Cell-free oxygen carriers: Scientific foundations, clinical development, and new directions

Biochimica et Biophysica Acta - Proteins and Proteomics

Volumn 1784, Issue 10, 2008, Pages 1382-1386

  Winslow, Robert M ^a,b  

^a SANGART INC   (United States)

^b UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

Author keywords

Blood substitutes; Hemoglobin; Oxygen; Oxygen carriers; Transfusion

Indexed keywords

BLOOD SUBSTITUTE; HEMOGLOBIN; HEMOGLOBIN BASED OXYGEN CARRIER; HEMOGLOBIN DERIVATIVE; HEMOSPAN; MACROGOL; NITRIC OXIDE; OXYGEN; RECOMBINANT HEMOGLOBIN; UNCLASSIFIED DRUG;

ANEMIA; ARTERIOLE; BLOOD TRANSFUSION; BRADYCARDIA; CLINICAL TRIAL; DRUG DOSE ESCALATION; DRUG EFFICACY; DRUG MECHANISM; DRUG SAFETY; GASTROINTESTINAL SYMPTOM; HUMAN; HYPERTENSION; HYPOTENSION; MICROCIRCULATION; MOLECULAR WEIGHT; NEPHROTOXICITY; NONHUMAN; OXYGEN TRANSPORT; PRIORITY JOURNAL; REVIEW; THEORETICAL STUDY; UNSPECIFIED SIDE EFFECT; VASCULAR RESISTANCE; VASOCONSTRICTION; VASODILATATION;

BLOOD SUBSTITUTES; CELL-FREE SYSTEM; CLINICAL TRIALS AS TOPIC; DRUG CARRIERS; HEMOGLOBINS; HUMANS; HYPERTENSION; KINETICS; MODELS, MOLECULAR; NITRIC OXIDE; OXYGEN; POLYETHYLENE GLYCOLS; PROTEIN CONFORMATION; REFERENCE VALUES;

EID: 52049114134     PISSN: 15709639     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bbapap.2008.04.032     Document Type: Review

References (44)

