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Volumn 2, Issue 9, 2010, Pages 1844-1866

Increasing the efficacy of oncolytic adenovirus vectors

Author keywords

Adenovirus; Replication competent; Tumor; Virotherapy

Indexed keywords

ADENOVIRUS VECTOR; ANTINEOPLASTIC AGENT; CYTOSINE DEAMINASE; ENDOSTATIN; FLUOROURACIL; FOLINIC ACID; HYPERIMMUNE GLOBULIN; ICOVIR 7; KD 3; LIPOSOME; MACROGOL; NEUTRALIZING ANTIBODY; NITROREDUCTASE; ONCOLYTIC ADENOVIRUS; ONCOLYTIC VIRUS; ONCORINE; ONYX 015; POLY[N (2 HYDROXYPROPYL)METHACRYLAMIDE]; PRODRUG; PROSTATE SPECIFIC ANTIGEN; THYMIDINE KINASE; UNCLASSIFIED DRUG; VASCULOTROPIN INHIBITOR; VIROTHERAPY AGENT; VRX 007;

EID: 79952151242     PISSN: None     EISSN: 19994915     Source Type: Journal    
DOI: 10.3390/v2091844     Document Type: Review
Times cited : (39)

References (141)
  • 1
    • 76949084531 scopus 로고    scopus 로고
    • Oncolytic (replication-competent) adenoviruses as anticancer agents
    • Toth, K.; Dhar, D.; Wold, W.S. Oncolytic (replication-competent) adenoviruses as anticancer agents. Exp. Opin. Biol. Ther. 2010, 10, 353-368.
    • (2010) Exp. Opin. Biol. Ther , vol.10 , pp. 353-368
    • Toth, K.1    Dhar, D.2    Wold, W.S.3
  • 2
    • 43449125456 scopus 로고    scopus 로고
    • Adenoviruses
    • 5th Edition; Knipe D.M., Howley P.M., Eds.; Lippincott, Williams, & Wilkins, Philadelphia, PA, USA
    • Wold, W.S.M.; Horwitz, M.S. Adenoviruses. In Field's Virology, 5th Edition; Knipe D.M., Howley P.M., Eds.; Lippincott, Williams, & Wilkins, Philadelphia, PA, USA. 2007; pp. 2395-2436.
    • (2007) Field's Virology , pp. 2395-2436
    • Wold, W.S.M.1    Horwitz, M.S.2
  • 3
    • 10444271098 scopus 로고    scopus 로고
    • Experimental infections of humans with wild-type adenoviruses and with replication-competent adenovirus vectors: Replication, safety, and transmission
    • Lichtenstein, D.L.; Wold, W.S.M. Experimental infections of humans with wild-type adenoviruses and with replication-competent adenovirus vectors: replication, safety, and transmission. Cancer Gene Ther. 2004, 11, 819-829.
    • (2004) Cancer Gene Ther , vol.11 , pp. 819-829
    • Lichtenstein, D.L.1    Wold, W.S.M.2
  • 4
    • 34447539077 scopus 로고    scopus 로고
    • Adenoviridae: The Viruses and Their Replication
    • 5th Edition; Knipe D.M., Howley P.M., Eds.; Lippincott, Williams, & Wilkins, Philadelphia, PA, USA
    • Berk, A.J. Adenoviridae: The Viruses and Their Replication. In Field's Virology, 5th Edition; Knipe D.M., Howley P.M., Eds.; Lippincott, Williams, & Wilkins, Philadelphia, PA, USA. 2007; pp. 2355-2394.
    • (2007) Field's Virology , pp. 2355-2394
    • Berk, A.J.1
  • 5
    • 59849102099 scopus 로고    scopus 로고
    • Adenoviruses: Update on structure and function
    • Russell, W.C. Adenoviruses: update on structure and function. J. Gen. Virol 2009, 90, 1-20.
    • (2009) J. Gen. Virol , vol.90 , pp. 1-20
    • Russell, W.C.1
  • 6
    • 0028559768 scopus 로고
    • An efficient and flexible system for construction of adenovirus vectors with insertions or deletions in early regions 1 and 3
    • Bett, A.J.; Haddara, W.; Prevec, L.; Graham, F.L. An efficient and flexible system for construction of adenovirus vectors with insertions or deletions in early regions 1 and 3. Proc. Natl. Acad. Sci. U. S. A. 1994, 91, 8802-8806.
    • (1994) Proc. Natl. Acad. Sci. U. S. A , vol.91 , pp. 8802-8806
    • Bett, A.J.1    Haddara, W.2    Prevec, L.3    Graham, F.L.4
  • 8
    • 27944502157 scopus 로고    scopus 로고
    • Viruses - seeking and destroying the tumor program
    • O'Shea, C.C. Viruses - seeking and destroying the tumor program. Oncogene 2005, 24, 7640-7655
    • (2005) Oncogene , vol.24 , pp. 7640-7655
    • O'Shea, C.C.1
  • 10
    • 0033665576 scopus 로고    scopus 로고
    • Efficacy of a replication-selective adenovirus against ovarian carcinomatosis is dependent on tumor burden, viral replication and p53 status
    • Heise, C.; Ganly, I.; Kim, Y.T.; Sampson-Johannes, A.; Brown, R.; Kirn, D. Efficacy of a replication-selective adenovirus against ovarian carcinomatosis is dependent on tumor burden, viral replication and p53 status. Gene Ther. 2000, 7, 1925-1929.
