Polynitroxylated pegylated hemoglobin: A novel neuroprotective hemoglobin for acute volume-limited fluid resuscitation after combined traumatic brain injury and hemorrhagic hypotension in mice

Critical Care Medicine

Volumn 39, Issue 3, 2011, Pages 494-505

  Shellington, David K ^a,b   Du, Lina ^a,b   Wu, Xianren ^a,b   Exo, Jennifer ^a   Vagni, Vincent ^a   Ma, Li ^b,c,d   Janesko Feldman, Keri ^a   Clark, Robert S B ^a,b   Bayir, Hülya ^a,b   Dixon, C Edward ^a,b   Jenkins, Larry W ^a,b   Hsia, Carleton J C ^b,c   Kochanek, Patrick M ^a,b  

^a UNIVERSITY OF PITTSBURGH   (United States)

^b UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^c Synzyme Technologies Inc   (United States)

^d GEORGIA SOUTHERN UNIVERSITY   (United States)

Author keywords

blast injury; blood substitute; head injury; hemoglobin based oxygen carrier; hemorrhagic shock; nitric oxide; nitroxide; oxidative stress; polyethylene glycol; polynitroxylation; polytrauma; superoxide

Indexed keywords

3 (4,5 DIMETHYL 2 THIAZOLYL) 2,5 DIPHENYLTETRAZOLIUM BROMIDE; EOSIN; GLUCOSE; GLUTAMIC ACID; GLYCINE; HEMATOXYLIN; HEMOGLOBIN; HETASTARCH; LACTATE DEHYDROGENASE; LACTIC ACID; MACROGOL; OXYGEN; POLYNITROXYLATED PEGYLATED HEMOGLOBIN; RINGER LACTATE SOLUTION; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTERIAL PRESSURE; ARTICLE; BLOOD GAS; BRAIN CELL; CONTROLLED STUDY; COW; CYTOTOXICITY; FETUS; FLUID RESUSCITATION; GLUCOSE BLOOD LEVEL; HEMORRHAGIC HYPOTENSION; HIPPOCAMPUS; IN VITRO STUDY; IN VIVO STUDY; LACTATE BLOOD LEVEL; MALE; MEAN ARTERIAL PRESSURE; MOUSE; NERVE CELL CULTURE; NERVE CELL LESION; NERVE CELL NECROSIS; NEUROPROTECTION; NEUROTOXICITY; NONHUMAN; OUTCOME ASSESSMENT; PRIORITY JOURNAL; PROSPECTIVE STUDY; RANDOMIZATION; RAT; TRAUMATIC BRAIN INJURY;

EID: 79952172406     PISSN: 00903493     EISSN: 15300293     Source Type: Journal    
DOI: 10.1097/CCM.0b013e318206b1fa     Document Type: Article

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