Gestational influences on the pharmacokinetics of gestagenic drugs: A combined in silico, in vitro and in vivo analysis

European Journal of Pharmaceutical Sciences

Volumn 42, Issue 4, 2011, Pages 318-331

  Pilari, Sabine ^a,c   Preuße, Cornelia ^b   Huisinga, Wilhelm ^c  

^a FREIE UNIVERSITÄT BERLIN   (Germany)

^b BAYER PHARMA AG   (Germany)

^c UNIVERSITY OF POTSDAM   (Germany)

Author keywords

Clearance induction; Gestagenic drug; PBPK; Pregnancy; Protein binding; SHBG

Indexed keywords

CYTOCHROME P450 3A4; ESTERASE; GESTAGEN; SEX HORMONE BINDING GLOBULIN;

ARTICLE; COMPUTER MODEL; DRUG ACCUMULATION; DRUG CLEARANCE; DRUG PROTEIN BINDING; ENZYME INDUCTION; HUMAN; IN VITRO STUDY; IN VIVO STUDY; NONHUMAN; PREGNANCY; PRIORITY JOURNAL; RABBIT;

ALGORITHMS; ANIMALS; CONTRACEPTIVES, ORAL, COMBINED; CYTOCHROME P-450 CYP3A; FEMALE; HAPLORHINI; HUMANS; MODELS, BIOLOGICAL; ORGAN SPECIFICITY; PREGNANCY; PROGESTINS; PROTEIN BINDING; RABBITS; RATS; SEX HORMONE-BINDING GLOBULIN;

EID: 79952282924     PISSN: 09280987     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejps.2010.12.003     Document Type: Article

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