-
1
-
-
50649101095
-
Puzzles, promises and a cure for ageing
-
1020 AGING, December 2010, Vol.2 No.1
-
Vijg J and Campisi J. Puzzles, promises and a cure for ageing. Nature. 2008; 454: 1065-1071. www.impactaging.com 1020 AGING, December 2010, Vol.2 No.12
-
(2008)
Nature
, vol.454
, pp. 1065-1071
-
-
Vijg, J.1
Campisi, J.2
-
4
-
-
74949110981
-
Human insulin/IGF-1 and familial longevity at middle age
-
Rozing MP, Westendorp RG, Frolich M, de Craen AJ, Beekman M, Heijmans BT, Mooijaart SP, Blauw GJ, Slagboom PE, van Heemst D. Human insulin/IGF-1 and familial longevity at middle age. Aging. 2009; 1: 714-722.
-
(2009)
Aging
, vol.1
, pp. 714-722
-
-
Rozing, M.P.1
Westendorp, R.G.2
Frolich, M.3
de Craen, A.J.4
Beekman, M.5
Heijmans, B.T.6
Mooijaart, S.P.7
Blauw, G.J.8
Slagboom, P.E.9
van Heemst, D.10
-
5
-
-
0027771804
-
A C. elegans mutant that lives twice as long as wild type
-
Kenyon C, Chang J, Gensch E, Rudner A, Tabtiang R. A C. elegans mutant that lives twice as long as wild type. Nature. 1993; 366: 461-464.
-
(1993)
Nature
, vol.366
, pp. 461-464
-
-
Kenyon, C.1
Chang, J.2
Gensch, E.3
Rudner, A.4
Tabtiang, R.5
-
6
-
-
0347416781
-
Genetic mouse models of extended lifespan
-
Liang H, Masoro EJ, Nelson JF, Strong R, McMahan CA, Richardson A. Genetic mouse models of extended lifespan. Exp Gerontol. 2003; 38: 1353-1364.
-
(2003)
Exp Gerontol
, vol.38
, pp. 1353-1364
-
-
Liang, H.1
Masoro, E.J.2
Nelson, J.F.3
Strong, R.4
McMahan, C.A.5
Richardson, A.6
-
7
-
-
84868615472
-
Growth hormone, insulin and aging: The benefits of endocrine defects
-
In Press
-
Bartke A. Growth hormone, insulin and aging: The benefits of endocrine defects. Exp Gerontol. 2010; In Press.
-
(2010)
Exp Gerontol
-
-
Bartke, A.1
-
8
-
-
0034626747
-
Genetic pathways that regulate ageing in model organisms
-
Guarente L and Kenyon C. Genetic pathways that regulate ageing in model organisms. Nature. 2000; 408: 255-262.
-
(2000)
Nature
, vol.408
, pp. 255-262
-
-
Guarente, L.1
Kenyon, C.2
-
9
-
-
42049117585
-
Nuclear envelope defects cause stem cell dysfunction in premature-aging mice
-
Espada J, Varela I, Flores I, Ugalde AP, Cadinanos J, Pendas AM, Stewart CL, Tryggvason K, Blasco MA, Freije JM, Lopez-Otin C. Nuclear envelope defects cause stem cell dysfunction in premature-aging mice. J Cell Biol. 2008; 181: 27-35.
-
(2008)
J Cell Biol
, vol.181
, pp. 27-35
-
-
Espada, J.1
Varela, I.2
Flores, I.3
Ugalde, A.P.4
Cadinanos, J.5
Pendas, A.M.6
Stewart, C.L.7
Tryggvason, K.8
Blasco, M.A.9
Freije, J.M.10
Lopez-Otin, C.11
-
10
-
-
67949102053
-
Recent progress in the biology and physiology of sirtuins
-
Finkel T, Deng CX, Mostoslavsky R. Recent progress in the biology and physiology of sirtuins. Nature. 2009; 460: 587-591.
-
(2009)
Nature
, vol.460
, pp. 587-591
-
-
Finkel, T.1
Deng, C.X.2
Mostoslavsky, R.3
-
11
-
-
77955747346
-
With TOR, less is more: a key role for the conserved nutrient-sensing TOR pathway in aging
-
Kapahi P, Chen D, Rogers AN, Katewa SD, Li PW, Thomas EL, Kockel L. With TOR, less is more: a key role for the conserved nutrient-sensing TOR pathway in aging. Cell Metab. 2010; 11: 453-465.