    • (2000) Gene Ther , vol.7 , pp. 1925-1929
    • Heise, C.1    Ganly, I.2    Kim, Y.T.3    Sampson-Johannes, A.4    Brown, R.5    Kirn, D.6
  • 11
    • 0033152894 scopus 로고    scopus 로고
    • Intravenous administration of ONYX-015, a selectively replicating adenovirus, induces antitumoral efficacy
    • Heise, C.C.; Williams, A.M.; Xue, S.; Propst, M.; Kirn, D.H. Intravenous administration of ONYX-015, a selectively replicating adenovirus, induces antitumoral efficacy. Cancer Res. 1999, 59, 2623-2628.
    • (1999) Cancer Res , vol.59 , pp. 2623-2628
    • Heise, C.C.1    Williams, A.M.2    Xue, S.3    Propst, M.4    Kirn, D.H.5
  • 12
    • 70449657531 scopus 로고    scopus 로고
    • New pancreatic carcinoma model for studying oncolytic adenoviruses in the permissive Syrian hamster
    • Spencer, J.F.; Sagartz, J.E.; Wold, W.S.M.; Toth, K. New pancreatic carcinoma model for studying oncolytic adenoviruses in the permissive Syrian hamster. Cancer Gene Ther. 2009, 16, 912-922.
    • (2009) Cancer Gene Ther , vol.16 , pp. 912-922
    • Spencer, J.F.1    Sagartz, J.E.2    Wold, W.S.M.3    Toth, K.4
  • 13
  • 15
    • 45849105224 scopus 로고    scopus 로고
    • Virotherapy as an approach against cancer stem cells
    • Ribacka, C.; Hemminki, A. Virotherapy as an approach against cancer stem cells. Current Gene Ther. 2008, 8, 88-96.
    • (2008) Current Gene Ther , vol.8 , pp. 88-96
    • Ribacka, C.1    Hemminki, A.2
  • 17
    • 73449142495 scopus 로고    scopus 로고
    • Oncolytic adenovirus: Preclinical and clinical studies in patients with human malignant gliomas
    • Jiang, H.; Gomez-Manzano, C.; Lang, F.F.; Alemany, R.; Fueyo, J. Oncolytic adenovirus: preclinical and clinical studies in patients with human malignant gliomas. Current Gene Ther. 2009, 9, 422-427.
    • (2009) Current Gene Ther , vol.9 , pp. 422-427
    • Jiang, H.1    Gomez-Manzano, C.2    Lang, F.F.3    Alemany, R.4    Fueyo, J.5
  • 18
    • 67650309264 scopus 로고    scopus 로고
    • Designing adenoviral vectors for tumor-specific targeting
    • Alemany, R. Designing adenoviral vectors for tumor-specific targeting. Methods Mol. Biol. 2009, 542, 57-74.
    • (2009) Methods Mol. Biol , vol.542 , pp. 57-74
    • Alemany, R.1
  • 19
    • 0033022039 scopus 로고    scopus 로고
    • Independent and -dependent requirements for E1B-55K in adenovirus type 5 replication
    • Harada, J.N.; Berk, A.J. p53-independent and -dependent requirements for E1B-55K in adenovirus type 5 replication. J. Virol. 1999, 73, 5333-5344.
    • (1999) J. Virol , vol.73 , pp. 5333-5344
    • Harada, J.N.1    Berk, A.J.2
  • 21
    • 22244479672 scopus 로고    scopus 로고
    • Heat shock phenocopies E1B-55K late functions and selectively sensitizes refractory tumor cells to ONYX-015 oncolytic viral therapy
    • O'Shea, C.C.; Soria, C.; Bagus, B.; McCormick, F. Heat shock phenocopies E1B-55K late functions and selectively sensitizes refractory tumor cells to ONYX-015 oncolytic viral therapy. Cancer Cell 2005, 8, 61-74.
    • (2005) Cancer Cell , vol.8 , pp. 61-74
    • O'Shea, C.C.1    Soria, C.2    Bagus, B.3    McCormick, F.4
  • 22
    • 0030917202 scopus 로고    scopus 로고
    • ONYX-015, an E1B gene-attenuated adenovirus, causes tumor-specific cytolysis and antitumoral efficacy that can be augmented by standard chemotherapeutic agents
    • Heise, C.; Sampson-Johannes, A.; Williams, A.; McCormick, F.; Von Hoff, D.D.; Kirn, D.H. ONYX-015, an E1B gene-attenuated adenovirus, causes tumor-specific cytolysis and antitumoral efficacy that can be augmented by standard chemotherapeutic agents. Nature Med. 1997, 3, 639-645.
    • (1997) Nature Med , vol.3 , pp. 639-645
    • Heise, C.1    Sampson-Johannes, A.2    Williams, A.3    McCormick, F.4    von Hoff, D.D.5    Kirn, D.H.6
  • 23
    • 0033218746 scopus 로고    scopus 로고
    • Efficacy of a replication-competent adenovirus (ONYX-015) following intratumoral injection: Intratumoral spread and distribution effects
    • Heise, C.C.; Williams, A.; Olesch, J.; Kirn, D.H. Efficacy of a replication-competent adenovirus (ONYX-015) following intratumoral injection: intratumoral spread and distribution effects. Cancer Gene Ther. 1999, 6, 499-504.
    • (1999) Cancer Gene Ther , vol.6 , pp. 499-504
    • Heise, C.C.1    Williams, A.2    Olesch, J.3    Kirn, D.H.4
  • 24
    • 38949207486 scopus 로고    scopus 로고
    • Adenovirus vector induced innate immune responses: Impact upon efficacy and toxicity in gene therapy and vaccine applications
    • Hartman, Z.C.; Appledorn, D.M.; Amalfitano, A. Adenovirus vector induced innate immune responses: impact upon efficacy and toxicity in gene therapy and vaccine applications. Virus Res. 2008, 132, 1-14.
