T cell receptor VB repertoire diversity in patients with immune thrombocytopenia following splenectomy

Clinical and Experimental Immunology

Volumn 133, Issue 3, 2003, Pages 461-466

  Fogarty, P F ^a   Rick, M E ^a   Zeng, W ^a   Risitano, A M ^a   Dunbar, Cynthia E ^a,c   Bussel, J B ^b  

^a NATIONAL INSTITUTES OF HEALTH   (United States)

^b WEILL CORNELL MEDICAL COLLEGE   (United States)

^c NATIONAL HEART LUNG AND BLOOD INSTITUTE   (United States)

Author keywords

Autoimmune disease; Immune thrombocytopenia; Platelets; Splenectomy; T cells

Indexed keywords

COMPLEMENTARY DNA; T LYMPHOCYTE RECEPTOR;

ADULT; ARTICLE; AUTOIMMUNE DISEASE; CLINICAL ARTICLE; CLONAL VARIATION; COMPLEMENTARITY DETERMINING REGION; CONTROLLED STUDY; FEMALE; HUMAN; IDIOPATHIC THROMBOCYTOPENIC PURPURA; MALE; PRIORITY JOURNAL; SPLENECTOMY; T LYMPHOCYTE; THROMBOCYTE COUNT;

ADULT; ANALYSIS OF VARIANCE; CASE-CONTROL STUDIES; FEMALE; GENES, T-CELL RECEPTOR BETA; HUMANS; IMMUNOGLOBULIN VARIABLE REGION; MALE; MIDDLE AGED; RECEPTOR-CD3 COMPLEX, ANTIGEN, T-CELL; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA; SPLENECTOMY; THROMBOCYTOPENIA; TREATMENT FAILURE; VARIATION (GENETICS);

EID: 0042326418     PISSN: 00099104     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2249.2003.02239.x     Document Type: Article

References (34)

