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Volumn 77, Issue 3, 2011, Pages 172-183

Thrombopoietic growth factors in the treatment of immune thrombocytopenic purpura

Author keywords

Immune thrombocytopenic purpura; Thrombopoietic growth factor

Indexed keywords

ELTROMBOPAG; PLACEBO; RECOMBINANT MEGAKARYOCYTE GROWTH AND DEVELOPMENT FACTOR; RECOMBINANT THROMBOPOIETIN; ROMIPLOSTIM; THROMBOPOIETIN;

EID: 79952188432     PISSN: 10408428     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.critrevonc.2010.03.001     Document Type: Review
Times cited : (13)

References (83)
  • 1
    • 0037187949 scopus 로고    scopus 로고
    • Immune thrombocytopenic purpura
    • Cines D.B., Blanchette V.S. Immune thrombocytopenic purpura. N Engl J Med 2002, 346:995-1008.
    • (2002) N Engl J Med , vol.346 , pp. 995-1008
    • Cines, D.B.1    Blanchette, V.S.2
  • 2
    • 13944266670 scopus 로고    scopus 로고
    • The effect of antiplatelet autoantibodies on megakaryocytopoiesis
    • McMillan R., Nugent D. The effect of antiplatelet autoantibodies on megakaryocytopoiesis. Int J Hematol 2005, 81:94-99.
    • (2005) Int J Hematol , vol.81 , pp. 94-99
    • McMillan, R.1    Nugent, D.2
  • 3
    • 0141684568 scopus 로고    scopus 로고
    • T-cell-mediated cytotoxicity toward platelets in chronic idiopathic thrombocytopenic purpura
    • Olsson B., Andersson P.O., Jernas M., et al. T-cell-mediated cytotoxicity toward platelets in chronic idiopathic thrombocytopenic purpura. Nat Med 2003, 9:1123-1124.
    • (2003) Nat Med , vol.9 , pp. 1123-1124
    • Olsson, B.1    Andersson, P.O.2    Jernas, M.3
  • 4
    • 0034641010 scopus 로고    scopus 로고
    • The bleeding risk and natural history of idiopathic thrombocytopenic purpura in patients with persistent low platelet counts
    • Cohen Y.C., Djulbegovic B., Shamai-Lubovitz O., Mozes B. The bleeding risk and natural history of idiopathic thrombocytopenic purpura in patients with persistent low platelet counts. Arch Intern Med 2000, 160:1630-1638.
    • (2000) Arch Intern Med , vol.160 , pp. 1630-1638
    • Cohen, Y.C.1    Djulbegovic, B.2    Shamai-Lubovitz, O.3    Mozes, B.4
  • 5
    • 1642546472 scopus 로고    scopus 로고
    • Management of immune thrombocytopenic purpura in adults
    • Stasi R., Provan D. Management of immune thrombocytopenic purpura in adults. Mayo Clin Proc 2004, 79:504-522.
    • (2004) Mayo Clin Proc , vol.79 , pp. 504-522
    • Stasi, R.1    Provan, D.2
  • 6
    • 0035353206 scopus 로고    scopus 로고
    • Morbidity and mortality in adults with idiopathic thrombocytopenic purpura
    • Portielje J.E., Westendorp R.G., Kluin-Nelemans H.C., Brand A. Morbidity and mortality in adults with idiopathic thrombocytopenic purpura. Blood 2001, 97:2549-2554.
    • (2001) Blood , vol.97 , pp. 2549-2554
    • Portielje, J.E.1    Westendorp, R.G.2    Kluin-Nelemans, H.C.3    Brand, A.4
  • 7
    • 33846918681 scopus 로고    scopus 로고
    • Systematic review: efficacy and safety of rituximab for adults with idiopathic thrombocytopenic purpura
    • Arnold D.M., Dentali F., Crowther M.A., et al. Systematic review: efficacy and safety of rituximab for adults with idiopathic thrombocytopenic purpura. Ann Intern Med 2007, 146:25-33.
    • (2007) Ann Intern Med , vol.146 , pp. 25-33
    • Arnold, D.M.1    Dentali, F.2    Crowther, M.A.3
  • 9
    • 0023218341 scopus 로고
    • Mechanisms of thrombocytopenia in chronic autoimmune thrombocytopenic purpura. Evidence of both impaired platelet production and increased platelet clearance
    • Ballem P.J., Segel G.M., Stratton J.E., et al. Mechanisms of thrombocytopenia in chronic autoimmune thrombocytopenic purpura. Evidence of both impaired platelet production and increased platelet clearance. J Clin Invest 1987, 80:33-40.
    • (1987) J Clin Invest , vol.80 , pp. 33-40
    • Ballem, P.J.1    Segel, G.M.2    Stratton, J.E.3
  • 10
    • 0344179126 scopus 로고    scopus 로고
    • Prospective evaluation of the immunobead assay for the diagnosis of adult chronic immune thrombocytopenic purpura (ITP)
    • McMillan R., Wang L., Tani P. Prospective evaluation of the immunobead assay for the diagnosis of adult chronic immune thrombocytopenic purpura (ITP). J Thromb Haemost 2003, 1:485-491.
    • (2003) J Thromb Haemost , vol.1 , pp. 485-491
    • McMillan, R.1    Wang, L.2    Tani, P.3
  • 11
    • 0029902152 scopus 로고    scopus 로고
    • Prospective evaluation of the clinical usefulness of an antigenspecific assay (MAIPA) in idiopathic thrombocytopenic purpura and other immune thrombocytopenias
    • Brighton T.A., Evans S., Castaldi P.A., et al. Prospective evaluation of the clinical usefulness of an antigenspecific assay (MAIPA) in idiopathic thrombocytopenic purpura and other immune thrombocytopenias. Blood 1996, 88:194-201.