    • (2008) Virus Res , vol.132 , pp. 1-14
    • Hartman, Z.C.1    Appledorn, D.M.2    Amalfitano, A.3
  • 25
    • 32944474223 scopus 로고    scopus 로고
    • Syrian hamster as a permissive immunocompetent animal model for the study of oncolytic adenovirus vectors
    • Thomas, M.A.; Spencer, J.F.; La Regina, M.C.; Dhar, D.; Tollefson, A.E.; Toth, K.; Wold, W.S. Syrian hamster as a permissive immunocompetent animal model for the study of oncolytic adenovirus vectors. Cancer Res. 2006, 66, 1270-1276.
    • (2006) Cancer Res , vol.66 , pp. 1270-1276
    • Thomas, M.A.1    Spencer, J.F.2    la Regina, M.C.3    Dhar, D.4    Tollefson, A.E.5    Toth, K.6    Wold, W.S.7
  • 27
    • 62549149856 scopus 로고    scopus 로고
    • Biodistribution of an oncolytic adenovirus after intracranial injection in permissive animals: A comparative study of Syrian hamsters and cotton rats
    • Sonabend, A.M.; Ulasov, I.V.; Han, Y.; Rolle, C.E.; Nandi, S.; Cao, D.; Tyler, M.A.; Lesniak, M.S. Biodistribution of an oncolytic adenovirus after intracranial injection in permissive animals: a comparative study of Syrian hamsters and cotton rats. Cancer Gene Ther. 2008, 16, 362-372.
    • (2008) Cancer Gene Ther , vol.16 , pp. 362-372
    • Sonabend, A.M.1    Ulasov, I.V.2    Han, Y.3    Rolle, C.E.4    Nandi, S.5    Cao, D.6    Tyler, M.A.7    Lesniak, M.S.8
  • 28
    • 54749109597 scopus 로고    scopus 로고
    • Immunosuppression enhances oncolytic adenovirus replication and anti tumor efficacy in the Syrian hamster model
    • Thomas, M.A.; Spencer, J.F.; Toth, K.; Sagartz, J.E.; Phillips, N.; Wold, W.S.M. Immunosuppression enhances oncolytic adenovirus replication and anti tumor efficacy in the Syrian hamster model. Mol. Ther. 2008, 16, 1665-1673.
    • (2008) Mol. Ther , vol.16 , pp. 1665-1673
    • Thomas, M.A.1    Spencer, J.F.2    Toth, K.3    Sagartz, J.E.4    Phillips, N.5    Wold, W.S.M.6
  • 30
    • 44449121495 scopus 로고    scopus 로고
    • Hexadecyloxypropyl-cidofovir, CMX001, prevents adenovirus-induced mortality in a permissive, immunosuppressed animal model
    • Toth, K.; Spencer, J.F.; Dhar, D.; Sagartz, J.E.; Buller, R.M.; Painter, G.R.; Wold, W.S.M. Hexadecyloxypropyl-cidofovir, CMX001, prevents adenovirus-induced mortality in a permissive, immunosuppressed animal model. Proc. Natl. Acad. Sci. U. S. A. 2008, 105, 7293-7297.
    • (2008) Proc. Natl. Acad. Sci. U. S. A , vol.105 , pp. 7293-7297
    • Toth, K.1    Spencer, J.F.2    Dhar, D.3    Sagartz, J.E.4    Buller, R.M.5    Painter, G.R.6    Wold, W.S.M.7
  • 31
    • 49249131785 scopus 로고    scopus 로고
    • Virus combinations and chemotherapy for the treatment of human cancers
    • Kumar, S.; Gao, L.; Yeagy, B.; Reid, T. Virus combinations and chemotherapy for the treatment of human cancers. Curr. Opin. Mol. Ther. 2008, 10, 371-379.
    • (2008) Curr. Opin. Mol. Ther , vol.10 , pp. 371-379
    • Kumar, S.1    Gao, L.2    Yeagy, B.3    Reid, T.4
  • 32
    • 33847319116 scopus 로고    scopus 로고
    • Cancer selective adenoviruses
    • Alemany, R. Cancer selective adenoviruses. Mol. Aspects Med. 2007, 28, 42-58.
    • (2007) Mol. Aspects Med , vol.28 , pp. 42-58
    • Alemany, R.1
  • 33
    • 33847370331 scopus 로고    scopus 로고
    • From ONYX-015 to armed vaccinia viruses: The education and evolution of oncolytic virus development
    • Crompton, A.M.; Kirn, D.H. From ONYX-015 to armed vaccinia viruses: the education and evolution of oncolytic virus development. Curr. Cancer Drug Targets 2007, 7, 133-139.
    • (2007) Curr. Cancer Drug Targets , vol.7 , pp. 133-139
    • Crompton, A.M.1    Kirn, D.H.2
  • 34
    • 10244253939 scopus 로고    scopus 로고
    • Intra-tumor injection of H101, a recombinant adenovirus, in combination with chemotherapy in patients with advanced cancers: A pilot phase II clinical trial
    • Lu, W.; Zheng, S.; Li, X.F.; Huang, J.J.; Zheng, X.; Li, Z. Intra-tumor injection of H101, a recombinant adenovirus, in combination with chemotherapy in patients with advanced cancers: a pilot phase II clinical trial. World J. Gastroenterol. 2004, 10, 3634-3638.
