Alzheimer's disease: A pathogenetic autoimmune disorder caused by herpes simplex in a gene-dependent manner

International Journal of Alzheimer's Disease

Volumn , Issue , 2010, Pages

  Carter, C J ^a  

^a Polygenic Pathways   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ADAPTOR PROTEIN; ALPHA SYNUCLEIN; AMYLOID BETA PROTEIN; APOLIPOPROTEIN E4; BETA SECRETASE 1; BETA SECRETASE 2; CHOLINE ACETYLTRANSFERASE; CLUSTERIN; COMPLEMENT COMPONENT C3B RECEPTOR; GAMMA SECRETASE; GENE PRODUCT; GLYCOGEN SYNTHASE; INTERLEUKIN 2; MITOGEN ACTIVATED PROTEIN KINASE 1; PHOSPHATIDYLINOSITOL BINDING CLATHRIN ASSEMBLY PROTEIN; PRESENILIN 1; PRESENILIN 2; TAU PROTEIN; UNCLASSIFIED DRUG;

ALZHEIMER DISEASE; ANTIBODY RESPONSE; ARTICLE; AUTOIMMUNITY; GENETIC ASSOCIATION; HERPES SIMPLEX; HERPES SIMPLEX VIRUS 1; HUMAN; IMMUNOGENICITY; IMMUNOPATHOGENESIS; MOLECULAR MIMICRY; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION; SEQUENCE HOMOLOGY;

EID: 79952176117     PISSN: None     EISSN: 20900252     Source Type: Journal    
DOI: 10.4061/2010/140539     Document Type: Article

References (74)

1. Itzhaki R. F., Dobson C. B., Lin W.-R., Wozniak M. A., Association of HSV1 and apolipoprotein E- 4 in Alzheimer's disease Journa (Pubitemid 34041059)
2. Itzhaki R. F., Dobson C. B., Wozniak M. A., Hemling N., Rytt M., Rinne J., Pllnen P., Broberg E., Tapio V., Vahlberg T., Hukkanen V., Herpes simplex virus type 1 and Alzheimer's disease Annals of Neurology 2004 55 2 299 301 (Pubitemid 38167013)
3. Itzhaki R. F., Wozniak M. A., Alzheimer's disease-like changes in herpes simplex virus type 1 infected cells: the case for antiviral therapy Rejuvenation Research 2008 11 2 319 320 (Pubitemid 351601179)
4. Wozniak M. A., Itzhaki R. F., Shipley S. J., Dobson C. B., Herpes simplex virus infection causes cellular -amyloid accumulation and secretase upregulation Neuroscience Letters 2007 429 2-3 95 100 (Pubitemid 350161114)
5. Wozniak M. A., Frost A. L., Itzhaki R. F., Alzheimer's disease-specific tau phosphorylation is induced by herpes simplex virus type 1 Journal of Alzheimer's Disease 2009 16 2 341 350
6. Armien A. G., Hu S., Little M. R., Robinson N., Lokensgard J. R., Low W. C., Cheeran M. C.-J., Chronic cortical and subcortical pathology with associated neurological deficits ensuing experimental herpes encephalitis Brain Pathology 2010 20 4 738 750
7. Letenneur L., Prs K., Fleury H., Garrigue I., Barberger-Gateau P., Helmer C., Orgogozo J.-M., Gauthier S., Dartigues J.-F., Seropositivity to herpes simplex virus antibodies and risk of Alzheimer's disease: a population-based cohort study PLoS ONE 2008 3 11
8. Altschul S. F., Madden T. L., Schffer A. A., Zhang J., Zhang Z., Miller W., Lipman D. J., Gapped BLAST and PSI-BLAST: a new generation of protein database search programs Nucleic Acids Research 1997 25 17 3389 3402 (Pubitemid 27359211)
9. Larsen J. E., Lund O., Nielsen M., Improved method for predicting linear B-cell epitopes Immunome Research 2006 2, article 2
10. Nielsen M., Lundegaard C., Lund O., Kemir C., The role of the proteasome in generating cytotoxic T-cell epitopes: insights obtained from improved predictions of proteasomal cleavage Immunogenetics 2005 57 1-2 33 41 (Pubitemid 40591245)
11. Carter C. J., Herpes simplex: host viral protein interactions. WikiGenes. In press