-
(2010)
Cell Metab
, vol.11
, pp. 453-465
-
-
Kapahi, P.1
Chen, D.2
Rogers, A.N.3
Katewa, S.D.4
Li, P.W.5
Thomas, E.L.6
Kockel, L.7
-
14
-
-
77950265945
-
Linking functional decline of telomeres, mitochondria and stem cells during ageing
-
Sahin E and Depinho RA. Linking functional decline of telomeres, mitochondria and stem cells during ageing. Nature. 2010; 464: 520-528.
-
(2010)
Nature
, vol.464
, pp. 520-528
-
-
Sahin, E.1
Depinho, R.A.2
-
15
-
-
28044460514
-
Age-related changes of nuclear architecture in Caenorhabditis elegans
-
Haithcock E, Dayani Y, Neufeld E, Zahand AJ, Feinstein N, Mattout A, Gruenbaum Y, Liu J. Age-related changes of nuclear architecture in Caenorhabditis elegans. Proc Natl Acad Sci U S A. 2005; 102: 16690-16695.
-
(2005)
Proc Natl Acad Sci U S A
, vol.102
, pp. 16690-16695
-
-
Haithcock, E.1
Dayani, Y.2
Neufeld, E.3
Zahand, A.J.4
Feinstein, N.5
Mattout, A.6
Gruenbaum, Y.7
Liu, J.8
-
17
-
-
77953625822
-
The central role of chromatin maintenance in aging
-
Pegoraro G and Misteli T. The central role of chromatin maintenance in aging. Aging. 2009; 1: 1017-1022.
-
(2009)
Aging
, vol.1
, pp. 1017-1022
-
-
Pegoraro, G.1
Misteli, T.2
-
18
-
-
33846484332
-
Human progeroid syndromes, aging and cancer: new genetic and epigenetic insights into old questions
-
Ramirez CL, Cadinanos J, Varela I, Freije JM, Lopez-Otin C. Human progeroid syndromes, aging and cancer: new genetic and epigenetic insights into old questions. Cell Mol Life Sci. 2007; 64: 155-170.
-
(2007)
Cell Mol Life Sci
, vol.64
, pp. 155-170
-
-
Ramirez, C.L.1
Cadinanos, J.2
Varela, I.3
Freije, J.M.4
Lopez-Otin, C.5
-
19
-
-
69949144385
-
Genomic instability and DNA damage responses in progeria arising from defective maturation of prelamin A
-
Musich PR and Zou Y. Genomic instability and DNA damage responses in progeria arising from defective maturation of prelamin A. Aging. 2009; 1: 28-37.
-
(2009)
Aging
, vol.1
, pp. 28-37
-
-
Musich, P.R.1
Zou, Y.2
-
20
-
-
77954950116
-
Progeria syndromes and ageing: what is the connection?
-
Burtner CR and Kennedy BK. Progeria syndromes and ageing: what is the connection? Nat Rev Mol Cell Biol. 2010; 11: 567-578.
-
(2010)
Nat Rev Mol Cell Biol
, vol.11
, pp. 567-578
-
-
Burtner, C.R.1
Kennedy, B.K.2
-
21
-
-
78249271058
-
Nuclear envelope alterations generate an aging-like epigenetic pattern in mice deficient in Zmpste24 metalloprotease
-
Osorio FG, Varela I, Lara E, Puente XS, Espada J, Santoro R, Freije JM, Fraga MF, Lopez-Otin C. Nuclear envelope alterations generate an aging-like epigenetic pattern in mice deficient in Zmpste24 metalloprotease. Aging Cell. 2010; 9: 947-957.
-
(2010)
Aging Cell
, vol.9
, pp. 947-957
-
-
Osorio, F.G.1
Varela, I.2
Lara, E.3
Puente, X.S.4
Espada, J.5
Santoro, R.6
Freije, J.M.7
Fraga, M.F.8
Lopez-Otin, C.9
-
22
-
-
33845269544
-
Hutchinson-Gilford progeria syndrome: review of the phenotype
-
Hennekam RC. Hutchinson-Gilford progeria syndrome: review of the phenotype. Am J Med Genet A. 2006; 140: 2603-2624.