    • (2004) World J. Gastroenterol , vol.10 , pp. 3634-3638
    • Lu, W.1    Zheng, S.2    Li, X.F.3    Huang, J.J.4    Zheng, X.5    Li, Z.6
  • 35
    • 33847389767 scopus 로고    scopus 로고
    • Clinical trials with oncolytic adenovirus in China
    • Yu, W.; Fang, H. Clinical trials with oncolytic adenovirus in China. Current Cancer Drug Targets 2007, 7, 141-148.
    • (2007) Current Cancer Drug Targets , vol.7 , pp. 141-148
    • Yu, W.1    Fang, H.2
  • 36
    • 32344443105 scopus 로고    scopus 로고
    • China offers alternative gateway for experimental drugs
    • Jia, H.; Kling, J. China offers alternative gateway for experimental drugs. Nat. Biotechnol. 2006, 24, 117-118.
    • (2006) Nat. Biotechnol , vol.24 , pp. 117-118
    • Jia, H.1    Kling, J.2
  • 37
    • 33644852717 scopus 로고    scopus 로고
    • China approves world's first oncolytic virus therapy for cancer treatment
    • Garber, K. China approves world's first oncolytic virus therapy for cancer treatment. J. Natl. Cancer Inst. 2006, 98, 298-300.
    • (2006) J. Natl. Cancer Inst , vol.98 , pp. 298-300
    • Garber, K.1
  • 39
    • 0035177690 scopus 로고    scopus 로고
    • Intra-arterial administration of a replication-selective adenovirus (dl1520) in patients with colorectal carcinoma metastatic to the liver: A phase I trial
    • Reid, T.; Galanis, E.; Abbruzzese, J.; Sze, D.; Andrews, J.; Romel, L.; Hatfield, M.; Rubin, J.; Kirn, D. Intra-arterial administration of a replication-selective adenovirus (dl1520) in patients with colorectal carcinoma metastatic to the liver: a phase I trial. Gene Ther. 2001, 8, 1618-1626.
    • (2001) Gene Ther , vol.8 , pp. 1618-1626
    • Reid, T.1    Galanis, E.2    Abbruzzese, J.3    Sze, D.4    Andrews, J.5    Romel, L.6    Hatfield, M.7    Rubin, J.8    Kirn, D.9
  • 40
    • 22944476168 scopus 로고    scopus 로고
    • Effects of Onyx-015 among metastatic colorectal cancer patients that have failed prior treatment with 5-FU/leucovorin
    • Reid, T.R.; Freeman, S.; Post, L.; McCormick, F.; Sze, D.Y. Effects of Onyx-015 among metastatic colorectal cancer patients that have failed prior treatment with 5-FU/leucovorin. Cancer Gene Ther. 2005, 12, 673-681.
    • (2005) Cancer Gene Ther , vol.12 , pp. 673-681
    • Reid, T.R.1    Freeman, S.2    Post, L.3    McCormick, F.4    Sze, D.Y.5
  • 41
  • 42
    • 33846198764 scopus 로고    scopus 로고
    • Minimal hepatic toxicity of Onyx-015: Spatial restriction of coxsackie-adenoviral receptor in normal liver
    • Au, T.; Thorne, S.; Korn, W.M.; Sze, D.; Kirn, D.; Reid, T.R. Minimal hepatic toxicity of Onyx-015: spatial restriction of coxsackie-adenoviral receptor in normal liver. Cancer Gene Ther. 2007, 14, 139-150.
    • (2007) Cancer Gene Ther , vol.14 , pp. 139-150
    • Au, T.1    Thorne, S.2    Korn, W.M.3    Sze, D.4    Kirn, D.5    Reid, T.R.6
  • 44
    • 34249279186 scopus 로고    scopus 로고
    • Prostate cancer gene therapy clinical trials
    • Freytag, S.O.; Stricker, H.; Movsas, B.; Kim, J.H. Prostate cancer gene therapy clinical trials. Mol. Ther. 2007, 15, 1042-1052.
    • (2007) Mol. Ther , vol.15 , pp. 1042-1052
    • Freytag, S.O.1    Stricker, H.2    Movsas, B.3    Kim, J.H.4
  • 46
    • 10744227813 scopus 로고    scopus 로고
    • Phase I study of replication-competent adenovirus-mediated double-suicide gene therapy in combination with conventional-dose three-dimensional conformal radiation therapy for the treatment of newly diagnosed, intermediate- to high-risk prostate cancer
    • Freytag, S.O.; Stricker, H.; Pegg, J.; Paielli, D.; Pradhan, D.G.; Peabody, J.; DePeralta-Venturina, M.; Xia, X.; Brown, S.; Lu, M.; Kim, J.H. Phase I study of replication-competent adenovirus-mediated double-suicide gene therapy in combination with conventional-dose three-dimensional conformal radiation therapy for the treatment of newly diagnosed, intermediate- to high-risk prostate cancer. Cancer Res. 2003, 63, 7497-7506.
    • (2003) Cancer Res , vol.63 , pp. 7497-7506
    • Freytag, S.O.1    Stricker, H.2    Pegg, J.3    Paielli, D.4    Pradhan, D.G.5    Peabody, J.6    Deperalta-Venturina, M.7    Xia, X.8    Brown, S.9    Lu, M.10    Kim, J.H.11
  • 47
    • 33847212832 scopus 로고    scopus 로고
    • Five-year follow-up of trial of replication-competent adenovirus-mediated suicide gene therapy for treatment of prostate cancer
    • Freytag, S.O.; Stricker, H.; Peabody, J.; Pegg, J.; Paielli, D.; Movsas, B.; Barton, K.N.; Brown, S.L.; Lu, M.; Kim, J.H. Five-year follow-up of trial of replication-competent adenovirus-mediated suicide gene therapy for treatment of prostate cancer. Mol. Ther. 2007, 15, 636-642.