    • (1996) Blood , vol.88 , pp. 194-201
    • Brighton, T.A.1    Evans, S.2    Castaldi, P.A.3
  • 12
    • 77649265485 scopus 로고    scopus 로고
    • International consensus report on the investigation and management of primary immune thrombocytopenia
    • [Epub ahead of print]
    • Provan D., Stasi R., Newland A.C., et al. International consensus report on the investigation and management of primary immune thrombocytopenia. Blood 2009, October 21, [Epub ahead of print].
    • (2009) Blood
    • Provan, D.1    Stasi, R.2    Newland, A.C.3
  • 13
    • 33846059033 scopus 로고    scopus 로고
    • + regulatory T cells in idiopathic thrombocytopenic purpura
    • + regulatory T cells in idiopathic thrombocytopenic purpura. Eur J Haematol 2007, 78(2):139-143.
    • (2007) Eur J Haematol , vol.78 , Issue.2 , pp. 139-143
    • Liu, B.1    Zhao, H.2    Poon, M.C.3
  • 14
    • 51649127854 scopus 로고    scopus 로고
    • Defective circulating CD25 regulatory T cells in patients with chronic immune thrombocytopenic purpura
    • Yu J., Heck S., Patel V., et al. Defective circulating CD25 regulatory T cells in patients with chronic immune thrombocytopenic purpura. Blood 2008, 112:1325-1328.
    • (2008) Blood , vol.112 , pp. 1325-1328
    • Yu, J.1    Heck, S.2    Patel, V.3
  • 15
    • 0032190549 scopus 로고    scopus 로고
    • Autoreactive T cells to platelet GPIIb-IIIa in immune thrombocytopenic purpura. Role in production of anti-platelet autoantibody
    • Kuwana M., Kaburaki J., Ikeda Y. Autoreactive T cells to platelet GPIIb-IIIa in immune thrombocytopenic purpura. Role in production of anti-platelet autoantibody. J Clin Invest 1998, 102:1393-1402.
    • (1998) J Clin Invest , vol.102 , pp. 1393-1402
    • Kuwana, M.1    Kaburaki, J.2    Ikeda, Y.3
  • 16
    • 0032484987 scopus 로고    scopus 로고
    • CD40 ligand on activated platelets triggers an inflammatory reaction of endothelial cells
    • Henn V., Slupsky J.R., Grafe M., et al. CD40 ligand on activated platelets triggers an inflammatory reaction of endothelial cells. Nature 1998, 391:591-594.
    • (1998) Nature , vol.391 , pp. 591-594
    • Henn, V.1    Slupsky, J.R.2    Grafe, M.3
  • 17
    • 0035075438 scopus 로고    scopus 로고
    • Platelet CD40 ligand (CD40L)-subcellular localization, regulation of expression, and inhibition by clopidogrel
    • Hermann A., Rauch B.H., Braun M., et al. Platelet CD40 ligand (CD40L)-subcellular localization, regulation of expression, and inhibition by clopidogrel. Platelets 2001, 12:74-82.
    • (2001) Platelets , vol.12 , pp. 74-82
    • Hermann, A.1    Rauch, B.H.2    Braun, M.3
  • 18
    • 19944426859 scopus 로고    scopus 로고
    • Platelet associated CD154 in immune thrombocytopenic purpura
    • Solanilla A., Pasquet J.M., Viallard J.F., et al. Platelet associated CD154 in immune thrombocytopenic purpura. Blood 2005, 105:215-218.
    • (2005) Blood , vol.105 , pp. 215-218
    • Solanilla, A.1    Pasquet, J.M.2    Viallard, J.F.3
  • 19
    • 0029964421 scopus 로고    scopus 로고
    • Differences in serum cytokine levels in acute and chronic autoimmune thrombocytopenic purpura: relationship to platelet phenotype and antiplatelet T-cell reactivity
    • Semple J.W., Milev Y., Cosgrave D., et al. Differences in serum cytokine levels in acute and chronic autoimmune thrombocytopenic purpura: relationship to platelet phenotype and antiplatelet T-cell reactivity. Blood 1996, 87:4245-4254.
    • (1996) Blood , vol.87 , pp. 4245-4254
    • Semple, J.W.1    Milev, Y.2    Cosgrave, D.3
  • 20
    • 0042326418 scopus 로고    scopus 로고
    • T cell receptor VB repertoire diversity in patients with immune thrombocytopenia following splenectomy
    • Fogarty P.F., Rick M.E., Zeng W., et al. T cell receptor VB repertoire diversity in patients with immune thrombocytopenia following splenectomy. Clin Exp Immunol 2003, 133:461-466.
    • (2003) Clin Exp Immunol , vol.133 , pp. 461-466
    • Fogarty, P.F.1    Rick, M.E.2    Zeng, W.3
  • 21
    • 35548960551 scopus 로고    scopus 로고
    • Response to B-cell depleting therapy with rituximab reverts the abnormalities of T cell subsets in patients with idiopathic thrombocytopenic purpura
    • Stasi R., Del Poeta G., Stipa E., et al. Response to B-cell depleting therapy with rituximab reverts the abnormalities of T cell subsets in patients with idiopathic thrombocytopenic purpura. Blood 2007, 110:2924-2930.
    • (2007) Blood , vol.110 , pp. 2924-2930
    • Stasi, R.1    Del Poeta, G.2    Stipa, E.3
  • 22
    • 22544456923 scopus 로고    scopus 로고
    • Type 1 and type 2 T-cell profiles in idiopathic thrombocytopenic purpura
    • Wang T., Zhao H., Ren H., et al. Type 1 and type 2 T-cell profiles in idiopathic thrombocytopenic purpura. Haematologica 2005, 90:914-923.
