Systemic lupus erythematosus exhibits a dynamic and continuum spectrum of effector/regulatory T cells

Scandinavian Journal of Rheumatology

Volumn 40, Issue 1, 2011, Pages 41-50

  Mesquita Jr , D ^a   De Melo Cruvinel, W ^a,b   Araujo, J A P ^a   Pucci, F V C ^b   Salmazi, K C ^c   Kallas, E G ^c   Andrade, L E C ^a  

^a FEDERAL UNIVERSITY OF SÃO PAULO   (Brazil)

^b PONTIFÍCIA UNIVERSIDADE CATÓLICA DE GOIÁS   (Brazil)

^c UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

[No Author keywords available]

Indexed keywords

INTERLEUKIN 2 RECEPTOR ALPHA; INTERLEUKIN 7 RECEPTOR; TRANSCRIPTION FACTOR FOXP3; FORKHEAD TRANSCRIPTION FACTOR; FOXP3 PROTEIN, HUMAN; IMMUNOGLOBULIN E RECEPTOR; INTERLEUKIN 7 RECEPTOR ALPHA;

ADULT; ANTIGEN EXPRESSION; ARTICLE; CD25+ T LYMPHOCYTE; CELL ACTIVITY; CONTROLLED STUDY; DISEASE ACTIVITY; DISEASE SEVERITY; EFFECTOR CELL; FEMALE; FLOW CYTOMETRY; HUMAN; MAJOR CLINICAL STUDY; MALE; PERIPHERAL BLOOD MONONUCLEAR CELL; PHENOTYPE; PRIORITY JOURNAL; REGULATORY T LYMPHOCYTE; SYSTEMIC LUPUS ERYTHEMATOSUS; SYSTEMIC LUPUS ERYTHEMATOSUS DISEASE ACTIVITY INDEX; CELL COUNT; HOSPITALIZATION; IMMUNOLOGY; IMMUNOPHENOTYPING; METABOLISM; METHODOLOGY; PATHOLOGY; PATHOPHYSIOLOGY;

ADULT; CELL COUNT; FEMALE; FLOW CYTOMETRY; FORKHEAD TRANSCRIPTION FACTORS; HUMANS; IMMUNOPHENOTYPING; INTERLEUKIN-7 RECEPTOR ALPHA SUBUNIT; LUPUS ERYTHEMATOSUS, SYSTEMIC; MALE; RECEPTORS, IGE; SEVERITY OF ILLNESS INDEX; T-LYMPHOCYTES, REGULATORY;

EID: 79952268314     PISSN: 03009742     EISSN: 15027732     Source Type: Journal    
DOI: 10.3109/03009742.2010.489229     Document Type: Article

References (45)