12. Huemer H. P., Wang Y., Garred P., Koistinen V., Oppermann S., Herpes simplex virus glycoprotein C: molecular mimicry of complement regulatory proteins by a viral protein Immunology 1993 79 4 639 647 (Pubitemid 23246904)
13. Tal-Singer R., Seidel-Dugan C., Fries L., Huemer H. P., Eisenberg R. J., Cohen G. H., Friedman H. M., Herpes simplex virus glycoprotein C is a receptor for complement component iC3b Journal of Infectious Diseases 1991 164 4 750 753
14. Carter C. J., Convergence of genes implicated in Alzheimer's disease on the cerebral cholesterol shuttle: APP, cholesterol, lipoproteins, and atherosclerosis Neurochemistry International 2007 50 1 12 38 (Pubitemid 44879669)
15. Jaeger S., Pietrzik C. U., Functional role of lipoprotein receptors in Alzheimer's disease Current Alzheimer Research 2008 5 1 15 25 (Pubitemid 351536350)
16. Martins I. J., Berger T., Sharman M. J., Verdile G., Fuller S. J., Martins R. N., Cholesterol metabolism and transport in the pathogenesis of Alzheimer's disease Journal of Neurochemistry 2009 111 6 1275 1308
17. Papassotiropoulos A., Wollmer M. A., Tsolaki M., Brunner F., Molyva D., Ltjohann D., Nitsch R. M., Hock C., A cluster of cholesterol-related genes confers susceptibility for Alzheimer's disease Journal of Clinical Psychiatry 2005 66 7 940 947 (Pubitemid 41032839)
18. Campadelli-Fiume G., Mirandola P., Menotti L., Human herpesvirus 6: an emerging pathogen Emerging Infectious Diseases 1999 5 3 353 366 (Pubitemid 29289449)
19. Hammond C. J., Hallock L. R., Howanski R. J., Appelt D. M., Little C. S., Balin B. J., Immunohistological detection of Chlamydia pneumoniae in the Alzheimer's disease brain BMC Neuroscience 2010 11, article 121
20. Stein P. S., Desrosiers M., Donegan S. J., Yepes J. F., Kryscio R. J., Tooth loss, dementia and neuropathology in the Nun Study Journal of the American Dental Association 2007 138 10 1314 1322
21. Miklossy J., Khalili K., Gern L., Ericson R. L., Darekar P., Bolle L., Hurlimann J., Paster B. J., Borrelia burgdorferi persists in the brain in chronic lyme neuroborreliosis and may be associated with Alzheimer disease Journal of Alzheimer's Disease 2004 6 6 639 649 (Pubitemid 40164170)
22. Lin W. R., Wozniak M. A., Cooper R. J., Wilcock J. K., Itzhaki R. F., Herpesviruses in brain and Alzheimer's disease Journal of Pathology 2002 197 3 395 402
23. Ala T. A., Doss R. C., Sullivan C. J., Reversible dementia: a case of cryptococcal meningitis masquerading as Alzheimer's disease Journal of Alzheimer's Disease 2004 6 5 503 508 (Pubitemid 40921721)
24. Hoffmann M., Muniz J., Carroll E., De Villasante J., Cryptococcal meningitis misdiagnosed as alzheimer's disease: complete neurological and cognitive recovery with treatment Journal of Alzheimer's Disease 2009 16 3 517 520
25. Kountouras J., Boziki M., Gavalas E., Zavos C., Grigoriadis N., Deretzi G., Tzilves D., Katsinelos P., Tsolaki M., Chatzopoulos D., Venizelos I., Eradication of Helicobacter pylori may be beneficial in the management of Alzheimer's disease Journal of Neurology 2009 256 5 758 767
26. Carter C. J, Proteins of the XMRV retrovirus implicated in chronic fatigue syndrome and prostate cancer are homologous to human proteins relevant to both diseases. Nature Precedings. In press