    • (2005) Haematologica , vol.90 , pp. 914-923
    • Wang, T.1    Zhao, H.2    Ren, H.3
  • 23
    • 0027283589 scopus 로고
    • Severe chronic autoimmune thrombocytopenic purpura is associated with an expansion of CD56+CD3- natural killer cells subset
    • Garcia-Suarez J., Prieto A., Reyes E., et al. Severe chronic autoimmune thrombocytopenic purpura is associated with an expansion of CD56+CD3- natural killer cells subset. Blood 1993, 82:1538-1545.
    • (1993) Blood , vol.82 , pp. 1538-1545
    • Garcia-Suarez, J.1    Prieto, A.2    Reyes, E.3
  • 24
    • 0024517811 scopus 로고
    • Platelet survival and turnover: important factors in predicting response to splenectomy in immune thrombocytopenic purpura
    • Siegel R.S., Rae J.L., Barth S., et al. Platelet survival and turnover: important factors in predicting response to splenectomy in immune thrombocytopenic purpura. Am J Hematol 1989, 30:206-212.
    • (1989) Am J Hematol , vol.30 , pp. 206-212
    • Siegel, R.S.1    Rae, J.L.2    Barth, S.3
  • 25
    • 0033119756 scopus 로고    scopus 로고
    • Platelet kinetic studies in patients with idiopathic thrombocytopenic purpura
    • Louwes H., Zeinali Lathori O.A., Vellenga E., de Wolf J.T. Platelet kinetic studies in patients with idiopathic thrombocytopenic purpura. Am J Med 1999, 106:430-434.
    • (1999) Am J Med , vol.106 , pp. 430-434
    • Louwes, H.1    Zeinali Lathori, O.A.2    Vellenga, E.3    de Wolf, J.T.4
  • 26
    • 0020031045 scopus 로고
    • Kinetics and sites of destruction of 111 indium-oxine-labeled platelets in idiopathic thrombocytopenic purpura: a quantitative study
    • Heyns A.D., Lotter M.G., Badenhorst P.N., et al. Kinetics and sites of destruction of 111 indium-oxine-labeled platelets in idiopathic thrombocytopenic purpura: a quantitative study. Am J Hematol 1982, 12:167-177.
    • (1982) Am J Hematol , vol.12 , pp. 167-177
    • Heyns, A.D.1    Lotter, M.G.2    Badenhorst, P.N.3
  • 27
    • 0022254538 scopus 로고
    • An antibody cytotoxic to megakaryocyte progenitor cells in a patient with immune thrombocytopenic purpura
    • Hoffman R., Zaknoen S., Yang H.H., et al. An antibody cytotoxic to megakaryocyte progenitor cells in a patient with immune thrombocytopenic purpura. N Engl J Med 1985, 312:1170-1174.
    • (1985) N Engl J Med , vol.312 , pp. 1170-1174
    • Hoffman, R.1    Zaknoen, S.2    Yang, H.H.3
  • 28
    • 0043245959 scopus 로고    scopus 로고
    • Immune thrombocytopenic purpura (ITP) plasma and purified ITP monoclonal autoantibodies inhibit megakaryocytopoiesis in vitro
    • Chang M., Nakagawa P.A., Williams S.A., et al. Immune thrombocytopenic purpura (ITP) plasma and purified ITP monoclonal autoantibodies inhibit megakaryocytopoiesis in vitro. Blood 2003, 102:887-895.
    • (2003) Blood , vol.102 , pp. 887-895
    • Chang, M.1    Nakagawa, P.A.2    Williams, S.A.3
  • 29
    • 0942287736 scopus 로고    scopus 로고
    • Ultrastructural study shows morphologic features of apoptosis and para-apoptosis in megakaryocytes from patients with idiopathic thrombocytopenic purpura
    • Howerzijl E.J., Blom N.R., Van der Want J.J.L., et al. Ultrastructural study shows morphologic features of apoptosis and para-apoptosis in megakaryocytes from patients with idiopathic thrombocytopenic purpura. Blood 2004, 103:500-506.
    • (2004) Blood , vol.103 , pp. 500-506
    • Howerzijl, E.J.1    Blom, N.R.2    Van der Want, J.J.L.3
  • 30
    • 51649128648 scopus 로고    scopus 로고
    • Recruitment of T cells into bone marrow of ITP patients possibly due to elevated expression of VLA-4 and CX3CR1
    • Olsson B., Ridell B., Carlsson L., et al. Recruitment of T cells into bone marrow of ITP patients possibly due to elevated expression of VLA-4 and CX3CR1. Blood 2008, 112:1078-1084.
    • (2008) Blood , vol.112 , pp. 1078-1084
    • Olsson, B.1    Ridell, B.2    Carlsson, L.3
  • 31
    • 0028332474 scopus 로고
    • Promotion of megakaryocyte progenitor expansion and differentiation by the c-Mpl ligand thrombopoietin
    • Kaushansky K., Lok S., Holly R.D., et al. Promotion of megakaryocyte progenitor expansion and differentiation by the c-Mpl ligand thrombopoietin. Nature 1994, 369:568-571.
    • (1994) Nature , vol.369 , pp. 568-571
    • Kaushansky, K.1    Lok, S.2    Holly, R.D.3
  • 32
    • 0028199208 scopus 로고
    • Cloning and expression of murine thrombopoietin cDNA and stimulation of platelet production in vivo
    • Lok S., Kaushansky K., Holly R.D., et al. Cloning and expression of murine thrombopoietin cDNA and stimulation of platelet production in vivo. Nature 1994, 369:565-568.
    • (1994) Nature , vol.369 , pp. 565-568
    • Lok, S.1    Kaushansky, K.2    Holly, R.D.3
  • 33
    • 0028343099 scopus 로고
    • Identification and cloning of a megakaryocyte growth and development factor that is a ligand for the cytokine receptor Mpl
    • Bartley T.D., Bogenberger J., Hunt P., et al. Identification and cloning of a megakaryocyte growth and development factor that is a ligand for the cytokine receptor Mpl. Cell 1994, 77:1117-1124.
