Development of a physiologically based pharmacokinetic model to describe the disposition of methanol in pregnant rats and mice

Toxicology and Applied Pharmacology

Volumn 145, Issue 2, 1997, Pages 311-322

  Ward, Keith W ^a,d   Blumenthal, Gregory M ^c,e   Welsch, Frank ^a,c   Pollack, Gary M ^a,b  

^a UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF NORTH CAROLINA   (United States)

^c CIIT CENTERS FOR HEALTH RESEARCH   (United States)

^d U S ENVIRONMENTAL PROTECTION AGENCY   (United States)

^e NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

METHANOL; XENOBIOTIC AGENT;

ANIMAL EXPERIMENT; AREA UNDER THE CURVE; ARTICLE; DRUG ABSORPTION; DRUG BLOOD LEVEL; DRUG DISPOSITION; FEMALE; MALE; MATERNAL BLOOD; MODEL; MOUSE; NONHUMAN; ORAL DRUG ADMINISTRATION; PARTITION COEFFICIENT; PHARMACOKINETICS; PREGNANCY;

ANIMALIA;

EID: 0031214089     PISSN: 0041008X     EISSN: None     Source Type: Journal    
DOI: 10.1006/taap.1997.8170     Document Type: Article

References (36)

1. Bolon B., Dorman D. C., Janszen D., Morgan K. T., Welsch F. Phase-specific developmental toxicity in mice following maternal methanol inhalation. Fundam. Appl. Toxicol. 21:1993;508-516.
2. Bolon B., Welsch F., Morgan K. T. Methanol-induced neural tube defects in mice: Pathogenesis during neurulation. Teratology. 49:1994;497-517.
3. Clarke D. O., Elswick B. A., Welsch F., Conolly R. B. Pharmacokinetics of 2-methoxyethanol and 2-methoxyacetic acid in the pregnant mouse: A physiologically based mathematical model. Toxicol. Appl. Pharmacol. 121:1993;239-252.
4. Collins M. D., Duggan C. A., Schreiner C. M., Scott W. J. Jr. Decreasing pH of rat embryos and fluids estimated by transplacental distribution of DMO. Am. J. Physiol. 257:1989;R542-R548.
5. Dorman D. C., Bolon B., Struve M. F., LaPerle K. M. D., Wong B. A., Elswick B., Welsch F. Role of formate in methanol-induced exencephaly in CD-1 mice. Teratology. 52:1995;30-40.
6. Fisher J. W., Whittaker T. A., Taylor D. H., Clewell H. J. III, Andersen M. E. Physiologically based pharmacokinetic modeling of the pregnant rat: A multiroute exposure model for trichloroethylene and its metabolite, trichloroacetic acid. Toxicol. Appl. Pharmacol. 99:1989;395-414.
7. Gabrielsson J. L., Paalzow L. K. A physiological pharmacokinetic model for morphine disposition in the pregnant rat. J. Pharmacokinet. Biopharm. 11:1983;147-163.
8. Gargas M. L., Burgess R. J., Voisard D. E., Cason G. H., Andersen M. E. Partition coefficients of low-molecular-weight volatile chemicals in various liquids and tissues. Toxicol. Appl. Pharmacol. 98:1989;87-99.
9. Gibaldi M., Perrier D. Pharmacokinetics. 1982;Marcel Dekker, New York.
10. Gumbleton M., Nicholls P. J., Taylor G. Differential influence of laboratory anaesthetic regimens upon renal and hepatosplanchnic haemodynamics in the rat. J. Pharm. Pharmacol. 42:1990;693-697.
11. Horiguchi T., Suzuki K., Comas-Heubach A. C., Boyer-Milic A. M., Baratz R. A., Morishima H. O., James L. S., Adamsons K. Effect of ethanol upon uterine activity and fetal acid-base state of the rhesus monkey. Am. J. Obstet. Gynecol. 109:1971;910-917.
12. Horton V. L., Higuchi M. A., Rickert D. E. Physiologically based pharmacokinetic model for methanol in rats, monkeys and humans. Toxicol. Appl. Pharmacol. 117:1992;26-36.
13. Jones P. J. H., Leichter J., Lee M. Placental blood flow in rats fed alcohol before and during gestation. Life Sci. 29:1981;1153-1159.
14. Krishnan K., Andersen M. E. Physiologically based pharmacokinetic modeling in toxicology. Principles and Methods of Toxicology. 1994;Raven Press, New York. p. 149-188.
15. Luecke R. H., Wosilait W. D., Pearce B. A., Young J. F. A physiologically based pharmacokinetic computer model for human pregnancy. Teratology. 49:1994;90-103.