    • (2007) Mol. Ther , vol.15 , pp. 636-642
    • Freytag, S.O.1    Stricker, H.2    Peabody, J.3    Pegg, J.4    Paielli, D.5    Movsas, B.6    Barton, K.N.7    Brown, S.L.8    Lu, M.9    Kim, J.H.10
  • 48
    • 0142058604 scopus 로고    scopus 로고
    • A Phase I/II dose escalation trial of the intra prostatic injection of CG7870, a prostate specific antigen-dependent oncolytic adenovirus in patients with locally recurrent prostate cancer following definitive radiotherapy
    • DeWeese, T.; Arterbery, E.; Michalski, J.; Sylvester, J.E.; Terris, M.K.; Wilding, G.; Yu, D.C.; Moore, L.; Kimball, L.; Ando, D.; Kirn, D. A Phase I/II dose escalation trial of the intra prostatic injection of CG7870, a prostate specific antigen-dependent oncolytic adenovirus in patients with locally recurrent prostate cancer following definitive radiotherapy. Cancer Gene Ther. 2003, 10, S13-S14.
    • (2003) Cancer Gene Ther , vol.10
    • Deweese, T.1    Arterbery, E.2    Michalski, J.3    Sylvester, J.E.4    Terris, M.K.5    Wilding, G.6    Yu, D.C.7    Moore, L.8    Kimball, L.9    Ando, D.10    Kirn, D.11
  • 50
    • 33745161873 scopus 로고    scopus 로고
    • Phase I trial of intravenous CG7870, a replication-selective, prostate-specific antigen-targeted oncolytic adenovirus, for the treatment of hormone-refractory, metastatic prostate cancer
    • Small, E.J.; Carducci, M.A.; Burke, J.M.; Rodriguez, R.; Fong, L.; van Ummersen, L.; Yu, D.C.; Aimi, J.; Ando, D.; Working, P.; Kirn, D.; Wilding, G. A phase I trial of intravenous CG7870, a replication-selective, prostate-specific antigen-targeted oncolytic adenovirus, for the treatment of hormone-refractory, metastatic prostate cancer. Mol. Ther. 2006, 14, 107-117.
    • (2006) Mol. Ther , vol.14 , pp. 107-117
    • Small, E.J.1    Carducci, M.A.2    Burke, J.M.3    Rodriguez, R.4    Fong, L.5    van Ummersen, L.6    Yu, D.C.7    Aimi, J.8    Ando, D.9    Working, P.10    Kirn, D.11    Wilding, G.A.12
  • 56
    • 0037457032 scopus 로고    scopus 로고
    • Intratumoral spread of wild-type adenovirus is limited after local injection of human xenograft tumors: Virus persists and spreads systemically at late time points
    • Sauthoff, H.; Hu, J.; Maca, C.; Goldman, M.; Heitner, S.; Yee, H.; Pipiya, T.; Rom, W.N.; Hay, J.G. Intratumoral spread of wild-type adenovirus is limited after local injection of human xenograft tumors: virus persists and spreads systemically at late time points. Hum. Gene Ther. 2003, 14, 425-433.
    • (2003) Hum. Gene Ther , vol.14 , pp. 425-433
    • Sauthoff, H.1    Hu, J.2    Maca, C.3    Goldman, M.4    Heitner, S.5    Yee, H.6    Pipiya, T.7    Rom, W.N.8    Hay, J.G.9
  • 58
    • 55349119141 scopus 로고    scopus 로고
    • Bioselection of a Gain of Function Mutation that Enhances Adenovirus 5 Release and Improves Its Antitumoral Potency
    • Gros, A.; Martinez-Quintanilla, J.; Puig, C.; Guedan, S.; Mollevi, D.G.; Alemany, R.; Cascallo, M. Bioselection of a Gain of Function Mutation that Enhances Adenovirus 5 Release and Improves Its Antitumoral Potency. Cancer Res. 2008, 68, 8928-8937.
    • (2008) Cancer Res , vol.68 , pp. 8928-8937
    • Gros, A.1    Martinez-Quintanilla, J.2    Puig, C.3    Guedan, S.4    Mollevi, D.G.5    Alemany, R.6    Cascallo, M.7
  • 59
    • 32444433144 scopus 로고    scopus 로고
    • Genetic identification of adenovirus type 5 genes that influence viral spread
    • Subramanian, T.; Vijayalingam, S.; Chinnadurai, G. Genetic identification of adenovirus type 5 genes that influence viral spread. J. Virol. 2006, 80, 2000-2012.
    • (2006) J. Virol , vol.80 , pp. 2000-2012
    • Subramanian, T.1    Vijayalingam, S.2    Chinnadurai, G.3
  • 61
    • 22944490239 scopus 로고    scopus 로고
    • Inefficient killing of quiescent human epithelial cells by replicating adenoviruses: Potential implications for their use as oncolytic agents
    • Vaillancourt, M.; Atencio, I.; Quijano, E.; Howe, J.A.; Ramachandra, M. Inefficient killing of quiescent human epithelial cells by replicating adenoviruses: potential implications for their use as oncolytic agents. Cancer Gene Ther. 2005, 12, 691-698.