    • (1994) Cell , vol.77 , pp. 1117-1124
    • Bartley, T.D.1    Bogenberger, J.2    Hunt, P.3
  • 34
    • 0028302409 scopus 로고
    • Stimulation of megakaryocytopoiesis and thrombopoiesis by the c-Mpl ligand
    • de Sauvage F.J., Hass P.E., Spencer S.D., et al. Stimulation of megakaryocytopoiesis and thrombopoiesis by the c-Mpl ligand. Nature 1994, 369:533-538.
    • (1994) Nature , vol.369 , pp. 533-538
    • de Sauvage, F.J.1    Hass, P.E.2    Spencer, S.D.3
  • 35
    • 34249723396 scopus 로고    scopus 로고
    • Thrombopoietin
    • Academic Press, New York, NY, J.J. Oppenheim, M. Feldmann, S.K. Durum, T. Hirano, J. Vilcek, N.A. Nicola (Eds.)
    • Kuter D.J. Thrombopoietin. Cytokine reference: a compendium of cytokines and other mediators of host defense 2000, 965-982. Academic Press, New York, NY. J.J. Oppenheim, M. Feldmann, S.K. Durum, T. Hirano, J. Vilcek, N.A. Nicola (Eds.).
    • (2000) Cytokine reference: a compendium of cytokines and other mediators of host defense , pp. 965-982
    • Kuter, D.J.1
  • 36
    • 0037071389 scopus 로고    scopus 로고
    • The molecular and cellular biology of thrombopoiet: the primary regulator of platelet production
    • Kaushansky K., Drachman J.G. The molecular and cellular biology of thrombopoiet: the primary regulator of platelet production. Oncogene 2002, 21:3359-3367.
    • (2002) Oncogene , vol.21 , pp. 3359-3367
    • Kaushansky, K.1    Drachman, J.G.2
  • 37
    • 0031035555 scopus 로고    scopus 로고
    • Localization of thrombopoietin mRNA expression in human kidney, liver, bone marrow, and spleen using in situ hybridization
    • Sungaran R., Markovic B., Chong B.H. Localization of thrombopoietin mRNA expression in human kidney, liver, bone marrow, and spleen using in situ hybridization. Blood 1997, 89:101-107.
    • (1997) Blood , vol.89 , pp. 101-107
    • Sungaran, R.1    Markovic, B.2    Chong, B.H.3
  • 39
    • 34249725822 scopus 로고    scopus 로고
    • Thrombopoietin receptor
    • Academic Press, New York, NY, J.J. Oppenheim, M. Feldmann, S.K. Durum, T. Hirano, J. Vilcek, N.A. Nicola (Eds.)
    • Kuter D.J., Li J.L. Thrombopoietin receptor. Cytokine reference: a compendium of cytokines and other mediators of host defense 2000, 1953-1968. Academic Press, New York, NY. J.J. Oppenheim, M. Feldmann, S.K. Durum, T. Hirano, J. Vilcek, N.A. Nicola (Eds.).
    • (2000) Cytokine reference: a compendium of cytokines and other mediators of host defense , pp. 1953-1968
    • Kuter, D.J.1    Li, J.L.2
  • 40
    • 10744223059 scopus 로고    scopus 로고
    • Structure of the receptor-binding domain of human thrombopoietin determined by complexation with a neutralizing antibody fragment
    • Feese M.D., Tamada T., Kato Y., et al. Structure of the receptor-binding domain of human thrombopoietin determined by complexation with a neutralizing antibody fragment. Proc Natl Acad Sci USA 2004, 101:1816-1821.
    • (2004) Proc Natl Acad Sci USA , vol.101 , pp. 1816-1821
    • Feese, M.D.1    Tamada, T.2    Kato, Y.3
  • 41
    • 0028832719 scopus 로고
    • Point mutations within a dimer interface homology domain of c-Mpl induce constitutive receptor activity and tumorigenicity
    • Alexander W.S., Metcalf D., Dunn A.R. Point mutations within a dimer interface homology domain of c-Mpl induce constitutive receptor activity and tumorigenicity. EMBO J 1995, 14:5569-5578.
    • (1995) EMBO J , vol.14 , pp. 5569-5578
    • Alexander, W.S.1    Metcalf, D.2    Dunn, A.R.3
  • 42
    • 0033168819 scopus 로고    scopus 로고
    • Deletion of the extracellular membrane-distal cytokine receptor homology module of Mpl results in constitutive cell growth and loss of thrombopoietin binding
    • Sabath D.F., Kaushansky K., Broudy V.C. Deletion of the extracellular membrane-distal cytokine receptor homology module of Mpl results in constitutive cell growth and loss of thrombopoietin binding. Blood. 1999, 94:365-367.
    • (1999) Blood. , vol.94 , pp. 365-367
    • Sabath, D.F.1    Kaushansky, K.2    Broudy, V.C.3
  • 43
    • 31044439372 scopus 로고    scopus 로고
    • The molecular mechanisms that control thrombopoiesis
    • Kaushansky K. The molecular mechanisms that control thrombopoiesis. J Clin Invest 2005, 115:3339-3347.
    • (2005) J Clin Invest , vol.115 , pp. 3339-3347
    • Kaushansky, K.1
  • 44
    • 0029030356 scopus 로고
    • The reciprocal relationship of thrombopoietin (c-Mpl ligand) to changes in the platelet mass during busulfan-induced thrombocytopenia in the rabbit
    • Kuter D.J., Rosenberg R.D. The reciprocal relationship of thrombopoietin (c-Mpl ligand) to changes in the platelet mass during busulfan-induced thrombocytopenia in the rabbit. Blood 1995, 85:2720-2730.