-
(2006)
Am J Med Genet A
, vol.140
, pp. 2603-2624
-
-
Hennekam, R.C.1
-
23
-
-
45449092970
-
HGPS and related premature aging disorders: from genomic identification to the first therapeutic approaches
-
Pereira S, Bourgeois P, Navarro C, Esteves-Vieira V, Cau P, De Sandre-Giovannoli A, Levy N. HGPS and related premature aging disorders: from genomic identification to the first therapeutic approaches. Mech Ageing Dev. 2008; 129: 449-459.
-
(2008)
Mech Ageing Dev
, vol.129
, pp. 449-459
-
-
Pereira, S.1
Bourgeois, P.2
Navarro, C.3
Esteves-Vieira, V.4
Cau, P.5
De Sandre-Giovannoli, A.6
Levy, N.7
-
24
-
-
0033615969
-
Loss of A-type lamin expression compromises nuclear envelope integrity leading to muscular dystrophy
-
Sullivan T, Escalante-Alcalde D, Bhatt H, Anver M, Bhat N, Nagashima K, Stewart CL, Burke B. Loss of A-type lamin expression compromises nuclear envelope integrity leading to muscular dystrophy. J Cell Biol. 1999; 147: 913-920.
-
(1999)
J Cell Biol
, vol.147
, pp. 913-920
-
-
Sullivan, T.1
Escalante-Alcalde, D.2
Bhatt, H.3
Anver, M.4
Bhat, N.5
Nagashima, K.6
Stewart, C.L.7
Burke, B.8
-
25
-
-
0036578920
-
Defective prelamin A processing and muscular and adipocyte alterations in Zmpste24 metalloproteinase-deficient mice
-
Pendas AM, Zhou Z, Cadinanos J, Freije JM, Wang J, Hultenby K, Astudillo A, Wernerson A, Rodriguez F, Tryggvason K, Lopez-Otin C. Defective prelamin A processing and muscular and adipocyte alterations in Zmpste24 metalloproteinase-deficient mice. Nat Genet. 2002; 31: 94-99.
-
(2002)
Nat Genet
, vol.31
, pp. 94-99
-
-
Pendas, A.M.1
Zhou, Z.2
Cadinanos, J.3
Freije, J.M.4
Wang, J.5
Hultenby, K.6
Astudillo, A.7
Wernerson, A.8
Rodriguez, F.9
Tryggvason, K.10
Lopez-Otin, C.11
-
26
-
-
25644440744
-
Accelerated ageing in mice deficient in Zmpste24 protease is linked to p53 signalling activation
-
Varela I, Cadinanos J, Pendas AM, Gutierrez-Fernandez A, Folgueras AR, Sanchez LM, Zhou Z, Rodriguez FJ, Stewart CL, Vega JA, Tryggvason K, Freije JM, Lopez-Otin C. Accelerated ageing in mice deficient in Zmpste24 protease is linked to p53 signalling activation. Nature. 2005; 437: 564-568.
-
(2005)
Nature
, vol.437
, pp. 564-568
-
-
Varela, I.1
Cadinanos, J.2
Pendas, A.M.3
Gutierrez-Fernandez, A.4
Folgueras, A.R.5
Sanchez, L.M.6
Zhou, Z.7
Rodriguez, F.J.8
Stewart, C.L.9
Vega, J.A.10
Tryggvason, K.11
Freije, J.M.12
Lopez-Otin, C.13
-
27
-
-
77957981121
-
Insulin-like growth factor 1 treatment extends longevity in a mouse model of human premature aging by restoring somatotroph axis function
-
Marino G, Ugalde AP, Fernandez AF, Osorio FG, Fueyo A, Freije JM, Lopez-Otin C. Insulin-like growth factor 1 treatment extends longevity in a mouse model of human premature aging by restoring somatotroph axis function. Proc Natl Acad Sci U S A. 2010; 107: 16268-16273.
-
(2010)
Proc Natl Acad Sci U S A
, vol.107
, pp. 16268-16273
-
-
Marino, G.1
Ugalde, A.P.2
Fernandez, A.F.3
Osorio, F.G.4
Fueyo, A.5
Freije, J.M.6
Lopez-Otin, C.7
-
28
-
-
0030756139
-
Response to nutritional and growth hormone treatment in progeria
-
Abdenur JE, Brown WT, Friedman S, Smith M, Lifshitz F. Response to nutritional and growth hormone treatment in progeria. Metabolism. 1997; 46: 851-856.
