Na+-glucose cotransporter (SGLT) inhibitors as antidiabetic agents. 4. Synthesis and pharmacological properties of 4'- dehydroxyphlorizin derivatives substituted on the B ring

Journal of Medicinal Chemistry

Volumn 42, Issue 26, 1999, Pages 5311-5324

  Tsujihara, Kenji ^a   Hongu, Mitsuya ^a   Saito, Kunio ^a   Kawanishi, Hiroyuki ^a   Kuriyama, Kayoko ^a   Matsumoto, Mamoru ^a   Akira, Oku ^a   Ueta, Kiichiro ^a   Tsuda, Minoru ^a   Saito, Akira ^a  

^a MITSUBISHI TANABE PHARMA CORPORATION   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

4' DEHYDROXYPHLORIZIN DERIVATIVE; ANTIDIABETIC AGENT; GLUCOPYRANOSIDE; GLUCOSE; GLUCOSE TRANSPORTER; PRODRUG; PROPIOPHENONE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DRUG METABOLISM; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; GLUCOSE BLOOD LEVEL; GLUCOSE URINE LEVEL; HYPERGLYCEMIA; MALE; MOUSE; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN;

ANIMALS; BIOTRANSFORMATION; BLOOD GLUCOSE; DIABETES MELLITUS, TYPE 2; DOGS; GLUCOSE; HAPLORHINI; HEMOGLOBIN A, GLYCOSYLATED; HUMANS; HYPOGLYCEMIC AGENTS; MALE; MEMBRANE GLYCOPROTEINS; MICE; MONOSACCHARIDE TRANSPORT PROTEINS; RATS; RATS, SPRAGUE-DAWLEY; SODIUM-GLUCOSE TRANSPORTER 1; SPECTRUM ANALYSIS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0033619999     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm990175n     Document Type: Article

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