    • (1995) Blood , vol.85 , pp. 2720-2730
    • Kuter, D.J.1    Rosenberg, R.D.2
  • 45
    • 0032842829 scopus 로고    scopus 로고
    • Interaction of thrombopoietin with the platelet c-mpl receptor in plasma: Binding, internalization, stability and pharmacokinetics
    • Li J., Xia Y., Kuter D. Interaction of thrombopoietin with the platelet c-mpl receptor in plasma: Binding, internalization, stability and pharmacokinetics. Br J Haematol 1999, 106:345-356.
    • (1999) Br J Haematol , vol.106 , pp. 345-356
    • Li, J.1    Xia, Y.2    Kuter, D.3
  • 46
    • 0030663382 scopus 로고    scopus 로고
    • Thrombopoietin levels in patients with primary and reactive thrombocytosis
    • Cerutti A., Custodi P., Duranti M., et al. Thrombopoietin levels in patients with primary and reactive thrombocytosis. Br J Haematol 1997, 99:281-284.
    • (1997) Br J Haematol , vol.99 , pp. 281-284
    • Cerutti, A.1    Custodi, P.2    Duranti, M.3
  • 47
    • 0031805239 scopus 로고    scopus 로고
    • The diagnostic value of thrombopoietin level measurements in thrombocytopenia
    • Porcelijn L., Folman C.C., Bossers B., et al. The diagnostic value of thrombopoietin level measurements in thrombocytopenia. Thromb Haemost 1998, 79:1101-1105.
    • (1998) Thromb Haemost , vol.79 , pp. 1101-1105
    • Porcelijn, L.1    Folman, C.C.2    Bossers, B.3
  • 48
    • 0033561457 scopus 로고    scopus 로고
    • Tissue uptake of circulating thrombopoietin is increased in immune-mediated compared with irradiated thrombocytopenic mice
    • Chang M., Qian J.X., Lee S.M., et al. Tissue uptake of circulating thrombopoietin is increased in immune-mediated compared with irradiated thrombocytopenic mice. Blood 1999, 93:2515-2524.
    • (1999) Blood , vol.93 , pp. 2515-2524
    • Chang, M.1    Qian, J.X.2    Lee, S.M.3
  • 49
    • 9344231924 scopus 로고    scopus 로고
    • Circulating thrombopoietin level in chronic immune thrombocytopenic purpura
    • Kosugi S., Kurata Y., Tomiyama Y., et al. Circulating thrombopoietin level in chronic immune thrombocytopenic purpura. Br J Haematol 1996, 93:704-706.
    • (1996) Br J Haematol , vol.93 , pp. 704-706
    • Kosugi, S.1    Kurata, Y.2    Tomiyama, Y.3
  • 50
    • 0036319342 scopus 로고    scopus 로고
    • Plasma thrombopoietin levels in patients with aplastic anemia and idiopathic thrombocytopenic purpura
    • Gu J., Lu L., Xu R., Chen X. Plasma thrombopoietin levels in patients with aplastic anemia and idiopathic thrombocytopenic purpura. Chin Med J (Engl) 2002, 115:983-986.
    • (2002) Chin Med J (Engl) , vol.115 , pp. 983-986
    • Gu, J.1    Lu, L.2    Xu, R.3    Chen, X.4
  • 51
    • 0034805374 scopus 로고    scopus 로고
    • Promegapoietin, a family of chimeric growth factors, supports megakaryocyte development through activation of IL-3 and c-Mpl ligand signaling pathways
    • Doshi P.D., Giri J.G., Abegg A.L., et al. Promegapoietin, a family of chimeric growth factors, supports megakaryocyte development through activation of IL-3 and c-Mpl ligand signaling pathways. Exp Hematol 2001, 29:1177-1184.
    • (2001) Exp Hematol , vol.29 , pp. 1177-1184
    • Doshi, P.D.1    Giri, J.G.2    Abegg, A.L.3
  • 52
    • 0030966361 scopus 로고    scopus 로고
    • Stimulation of megakaryocyte and platelet production by a single dose of recombinant human thrombopoietin in patients with cancer
    • Vadhan-Raj S., Murray L.J., Bueso-Ramos C., et al. Stimulation of megakaryocyte and platelet production by a single dose of recombinant human thrombopoietin in patients with cancer. Ann Int Med 1997, 126:673-681.
    • (1997) Ann Int Med , vol.126 , pp. 673-681
    • Vadhan-Raj, S.1    Murray, L.J.2    Bueso-Ramos, C.3
  • 53
    • 0034050651 scopus 로고    scopus 로고
    • Recombinant human thrombopoietin attenuates carboplatin-induced severe thrombocytopenia and the need for platelet transfusions in patients with gynecologic cancer
    • Vadhan-Raj S., Verschraegen C.F., Bueso-Ramos C., et al. Recombinant human thrombopoietin attenuates carboplatin-induced severe thrombocytopenia and the need for platelet transfusions in patients with gynecologic cancer. Ann Intern Med 2000, 132:364-368.
    • (2000) Ann Intern Med , vol.132 , pp. 364-368
    • Vadhan-Raj, S.1    Verschraegen, C.F.2    Bueso-Ramos, C.3
  • 54
    • 0034032956 scopus 로고    scopus 로고
    • Biologic and structural differences of thrombopoietic growth factors
    • Begley C.G., Basser R.L. Biologic and structural differences of thrombopoietic growth factors. Semin Hematol 2000, 37:19-27.