    • (2005) Cancer Gene Ther , vol.12 , pp. 691-698
    • Vaillancourt, M.1    Atencio, I.2    Quijano, E.3    Howe, J.A.4    Ramachandra, M.5
  • 62
    • 70349873326 scopus 로고    scopus 로고
    • Pre-existing Immunity and Passive Immunity to Adenovirus 5 Prevents Toxicity Caused by an Oncolytic Adenovirus Vector in the Syrian Hamster Model
    • Dhar, D.; Spencer, J.F.; Toth, K.; Wold, W.S. Pre-existing Immunity and Passive Immunity to Adenovirus 5 Prevents Toxicity Caused by an Oncolytic Adenovirus Vector in the Syrian Hamster Model. Mol. Ther 2009, 17, 1724-1732.
    • (2009) Mol. Ther , vol.17 , pp. 1724-1732
    • Dhar, D.1    Spencer, J.F.2    Toth, K.3    Wold, W.S.4
  • 63
    • 0037455562 scopus 로고    scopus 로고
    • Overexpression of the ADP (E3-11.6K) protein increases cell lysis and spread of adenovirus
    • Doronin, K.; Toth, K.; Kuppuswamy, M.; Krajcsi, P.; Tollefson, A.E.; Wold, W.S.M. Overexpression of the ADP (E3-11.6K) protein increases cell lysis and spread of adenovirus. Virology 2003, 305, 378-387.
    • (2003) Virology , vol.305 , pp. 378-387
    • Doronin, K.1    Toth, K.2    Kuppuswamy, M.3    Krajcsi, P.4    Tollefson, A.E.5    Wold, W.S.M.6
  • 65
    • 0034086730 scopus 로고    scopus 로고
    • Tumor-specific, replication-competent adenovirus vectors overexpressing the Adenovirus Death Protein
    • Doronin, K.; Toth, K.; Kuppuswamy, M.; Ward, P.; Tollefson, A.E.; Wold, W.S.M. Tumor-specific, replication-competent adenovirus vectors overexpressing the Adenovirus Death Protein. J. Virol. 2000, 74, 6147-6155.
    • (2000) J. Virol , vol.74 , pp. 6147-6155
    • Doronin, K.1    Toth, K.2    Kuppuswamy, M.3    Ward, P.4    Tollefson, A.E.5    Wold, W.S.M.6
  • 66
    • 0037345702 scopus 로고    scopus 로고
    • Radiation increases the activity of oncolytic adenovirus cancer gene therapy vectors that overexpress the ADP (E3-11.6K) protein
    • Toth, K.; Tarakanova, V.; Doronin, K.; Ward, P.; Kuppuswamy, M.; Locke, J.L.; Dawson, J.E.; Kim, H.J.; Wold, W.S.M. Radiation increases the activity of oncolytic adenovirus cancer gene therapy vectors that overexpress the ADP (E3-11.6K) protein. Cancer Gene Ther. 2003, 10, 193-200.
    • (2003) Cancer Gene Ther , vol.10 , pp. 193-200
    • Toth, K.1    Tarakanova, V.2    Doronin, K.3    Ward, P.4    Kuppuswamy, M.5    Locke, J.L.6    Dawson, J.E.7    Kim, H.J.8    Wold, W.S.M.9
  • 68
    • 0036904741 scopus 로고    scopus 로고
    • Intravascular adenoviral agents in cancer patients: Lessons from clinical trials
    • Reid, T.; Warren, R.; Kirn, D. Intravascular adenoviral agents in cancer patients: Lessons from clinical trials. Cancer Gene Ther. 2002, 9, 979-986.
    • (2002) Cancer Gene Ther , vol.9 , pp. 979-986
    • Reid, T.1    Warren, R.2    Kirn, D.3
  • 69
    • 31544478298 scopus 로고    scopus 로고
    • CG0070, a conditionally replicating granulocyte macrophage colony-stimulating factor--armed oncolytic adenovirus for the treatment of bladder cancer
    • Ramesh, N.; Ge, Y.; Ennist, D.L.; Zhu, M.; Mina, M.; Ganesh, S.; Reddy, P.S.; Yu, D.C. CG0070, a conditionally replicating granulocyte macrophage colony-stimulating factor--armed oncolytic adenovirus for the treatment of bladder cancer. Clin. Cancer Res. 2006, 12, 305-313.
    • (2006) Clin. Cancer Res , vol.12 , pp. 305-313
    • Ramesh, N.1    Ge, Y.2    Ennist, D.L.3    Zhu, M.4    Mina, M.5    Ganesh, S.6    Reddy, P.S.7    Yu, D.C.8
  • 70
    • 30944446391 scopus 로고    scopus 로고
    • Efficacy of a single intravesical treatment with Ad-IFN/Syn 3 is dependent on dose and urine IFN concentration obtained: Implications for clinical investigation
    • Tao, Z.; Connor, R.J.; Dinney, C.P.; Munsell, M.; Philopena, J.A.; Benedict, W.F. Efficacy of a single intravesical treatment with Ad-IFN/Syn 3 is dependent on dose and urine IFN concentration obtained: implications for clinical investigation. Cancer Gene Ther. 2006, 13, 125-130.
    • (2006) Cancer Gene Ther , vol.13 , pp. 125-130
    • Tao, Z.1    Connor, R.J.2    Dinney, C.P.3    Munsell, M.4    Philopena, J.A.5    Benedict, W.F.6
  • 71
    • 4644259118 scopus 로고    scopus 로고
    • Identification of pretreatment agents to enhance adenovirus infection of bladder epithelium
    • Ramesh, N.; Memarzadeh, B.; Ge, Y.; Frey, D.; Vanroey, M.; Rojas, V.; Yu, D.C. Identification of pretreatment agents to enhance adenovirus infection of bladder epithelium. Mol. Ther. 2004, 10, 697-705.
