메뉴 건너뛰기




Volumn 79, Issue SUPPL. 120, 2011, Pages

SGLT2 inhibitors: Molecular design and potential differences in effect

Author keywords

dapagliflozin; diabetes; glucosuria; insulin resistance; phlorizin; SGLT2

Indexed keywords

3 (5 BENZOFURANYL) 1 [2 HYDROXY 6 [6 O (METHOXYCARBONYL) BETA DEXTRO GLUCOPYRANOSYL] 4 METHYLPHENYL] 1 PROPANONE; 4' DEHYDROXYPHLORIZIN DERIVATIVE; ANTIDIABETIC AGENT; ASP 1941; AVE 2268; BI 10773; BI 44847; BI 448747; CANAGLIFLOZIN; DAPAGLIFLOZIN; LX 4211; PHLORIZIN; R 7201; REMOGLIFLOZIN ETABONATE; SERGLIFLOZIN; SODIUM GLUCOSE COTRANSPORTER 2 INHIBITOR; TS 033; TS 071; UNCLASSIFIED DRUG; WAY 123783; YM 543;

EID: 79952229724     PISSN: 00852538     EISSN: 15231755     Source Type: Journal    
DOI: 10.1038/ki.2010.511     Document Type: Review
Times cited : (52)

References (52)
  • 1
    • 45749084498 scopus 로고    scopus 로고
    • The changing shape of type 2 diabetes
    • Medscape
    • Brunton SA. The changing shape of type 2 diabetes. Medscape J Med 2008; 10: 143.
    • (2008) J Med , vol.10 , pp. 143
    • Brunton, S.A.1
  • 2
    • 43249090768 scopus 로고    scopus 로고
    • Prevention and treatment of type 2 diabetes: Current role of lifestyle, natural product, and pharmacological interventions
    • Hays NP, Galassetti PR, Coker RH. Prevention and treatment of type 2 diabetes: current role of lifestyle, natural product, and pharmacological interventions. Pharmacol Ther 2008; 118: 181-191.
    • (2008) Pharmacol Ther , vol.118 , pp. 181-191
    • Hays, N.P.1    Galassetti, P.R.2    Coker, R.H.3
  • 3
    • 33745780301 scopus 로고    scopus 로고
    • Management of hyperglycaemia in type 2 diabetes: A consensus algorithm for the initiation and adjustment of therapy - A consensus statement from the American Diabetes Association and the European Association for the Study of Diabetes
    • DOI 10.1007/s00125-006-0316-2
    • Nathan DM, Buse JB, Davidson MB et al. Management of hyperglycaemia in type 2 diabetes: a consensus algorithm for the initiation and adjustment of therapy. A consensus statement from the American Diabetes Association and the European Association for the Study of Diabetes. Diabetologia 2006; 49: 1711-1721. (Pubitemid 44025023)
    • (2006) Diabetologia , vol.49 , Issue.8 , pp. 1711-1721
    • Nathan, D.M.1    Buse, J.B.2    Davidson, M.B.3    Heine, R.J.4    Holman, R.R.5    Sherwin, R.6    Zinman, B.7
  • 4
    • 66649100887 scopus 로고    scopus 로고
    • Glycemic control in type 2 diabetes: Time for an evidence-based about-face?
    • Montori VM, Fernandez-Balsells M. Glycemic control in type 2 diabetes: time for an evidence-based about-face? Ann Intern Med 2009; 150: 803-808.
    • (2009) Ann Intern Med , vol.150 , pp. 803-808
    • Montori, V.M.1    Fernandez-Balsells, M.2
  • 5
    • 64749089393 scopus 로고    scopus 로고
    • Inhibition of renal glucose reabsorption: A novel strategy for achieving glucose control in type 2 diabetes mellitus
    • Abdul-Ghani MA, DeFronzo RA. Inhibition of renal glucose reabsorption: a novel strategy for achieving glucose control in type 2 diabetes mellitus. Endocr Pract 2008; 14: 782-790.
    • (2008) Endocr Pract , vol.14 , pp. 782-790
    • Abdul-Ghani, M.A.1    Defronzo, R.A.2
  • 6
    • 10444256208 scopus 로고    scopus 로고
    • +-glucose cotransporters: SLC5
    • Wright EM, Loo DD, Hirayama BA et al. Surprising versatility of Na+-glucose cotransporters: SLC5. Physiology (Bethesda) 2004; 19: 370-376. (Pubitemid 39636085)
    • (2004) Physiology , Issue.6 , pp. 370-376
    • Wright, E.M.1    Loo, D.D.F.2    Hirayama, B.A.3    Turk, E.4
  • 7
    • 64749099761 scopus 로고    scopus 로고
    • Glucose control by the kidney: An emerging target in diabetes
    • Marsenic O. Glucose control by the kidney: an emerging target in diabetes. Am J Kidney Dis 2009; 53: 875-883.