    • (2000) Semin Hematol , vol.37 , pp. 19-27
    • Begley, C.G.1    Basser, R.L.2
  • 55
    • 0035469813 scopus 로고    scopus 로고
    • Thrombopoietin therapy increases platelet yields in healthy platelet donors
    • Kuter D.J., Goodnough L.T., Romo J., et al. Thrombopoietin therapy increases platelet yields in healthy platelet donors. Blood 2001, 98:1339-1345.
    • (2001) Blood , vol.98 , pp. 1339-1345
    • Kuter, D.J.1    Goodnough, L.T.2    Romo, J.3
  • 56
    • 0033135719 scopus 로고    scopus 로고
    • Recombinant human thrombopoietin in combination with granulocyte colony-stimulating factor enhances mobilization of peripheral blood progenitor cells, increases peripheral blood platelet concentration, and accelerates hematopoietic recovery following high-dose chemotherapy
    • Somlo G., Sniecinski I., ter Veer A., et al. Recombinant human thrombopoietin in combination with granulocyte colony-stimulating factor enhances mobilization of peripheral blood progenitor cells, increases peripheral blood platelet concentration, and accelerates hematopoietic recovery following high-dose chemotherapy. Blood 1999, 93:2798-2806.
    • (1999) Blood , vol.93 , pp. 2798-2806
    • Somlo, G.1    Sniecinski, I.2    ter Veer, A.3
  • 57
    • 17944389931 scopus 로고    scopus 로고
    • Randomized, blinded, placebo-controlled phase I trial of pegylated recombinant human megakaryocyte growth and development factor with filgrastim after dose-intensive chemotherapy in patients with advanced cancer
    • Basser R.L., Rasko J.E., Clarke K., et al. Randomized, blinded, placebo-controlled phase I trial of pegylated recombinant human megakaryocyte growth and development factor with filgrastim after dose-intensive chemotherapy in patients with advanced cancer. Blood 1997, 89:3118-3128.
    • (1997) Blood , vol.89 , pp. 3118-3128
    • Basser, R.L.1    Rasko, J.E.2    Clarke, K.3
  • 58
    • 10344235968 scopus 로고    scopus 로고
    • Thrombopoietic effects of pegylated recombinant human megakaryocyte growth and development factor (PEGrHuMGDF) in patients with advanced cancer
    • Basser R.L., Rasko J.E., Clarke K., et al. Thrombopoietic effects of pegylated recombinant human megakaryocyte growth and development factor (PEGrHuMGDF) in patients with advanced cancer. Lancet 1996, 348:1279-1281.
    • (1996) Lancet , vol.348 , pp. 1279-1281
    • Basser, R.L.1    Rasko, J.E.2    Clarke, K.3
  • 59
    • 0033861984 scopus 로고    scopus 로고
    • Enhancement of platelet recovery after myelosuppressive chemotherapy by recombinant human megakaryocyte growth and development factor in patients with advanced cancer
    • Basser R.L., Underhill C., Davis I., et al. Enhancement of platelet recovery after myelosuppressive chemotherapy by recombinant human megakaryocyte growth and development factor in patients with advanced cancer. J Clin Oncol 2000, 18:2852-2861.
    • (2000) J Clin Oncol , vol.18 , pp. 2852-2861
    • Basser, R.L.1    Underhill, C.2    Davis, I.3
  • 60
    • 0031049879 scopus 로고    scopus 로고
    • Effects of polyethylene glycolconjugated recombinant human megakaryocyte growth and development factor on platelet counts after chemotherapy for lung cancer
    • Fanucchi M., Glaspy J., Crawford J., et al. Effects of polyethylene glycolconjugated recombinant human megakaryocyte growth and development factor on platelet counts after chemotherapy for lung cancer. N Engl J Med 1997, 336:404-409.
    • (1997) N Engl J Med , vol.336 , pp. 404-409
    • Fanucchi, M.1    Glaspy, J.2    Crawford, J.3
  • 61
    • 0033485568 scopus 로고    scopus 로고
    • A randomized, double-blind, placebo-controlled study with pegylated recombinant human megakaryocyte growth and development factor (PEG-rHuMGDF) as an adjunct to chemotherapy for adults with de novo acute myeloid leukemia
    • Archimbaud E., Ottmann O.G., Yin J.A., et al. A randomized, double-blind, placebo-controlled study with pegylated recombinant human megakaryocyte growth and development factor (PEG-rHuMGDF) as an adjunct to chemotherapy for adults with de novo acute myeloid leukemia. Blood 1999, 94:3694-3701.
    • (1999) Blood , vol.94 , pp. 3694-3701
    • Archimbaud, E.1    Ottmann, O.G.2    Yin, J.A.3
  • 62
    • 0033930709 scopus 로고    scopus 로고
    • Phase 1 study of pegylated recombinant human megakaryocyte growth and development factor (PEGrHuMGDF) in breast cancer patients after autologous peripheral blood progenitor cell (PBPC) transplantation
    • Bolwell B., Vredenburgh J., Overmoyer B., et al. Phase 1 study of pegylated recombinant human megakaryocyte growth and development factor (PEGrHuMGDF) in breast cancer patients after autologous peripheral blood progenitor cell (PBPC) transplantation. Bone Marrow Transplant 2000, 26:141-145.
    • (2000) Bone Marrow Transplant , vol.26 , pp. 141-145
    • Bolwell, B.1    Vredenburgh, J.2    Overmoyer, B.3
  • 63
    • 0033631018 scopus 로고    scopus 로고
    • A phase I trial of recombinant human thrombopoietin in patients with delayed platelet recovery after hematopoietic stem cell transplantation
    • Nash R.A., Kurzrock R., DiPersio J., et al. A phase I trial of recombinant human thrombopoietin in patients with delayed platelet recovery after hematopoietic stem cell transplantation. Biol Blood Marrow Transplant 2000, 6:25-34.