27. Carter C. J., Extensive Viral mimicry of human proteins in AIDS, autoimmune disorders, late-onset and familial Alzheimer;s disease and other genetic diseases. Nature Precedings. In press
28. Schwab C., Akiyama H., McGeer E. G., McGeer P. L., Extracellular neurofibrillary tangles are immunopositive for the 40 carboxy-terminal sequence of -amyloid protein Journal of Neuropathology and Experimental Neurology 1998 57 12 1131 1137 (Pubitemid 28562741)
29. Haldane J. B. S., The origin of life Rationalist Annual 1988 148 3 10
30. D'Herelle F., The Bacteriophage; Its Role in Immunity 1922 Paris, France Masson et Cie
31. Khodosevich K., Lebedev Y., Sverdlov E., Endogenous retroviruses and human evolution Comparative and Functional Genomics 2002 3 6 494 498 (Pubitemid 36054271)
32. Carter C. J., Familial and late-onset Alzheimer's disease: autoimmune disorders triggered by viral, microbial and allergen mimics of beta-amyloid and APP mutants ? Nature Precedings. In press
33. Carter C. J., The human genome is composed of viral DNA: Viral homologues of the protein products cause Alzheimer's disease and others via autoimmune mechanisms. Nature Precedings. In press
34. Seabrook G. R., Rosahl T. W., Transgenic animals relevant to Alzheimer's disease Neuropharmacology 1999 38 1 1 17 (Pubitemid 29073523)
35. Senechal Y., Kelly P. H., Cryan J. F., Natt F., Dev K. K., Amyloid precursor protein knockdown by siRNA impairs spontaneous alternation in adult mice Journal of Neurochemistry 2007 102 6 1928 1940 (Pubitemid 47329267)
36. Spires T. L., Hyman B. T., Transgenic models of Alzheimer's disease: learning from animals NeuroRx 2005 2 3 423 437 (Pubitemid 41444876)
37. Zhang D.-L., Chen Y.-Q., Jiang X., Ji T.-T., Mei B., Oxidative damage increased in presenilin1/presenilin2 conditional double knockout mice Neuroscience Bulletin 2009 25 3 131 137
38. Hiltunen M., Van Groen T., Jolkkonen J., Functional roles of amyloid- protein precursor and amyloid- peptides: evidence from experimental studies Journal of Alzheimer's Disease 2009 18 2 401 412
39. Langui D., Lachapelle F., Duyckaerts C., Animal models of neurodegenerative diseases Medecine/Sciences 2007 23 2 180 186 (Pubitemid 46293864)
40. Eikelenboom P., Van Exel E., Hoozemans J. J.M., Veerhuis R., Rozemuller A. J.M., Van Gool W. A., Neuroinflammationan early event in both the history and pathogenesis of Alzheimer's disease Neurodegenerative Diseases 2010 7 13 38 41
41. Veerhuis R., Janssen I., Hack C. E., Eikelenboom P., Early complement components in Alzheimer's disease brains Acta Neuropathologica 1996 91 1 53 60
42. Veerhuis R., Janssen I., De Groot C. J. A., Van Muiswinkel F. L., Hack C. E., Eikelenboom P., Cytokines associated with amyloid plaques in Alzheimer's disease brain stimulate human glial and neuronal cell cultures to secrete early complement proteins, but not C1-inhibitor Experimental Neurology 1999 160 1 289 299
43. D'Andrea M. R., Evidence linking neuronal cell death to autoimmunity in Alzheimer's disease Brain Research 2003 982 1 19 30 (Pubitemid 37288794)
44. Veerhuis R., Van der Valk P., Janssen I., Zhan S. S., Van Nostrand W. E., Eikelenboom P., Complement activation in amyloid plaques in Alzheimer's disease brains does not proceed further than C3 Virchows Archiv 1995 426 6 603 610
45. McGeer P. L., Akiyama H., Itagaki S., McGeer E. G., Activation of the classical complement pathway in brain tissue of Alzheimer patients Neuroscience Letters 1989 107 13 341 346 (Pubitemid 20013261)
