Polynitroxyl albumin reduces infarct size in transient focal cerebral ischemia in the rat: Potential mechanisms studied by magnetic resonance imaging

Journal of Cerebral Blood Flow and Metabolism

Volumn 18, Issue 9, 1998, Pages 1022-1031

  Beaulieu, Christian ^a,c   Busch, Elmar ^a   Röther, Joachim ^a   De Crespigny, Alexander ^a   Hsia, Carleton J C ^b   Moseley, Michael E ^a  

^a STANFORD UNIVERSITY   (United States)

^b Synzyme Technologies Inc   (United States)

^c STANFORD UNIVERSITY   (United States)

Author keywords

Albumin; Cerebral ischemia, focal; Diffusion; Magnetic resonance imaging; Nitroxide; Perfusion; Rats; Stroke

Indexed keywords

ALBUMIN; NITROXIDE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BRAIN INFARCTION; BRAIN ISCHEMIA; BRAIN PERFUSION; CONTROLLED STUDY; COVALENT BOND; DIFFUSION; MIDDLE CEREBRAL ARTERY OCCLUSION; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; PRIORITY JOURNAL; RAT; STROKE; TISSUE INJURY;

EID: 0031754206     PISSN: 0271678X     EISSN: None     Source Type: Journal    
DOI: 10.1097/00004647-199809000-00012     Document Type: Article

References (42)