-
(1997)
Metabolism
, vol.46
, pp. 851-856
-
-
Abdenur, J.E.1
Brown, W.T.2
Friedman, S.3
Smith, M.4
Lifshitz, F.5
-
29
-
-
73449086958
-
Reciprocal regulation of microRNA-1 and insulin-like growth factor-1 signal transduction cascade in cardiac and skeletal muscle in physiological and pathological conditions
-
Elia L, Contu R, Quintavalle M, Varrone F, Chimenti C, Russo MA, Cimino V, De Marinis L, Frustaci A, Catalucci D, Condorelli G. Reciprocal regulation of microRNA-1 and insulin-like growth factor-1 signal transduction cascade in cardiac and skeletal muscle in physiological and pathological conditions. Circulation. 2009; 120: 2377-2385.
-
(2009)
Circulation
, vol.120
, pp. 2377-2385
-
-
Elia, L.1
Contu, R.2
Quintavalle, M.3
Varrone, F.4
Chimenti, C.5
Russo, M.A.6
Cimino, V.7
De Marinis, L.8
Frustaci, A.9
Catalucci, D.10
Condorelli, G.11
-
30
-
-
46249086799
-
Premature aging in mice activates a systemic metabolic response involving autophagy induction
-
Marino G, Ugalde AP, Salvador-Montoliu N, Varela I, Quiros PM, Cadinanos J, van der Pluijm I, Freije JM, Lopez-Otin C. Premature aging in mice activates a systemic metabolic response involving autophagy induction. Hum Mol Genet. 2008; 17: 2196-2211.
-
(2008)
Hum Mol Genet
, vol.17
, pp. 2196-2211
-
-
Marino, G.1
Ugalde, A.P.2
Salvador-Montoliu, N.3
Varela, I.4
Quiros, P.M.5
Cadinanos, J.6
van der Pluijm, I.7
Freije, J.M.8
Lopez-Otin, C.9
-
31
-
-
70349859881
-
DNA damage, aging, and cancer
-
Hoeijmakers JH. DNA damage, aging, and cancer. N Engl J Med. 2009; 361: 1475-1485.
-
(2009)
N Engl J Med
, vol.361
, pp. 1475-1485
-
-
Hoeijmakers, J.H.1
-
32
-
-
33845914051
-
A new progeroid syndrome reveals that genotoxic stress suppresses the somatotroph axis
-
Niedernhofer LJ, Garinis GA, Raams A, Lalai AS, Robinson AR, Appeldoorn E, Odijk H, Oostendorp R, Ahmad A, van Leeuwen W, Theil AF, Vermeulen W, van der Horst GT, Meinecke P, Kleijer WJ, Vijg J, Jaspers NG, Hoeijmakers JH. A new progeroid syndrome reveals that genotoxic stress suppresses the somatotroph axis. Nature. 2006; 444: 1038-1043.
-
(2006)
Nature
, vol.444
, pp. 1038-1043
-
-
Niedernhofer, L.J.1
Garinis, G.A.2
Raams, A.3
Lalai, A.S.4
Robinson, A.R.5
Appeldoorn, E.6
Odijk, H.7
Oostendorp, R.8
Ahmad, A.9
van Leeuwen, W.10
Theil, A.F.11
Vermeulen, W.12
van der Horst, G.T.13
Meinecke, P.14
Kleijer, W.J.15
Vijg, J.16
Jaspers, N.G.17
Hoeijmakers, J.H.18
-
33
-
-
33846030099
-
Impaired genome maintenance suppresses the growth hormone-insulinlike growth factor 1 axis in mice with Cockayne syndrome
-
van der Pluijm I, Garinis GA, Brandt RM, Gorgels TG, Wijnhoven SW, Diderich KE, de Wit J, Mitchell JR, van Oostrom C, Beems R, Niedernhofer LJ, Velasco S, Friedberg EC, Tanaka K, van Steeg H, Hoeijmakers JH, van der Horst GT. Impaired genome maintenance suppresses the growth hormone-insulinlike growth factor 1 axis in mice with Cockayne syndrome. PLoS Biol. 2007; 5: e2.