    • (2009) Am J Kidney Dis , vol.53 , pp. 875-883
    • Marsenic, O.1
  • 8
    • 0028044629 scopus 로고
    • The human kidney low affinity Na+/glucose cotransporter SGLT2. Delineation of the major renal reabsorptive mechanism for D-glucose
    • Kanai Y, Lee WS, You G et al. The human kidney low affinity Na+/glucose cotransporter SGLT2. Delineation of the major renal reabsorptive mechanism for D-glucose. J Clin Invest 1994; 93: 397-404.
    • (1994) J Clin Invest , vol.93 , pp. 397-404
    • Kanai, Y.1    Lee, W.S.2    You, G.3
  • 9
    • 34147155657 scopus 로고    scopus 로고
    • Sodium-glucose cotransporter inhibitors for diabetes
    • Isaji M. Sodium-glucose cotransporter inhibitors for diabetes. Curr Opin Investig Drugs 2007; 8: 285-292. (Pubitemid 46557988)
    • (2007) Current Opinion in Investigational Drugs , vol.8 , Issue.4 , pp. 285-292
    • Isaji, M.1
  • 12
    • 0036937335 scopus 로고    scopus 로고
    • Autosomal recessive renal glucosuria attributable to a mutation in the sodium glucose cotransporter (SGLT2)
    • DOI 10.1007/s00439-002-0820-5
    • van den Heuvel LP, Assink K, Willemsen M et al. Autosomal recessive renal glucosuria attributable to a mutation in the sodium glucose cotransporter (SGLT2). Hum Genet 2002; 111: 544-547. (Pubitemid 36075086)
    • (2002) Human Genetics , vol.111 , Issue.6 , pp. 544-547
    • Van Den Heuvel, L.P.1    Assink, K.2    Willemsen, M.3    Monnens, L.4
  • 13
    • 47149118686 scopus 로고    scopus 로고
    • Sodium glucose co-transporter 2 inhibitors: Blocking renal tubular reabsorption of glucose to improve glycaemic control in patients with diabetes
    • DOI 10.1111/j.1742-1241.2008.01829.x
    • Jabbour SA, Goldstein BJ. Sodium glucose co-transporter 2 inhibitors: blocking renal tubular reabsorption of glucose to improve glycaemic control in patients with diabetes. Int J Clin Pract 2008; 62: 1279-1284. (Pubitemid 351977622)
    • (2008) International Journal of Clinical Practice , vol.62 , Issue.8 , pp. 1279-1284
    • Jabbour, S.A.1    Goldstein, B.J.2
  • 14
    • 67449084943 scopus 로고    scopus 로고
    • Dapagliflozin: An emerging treatment option in type 2 diabetes
    • Kipnes M. Dapagliflozin: an emerging treatment option in type 2 diabetes. Expert Opin Investig Drugs 2009; 18: 327-334.
    • (2009) Expert Opin Investig Drugs , vol.18 , pp. 327-334
    • Kipnes, M.1
  • 15
    • 27944488002 scopus 로고    scopus 로고
    • Sodium glucose co-transporter 2 (SGLT2) inhibitors as potential antidiabetic agents
    • DOI 10.1517/13543776.15.11.1531
    • Handlon AL. Sodium glucose co-transporter 2 (SGLT2) inhibitors as potential antidiabetic agents. Expert Opin Ther Pat 2005; 15: 1531-1540. (Pubitemid 41671615)
    • (2005) Expert Opinion on Therapeutic Patents , vol.15 , Issue.11 , pp. 1531-1540
    • Handlon, A.L.1
  • 18
    • 33845873376 scopus 로고    scopus 로고
    • Sergliflozin, a novel selective inhibitor of low-affinity sodium glucose cotransporter (SGLT2), validates the critical role of SGLT2 in renal glucose reabsorption and modulates plasma glucose level
    • DOI 10.1124/jpet.106.110296
    • Katsuno K, Fujimori Y, Takemura Y et al. Sergliflozin, a novel selective inhibitor of low-affinity sodium glucose cotransporter (SGLT2), validates the critical role of SGLT2 in renal glucose reabsorption and modulates plasma glucose level. J Pharmacol Exp Ther 2007; 320: 323-330. (Pubitemid 46025747)
    • (2007) Journal of Pharmacology and Experimental Therapeutics , vol.320 , Issue.1 , pp. 323-330
    • Katsuno, K.1    Fujimori, Y.2    Takemura, Y.3    Hiratochi, M.4    Itoh, F.5    Komatsu, Y.6    Fujikura, H.7    Isaji, M.8
  • 19
    • 52649083832 scopus 로고    scopus 로고
    • Remogliflozin etabonate, in a novel category of selective low-affinity sodium glucose cotransporter (SGLT2) inhibitors, exhibits antidiabetic efficacy in rodent models
    • Fujimori Y, Katsuno K, Nakashima I et al. Remogliflozin etabonate, in a novel category of selective low-affinity sodium glucose cotransporter (SGLT2) inhibitors, exhibits antidiabetic efficacy in rodent models. J Pharmacol Exp Ther 2008; 327: 268-276.
