Promegapoietin, a family of chimeric growth factors, supports megakaryocyte development through activation of IL-3 and c-Mpl ligand signaling pathways

Experimental Hematology

Volumn 29, Issue 10, 2001, Pages 1177-1184

  Doshi, Parul D ^a   Giri, Judith G ^a   Abegg, Ann L ^a   Favara, Jean P ^a   Huynh, Michiko S ^a   Kahn, Larry E ^a   Minnerly, John C ^a   Pegg, Lyle E ^a   Villani Price, Doreen ^a   Siegel, Ned R ^a   Staten, Nicholas R ^a   Thomas, John W ^a   McKearn, John P ^a   Smith, Walter G ^a  

^a PFIZER INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD34 ANTIGEN; CYCLIN D2; CYCLIN D3; CYTOKINE; CYTOKINE RECEPTOR; GROWTH FACTOR; IMMUNOGLOBULIN G2B; INTERLEUKIN 3 RECEPTOR; PROMEGAPOIETIN; PROMEGAPOIETIN 1; PROMEGAPOIETIN 1A; STAT3 PROTEIN; STAT5B PROTEIN; UNCLASSIFIED DRUG;

ANIMAL CELL; BINDING AFFINITY; CELL PROLIFERATION; FLOW CYTOMETRY; HEMATOPOIETIC STEM CELL; HUMAN; HUMAN CELL; IMMUNOBLOTTING; MEGAKARYOCYTE; MEGAKARYOPOIESIS; MOLECULAR CLONING; NONHUMAN; NORTHERN BLOTTING; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; REVIEW; RHESUS MONKEY; SIGNAL TRANSDUCTION; THROMBOCYTOPOIESIS;

EID: 0034805374     PISSN: 0301472X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0301-472X(01)00694-4     Document Type: Article

References (40)

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6. Human platelets display high-affinity receptors for thrombopoietin
7. The c-Mpl ligand (thrombopoietin) stimulates tyrosine phosphorylation of Jak2, Shc, and c-Mpl
8. Distinct regions of c-Mpl cytoplasmic domain are coupled to the JAK-STAT signal transduction pathway and Shc phosphorylation
9. Recombinant thrombopoietin induces rapid protein tyrosine phosphorylation of Janus kinase 2 and Shc in human blood platelets
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12. Thrombopoietin induces tyrosine phosphorylation of Stat3 and Stat5 in human blood platelets
13. Increased D-type cyclin expression together with decreased cdc2 activity confers megakaryocytic differentiation of a human thrombopoietin-dependent hematopoietic cell line
14. Thrombopoietin, the c-mpl ligand, is a major regulator of platelet production
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37. The thrombopoietin receptor can mediate proliferation without activation of the Jak-STAT pathway
38. Megakaryocyte growth and development factor and interleukin-3 induce patterns of protein-tyrosine phosphorylation that correlate with dominant differentiation over proliferation of mpl-transfected 32D cells
39. Thrombopoietin induces tyrosine phosphorylation of a common beta subunit of GM-CSF receptor and its association with Stat5 in TF-1/TPO cells
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