-
(2007)
PLoS Biol
, vol.5
-
-
van der Pluijm, I.1
Garinis, G.A.2
Brandt, R.M.3
Gorgels, T.G.4
Wijnhoven, S.W.5
Diderich, K.E.6
de Wit, J.7
Mitchell, J.R.8
van Oostrom, C.9
Beems, R.10
Niedernhofer, L.J.11
Velasco, S.12
Friedberg, E.C.13
Tanaka, K.14
van Steeg, H.15
Hoeijmakers, J.H.16
van der Horst, G.T.17
-
34
-
-
67349287384
-
-
Persistent transcription-blocking DNA lesions trigger somatic, 1021 AGING, December 2010, Vol.2 No.12 growth attenuation associated with longevity
-
Garinis GA, Uittenboogaard LM, Stachelscheid H, Fousteri M, van Ijcken W, Breit TM, van Steeg H, Mullenders LH, van der Horst GT, Bruning JC, Niessen CM, Hoeijmakers JH, Schumacher B. Persistent transcription-blocking DNA lesions trigger somatic www.impactaging.com 1021 AGING, December 2010, Vol.2 No.12 growth attenuation associated with longevity. Nat Cell Biol. 2009; 11: 604-615.
-
(2009)
Nat Cell Biol
, vol.11
, pp. 604-615
-
-
Garinis, G.A.1
Uittenboogaard, L.M.2
Stachelscheid, H.3
Fousteri, M.4
van Ijcken, W.5
Breit, T.M.6
van Steeg, H.7
Mullenders, L.H.8
van der Horst, G.T.9
Bruning, J.C.10
Niessen, C.M.11
Hoeijmakers, J.H.12
Schumacher, B.13
-
35
-
-
1542466784
-
Inhibition of growth hormone action improves insulin sensitivity in liver IGF-1- deficient mice
-
Yakar S, Setser J, Zhao H, Stannard B, Haluzik M, Glatt V, Bouxsein ML, Kopchick JJ, LeRoith D. Inhibition of growth hormone action improves insulin sensitivity in liver IGF-1- deficient mice. J Clin Invest. 2004; 113: 96-105.
-
(2004)
J Clin Invest
, vol.113
, pp. 96-105
-
-
Yakar, S.1
Setser, J.2
Zhao, H.3
Stannard, B.4
Haluzik, M.5
Glatt, V.6
Bouxsein, M.L.7
Kopchick, J.J.8
LeRoith, D.9
-
36
-
-
0027178438
-
Effects of long-term elevated serum levels of growth hormone on life expectancy of mice: lessons from transgenic animal models
-
Wolf E, Kahnt E, Ehrlein J, Hermanns W, Brem G, Wanke R. Effects of long-term elevated serum levels of growth hormone on life expectancy of mice: lessons from transgenic animal models. Mech Ageing Dev. 1993; 68: 71-87.
-
(1993)
Mech Ageing Dev
, vol.68
, pp. 71-87
-
-
Wolf, E.1
Kahnt, E.2
Ehrlein, J.3
Hermanns, W.4
Brem, G.5
Wanke, R.6
-
37
-
-
34848845313
-
Modifying IGF1 activity: an approach to treat endocrine disorders, atherosclerosis and cancer
-
Clemmons DR. Modifying IGF1 activity: an approach to treat endocrine disorders, atherosclerosis and cancer. Nat Rev Drug Discov. 2007; 6: 821-833.
-
(2007)
Nat Rev Drug Discov
, vol.6
, pp. 821-833
-
-
Clemmons, D.R.1
-
38
-
-
46849106102
-
Combined treatment with statins and aminobisphosphonates extends longevity in a mouse model of human premature aging
-
Varela I, Pereira S, Ugalde AP, Navarro CL, Suarez MF, Cau P, Cadinanos J, Osorio FG, Foray N, Cobo J, de Carlos F, Levy N, Freije JM, Lopez-Otin C. Combined treatment with statins and aminobisphosphonates extends longevity in a mouse model of human premature aging. Nat Med. 2008; 14: 767-772.
-
(2008)
Nat Med
, vol.14
, pp. 767-772
-
-
Varela, I.1
Pereira, S.2
Ugalde, A.P.3
Navarro, C.L.4
Suarez, M.F.5
Cau, P.6
Cadinanos, J.7
Osorio, F.G.8
Foray, N.9
Cobo, J.10
de Carlos, F.11
Levy, N.12
Freije, J.M.13
Lopez-Otin, C.14
|