1. Sakaguchi S, Sakaguchi N, Asano M, Itoh M, Toda M. Immuno-logic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mecha-nism of self-tolerance causes various autoimmune diseases. J Immunol 1995;155:1151-64.
2. Baecher-Allan C, Brown JA, Freeman GJ, Hafler DA. CD4+CD25high regulatory cells in human peripheral blood. J Immunol 2001;167:1245-53. (Pubitemid 32703119)
3. Hori S, Nomura T, Sakaguchi S. Control of regulatory T cell development by the transcription factor Foxp3. Science 2003;299:1057-61. (Pubitemid 36222930)
4. Cao D, van Vollenhoven R, Klareskog L, Trollmo C, Malmstrom V. CD25brightCD4+ regulatory T cells are enriched in inflamed joints of patients with chronic rheumatic disease. Arthritis Res Ther 2004;6:335-46.
5. Liu W, Putnam AL, Xu-Yu Z, Szot GL, Lee MR, Zhu S, et al. CD127 expression inversely correlates with FoxP3 and suppressive function of human CD4+ T reg cells. J Exp Med 2006;203:1701-11. (Pubitemid 44036276)
6. Seddiki N, Santner-Nanan B, Martinson J, Zaunders J, Sasson S, Landay A, et al. Expression of interleukin (IL)-2 and IL-7 recep-tors discriminates between human regulatory and activated T cells. J Exp Med 2006;203:1693-700. (Pubitemid 44036275)
7. Hartigan-O'Connor DJ, Poon C, Sinclair E, McCune JM. Human CD4+ regulatory T cells express lower levels of the IL-7 receptor alpha chain (CD127), allowing consistent identification and sort-ing of live cells. J Immunol Methods 2007;319:41-52. (Pubitemid 46110995)
8. Crispin JC, Martinez A, Alcocer-Varela J. Quantification of regu-latory T cells in patients with systemic lupus erythematosus. J Autoimmun 2003;21:273-6. (Pubitemid 37410115)
9. Liu MF, Wang CR, Fung LL, Wu CR. Decreased CD4+CD25+ T cells in peripheral blood of patients with systemic lupus erythema-tosus. Scand J Immunol 2004;59:198-202.
10. Miyara M, Amoura Z, Parizot C, Badoual C, Dorgham K, Trad S, et al. Global natural regulatory T cell depletion in active systemic lupus erythematosus. J Immunol 2005;175:8392-400. (Pubitemid 41798406)
11. Mellor-Pita S, Citores MJ, Castejon R, Tutor-Ureta P, Yebra-Bango M, Andreu JL, et al. Decrease of regulatory T cells in patients with systemic lupus erythematosus. Ann Rheum Dis 2006;65:553-4.
12. HY, Hong YK, Yun HJ, Kim YM, Kim JR, Yoo WH. Altered frequency and migration capacity of CD4+CD25+ regulatory T cells in systemic lupus erythematosus. Rheumatology (Oxford) 2008;47:789-94.
13. Suarez A, Lopez P, Gomez J, Gutierrez C Enrichment of CD4+ CD25high T cell population in patients with systemic lupus ery-thematosus treated with glucocorticoids. Ann Rheum Dis 2006;65:1512-17. (Pubitemid 44629132)
14. Sanchez B, Castro B, Perez, Baranda L, Espinosa E, Mendoza C, et al. Regulatory T cells in patients with systemic lupus erythema-tosus. J Autoimmun 2006;27:110-18. (Pubitemid 44528260)
15. Tsutsumi Y, Jie X, Ihara K, Nomura A, Kanemitsu S, Takada H, et al. Phenotypic and genetic analyses of T-cell-mediated immunoregula-tion in patients with Type 1 diabetes. Diabet Med 2006;23:1145-50. (Pubitemid 44401147)
16. Valencia X, Yarboro C, Illei G, Lipsky PE. Deficient CD4+CD25high T regulatory cell function in patients with active systemic lupus erythematosus. J Immunol 2007;178:2579-88. (Pubitemid 46233461)
17. Barath S, Aleksza M, Tarr T, Sipka S, Szegedi G, Kiss E. Meas-urement of natural (CD4+CD25high) and inducible (CD4+IL-10+) regulatory T cells in patients with systemic lupus erythema-tosus. Lupus 2007;16:489-96. (Pubitemid 47242522)
18. Lin SC, Chen KH, Lin CH, Kuo CC, Ling QD, Chan CH. The quantitative analysis of peripheral blood FOXP3-expressing T cells in systemic lupus erythematosus and rheumatoid arthritis patients. Eur J Clin Invest 2007;37:987-96.
19. Franz B, Fritzsching B, Riehl A, Oberle N, Klemke CD, Sykora J, et al. Low number of regulatory T cells in skin lesions of patients with cutaneous lupus erythematosus. Arthritis Rheum 2007;56:1910-20. (Pubitemid 47110390)
20. Bonelli M, Savitskaya A, von Dalwigk K, Steiner CW, Aletaha D, Smolen JS, et al. Foxp3 expression in CD4+ T cells of patients with systemic lupus erythematosus: a comparative phenotypic analysis. Ann Rheum Dis 2008;67:664-71. (Pubitemid 351571931)
21. Zhang B, Zhang X, Tang FL, Zhu LP, Liu Y, Lipsky PE. Clinical significance of increased CD4+CD25-Foxp3+ T cells in patients with new-onset systemic lupus erythematosus. Ann Rheum Dis 2008;67:1037-40. (Pubitemid 351956671)
22. Lee HY, Hong YK, Yun HJ, Kim YM, Kim JR, Yoo WH. Altered frequency and migration capacity of CD4+CD25+ regulatory T cells in systemic lupus erythematosus. Rheumatology (Oxford) 2008;47:789-94.
23. Yan B, Ye S, Chen G, Kuang M, Shen N, Chen S. Dysfunctional CD4+,CD25+ regulatory T cells in untreated active systemic lupus erythematosus secondary to interferon-alpha-producing antigen-presenting cells. Arthritis Rheum 2008;58:801-12. (Pubitemid 351364878)
