Zfra is a small wizard in the mitochondrial apoptosis

Aging

Volumn 2, Issue 12, 2010, Pages 1023-1029

  Dudekula, Subhan ^a   Lee, Ming Hui ^a   Hsu, Li Jin ^a   Chen, Shean Jen ^a   Chang, Nan Shan ^a,b  

^a NATIONAL CHENG KUNG UNIVERSITY   (Taiwan)

^b State University of New York Upstate Medical University: College of Medicine   (United States)

Author keywords

Aging; Apoptosis; Cytochrome c; Mitochondria; TNF signaling; Zfra

Indexed keywords

APBB2 PROTEIN, HUMAN; OXIDOREDUCTASE; PROTEIN P53; SIGNAL TRANSDUCING ADAPTOR PROTEIN; TUMOR SUPPRESSOR PROTEIN; WWOX PROTEIN, HUMAN;

ANIMAL; APOPTOSIS; ARTICLE; CELL AGING; HUMAN; METABOLISM; MITOCHONDRIAL MEMBRANE POTENTIAL; MITOCHONDRION; NERVE DEGENERATION; PATHOLOGY; SIGNAL TRANSDUCTION;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ANIMALS; APOPTOSIS; CELL AGING; HUMANS; MEMBRANE POTENTIAL, MITOCHONDRIAL; MITOCHONDRIA; NERVE DEGENERATION; OXIDOREDUCTASES; SIGNAL TRANSDUCTION; TUMOR SUPPRESSOR PROTEIN P53; TUMOR SUPPRESSOR PROTEINS;

EID: 79952272098     PISSN: 19454589     EISSN: None     Source Type: Journal    
DOI: 10.18632/aging.100263     Document Type: Article

References (51)