1. Bederson JB, Pitts LH, Tsuji M, Nishimura MC, Davis RL, Barkowski H (1986) Rat middle cerebral artery occlusion: evaluation of the model and development of a neurological examination. Stroke 17: 472-476
2. Beit-Yannai E, Zhang R, Trembovler V, Samuni A, Shohami E (1996) Cerebroprotective effect of stable nitroxide radicals in closed head injury in the rat. Brain Res 717:22-28
3. Busch E, Gyngell ML, Eis M, Hoehn-Berlage M, Hossman KA (1996) Potassium-induced cortical spreading depressions during focal cerebral ischemia in rats: contribution to lesion growth assessed by diffusion-weighted NMR and biochemical imaging. J Cereb Blood Flow Metab 16:1090-1099
4. Butts K, Pauly JM, de Crespigny A, Moseley ME (1997) Isotropic diffusion-weighted and spiral-navigated interleaved EPI for routine imaging of acute stroke. Magn Reson Med 38:741-749
5. Folbergrová J, Zhao Q, Katsura K-I, Siesjö BK (1995) N-tert-butyl-α-phenylnitrone improves recovery of brain energy state in rats following transient focal ischemia. Proc Natl Acad Sci USA 92:5057-5061
6. Gelvan D, Saltman P, Powell SR (1991) Cardiac reperfusion damage prevented by a nitroxide free radical. Proc Natl Acad Sci 88:4680-4684
7. Hahn SM, Krishna CM, Samuni A, DeGraff W, Cuscela DO, Johnstone P, Mitchell JB (1994) Potential use of nitroxides in radiation oncology. Cancer Res 54:2006s-2010s
8. Hasegawa Y, Latour LL, Sotak CH, Dardzinski BJ, Fisher M (1994) Temperature dependent change of apparent diffusion coefficient of water in normal and ischemic brain of rats. J Cereb Blood Flow Metab 14:383-390
9. Iadecola C (1997) Bright and dark sides of nitric oxide in ischemic brain injury. Trends Neurosci 20:132-139
10. Katusic ZS (1996) Superoxide anion and endothelial regulation of arterial tone. Free Rad Biol Med 20:443-448
11. Kohno K, Hoehn-Berlage M, Mies G, Back T, Hossman KA (1995) Relationship between diffusion-weighted MR images, cerebral blood flow, and energy state in experimental brain infarction. Magn Reson Imaging 13:73-80
12. Koizumi J, Yoshida Y, Nakazawa T, Ooneda G (1986) Experimental studies of ischemic brain edema. I. A new experimental model of cerebral embolism in which recirculation can be introduced in the ischemic area. Jpn J Stroke 8:1-8
13. Konorev EA, Tarpey MM, Joseph J, Baker JE, Kalyanaraman B (1995) Nitronyl nitroxides as probes to study the mechanism of vasodilatory action of nitrovasodilators, nitrone spin traps, and nitroxides: role of nitric oxide. Free Rad Biol Med 18:169-177
14. G-nitro-L-arginine delays the development of brain injury during focal ischemia in rats. Stroke 26:282-289
15. .- or as SOD mimics? J Biol Chem 271:26026-26031
16. Krishna MC, Samuni A (1994) Nitroxides as antioxidants. Methods Enzymol 234:580-589
17. Kumar M, Liu GJ, Floyd RA, Grammas P (1996) Anoxic injury of endothelial cells increases production of nitric oxide and hydroxyl radicals. Biochem Biophys Res Commun 219:497-501
18. Kuppusamy P, Wang P, Zweier JL, Krishna MC, Mitchell JB, Ma L, Trimble CE, Hsia CJC (1996) Electron paramagnetic resonance imaging of rat heart with nitroxide and polynitroxyl albumin. Biochemistry 35:7051-7057
19. Le Bihan D, Breton E, Lallemand D, Grenier P, Cabanis E, Laval-Jeantet M (1986) MR imaging of intravoxel incoherent motions: application to diffusion and perfusion in neurologic disorders. Radiology 161:401-407
20. Lythgoe MF, Busza AL, Calamante F, Sotak CH, King MD, Bingham AC, Williams SR, Gadian DG (1997) Effect of diffusion anisotropy on lesion delineation in a rat model of cerebral ischemia. Magn Reson Med 38:662-668
21. Matsui T, Sinyama H, Asano T (1993) Beneficial effect of prolonged administration of albumin on ischemic cerebral edema and infarction after occlusion of middle cerebral artery in rats. Neurosurgery 33:293-300
22. McCord JM (1985) Oxygen-derived free radicals in postischemic tissue injury. N Engl J Med 312:159-163
23. Menzies SA, Hoff JT, Betz LA (1992) Middle cerebral artery occlusion in rats: a neurological and pathological evaluation of a reproducible model. Neurosurgery 31:100-107
24. Minematsu K, Fisher M, Li L, Sotak CH (1993) Diffusion and perfusion magnetic resonance imaging studies to evaluate a noncompetitive N-methyl-D-aspartate antagonist and reperfusion in experimental stroke in rats. Stroke 24:2074-2081
25. Minematsu K, Li L, Fisher M, Sotak CH, Davis MA, Fiandaca MS (1992) Diffusion-weighted magnetic resonance imaging: rapid and quantitative detection of focal brain ischemia. Neurology 42:235-240
26. Mitchell JB, Samuni A, Krishna MC, DeGraff WG, Ahn MS, Samuni U, Russo A (1990) Biologically active metal-independent superoxide dismutase mimics. Biochemistry 29:2802-2807
27. 2-weighted and magnetic susceptibility-enhanced MR imaging in cats. Am J Neuroradiol 11:423-429
28. Müller TB, Haraldseth O, Jones RA, Sebastiani G, Lindboe CF, Unsgård G, Øksendal AN (1995) Perfusion and diffusion-weighted MR imaging for in vivo evaluation of treatment with U74389G in a rat stroke model. Stroke 26:1453-1458
29. Nilsson UA, Olsson LI, Carlin G, Bylund-Fellenius A-C (1989) Inhibition of lipid peroxidation by spin labels: relationships between structure and function. J Biol Chem 264:11131-11135
30. Quast MJ, Huang NC, Hillman GR, Kent TA (1993) The evolution of acute stroke recorded by multimodal magnetic resonance imaging. Magn Reson Imaging 11:465-471
31. Röther J, de Crespigny AJ, D'Arceuil H, Iwai K, Moseley ME (1996a) Recovery of apparent diffusion coefficient after ischemia-induced spreading depression relates to cerebral perfusion gradient. Stroke 27:980-987
32. Röther J, de Crespigny AJ, D'Arceuil H, Moseley ME (1996b) MR detection of cortical spreading depression immediately after focal ischemia in the rat. J Cereb Blood Flow Metab 16:214-220
33. Samuni A, Godinger D, Aronovitch J, Russo A, Mitchell JB (1991a) Nitroxides block DNA scission and protect cells from oxidative damage. Biochemistry 30:555-561
34. Samuni A, Winkelsberg D, Pinson A, Hahn SM, Mitchell JB, Russo A (1991b) Nitroxide stable radicals protect beating cardiomyocytes against oxidative damage. J Clin Invest 87:1526-1530
35. Siesjo BK, Agardth CD, Bengtsson F (1989) Free radicals and brain damage. Cerebrovasc Brain Metab Rev 1:165-211
36. Sorenson AG, Buonanno FS, Gonzalez RG, et al (1996) Hyperacute stroke: evaluation with combined multisection diffusion-weighted and hemodynamically weighted echo planar MR imaging. Radiology 199:391-401
37. Takeda Y, Hashimoto H, Kosaka F, Hirakawa M, Inoue M (1993) Albumin-binding superoxide dismutase with a prolonged half-life reduces reperfusion injury. Am J Physiol 264:H1708-H1715
38. Traystman RJ, Kirsch JR, Koehler RC (1991) Oxygen radical mechanisms of brain injury following ischemia and reperfusion. J Appl Physiol 71:1185-1195
39. van Gelderen P, de Vleeschouwer MHM, DesPres D, Pekar J, van Zijl PCM, Moonen CTW (1994) Water diffusion and acute stroke. Magn Reson Med 31:154-163
40. Villringer A, Rosen BR, Belliveau JW, Ackerman JL, Lauffer RB, Buxton RB, Chao YS, Wedeen VJ, Brady TJ (1988) Dynamic imaging with lanthanide chelates in normal brain: contrast due to magnetic susceptibility effects. Magn Reson Med 6:164-174
41. Wong EC, Cox RW, Song AW (1995) Optimized isotropic diffusion weighting. Magn Reson Med 34:139-143
42. Zhao Q, Pahlmark K, Smith M-L, Siesjö BK (1994) Delayed treatment with the spin trap α-phenyl-N-tert-butyl nitrone (PBN) reduces infarct size following transient middle cerebral artery occlusion in rats. Acta Physiol Scand 152:349-350