    • (2000) Biol Blood Marrow Transplant , vol.6 , pp. 25-34
    • Nash, R.A.1    Kurzrock, R.2    DiPersio, J.3
  • 64
    • 0034655649 scopus 로고    scopus 로고
    • A double-blind, placebo-controlled trial of pegylated recombinant human megakaryocyte growth and development factor as an adjunct to induction and consolidation therapy for patients with acute myeloid leukemia
    • Schiffer C.A., Miller K., Larson R.A., et al. A double-blind, placebo-controlled trial of pegylated recombinant human megakaryocyte growth and development factor as an adjunct to induction and consolidation therapy for patients with acute myeloid leukemia. Blood 2000, 95:2530-2535.
    • (2000) Blood , vol.95 , pp. 2530-2535
    • Schiffer, C.A.1    Miller, K.2    Larson, R.A.3
  • 65
    • 4243689989 scopus 로고    scopus 로고
    • Pegylated recombinant human megakaryocyte growth and development factor (PEG-rHuMGDF) increased platelet counts (PLT) in patients (pts) with aplastic anemia (AA) and myelodysplastic syndrome (MDS)
    • Komatsu N., Okamoto T., Yoshida T., et al. Pegylated recombinant human megakaryocyte growth and development factor (PEG-rHuMGDF) increased platelet counts (PLT) in patients (pts) with aplastic anemia (AA) and myelodysplastic syndrome (MDS). Blood 2000, 96:296a.
    • (2000) Blood , vol.96
    • Komatsu, N.1    Okamoto, T.2    Yoshida, T.3
  • 66
    • 4243219531 scopus 로고    scopus 로고
    • Correction of thrombocytopenia and ineffective platelet production in patients with human immunodeficiency virus (HIV) by PEG-rHuMGDF therapy
    • Harker L.A., Carter R.A., Marzec U.M., et al. Correction of thrombocytopenia and ineffective platelet production in patients with human immunodeficiency virus (HIV) by PEG-rHuMGDF therapy. Blood 1998, 92:707a.
    • (1998) Blood , vol.92
    • Harker, L.A.1    Carter, R.A.2    Marzec, U.M.3
  • 67
    • 0037100423 scopus 로고    scopus 로고
    • Effects of pegylated recombinant human megakaryocyte growth and development factor in patients with idiopathic thrombocytopenic purpura
    • Nomura S., Dan K., Hotta T., et al. Effects of pegylated recombinant human megakaryocyte growth and development factor in patients with idiopathic thrombocytopenic purpura. Blood 2002, 100:728-730.
    • (2002) Blood , vol.100 , pp. 728-730
    • Nomura, S.1    Dan, K.2    Hotta, T.3
  • 68
    • 0035760892 scopus 로고    scopus 로고
    • Thrombocytopenia caused by the development of antibodies to thrombopoietin
    • Li J., Yang C., Xia Y., et al. Thrombocytopenia caused by the development of antibodies to thrombopoietin. Blood 2001, 98:3241-3248.
    • (2001) Blood , vol.98 , pp. 3241-3248
    • Li, J.1    Yang, C.2    Xia, Y.3
  • 69
    • 18944367842 scopus 로고    scopus 로고
    • A multi-center clinical trial of recombinant human thrombopoietin in chronic refractory idiopathic thrombocytopenic purpura
    • Zhao Y.Q., Wang Q.Y., Zhai M., et al. A multi-center clinical trial of recombinant human thrombopoietin in chronic refractory idiopathic thrombocytopenic purpura. Zhonghua Nei Ke Za Zhi 2004, 43:608-610.
    • (2004) Zhonghua Nei Ke Za Zhi , vol.43 , pp. 608-610
    • Zhao, Y.Q.1    Wang, Q.Y.2    Zhai, M.3
  • 70
    • 10044296968 scopus 로고    scopus 로고
    • Pharmacodynamics and pharmacokinetics of AMG 531, a novel thrombopoietin receptor ligand
    • Wang B., Nichol J.L., Sullivan J.T. Pharmacodynamics and pharmacokinetics of AMG 531, a novel thrombopoietin receptor ligand. Clin Pharmacol Ther 2004, 76:628-638.
    • (2004) Clin Pharmacol Ther , vol.76 , pp. 628-638
    • Wang, B.1    Nichol, J.L.2    Sullivan, J.T.3
  • 71
    • 36148972012 scopus 로고    scopus 로고
    • Pharmacodynamics and pharmacokinetics of AMG 531, a thrombopoiesis-stimulating peptibody in healthy Japanese subjects: a randomized, placebo-controlled study
    • Kumagai Y., Fujita T., Ozaki M., et al. Pharmacodynamics and pharmacokinetics of AMG 531, a thrombopoiesis-stimulating peptibody in healthy Japanese subjects: a randomized, placebo-controlled study. J Clin Pharmacol 2007, 47:1489-1497.
    • (2007) J Clin Pharmacol , vol.47 , pp. 1489-1497
    • Kumagai, Y.1    Fujita, T.2    Ozaki, M.3
  • 72
    • 33750035507 scopus 로고    scopus 로고
    • AMG 531, a thrombopoiesis stimulating protein, for chronic ITP
    • Bussel J.B., Kuter D.J., George J.N., et al. AMG 531, a thrombopoiesis stimulating protein, for chronic ITP. N Engl J Med 2006, 355:1672-1681.
    • (2006) N Engl J Med , vol.355 , pp. 1672-1681
    • Bussel, J.B.1    Kuter, D.J.2    George, J.N.3
  • 73
    • 33750051618 scopus 로고    scopus 로고
    • An open-label, unit dosefinding study of AMG 531, a novel thrombopoiesis-stimulating peptibody, in patients with immune thrombocytopenic purpura
    • Newland A., Caulier M.T., Kappers-Klunne M., et al. An open-label, unit dosefinding study of AMG 531, a novel thrombopoiesis-stimulating peptibody, in patients with immune thrombocytopenic purpura. Br J Haematol 2006, 135:547-553.