    • (2004) Mol. Ther , vol.10 , pp. 697-705
    • Ramesh, N.1    Memarzadeh, B.2    Ge, Y.3    Frey, D.4    Vanroey, M.5    Rojas, V.6    Yu, D.C.7
  • 72
    • 33645468259 scopus 로고    scopus 로고
    • Mesenchymal progenitor cells as cellular vehicles for delivery of oncolytic adenoviruses
    • Komarova, S.; Kawakami, Y.; Stoff-Khalili, M.A.; Curiel, D.T.; Pereboeva, L. Mesenchymal progenitor cells as cellular vehicles for delivery of oncolytic adenoviruses. Mol. Cancer Ther. 2006, 5, 755-766.
    • (2006) Mol. Cancer Ther , vol.5 , pp. 755-766
    • Komarova, S.1    Kawakami, Y.2    Stoff-Khalili, M.A.3    Curiel, D.T.4    Pereboeva, L.5
  • 73
    • 34547619243 scopus 로고    scopus 로고
    • Mesenchymal stem cells in cancer: Tumor-associated fibroblasts and cell-based delivery vehicles
    • Hall, B.; Dembinski, J.; Sasser, A.K.; Studeny, M.; Andreeff, M.; Marini, F. Mesenchymal stem cells in cancer: tumor-associated fibroblasts and cell-based delivery vehicles. Int. J. Hematol. 2007, 86, 8-16.
    • (2007) Int. J. Hematol , vol.86 , pp. 8-16
    • Hall, B.1    Dembinski, J.2    Sasser, A.K.3    Studeny, M.4    Andreeff, M.5    Marini, F.6
  • 74
    • 34547543191 scopus 로고    scopus 로고
    • Human mesenchymal stem cells lack tumor tropism but enhance the antitumor activity of oncolytic adenoviruses in orthotopic lung and breast tumors
    • Hakkarainen, T.; Sarkioja, M.; Lehenkari, P.; Miettinen, S.; Ylikomi, T.; Suuronen, R.; Desmond, R.A.; Kanerva, A.; Hemminki, A. Human mesenchymal stem cells lack tumor tropism but enhance the antitumor activity of oncolytic adenoviruses in orthotopic lung and breast tumors. Human Gene Ther. 2007, 18, 627-641.
    • (2007) Human Gene Ther , vol.18 , pp. 627-641
    • Hakkarainen, T.1    Sarkioja, M.2    Lehenkari, P.3    Miettinen, S.4    Ylikomi, T.5    Suuronen, R.6    Desmond, R.A.7    Kanerva, A.8    Hemminki, A.9
  • 75
    • 0033556093 scopus 로고    scopus 로고
    • Loss of adenoviral receptor expression in human bladder cancer cells: A potential impact on the efficacy of gene therapy
    • Li, Y.; Pong, R.C.; Bergelson, J.M.; Hall, M.C.; Sagalowsky, A.I.; Tseng, C.P.; Wang, Z.; Hsieh, J.T. Loss of adenoviral receptor expression in human bladder cancer cells: a potential impact on the efficacy of gene therapy. Cancer Res. 1999, 59, 325-330.
    • (1999) Cancer Res , vol.59 , pp. 325-330
    • Li, Y.1    Pong, R.C.2    Bergelson, J.M.3    Hall, M.C.4    Sagalowsky, A.I.5    Tseng, C.P.6    Wang, Z.7    Hsieh, J.T.8
  • 76
    • 0031775399 scopus 로고    scopus 로고
    • An adenovirus vector with genetically modified fibers demonstrates expanded tropism via utilization of a coxsackievirus and adenovirus receptor-independent cell entry mechanism
    • Dmitriev, I.; Krasnykh, V.; Miller, C.R.; Wang, M.; Kashentseva, E.; Mikheeva, G.; Belousova, N.; Curiel, D.T. An adenovirus vector with genetically modified fibers demonstrates expanded tropism via utilization of a coxsackievirus and adenovirus receptor-independent cell entry mechanism. J. Virol. 1998, 72, 9706-9713.
    • (1998) J. Virol , vol.72 , pp. 9706-9713
    • Dmitriev, I.1    Krasnykh, V.2    Miller, C.R.3    Wang, M.4    Kashentseva, E.5    Mikheeva, G.6    Belousova, N.7    Curiel, D.T.8
  • 78
    • 77955020560 scopus 로고    scopus 로고
    • Integrin alpha v beta 5 is a primary receptor for adenovirus in CAR-negative cells
    • Lyle, C.; McCormick, F. Integrin alpha v beta 5 is a primary receptor for adenovirus in CAR-negative cells. Virol. J. 2010, 7, 148.
    • (2010) Virol. J , vol.7 , pp. 148
    • Lyle, C.1    McCormick, F.2
  • 79
    • 2342625392 scopus 로고    scopus 로고
    • Analysis of adenovirus sequestration in the liver, transduction of hepatic cells, and innate toxicity after injection of fiber-modified vectors
    • Shayakhmetov, D.M.; Li, Z.Y.; Ni, S.; Lieber, A. Analysis of adenovirus sequestration in the liver, transduction of hepatic cells, and innate toxicity after injection of fiber-modified vectors. J. Virol. 2004, 78, 5368-5381.
    • (2004) J. Virol , vol.78 , pp. 5368-5381
    • Shayakhmetov, D.M.1    Li, Z.Y.2    Ni, S.3    Lieber, A.4
  • 81
    • 45849105224 scopus 로고    scopus 로고
    • Virotherapy as an approach against cancer stem cells
    • Ribacka, C.; Hemminki, A. Virotherapy as an approach against cancer stem cells. Current Gene Ther. 2008, 8, 88-96.