16. Marcus W. J. Methanol: Drinking water heath advisory, Office of Drinking Water, U.S. Environmental Protection Agency. J. Environ. Path. Toxicol. Oncol. 12:1993;115-138.
17. Mukherjee A. B., Hodgen G. D. Maternal ethanol exposure induces transient impairment of umbilical circulation and fetal hypoxia in monkeys. Science. 218:1982;700-702.
18. Nelson B. K., Brightwell S., MacKenzie D. R., Khan A., Burg J. R., Weigel W. W., Goad P. T. Teratological assessment of methanol and ethanol at high inhalation levels in rats. Fundam. Appl. Toxicol. 5:1985;727-736.
19. O'Flaherty E. J. Physiologically based pharmacokinetic models in developmental toxicology. Risk Anal. 14:1994;605-611.
20. O'Flaherty E. J., Scott W., Schreiner C., Beliles R. P. A physiologically based kinetic model of rat and mouse gestation: Disposition of a weak acid. Toxicol. Appl. Pharmacol. 112:1992;245-256.
21. Olanoff L. S., Anderson J. M. Controlled release of tetracycline. III. A physiological pharmacokinetic model of the pregnant rat. J. Pharmacokinet. Biopharm. 8:1980;599-620.
22. R. A. Perkins, 1994, The Toxicokinetics of Inhaled Methanol, The University of North Carolina. UNC, Chapel Hill.
23. Perkins R. A., Ward K. W., Pollack G. M. Comparative toxicokinetics of inhaled methanol in the female CD-1 mouse and Sprague-Dawley rat. Fundam. Appl. Toxicol. 28:1995a;245-254.
24. Perkins R. A., Ward K. W., Pollack G. M. Methanol toxicokinetics: A pharmacokinetic model of methanol in the human and comparison to methanol disposition in the mouse and rat. Environ. Health Perspect. 103:1995b;726-733.
25. Perkins R. A., Ward K. W., Pollack G. M. Ventilation of ambulatory rats exposed to methanol vapor in a flow-through exposure system: Measurement and input to toxicokinetic models. Inhal. Toxicol. 8:1996a;143-162.
26. Perkins R. A., Ward K. W., Pollack G. M. Methanol inhalation: Site and other factors influencing absorption, and an inhalation toxicokinetic model for the rat. Pharm. Res. 13:1996b;749-755.
27. Pollack G. M., Brouwer K. L. R., Kawagoe J. L. Toxicokinetics of intravenous methanol in the female rat. Fundam. Appl. Toxicol. 21:1993;105-110.
28. Pollack G. M., Kawagoe J. L. Determination of methanol in whole blood by capillary gas chromatography with direct on-column injection. J. Chromatogr. Biomed. Appl. 570:1991;406-411.
29. Rall T. W. Hypnotics and sedatives: Ethanol. Gilman A. G., Rall T. W., Nies A. S., Taylor P. Goodman and Gilman's The Pharmacological Basis of Therapeutics. 1990;345-382 Pergamon Press, New York.
30. Richardson B. S., Patrick J. E., Bousquet J., Homan J., Brien J. F. Cerebral metabolism in fetal lamb after maternal infusion of ethanol. Am. J. Physiol. 249:1985;R505-509.
31. Rogers J. M., Mole M. L., Chernoff N., Barbee B. D., Turner C. I., Logsdon T. R., Kavlock R. J. The developmental toxicity of inhaled methanol in the CD-1 mouse, with quantitative dose-response modeling for estimation of benchmark doses. Teratology. 47:1993;175-188.
32. Terry K. K., Elswick B. A., Welsch F., Conolly R. B. Development of a physiologically based pharmacokinetic model describing 2-methoxyacetic acid disposition in the pregnant mouse. Toxicol. Appl. Pharmacol. 132:1995;103-114.
33. Von Burg R. Toxicology update: Methanol. J. Appl. Toxicol. 14:1994;309-313.
34. Ward K. W., Perkins R. A., Pollack G. M. Comparative toxicokinetics of methanol in the female mouse and rat. Fundam. Appl. Toxicol. 26:1995;258-264.
35. Ward K. W., Pollack G. M. Comparative toxicokinetics of methanol in pregnant and nonpregnant rodents. Drug Metab. Dispos. 24:1996a;1062-1070.
36. Ward K. W., Pollack G. M. Use of intrauterine microdialysis to investigate methanol-induced alterations in uteroplacental blood flow. Toxicol. Appl. Pharmacol. 140:1996b;203-210.