    • (2008) J Pharmacol Exp Ther , vol.327 , pp. 268-276
    • Fujimori, Y.1    Katsuno, K.2    Nakashima, I.3
  • 21
    • 0034716014 scopus 로고    scopus 로고
    • A method for preparing C-glycosides related to phlorizin
    • Link JT, Sorensen BK. A method for preparing C-glycosides related to phlorizin. Tetrahedron Lett 2000; 41: 9213-9217.
    • (2000) Tetrahedron Lett , vol.41 , pp. 9213-9217
    • Link, J.T.1    Sorensen, B.K.2
  • 23
    • 0023275573 scopus 로고
    • Correction of hyperglycemia with phlorizin normalizes tissues sensitivity to insulin in diabetic rats
    • Rossetti L, Smith D, Shulman GI et al. Correction of hyperglycemia with phlorizin normalizes tissue sensitivity to insulin in diabetic rats. J Clin Invest 1987; 79: 1510-1515. (Pubitemid 17099657)
    • (1987) Journal of Clinical Investigation , vol.79 , Issue.5 , pp. 1510-1515
    • Rossetti, L.1    Smith, D.2    Shulman, G.I.3
  • 29
    • 33750585132 scopus 로고    scopus 로고
    • Glucose toxicity is responsible for the development of impaired regulation of endogenous glucose production and hepatic glucokinase in zucker diabetic fatty rats
    • DOI 10.2337/db05-1511
    • Fujimoto Y, Torres TP, Donahue EP et al. Glucose toxicity is responsible for the development of impaired regulation of endogenous glucose production and hepatic glucokinase in Zucker diabetic fatty rats. Diabetes 2006; 55: 2479-2490. (Pubitemid 44871148)
    • (2006) Diabetes , vol.55 , Issue.9 , pp. 2479-2490
    • Fujimoto, Y.1    Torres, T.P.2    Donahue, E.P.3    Shiota, M.4
  • 32
    • 15544383811 scopus 로고    scopus 로고
    • +-glucose cotransporter inhibitor T-1095 causes sustained improvement in hyperglycemia and prevents diabetic neuropathy in Goto-Kakizaki Rats
    • DOI 10.1016/j.lfs.2004.09.038
    • Ueta K, Ishihara T, Matsumoto Y et al. Long-term treatment with the Na+-glucose cotransporter inhibitor T-1095 causes sustained improvement in hyperglycemia and prevents diabetic neuropathy in Goto-Kakizaki Rats. Life Sci 2005; 76: 2655-2668. (Pubitemid 40404055)
    • (2005) Life Sciences , vol.76 , Issue.23 , pp. 2655-2668
    • Ueta, K.1    Ishihara, T.2    Matsumoto, Y.3    Oku, A.4    Nawano, M.5    Fujita, T.6    Saito, A.7    Arakawa, K.8
  • 33
    • 40149101914 scopus 로고    scopus 로고
    • Acarbose: Oral antidiabetes drug with additional cardiovascular benefits
    • DOI 10.1586/14779072.6.2.153
    • Hanefeld M, Schaper F. Acarbose: oral anti-diabetes drug with additional cardiovascular benefits. Expert Rev Cardiovasc Ther 2008; 6: 153-163. (Pubitemid 351372584)
    • (2008) Expert Review of Cardiovascular Therapy , vol.6 , Issue.2 , pp. 153-163
    • Hanefeld, M.1    Schaper, F.2
  • 34
    • 0029060727 scopus 로고
    • The effects of streptozotocin diabetes on sodium-glucose transporter (SGLT1) expression and function in rat jejunal and ileal villus-attached enterocytes
    • Debnam ES, Smith MW, Sharp PA et al. The effects of streptozotocin diabetes on sodium-glucose transporter (SGLT1) expression and function in rat jejunal and ileal villus-attached enterocytes. Pflugers Arch 1995; 430: 151-159.