24. Zhang B, Zhang X, Tang F, Zhu L, Liu Y. Reduction of forkhead box P3 levels in CD4+CD25high T cells in patients with new-onset systemic lupus erythematosus. Clin Exp Immunol 2008;153:182-7. (Pubitemid 351989160)
25. Azab NA, Bassyouni IH, Emad Y, Abd El-Wahab GA, Hamdy G, Mashahit MA. CD4+CD25+ regulatory T cells (Treg) in systemic lupus erythematosus (SLE) patients: the possible influence of treatment with corticosteroids. Clin Immunol 2008;127:151-7.
26. Yates J, Whittington A, Mitchell P, Lechler RI, Lightstone L, Lombardi G. Natural regulatory T cells: number and function are normal in the majority of patients with lupus nephritis. Clin Exp Immunol 2008;153:44-55. (Pubitemid 351809334)
27. Suen JL, Li HT, Jong YJ, Chiang BL, Yen JH. Altered homeosta-sis of CD4 FoxP3 regulatory T-cell subpopulations in systemic lupus erythematosus. Immunology 2008;127:196-205.
28. Venigalla RK, Tretter T, Krienke S, Max R, Eckstein V, Blank N, et al. Reduced CD4+,CD25-T cell sensitivity to the suppressive function of CD4+,CD25high,CD127-/low regulatory T cells in patients with active systemic lupus erythematosus. Arthritis Rheum 2008;58:2120-30. (Pubitemid 351988104)
29. Bonelli M, Savitskaya A, von Dalwigk K, Steiner CW, Aletaha D, Smolen JS, et al. Quantitative and qualitative deficiencies of regu-latory T cells in patients with systemic lupus erythematosus (SLE). Int Immunol 2008;20:861-8. (Pubitemid 351876312)
30. Bonelli M, Savitskaya A, Steiner CW, Rath E, Smolen JS, Schei-necker C Phenotypic and functional analysis of CD4+CD25-FoxP3+ T cells in patients with systemic lupus erythematosus. J Immunol 2009;182:1689-95.
31. Barreto M, Ferreira RC, Lourenço L, Moraes-Fontes MF, Santos E, Alves M, et al. Low frequency of CD4+CD25+ Treg in SLE patients: a heritable trait associated with CTLA4 and TGFbeta gene variants. BMC Immunol 2009;10:5.
32. Yang J, Chu Y, Yang X, Gao D, Zhu L, Yang X. Th17 and natural Treg cell population dynamics in systemic lupus erythematosus. Arthritis Rheum 2009;60:1472-83.
33. Tan EM, Cohen AS, Fries JF, Masi AT, McShane DJ, Rothfield NF, et al. The 1982 revised criteria for the classification of sys-temic lupus erythematosus. Arthritis Rheum 1982;25:1271-7. (Pubitemid 13221242)
34. Bombardier C, Gladman DD, Urowitz MB, Caron D, Chang CH. Derivation of the SLEDAI. A disease activity index for lupus patients. The Committee on Prognosis studies in SLE. Arthritis Rheum 1992;35:630-40.
35. Hoffmann P, Boeld TJ, Eder R, Huehn J, Floess S, Wieczorek G, et al. Loss of FOXP3 expression in natural human CD4+CD25+ regulatory T cells upon repetitive in vitro stimulation. Eur J Immunol 2009;39:1088-97.
36. Mandapathil M, Lang S, Gorelik E, Whiteside TL. Isolation of functional human regulatory T cells (Treg) from the peripheral blood based on the CD39 expression. J Immunol Methods 2009;346:55-63.
37. Morgan ME, van Bilsen JH, Bakker AM, Heemskerk B, Schilham MW, Hartgers FC, et al. 2005. Expression of FOXP3 mRNA is not confined to CD4+CD25+ T regulatory cells in humans. Hum Immunol 2005;66:13-20. (Pubitemid 40037706)
38. Wang J, Ioan-Facsinay A, van der Voort EI, Huizinga TW, Toes RE. Transient expression of FOXP3 in human activated nonregu-latory CD4+ T cells. Eur J Immunol 2007;37:129-38. (Pubitemid 46128793)
39. Ziegler SF. FOXP3: not just for regulatory T cells anymore. Eur J Immunol 2007;37:21-3. (Pubitemid 46128782)
40. Walker MR, Kasprowicz DJ, Gersuk VH, Benard A, Van Lan-deghen M, Buckner JH, et al. Induction of FoxP3 and acquisition of T regulatory activity by stimulated human CD4+CD25-T cells. J Clin Invest 2003;112:1437-43. (Pubitemid 38057697)
41. Aandahl EM, Michaelsson J, Moretto WJ, Hecht FM, Nixon DF. Human CD4+ CD25+ regulatory T cells control T-cell responses to human immunodeficiency virus and cytomegalovirus antigens. J Virol 2004;78:2454-9. (Pubitemid 38228938)
42. Sakaguchi S, Ono M, Setoguchi R, Yagi H, Hori S, Fehervari Z, et al. FoxP3+ CD25+ CD4+ natural regulatory T cells in domi-nant self-tolerance and autoimmune disease. Immunol Rev 2006;212:8-27. (Pubitemid 44116697)
43. Zhou X, Bailey-Bucktrout SL, Jeker LT, Penaranda C, Martínez- Llordella M, Ashby M, et al. Instability of the transcription factor FoxP3 leads to the generation of pathogenic memory T cells in vivo. Nat Immunol 2009;10:1000-9.
44. Habib HM, Taher TE, Isenberg DA, Mageed RA. Enhanced propensity of T lymphocytes in patients with systemic lupus erythematosus to apoptosis in the presence of tumour necrosis factor alpha. Scand J Rheumatol 2009;38:112-20.
45. Voo KS, Wang YH, Santori FR, Boggiano C, Wang YH, Arima K, et al. Identification of IL-17-producing FOXP3+ regulatory T cells in humans. Proc Natl Acad Sci USA 2009; 106:4793-8.