46. Itagaki S., Akiyama H., Saito H., McGeer P. L., Ultrastructural localization of complement membrane attack complex (MAC)-like immunoreactivity in brains of patients with Alzheimer's disease Brain Research 1994 645 1-2 78 84 (Pubitemid 24140113)
47. Zanjani H., Finch C. E., Kemper C., Atkinson J., McKeel D., Morris J. C., Price J. L., Complement activation in very early Alzheimer disease Alzheimer Disease and Associated Disorders 2005 19 2 55 66 (Pubitemid 41073081)
48. Rosenmann H., Grigoriadis N., Karussis D., Boimel M., Touloumi O., Ovadia H., Abramsky O., Tauopathy-like abnormalities and neurologic deficits in mice immunized with neuronal tau protein Archives of Neurology 2006 63 10 1459 1467 (Pubitemid 44547559)
49. Morelli M. A. C., DeBiasi M., DeStradis A., Tamburro A. M., An aggregating elastin-like pentapeptide Journal of Biomolecular Structure and Dynamics 1993 11 1 181 190 (Pubitemid 23275243)
50. Cribbs D. H., Azizeh B. Y., Cotman C. W., LaFerla F. M., Fibril formation and neurotoxicity by a herpes simplex virus glycoprotein B fragment with homology to the Alzheimer's A peptide Biochemistry 2000 39 20 5988 5994 (Pubitemid 30327072)
51. Schenk D., Barbour R., Dunn W., Gordon G., Grajeda H., Guldo T., Hu K., Huang J., Johnson-Wood K., Khan K., Kholodenko D., Lee M., Liao Z., Lieberburg I., Motter R., Mutter L., Soriano F., Shopp G., Vasquez N., Vandevert C., Walker S., Wogulis M., Yednock T., Games D., Seubert P., Immunization with amyloid- attenuates Alzheimer disease-like pathology in the PDAPP mouse Nature 1999 400 6740 173 177 (Pubitemid 29327547)
52. Rskam S., Neff F., Schwarting R., Bacher M., Dodel R., APP transgenic mice: the effect of active and passive immunotherapy in cognitive tasks Neuroscience and Biobehavioral Reviews 2010 34 487 499
53. Nath A., Hall E., Tuzova M., Dobbs M., Jones M., Anderson C., Woodward J., Guo Z., Fu W., Kryscio R., Wekstein D., Smith C., Markesbery W. R., Mattson M. P., Autoantibodies to amyloid -peptide (A ) are increased in Alzheimer's disease patients and A antibodies can enhance A neurotoxicity: implications for disease pathogenesis and vaccine development NeuroMolecular Medicine 2003 3 1 29 39 (Pubitemid 37070580)
54. Das P., Chapoval S., Howard V., David C. S., Golde T. E., Immune responses against A 1-42 in HLA class II transgenic mice: implications for A 1-42 immune-mediated therapies Neurobiology of Aging 2003 24 7 969 976 (Pubitemid 36962983)
55. Ferrer I., Boada Rovira M., Snchez Guerra M. L., Rey M. J., Costa-Juss F., Neuropathology and pathogenesis of encephalitis following amyloid- immunization in Alzheimer's disease Brain Pathology 2004 14 1 11 20 (Pubitemid 38200585)
56. Paul S., Planque S., Nishiyama Y., Immunological origin and functional properties of catalytic autoantibodies to amyloid peptide Journal of Clinical Immunology 2010 30 supplement 1 S43 S49
57. Taguchi H., Planque S., Sapparapu G., Boivin S., Hara M., Nishiyama Y., Paul S., Exceptional amyloid peptide hydrolyzing activity of nonphysiological immunoglobulin variable domain scaffolds Journal of Biological Chemistry 2008 283 52 36724 36733
58. Burgos J. S., Ramirez C., Sastre I., Valdivieso F., Effect of apolipoprotein E on the cerebral load of latent herpes simplex virus type 1 DNA Journal of Virology 2006 80 11 5383 5387