    • (1995) Pflugers Arch , vol.430 , pp. 151-159
    • Debnam, E.S.1    Smith, M.W.2    Sharp, P.A.3
  • 35
    • 0025891622 scopus 로고
    • +/glucose cotransporter
    • Turk E, Zabel B, Mundlos S et al. Glucose/galactose malabsorption caused by a defect in the Na+/glucose cotransporter. Nature 1991; 350: 354-356. (Pubitemid 21912230)
    • (1991) Nature , vol.350 , Issue.6316 , pp. 354-356
    • Turk, E.1    Zabel, B.2    Mundlos, S.3    Dyer, J.4    Wright, E.M.5
  • 37
    • 0029793541 scopus 로고    scopus 로고
    • New potent antihyperglycemic agents in db/db mice: Synthesis and structure-activity relationship studies of (4-substituted benzyl) (trifluoromethyl)pyrazoles and -pyrazolones
    • DOI 10.1021/jm960444z
    • Kees KL, Fitzgerald Jr JJ, Steiner KE et al. New potent antihyperglycemic agents in db/db mice: synthesis and structure-activity relationship studies of (4-substituted benzyl) (trifluoromethyl)pyrazoles and-pyrazolones. J Med Chem 1996; 39: 3920-3928. (Pubitemid 26327429)
    • (1996) Journal of Medicinal Chemistry , vol.39 , Issue.20 , pp. 3920-3928
    • Kees, K.L.1    Fitzgerald Jr., J.J.2    Steiner, K.E.3    Mattes, J.F.4    Mihan, B.5    Tosi, T.6    Mondoro, D.7    McCaleb, M.L.8
  • 39
    • 64549093267 scopus 로고    scopus 로고
    • Sergliflozin etabonate, a selective SGLT2 inhibitor, improves glycemic control in streptozotocin-induced diabetic rats and Zucker fatty rats
    • Fujimori Y, Katsuno K, Ojima K et al. Sergliflozin etabonate, a selective SGLT2 inhibitor, improves glycemic control in streptozotocin-induced diabetic rats and Zucker fatty rats. Eur J Pharmacol 2009; 609: 148-154.
    • (2009) Eur J Pharmacol , vol.609 , pp. 148-154
    • Fujimori, Y.1    Katsuno, K.2    Ojima, K.3
  • 40
    • 77149180212 scopus 로고    scopus 로고
    • A double-blind randomized repeat dose to assess the safety, tolerability, pharmacokinetics and pharmacodynamics of three times daily dosing of sergliflozin, a novel inhibitor of renal glucose reabsorption, in healthy overweight and obese subjects [0491-P]
    • Hussey EK, Dobbins RI, Stolz RR et al. A double-blind randomized repeat dose to assess the safety, tolerability, pharmacokinetics and pharmacodynamics of three times daily dosing of sergliflozin, a novel inhibitor of renal glucose reabsorption, in healthy overweight and obese subjects [0491-P]. Diabetes 2007; 56: A491.
    • (2007) Diabetes , vol.56
    • Hussey, E.K.1    Dobbins, R.I.2    Stolz, R.R.3
  • 42
    • 79952207332 scopus 로고    scopus 로고
    • First human dose-escalation study with remogliflozin etabonate (RE) in healthy subjects and in subjects with type 2 diabetes mellitus (T2DM) [509-P]
    • Kapur A, O'Connor-Semmes R, Hussey E et al. First human dose-escalation study with remogliflozin etabonate (RE) in healthy subjects and in subjects with type 2 diabetes mellitus (T2DM) [509-P]. Diabetes 2009; 58: A136.
    • (2009) Diabetes , vol.58
    • Kapur, A.1    O'Connor-Semmes, R.2    Hussey, E.3
  • 43
    • 67349275999 scopus 로고    scopus 로고
    • Dapagliflozin, a novel, selective SGLT2 inhibitor, improved glycemic control over 2 weeks in patients with type 2 diabetes mellitus
    • Komoroski B, Vachharajani N, Feng Y et al. Dapagliflozin, a novel, selective SGLT2 inhibitor, improved glycemic control over 2 weeks in patients with type 2 diabetes mellitus. Clin Pharmacol Ther 2009; 85: 513-519.