1. Winslow R.M. Blood Substitutes (2006), Elsevier, Inc., London
2. Olson J., and Maillett D. Designing recombinant hemoglobin for use as a blood substitute. In: Winslow R. (Ed). Blood Substitutes (2006), Elsevier, Inc., London 354-374
3. Rohlfs R.J., Bruner E., Chiu A., Gonzales A., Gonzales M.L., Magde D., Magde M.D.J., Vandegriff K.D., and Winslow R.M. Arterial blood pressure responses to cell-free hemoglobin solutions and the reaction with nitric oxide. J. Biol. Chem. 273 (1998) 12128
4. Page T., and Hellums J. Oxygen transport properties of hemoglobin-based oxygen carriers: studies using artificial capillaries and mathematical simulation. In: Winslow R. (Ed). Blood Substitutes (2006), Elsevier, Inc., London 72-83
5. Winslow R. Hemoglobin-Based Red Cell Substitutes (1992), Johns Hopkins University Press, Baltimore
6. Winslow R. Red cell substitutes. Sem. Hematol. 44 (2007) 51
7. Marini M., Moore G., Fishman R., Jesse R., Medina F., Snell S., and Zegna A. Reexamination of the polymerization of pyridoxylated hemoglobin with glutaraldehyde. Biopolymers 29 (1990) 871
8. 0. Biopolymers 28 (1989) 2071
9. Walder J., Zaugg R., Walder R., Steele J., and Klotz I. Diaspirins that cross-link B chains of hemoglobin: bis(3,5-dibromo salicyl) succinate and bis(3,5-dibromosalicyl) fumarate. Biochem 18 (1979) 4265
10. Macdonald V., and Winslow R. Oxygen delivery and myocardial function in rabbit hearts perfused with cell-free hemoglobin. J. Appl. Physiol. 72 (1992) 476
11. Hess J., Macdonald V., and Brinkley W. Systemic and pulmonary hypertension after resuscitation with cell-free hemoglobin. J. Appl. Physiol. 74 (1993) 1769
12. Sloan E.P., Koenigsberg M., Gens D., Cipolle M., Runge J., Mallory M.N., and Rodman Jr. G. Diaspirin cross-linked hemoglobin (DCLHb) in the treatment of severe traumatic hemorrhagic shock. A randomized controlled efficacy trial. JAMA 282 (1999) 1857
13. Saxena R., Wijnhoud A.D., Carton H., Hacke W., Kaste M., Przybelski R.J., Stern K.N., and Koudstaal P.J. Controlled safety study of a hemoglobin-based oxygen carrier, DCLHb, in acute ischemic stroke. Stroke 30 (1999) 993
14. Raat N.J. Effects of recombinant hemoglobin solutions rHb2.0 and rHb1.1 on blood pressure, intestinal blood flow and gut oxygenation in a rat model of hemorrhagic shock. J. Lab. Clin. Med. 146 (2005) 304
15. Gibson Q.H., and Roughton F.J.W. The kinetics and equilibria of the reactions of nitric oxide with sheep hemoglobin. J. Appl. Physiol. 136 (1956) 123
16. Doherty D.H., Doyle M.P., Curry S.R., Vali R.J., Fattor T.J., Olson J.S., and Lemon D.D. Rate of reaction with nitric oxide determines the hypertensive effect of cell-free hemoglobin. Nat. Biotechnol. 16 (1998) 672
17. Winslow R.M., Gonzales A., Gonzales M., Magde M., McCarthy M., Rohlfs R.J., and Vandegriff K.D. Vascular resistance and the efficacy of red cell substitutes in a rat hemorrhage model. J. Appl. Physiol. 85 (1998) 993
18. McCarthy M.R., Vandegriff K.D., and Winslow R.M. The role of facilitated diffusion in oxygen transport by cell-free hemoglobins: implications for the design of hemoglobin-based oxygen carriers. Biophys. Chem. 92 (2001) 103
19. Vandegriff K.D. The role of oxygen and hemoglobin diffusion in oxygen transport by cell-free hemoglobins. In: Winslow R. (Ed). Blood Substitutes (2006), Elsevier, Inc., London 60-71
20. Acharya S.A., and Manjula B. Surface decoration of hemoglobin with polyethylene glycol. In: Winslow R. (Ed). Blood Substitutes (2006), Elsevier, Inc., London 460-469
21. Vandegriff K.D., Malavalli A., Wooldridge J., Lohman J., and Winslow R.M. MP4, a new nonvasoactive PEG-Hb conjugate. Transfusion 43 (2003) 509
22. Svergun D.I., Ekstrom F., Vandegriff K.D., Malavalli A., Baker D.A., Nilsson C., and Winslow R.M. Solution structure of poly(ethylene) glycol-conjugated hemoglobin revealed by small-angle X-ray scattering: implications for a new oxygen therapeutic. Biophys. J. 94 (2008) 173
23. Vandegriff K.D., Malavalli A., Mann C., Jiang E., Lohman J., Young M.A., Samaja M., and Winslow R.M. Oxidation and haem loss kinetics of poly(ethylene gycol)-conjugated hemoglobin (MP4): dissociation between in vitro and in vivo oxidation rates. Biochem. J. 399 (2006) 463