    • (2006) Br J Haematol , vol.135 , pp. 547-553
    • Newland, A.1    Caulier, M.T.2    Kappers-Klunne, M.3
  • 74
    • 38649120593 scopus 로고    scopus 로고
    • Efficacy of romiplostim in patients with chronic immune thrombocytopenic purpura: a double-blind randomised controlled trial
    • Kuter D.J., Bussel J.B., Lyons R.M., et al. Efficacy of romiplostim in patients with chronic immune thrombocytopenic purpura: a double-blind randomised controlled trial. Lancet 2008, 371:395-403.
    • (2008) Lancet , vol.371 , pp. 395-403
    • Kuter, D.J.1    Bussel, J.B.2    Lyons, R.M.3
  • 75
    • 63849111465 scopus 로고    scopus 로고
    • Safety and efficacy of long-term treatment with rombiplostim in thrombocytopenic patients with chronic ITP
    • Bussel J.B., Kuter D.J., Pullarkat V., et al. Safety and efficacy of long-term treatment with rombiplostim in thrombocytopenic patients with chronic ITP. Blood 2009, 113:2161-2171.
    • (2009) Blood , vol.113 , pp. 2161-2171
    • Bussel, J.B.1    Kuter, D.J.2    Pullarkat, V.3
  • 76
    • 34249719511 scopus 로고    scopus 로고
    • Phase 1 clinical study of eltrombopag, an oral, nonpeptide thrombopoietin receptor agonist
    • Jenkins J.M., Williams D., Deng Y., et al. Phase 1 clinical study of eltrombopag, an oral, nonpeptide thrombopoietin receptor agonist. Blood 2007, 109:4739-4741.
    • (2007) Blood , vol.109 , pp. 4739-4741
    • Jenkins, J.M.1    Williams, D.2    Deng, Y.3
  • 77
    • 36549001698 scopus 로고    scopus 로고
    • Eltrombopag for the treatment of chronic idiopathic thrombocytopenic purpura
    • Bussel J.B., Cheng G., Saleh M.N., et al. Eltrombopag for the treatment of chronic idiopathic thrombocytopenic purpura. N Engl J Med 2007, 357:2237-2247.
    • (2007) N Engl J Med , vol.357 , pp. 2237-2247
    • Bussel, J.B.1    Cheng, G.2    Saleh, M.N.3
  • 78
    • 60249099882 scopus 로고    scopus 로고
    • Effect of eltrombopag on platelet counts and bleeding during treatment of chronic idiopathic thrombocytopenic purpura: a randomised, double-blind, placebo-controlled trial
    • Bussel J.B., Provan D., Shamsi T., et al. Effect of eltrombopag on platelet counts and bleeding during treatment of chronic idiopathic thrombocytopenic purpura: a randomised, double-blind, placebo-controlled trial. Lancet 2009, 373:641-648.
    • (2009) Lancet , vol.373 , pp. 641-648
    • Bussel, J.B.1    Provan, D.2    Shamsi, T.3
  • 79
    • 60949113565 scopus 로고    scopus 로고
    • Safety and efficacy of longterm treatment with oral eltrombopag for chronic idiopathic thrombocytopenic purpura
    • [abstr]
    • Bussel J.B., Cheng G., Saleh M.N., et al. Safety and efficacy of longterm treatment with oral eltrombopag for chronic idiopathic thrombocytopenic purpura. Blood 2008, 112:1177. [abstr].
    • (2008) Blood , vol.112 , pp. 1177
    • Bussel, J.B.1    Cheng, G.2    Saleh, M.N.3
  • 80
    • 60249095603 scopus 로고    scopus 로고
    • Oral eltrombopag for the long-term treatment of patients with chronic idiopathic thrombocytopenic purpura: results of a phase III, double-blind, placebo-controlled study (RAISE)
    • [abstr]
    • Cheng G., Saleh M.N., Bussel J.B., et al. Oral eltrombopag for the long-term treatment of patients with chronic idiopathic thrombocytopenic purpura: results of a phase III, double-blind, placebo-controlled study (RAISE). Blood 2008, 112:153. [abstr].
    • (2008) Blood , vol.112 , pp. 153
    • Cheng, G.1    Saleh, M.N.2    Bussel, J.B.3
  • 81
    • 34249733156 scopus 로고    scopus 로고
    • New thrombopoietic growth factors
    • Kuter D.J. New thrombopoietic growth factors. Blood 2007, 109:4607-4616.
    • (2007) Blood , vol.109 , pp. 4607-4616
    • Kuter, D.J.1
  • 82
    • 47549100414 scopus 로고    scopus 로고
    • Phase 1/2 study of AMG531 in thrombocytopenic patients with low-risk myelodysplastic syndrome: update including extended treatment
    • [abstr]
    • Kantarjian H., Fenaux P., Sekeres M.A., et al. Phase 1/2 study of AMG531 in thrombocytopenic patients with low-risk myelodysplastic syndrome: update including extended treatment. Blood 2007, 110:250. [abstr].
    • (2007) Blood , vol.110 , pp. 250
    • Kantarjian, H.1    Fenaux, P.2    Sekeres, M.A.3
  • 83
    • 0037111643 scopus 로고    scopus 로고
    • Prominent role of TGF-beta 1 in thrombopoietin-induced myelofibrosis in mice
    • Chagraoui H., Komura E., Tulliez M., et al. Prominent role of TGF-beta 1 in thrombopoietin-induced myelofibrosis in mice. Blood 2002, 100:3495-3503.
    • (2002) Blood , vol.100 , pp. 3495-3503
    • Chagraoui, H.1    Komura, E.2    Tulliez, M.3


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