    • (2009) Clin Pharmacol Ther , vol.85 , pp. 513-519
    • Komoroski, B.1    Vachharajani, N.2    Feng, Y.3
  • 44
    • 85206955954 scopus 로고    scopus 로고
    • Remogliflozin etabonate, a selective inhibitor of the sodium-glucose transporter 2 (SGLT2) reduces serum glucose in type 2 diabetes mellitus (T2DM) patients [573-P]
    • Dobbins R, Kapur A, Kapitza C et al. Remogliflozin etabonate, a selective inhibitor of the sodium-glucose transporter 2 (SGLT2) reduces serum glucose in type 2 diabetes mellitus (T2DM) patients [573-P]. Diabetes 2009; 58: A154.
    • (2009) Diabetes , vol.58
    • Dobbins, R.1    Kapur, A.2    Kapitza, C.3
  • 45
    • 48249146624 scopus 로고    scopus 로고
    • Dapagliflozin, a selective SGLT2 inhibitor, improves glucose homeostasis in normal and diabetic rats
    • Han S, Hagan DL, Taylor JR et al. Dapagliflozin, a selective SGLT2 inhibitor, improves glucose homeostasis in normal and diabetic rats. Diabetes 2008; 57: 1723-1729.
    • (2008) Diabetes , vol.57 , pp. 1723-1729
    • Han, S.1    Hagan, D.L.2    Taylor, J.R.3
  • 46
    • 65349196064 scopus 로고    scopus 로고
    • Sodium-glucose cotransport inhibition with dapagliflozin in type 2 diabetes
    • List JF, Woo V, Morales E et al. Sodium-glucose cotransport inhibition with dapagliflozin in type 2 diabetes. Diabetes Care 2009; 32: 650-657.
    • (2009) Diabetes Care , vol.32 , pp. 650-657
    • List, J.F.1    Woo, V.2    Morales, E.3
  • 47
    • 67649359913 scopus 로고    scopus 로고
    • From victim to ally: The kidney as an emerging target for the treatment of diabetes mellitus
    • Bays H. From victim to ally: the kidney as an emerging target for the treatment of diabetes mellitus. Curr Med Res Opin 2009; 25: 671-681.
    • (2009) Curr Med Res Opin , vol.25 , pp. 671-681
    • Bays, H.1
  • 48
    • 57649135211 scopus 로고    scopus 로고
    • Effects of AVE2268, a substituted glycopyranoside, on urinary glucose excretion and blood glucose in mice and rats
    • Bickel M, Brummerhop H, Frick W et al. Effects of AVE2268, a substituted glycopyranoside, on urinary glucose excretion and blood glucose in mice and rats. Arzneimittelforschung 2008; 58: 574-580.
    • (2008) Arzneimittelforschung , vol.58 , pp. 574-580
    • Bickel, M.1    Brummerhop, H.2    Frick, W.3
  • 49
    • 0031885358 scopus 로고    scopus 로고
    • Juxtaglomerular cell complex in the regulation of renal salt excretion
    • Schnermann J. Juxtaglomerular cell complex in the regulation of renal salt excretion. Am J Physiol 1998; 274: R263-R279.
    • (1998) Am J Physiol , vol.274
    • Schnermann, J.1
  • 50
    • 57149085524 scopus 로고    scopus 로고
    • Glomerulotubular balance, tubuloglomerular feedback, and salt homeostasis
    • Thomson SC, Blantz RC. Glomerulotubular balance, tubuloglomerular feedback, and salt homeostasis. J Am Soc Nephrol 2008; 19: 2272-2275.
    • (2008) J Am Soc Nephrol , vol.19 , pp. 2272-2275
    • Thomson, S.C.1    Blantz, R.C.2
  • 51
    • 33644932611 scopus 로고    scopus 로고
    • Postprandial glucose regulation: New data and new implications
    • Leiter LA, Ceriello A, Davidson JA et al. Postprandial glucose regulation: new data and new implications. Clin Ther 2005; 27(Suppl B): S42-S46.
    • (2005) Clin Ther , vol.27 , Issue.SUPPL. B
    • Leiter, L.A.1    Ceriello, A.2    Davidson, J.A.3
  • 52
    • 33745848775 scopus 로고    scopus 로고
    • Glucose transport and sensing in the maintenance of glucose homeostasis and metabolic harmony
    • DOI 10.1172/JCI29027
    • Herman MA, Kahn BB. Glucose transport and sensing in the maintenance of glucose homeostasis and metabolic harmony. J Clin Invest 2006; 116: 1767-1775. (Pubitemid 44033296)
    • (2006) Journal of Clinical Investigation , vol.116 , Issue.7 , pp. 1767-1775
    • Herman, M.A.1    Kahn, B.B.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.