stem-like cells and blocks engraftment in embryonal brain tumors Cancer Res 66 7445 7452 1:CAS:528:DC%2BD28XnsFyrtLY%3D 10.1158/0008-5472.CAN-06-0858 16885340 (Pubitemid 44289197)
54. N Platet SY Liu ME Atifi L Oliver FM Vallette F Berger D Wion 2007 Influence of oxygen tension on CD133 phenotype in human glioma cell cultures Cancer Lett 258 286 290 1:CAS:528:DC%2BD2sXhtlagsb7O 10.1016/j.canlet.2007.09. 012 17977646 (Pubitemid 350110377)
55. R Chen MC Nishimura SM Bumbaca S Kharbanda WF Forrest, et al. 2010 A hierarchy of self-renewing tumor-initiating cell types in glioblastoma Cancer Cell 17 362 375 1:CAS:528:DC%2BC3cXmsF2msLY%3D 10.1016/j.ccr.2009.12.049 20385361
56. - tumor-initiating cells in adult human gliomas Neurosurgery 62 505 514 10.1227/01.neu.0000316019.28421.95 18382330