1. Chang NS. A potential role of p53 and WOX1 in mitochondrial apoptosis (Review). Int J Mol Med. 2002;9:19-24.
2. Chang NS, Doherty J, Ensign A, Lewis J, Heath J, Schultz L et al. Molecular mechanisms underlying WOX1 activation during apoptotic and stress responses. Biochem Pharmacol. 2003;66:1347-1354.
3. Chang NS, Hsu LJ, Lin YS, Lai FJ, Sheu HM. WW domaincontaining oxidoreductase: a candidate tumor suppressor. Trends Mol Med. 2007;13:12-22.
4. O'Keefe LV and Richards RI. Common chromosomal fragile sites and cancer: focus on FRA16D. Cancer Lett. 2006;232:37-47. Review
5. Smith DI, McAvoy S, Zhu Y, Perez DS. Large common fragile site genes and cancer. Semin Cancer Biol. 2007;17:31-41. Review.
6. Aqeilan RI and Croce CM. WWOX in biological control and tumorigenesis. J Cell Physiol. 2007;212:307-310.
7. Chang JY, He RY, Lin HP, Hsu LJ, Lai FJ, Hong Q et al. Signaling from membrane receptors to tumor suppressor WW domaincontaining oxidoreductase. Exp Biol Med. (Maywood) 2010;235:796-804. Review.
8. Chang NS, Pratt N, Heath J, Schultz L, Sleve D, Carey GB et al. Hyaluronidase induction of a WW domain-containing oxidoreductase that enhances tumor necrosis factor cytotoxicity. J Biol Chem. 2001;276:3361-3370.
9. Aqeilan RI, Hassan MQ, de Bruin A, Hagan JP, Volinia S, Palumbo T et al. The WWOX tumor suppressor is essential for postnatal survival and normal bone metabolism. J Biol Chem. 2008;283:21629-21639.
10. Lee JC, Weissglas-Volkov D, Kyttälä M, Dastani Z, Cantor RM, Sobel EM et al. WW-domain-containing oxidoreductase is associated with low plasma HDL-C levels. Am J Hum Genet. 2008;83:180-192.
11. Iliopoulos D, Malizos KN, Oikonomou P, Tsezou A. Integrative microRNA and proteomic approaches identify novel osteoarthritis genes and their collaborative metabolic and inflammatory networks. PLoS One. 2008;3:e3740.
12. Ludes-Meyers JH, Kil H, Parker-Thornburg J, Kusewitt DF, Bedford MT, Aldaz CM. Generation and characterization of mice carrying a conditional allele of the Wwox tumor suppressor gene. PLoS One. 2009;4:e7775.
13. Oõkeefe LV, Colella A, Dayan S, Chen Q, Choo A, Jacob R et al. Drosophila orthologue of WWOX, the chromosomal fragile site FRA16D tumour suppressor gene, functions in aerobic metabolism and regulates reactive oxygen species. Hum Mol Genet. 2010, in press.
14. Sze CI, Su M, Pugazhenthi S, Jambal P, Hsu LJ, Heath J et al. Down-regulation of WW domain-containing oxidoreductase induces Tau phosphorylation in vitro. A potential role in Alzheimer's disease. J Biol Chem. 2004;279:30498-30506.
15. Chen ST, Chuang JI, Wang JP, Tsai MS, Li H, Chang NS. Expression of WW domain-containing oxidoreductase WOX1 in the developing murine nervous system. Neuroscience. 2004;124:831-839.
16. Chen ST, Chuang JI, Cheng CL, Hsu LJ, Chang NS. Lightinduced retinal damage involves tyrosine 33 phosphorylation, mitochondrial and nuclear translocation of WW domaincontaining oxidoreductase in vivo. Neuroscience. 2005;130:397-407.
17. Lo CP, Hsu LJ, Li MY, Hsu SY, Chuang JI, Tsai MS et al. MPP+-induced neuronal death in rats involves tyrosine 33 phosphorylation of WW domain-containing oxidoreductase WOX1. Eur J Neurosci. 2008;27:1634-1646.
18. Li MY, Lai FJ, Hsu LJ, Lo CP, Cheng CL, Tsai MS et al. Dramatic co-activation of WOX1 with CREB and NF-κB in delayed loss of small dorsal root ganglion neurons upon sciatic nerve transection in rats. PLoS One. 2009;4:e7820.
19. Suzuki H, Katayama K, Takenaka M, Amakasu K, Saito K, Suzuki K. A spontaneous mutation of the Wwox gene and audiogenic seizures in rats with lethal dwarfism and epilepsy. Genes Brain Behav. 2009;8:650-660.
20. Scrable H, Burns-Cusato M, Medrano S. Anxiety and the aging brain: stressed out over p53? Biochim Biophys Acta. 2009;1790:1587-1591. Review.
21. Feng Z, Hu W, Rajagopal G, Levine AJ. The tumor suppressor p53: cancer and aging. Cell Cycle. 2008;7:842-847. Review.
22. Rodier F, Campisi J, Bhaumik D. Two faces of p53: aging and tumor suppression. Nucleic Acids Res. 2007;35:7475-7484. Review.
23. Holley AK, Dhar SK, St Clair DK. Manganese superoxide dismutase versus p53: the mitochondrial center. Ann N Y Acad Sci. 2010;1201:72-78. Review.
24. Speidel D. Transcription-independent p53 apoptosis: an alternative route to death. Trends Cell Biol. 2010;20:14-24. Review.
25. Sebastian S, Azzariti A, Silvestris N, Porcelli L, Russo A, Paradiso A. p53 as the main traffic controller of the cell signaling network. Front Biosci. 2010;15:1172-1190. Review.