59. Carter C. J., Interactions between the products of the Herpes simplex genome and Alzheimer's disease susceptibility genes: relevance to pathological-signalling cascades Neurochemistry International 2008 52 6 920 934
60. Honjo K., van Reekum R., Verhoeff N. P. L. G., Alzheimer's disease and infection: do infectious agents contribute to progression of Alzheimer's disease? Alzheimer's and Dementia 2009 5 4 348 360
61. Itzhaki R., Herpes simplex virus type 1, apolipoprotein E and alzheimer's disease Herpes 2004 11 supplement 2 77A 82A
62. Itzhaki R. F., Lin W.-R., Shang D., Wilcock G. K., Faragher B., Jamieson G. A., Herpes simplex virus type 1 in brain and risk of Alzheimer's disease Lancet 1997 349 9047 241 244 (Pubitemid 27050990)
63. Itzhaki R. F., Wozniak M. A., Appelt D. M., Balin B. J., Infiltration of the brain by pathogens causes Alzheimer's disease Neurobiology of Aging 2004 25 5 619 627 (Pubitemid 38686484)
64. Kuhlmann I., Minihane A. M., Huebbe P., Nebel A., Rimbach G., Apolipoprotein e genotype and hepatitis C, HIV and herpes simplex disease risk: a literature review Lipids in Health and Disease 2010 9, article 8
65. Lin W.-R., Shang D., Itzhaki R. F., Neurotropic viruses and Alzheimer disease: interaction of herpes simplex type I virus and apolipoprotein E in the etiology of the disease Molecular and Chemical Neuropathology 1996 28 13 135 141 (Pubitemid 26275061)
66. Pyles R. B., The association of herpes simplex virus and Alzheimer's disease: a potential synthesis of genetic and environmental factors Herpes 2001 8 3 64 68
67. Wozniak M. A., Shipley S. J., Combrinck M., Wilcock G. K., Itzhaki R. F., Productive herpes simplex virus in brain of elderly normal subjects and Alzheimer's disease patients Journal of Medical Virology 2005 75 2 300 306 (Pubitemid 40053743)
68. Itzhaki R. F., Wozniak M. A., Herpes simplex virus type 1 in Alzheimer's disease: the enemy within Journal of Alzheimer's Disease 2008 13 4 393 405 (Pubitemid 352039023)
69. Mori I., Kimura Y., Naiki H., Matsubara R., Takeuchi T., Yokochi T., Nishiyama Y., Reactivation of HSV-1 in the brain of patients with familial Alzheimer's disease Journal of Medical Virology 2004 73 4 605 611 (Pubitemid 38857213)
70. Zambrano., Solis L., Salvadores N., Corts M., Lerchundi R., Otth C., Neuronal cytoskeletal dynamic modification and neurodegeneration induced by infection with herpes simplex virus type 1 Journal of Alzheimer's Disease 2008 14 3 259 269 (Pubitemid 352040042)
71. Roe C. M., Behrens M. I., Xiong C., Miller J. P., Morris J. C., Alzheimer disease and cancer Neurology 2005 64 5 895 898 (Pubitemid 40316334)
72. Roe C. M., Fitzpatrick A. L., Xiong C., Sieh W., Kuller L., Miller J. P., Williams M. M., Kopan R., Behrens M. I., Morris J. C., Cancer linked to Alzheimer disease but not vascular dementia Neurology 2010 74 2 106 112
73. Garland S. M., Smith J. S., Human papillomavirus vaccines: current status and future prospects Drugs 2010 70 9 1079 1098
74. Wagner S., Janzen R. W.C., Mohs C., Pohlmann S., Klingel R., Grtzmacher P. W., Long-term treatment of refractory myasthenia gravis with immunoadsorption Langzeitbehandlung der therapierefraktren myasthenia gravis mittels immunadsorption Deutsche Medizinische Wochenschrift 2008 133 46 2377 2382