1. Berchtold P, Wenger M. Autoantibodies against platelet glycoproteins in autoimmune thrombocytopenic purpura: their clinical significance and response to treatment. Blood 1993; 81:1246-50.
2. He R, Reid DM, Jones CE, Shulman NR. Spectrum of Ig classes, specificities, and titers of serum antiglycoproteins in chronic idiopathic thrombocytopenic purpura. Blood 1994; 83:1024-32.
3. Kiefel V, Freitag E, Kroll H, Santoso S, Mueller-Eckhardt C. Platelet autoantibodies (IgG, IgM, IgA) against glycoproteins IIb/IIIa and Ib/IX in patients with thrombocytopenia. Ann Hematol 1996; 72:280-5.
4. Stratton JR, Ballem PJ, Gernsheimer T, Cerqueira M, Slichter SJ. Platelet destruction in autoimmune thrombocytopenic purpura: kinetics and clearance of indium-111-labeled autologous platelets. J Nucl Med 1989; 30:629-37.
5. Semple JW, Freedman J. Increased antiplatelet T helper lymphocyte reactivity in patients with autoimmune thrombocytopenia. Blood 1991; 78:2619-25.
6. Semple JW, Milev Y, Cosgrave D et al. Differences in serum cytokine levels in acute and chronic autoimmune thrombocytopenic purpura: relationship to platelet phenotype and antiplatelet T-cell reactivity. Blood 1996; 87:4245-54.
7. Ware RE, Howard TA. Phenotypic and clonal analysis of T lymphocytes in childhood immune thrombocytopenic purpura. Blood 1993; 82:2137-42.
8. Kuwana M, Kaburaki J, Ikeda Y. Autoreactive T cells to platelet GPIIb-IIIa in immune thrombocytopenic purpura. Role in production of anti-platelet autoantibody. J Clin Invest 1998; 102:1393-402.
9. Kuwana M, Kaburaki J, Kitasato H et al. Immunodominant epitopes on glycoprotein IIb-IIIa recognized by autoreactive T cells in patients with immune thrombocytopenic purpura. Blood 2001; 98:130-9.
10. Posnett DN, Gottlieb A, Bussel JB et al. T cell antigen receptors in autoimmunity. J Immunol 1988; 141:1963-9.
11. Shimomura T, Fujimura K, Takafuta T et al. Oligoclonal accumulation of T cells in peripheral blood from patients with idiopathic thrombocytopenic purpura. Br J Haematol 1996; 95:732-7.
12. Kuwana M, Kawakami Y, Ikeda Y. Suppression of autoreactive T-cell response to glycoprotein IIb/IIIa by blockade of CD40/CD154 interaction: implications for treatment of immune thrombocytopenic purpura. Blood 2003; 101:621-3.
13. Bussel JB. Overview of idiopathic thrombocytopenic purpura: new approach to refractory patients. Semin Oncol 2000; 27:91-8.
14. Armitage RJ, Fanslow WC, Strockbine L et al. Molecular and biological characterization of a murine ligand for CD40. Nature 1992; 357:80-2.
15. Even J, Lim A, Puisieux I et al. T-cell repertoires in healthy and diseased human tissues analysed by T-cell receptor beta-chain CDR3 size determination: evidence for oligoclonal expansions in tumours and inflammatory diseases. Res Immunol 1995; 146:65-80.
16. Currier JR, Deulofeut H, Barron KS, Kehn PJ, Robinson MA. Mitogens, superantigens, and nominal antigens elicit distinctive patterns of TCRB CDR3 diversity. Hum Immunol 1996; 48:39-51.
17. Zeng W, Nakao S, Takamatsu H et al. Characterization of T-cell repertoire of the bone marrow in immune-mediated aplastic anemia: evidence for the involvement of antigen-driven T-cell response in cyclosporine-dependent aplastic anemia. Blood 1999; 93:3008-16.
18. Lim A, Toubert A, Pannetier C et al. Spread of clonal T-cell expansions in rheumatoid arthritis patients. Hum Immunol 1996; 48:77-83.
19. Li Y, Sun GR, Tumang JR, Crow MK, Friedman SM. CDR3 sequence motifs shared by oligoclonal rheumatoid arthritis synovial T cells. Evidence for an antigen-driven response. J Clin Invest 1994; 94:2525-31.
20. + T cells in rheumatoid arthritis. J Clin Invest 1994; 94:2068-76.
21. Okubo M, Kurokawa M, Ohto H et al. Clonotype analysis of peripheral blood T cells and autoantigen-reactive T cells from patients with mixed connective tissue disease. J Immunol 1994; 153:3784-90.
22. Oksenberg JR, Panzara MA, Begovich AB et al. Selection for T-cell receptor V beta-D beta-J beta gene rearrangements with specificity for a myelin basic protein peptide in brain lesions of multiple sclerosis. Nature 1993; 362:68-70.
23. +T-cell population in newly diagnosed and untreated HLA-DR2 multiple sclerosis patients. Proc Natl Acad Sci USA 1996; 93:12461-6.
24. Karadimitris A, Manavalan JS, Thaler HT et al. Abnormal T-cell repertoire is consistent with immune process underlying the pathogenesis of paroxysmal nocturnal hemoglobinuria. Blood 2000; 96:2613-20.
25. Yassai M, McFarland JG, Newton-Nash D, Newman PJ, Eckels DD, Gorski J. T cell receptor and alloimmune thrombocytopenias: a model for autoimmune diseases? Ann Med Interne (Paris) 1992; 143:365-70.
26. Alatrakchi N, Farace F, Frau E, Carde P, Munck JN, Triebel F. T-cell clonal expansion in patients with B-cell lymphoproliferative disorders. J Immunother 1998; 21:363-70.
27. Gorski J, Yassai M, Zhu X et al. Circulating T cell repertoire complexity in normal individuals and bone marrow recipients analyzed by CDR3 size spectratyping. Correlation with immune status. J Immunol 1994; 152:5109-19.
28. McMillan R, Longmire RL, Yelenosky R, Donnell RL, Armstrong S. Quantitation of platelet-binding IgG produced in vitro by spleens from patients with idiopathic thrombocytopenic purpura. N Engl J Med 1974; 291:812-7.
29. Karpatkin S, Strick N, Siskind GW. Detection of splenic anti-platelet antibody synthesis in idiopathic autoimmune thrombocytopenic purpura (ATP). Br J Haematol 1972; 23:167-76.
30. Schwartz J, Leber MD, Gillis S, Giunta A, Eldor A, Bussel JB. Long term follow-up after splenectomy performed for immune thrombocytopenic purpura (ITP). Am J Hematol 2003; 72:94-8.
31. + T cells and impaired primary immune response after post-traumatic splenectomy. Br J Haematol 1999; 107:55-68.
32. +) T lymphocytes in children with immune thrombocytopenic purpura. J Clin Immunol 1994; 14:237-47.
33. Yamamoto K, Sakoda H, Nakajima T et al. Accumulation of multiple T cell clonotypes in the synovial lesions of patients with rheumatoid arthritis revealed by a novel clonality analysis. Int Immunol 1992; 4:1219-23.
34. Ruivard M, Caulier MT, Vantelon JM et al. The response to high-dose intravenous immunoglobulin or steroids is not predictive of outcome after splenectomy in adults with autoimmune thrombocytopenic purpura. Br J Haematol 1999; 105:1130-2.