26. Chang NS, Doherty J, Ensign A, Schultz L, Hsu LJ, Hong Q. WOX1 is essential for tumor necrosis factor-, UV lightstaurosporine-, and p53-mediated cell death, and its tyrosine 33-phosphorylated form binds and stabilizes serine 46-phosphorylated p53. J Biol Chem. 2005;280:43100-43108.
27. Hsu LJ, Schultz L, Mattison J, Lin YS, Chang NS. Cloning and characterization of a small-size peptide Zfra that regulates the cytotoxic function of tumor necrosis factor by interacting with JNK1. Biochem Biophys Res Commun. 2005;327:415-423.
28. Hong Q, Hsu LJ, Schultz L, Pratt N, Mattison J, Chang NS. Zfra affects TNFmediated cell death by interacting with death domain protein TRADD and negatively regulates the activation of NFkappaB, JNK1, p53 and WOX1 during stress response. BMC Mol Biol. 2007;8:50.
29. Hsu LJ, Hong Q, Schultz L, Kuo E, Lin SR, Lee MH et al. Zfra is an inhibitor of Bcl-2 expression and cytochrome c release from the mitochondria. Cell Signal. 2008;20:1303-1312.
30. Chung HY, Cesari M, Anton S, Marzetti E, Giovannini S, Seo AY et al. Molecular inflammation: underpinnings of aging and age-related diseases. Ageing Res Rev. 2009;8:18-30. Review
31. Vandenabeele P, Declercq W, Van Herreweghe F, Vanden Berghe T. The role of the kinases RIP1 and RIP3 in TNF-induced necrosis. Sci Signal. 2010;3:re4. Review.
32. Wertz IE and Dixit VM. Regulation of death receptor signaling by the ubiquitin system. Cell Death Differ. 2010;17:14-24. Review.
33. O'Donnell MA, Ting AT. Chronicles of a death foretold: Dual sequential cell death checkpoints in TNF signaling. Cell Cycle. 2010;9:1065-1071.
34. Bianchi K and Meier P. A tangled web of ubiquitin chains: breaking news in TNF-R1 signaling. Mol Cell. 2009;36:736-742. Review.
35. Puca R, Nardinocchi L, Sacchi A, Rechavi G, Givol D, D'Orazi G. HIPK2 modulates p53 activity towards pro-apoptotic transcription. Mol Cancer. 2009;8:85.
36. Kurihara A, Nagoshi H, Yabuki M, Okuyama R, Obinata M, Ikawa S. Ser46 phosphorylation of p53 is not always sufficient to induce apoptosis: multiple mechanisms of regulation of p53-dependent apoptosis. Genes Cells. 2007;12:853-861.
37. Furukawa T, Adachi Y, Fujisawa J, Kambe T, Yamaguchi-Iwai Y, Sasaki R et al. Involvement of PLAGL2 in activation of iron deficient- and hypoxia-induced gene expression in mouse cell lines. Oncogene. 2001;20:4718-4727.
38. Kim YS, Nakanishi G, Lewandoski M, Jetten AM. GLIS3, a novel member of the GLIS subfamily of Krüppel-like zinc finger proteins with repressor and activation functions. Nucleic Acids Res. 2003;31:5513-5525.
39. Huang C, Wang Y, Li D, Li Y, Luo J, Yuan W et al. Inhibition of transcriptional activities of AP-1 and c-Jun by a new zinc finger protein ZNF394. Biochem Biophys Res Commun. 2004;320:1298-1305.
40. Huang G, Shi LZ, Chi H. Regulation of JNK and p38 MAPK in the immune system: signal integration, propagation and termination. Cytokine. 2009;48:161-169. Review.
41. Rolland SG and Conradt B. New role of the BCL2 family of proteins in the regulation of mitochondrial dynamics. Curr Opin Cell Biol. 2010;22:852-858.
42. Soriano ME and Scorrano L. The interplay between BCL-2 family proteins and mitochondrial morphology in the regulation of apoptosis. Adv Exp Med Biol. 2010;687:97-114. Review.
43. Tait SW and Green DR. Mitochondria and cell death: outer membrane permeabilization and beyond. Nat Rev Mol Cell Biol. 2010;11:621-632. Review.
44. Thomadaki H and Scorilas A. BCL2 family of apoptosis-related genes: functions and clinical implications in cancer. Crit Rev Clin Lab Sci. 2006;43:1-67. Review.
45. Ruvolo PP, Deng X, May WS. Phosphorylation of Bcl2 and regulation of apoptosis. Leukemia. 2001;15:515-522. Review.
46. Vier J, Linsinger G, Häcker G. Cytochrome c is dispensable for fas-induced caspase activation and apoptosis. Biochem Biophys Res Commun.1999;261:71-78.
47. Von Ahsen O, Waterhouse NJ, Kuwana T, Newmeyer DD, Green DR. The 'harmless' release of cytochrome c. Cell Death Differ. 2000;7:1192-1199.
48. Bossy-Wetzel E, Newmeyer DD, Green DR. Mitochondrial cytochrome c release in apoptosis occurs upstream of DEVDspecific caspase activation and independently of mitochondrial transmembrane depolarization. EMBO J. 1998;17:37-49.
49. Vilborg A, Wilhelm MT, Wiman KG. Regulation of tumor suppressor p53 at the RNA level. J Mol Med. 2010;88:645-652. Review.
50. Rass U, Ahel I, West SC. Defective DNA repair and neurodegenerative disease. Cell. 2007;130:991-1004. Review.
51. Shulman JM, Chibnik LB, Aubin C, Schneider JA, Bennett DA, De Jager PL. Intermediate phenotypes identify divergent pathways to Alzheimer's disease. PLoS One. 2010;5:e11244.