24. 2 binding to MP4, a polyethylene glycol conjugated hemoglobin. Biochem. J. 382 (2004) 183
25. Drobin D., Kjellström B., Malm E., Malavalli A., Lohman J., Vandegriff K., Young M., and Winslow R. Hemodynamic response and oxygen transport in pigs resuscitated with maleimide-polyethylene glycol-modified hemoglobin (MP4). J. Appl. Physiol. 96 (2004) 1843
26. Young M., Riddez L., Kjellström T., Bursell J., Winslow F., Lohman J., and Winslow R. MalPEG-hemoglobin (MP4) improves hemodynamics, acid-base status, and survival after uncontrolled hemorrhage in anesthetized swine. Crit. Care Med. 33 (2005) 1794
27. Young M.A., Riddez L., Kjellström B.T., and Winslow R.M. Effect of MalPEG-hemoglobin (MP4) on hemodynamics and acid-base status after uncontrolled hemorrhage in anesthetized swine: Comparison with crystalloid and blood. J. Trauma 63 (2007) 1234
28. Young M.A., Malavalli A., Winslow N., Vandergriff K.D., and Winslow R.M. Toxicity and hemodynamic effects after single dose administration of MalPEG-hemoglobin (MP4) in rhesus monkeys. Transl. Res. 149 (2007) 333
29. Björkholm M., Fagrell B., Przybelski R., Winslow N., Young M., and Winslow R. A phase I single blind clinical trial of a new oxygen transport agent (MP4), human hemoglobin modified with maleimide-activated polyethylene glycol. Haematologica 90 (2005) 505
30. Olofsson C., Nygards E., Ponzer S., Fagrell B., Przybelski R., Keipert P., Winslow N., and Winslow R. A randomized, single blind, increasing dose safety trial of an oxygen-carrying plasma expander (Hemospan® administered to orthopedic surgery patients with spinal anesthesia. Transfus. Med. 18 (2008) 28
31. Olofsson C., Ahl T., Johansson T., Larsson S., Nellgård P., Ponzer S., Fagrell B., Przybelski R., Keipert P., Winslow N., and Winslow R. A multi-center clinical study of the safety and activity of maleimide-polyethylene glycol hemoglobin (Hemospan®) in patients undergoing major orthopedic surgery. Anesthesiology 105 (2006) 1153
32. Silverman T., Aebersold P., Landow L., and Lindsey K. Regulatory perspectives on clinical trials for oxygen therapeutics in trauma and transfusion practice. In: Winslow R. (Ed). Blood Substitutes (2006), Elsevier, Inc., London 34-41
33. Klein H. Transfusion medicine. In: Winslow R. (Ed). Blood Substitutes (2006), Elsevier, Inc., London 17-33
34. Stehling L., and Simon T. The red blood cell transfusion trigger. Physiology and clinical studies. Arch. Pathol. Lab. Med. 118 (1994) 429
35. Tsai A., Cabrales P., Winslow R., and Intagliatta M. Microvascular oxygen distribution in the awake hamster window chamber model during hyperoxia. Am. J. Physiol. 285 (2003) H1537-H1545
36. Kunert M., Liard J., Lombard J., and Abraham D. Low Affinity Hemoglobin Increases Tissue PO2 and Decreases Arteriolar Diameter and Flow in the Rat Cremaster Muscle (1995) p.23
37. Winslow R. Oxygen transport agents: a new approach to red blood cell alternatives. TATM 5 (2004) 498
38. Wittenberg J.B., and Wittenberg B.A. Myoglobin function reassessed. J. Exp. Biol. 206 (2003) 2011
39. Cole R.H., Vandegriff K.D., Szeri A.J., Savas Ö., Baker D.A., and Winslow R.M. A quantitative framework for the design of acellular hemoglobins as blood substitutes: implications of dynamic flow conditions. Biophys. Chem. 128 (2007) 63
40. 2 measurements by phosphorescence decay method. Am. J. Physiol. 265 (1993) H1434-H1438
41. Intaglietta M., Johnson P., and Winslow R. Microvascular and tissue oxygen distribution. Cardiovasc. Res. 32 (1996) 632
42. 2 therapeutics. Am. J. Physiol. 285 (2003) H1411-H1419
43. Tsai A.G., Cabrales P., Acharya S., Manjula B.N., Winslow R.M., and Intaglietta M. Dissociation of local nitric oxide concentration and vasoconstriction in the presence of cell-free hemoglobin oxygen carriers. Blood 108 (2006) 3603
44. Nagababu E., Ramasamy S., Rifkind J.M., and Alayash A.I. Site-specific crosslinking of human and bovine hemoglobins differentially alters oxygen binding and redox side reactions producing rhombic heme and heme degradation. Biochemistry 41 (2002) 7407