    • (2008) Current Gene Ther , vol.8 , pp. 88-96
    • Ribacka, C.1    Hemminki, A.2
  • 82
    • 67449164628 scopus 로고    scopus 로고
    • Adenovirus receptors: Implications for tropism, treatment and targeting
    • Arnberg, N. Adenovirus receptors: implications for tropism, treatment and targeting. Rev. Med. Virol. 2009, 19, 165-178.
    • (2009) Rev. Med. Virol , vol.19 , pp. 165-178
    • Arnberg, N.1
  • 83
    • 42449112872 scopus 로고    scopus 로고
    • Cellular genetic tools to control oncolytic adenoviruses for virotherapy of cancer
    • Nettelbeck, D.M. Cellular genetic tools to control oncolytic adenoviruses for virotherapy of cancer. J. Mol. Med. 2008, 86, 363-377.
    • (2008) J. Mol. Med , vol.86 , pp. 363-377
    • Nettelbeck, D.M.1
  • 84
    • 0034006112 scopus 로고    scopus 로고
    • Efficient gene transfer into human CD34(+) cells by a retargeted adenovirus vector
    • Shayakhmetov, D.M.; Papayannopoulou, T.; Stamatoyannopoulos, G.; Lieber, A. Efficient gene transfer into human CD34(+) cells by a retargeted adenovirus vector. J. Virol. 2000, 74, 2567-2583.
    • (2000) J. Virol , vol.74 , pp. 2567-2583
    • Shayakhmetov, D.M.1    Papayannopoulou, T.2    Stamatoyannopoulos, G.3    Lieber, A.4
  • 85
    • 0345708273 scopus 로고    scopus 로고
    • CD46 is a cellular receptor for group B adenoviruses
    • Gaggar, A.; Shayakhmetov, D.M.; Lieber, A. CD46 is a cellular receptor for group B adenoviruses. Nature Med. 2003, 9, 1408-1412.
    • (2003) Nature Med , vol.9 , pp. 1408-1412
    • Gaggar, A.1    Shayakhmetov, D.M.2    Lieber, A.3
  • 86
    • 1942424970 scopus 로고    scopus 로고
    • Adenovirus serotype 3 utilizes CD80 (B7.1) and CD86 (B7.2) as cellular attachment receptors
    • Short, J.J.; Pereboev, A.V.; Kawakami, Y.; Vasu, C.; Holterman, M.J.; Curiel, D.T. Adenovirus serotype 3 utilizes CD80 (B7.1) and CD86 (B7.2) as cellular attachment receptors. Virology 2004, 322, 349-359.
    • (2004) Virology , vol.322 , pp. 349-359
    • Short, J.J.1    Pereboev, A.V.2    Kawakami, Y.3    Vasu, C.4    Holterman, M.J.5    Curiel, D.T.6
  • 87
    • 0031913203 scopus 로고    scopus 로고
    • Characterization of an adenovirus vector containing a heterologous peptide epitope in the HI loop of the fiber knob
    • Krasnykh, V.; Dmitriev, I.; Mikheeva, G.; Miller, C.R.; Belousova, N.; Curiel, D.T. Characterization of an adenovirus vector containing a heterologous peptide epitope in the HI loop of the fiber knob. J. Virol. 1998, 72, 1844-1852.
    • (1998) J. Virol , vol.72 , pp. 1844-1852
    • Krasnykh, V.1    Dmitriev, I.2    Mikheeva, G.3    Miller, C.R.4    Belousova, N.5    Curiel, D.T.6
  • 88
    • 0029858682 scopus 로고    scopus 로고
    • Adenovirus targeted to heparan-containing receptors increases its gene delivery efficiency to multiple cell types
    • Wickham, T.J.; Roelvink, P.W.; Brough, D.E.; Kovesdi, I. Adenovirus targeted to heparan-containing receptors increases its gene delivery efficiency to multiple cell types. Nat. Biotechnol. 1996, 14, 1570-1573.
    • (1996) Nat. Biotechnol , vol.14 , pp. 1570-1573
    • Wickham, T.J.1    Roelvink, P.W.2    Brough, D.E.3    Kovesdi, I.4
  • 89
    • 42049117419 scopus 로고    scopus 로고
    • A ligand-pseudoreceptor system based on de novo designed peptides for the generation of adenoviral vectors with altered tropism
    • Zeng, Y.; Pinard, M.; Jaime, J.; Bourget, L.; Uyen, L.P.; O'Connor-McCourt, M.D.; Gilbert, R.; Massie, B. A ligand-pseudoreceptor system based on de novo designed peptides for the generation of adenoviral vectors with altered tropism. J. Gene Med. 2008, 10, 355-367.
    • (2008) J. Gene Med , vol.10 , pp. 355-367
    • Zeng, Y.1    Pinard, M.2    Jaime, J.3    Bourget, L.4    Uyen, L.P.5    O'connor-McCourt, M.D.6    Gilbert, R.7    Massie, B.8
  • 90
    • 37849014587 scopus 로고    scopus 로고
    • Modification of adenovirus capsid with a designed protein ligand yields a gene vector targeted to a major molecular marker of cancer
    • Belousova, N.; Mikheeva, G.; Gelovani, J.; Krasnykh, V. Modification of adenovirus capsid with a designed protein ligand yields a gene vector targeted to a major molecular marker of cancer. J. Virol. 2008, 82, 630-637.
    • (2008) J. Virol , vol.82 , pp. 630-637
    • Belousova, N.1    Mikheeva, G.2    Gelovani, J.3    Krasnykh, V.4
  • 91
    • 34247102265 scopus 로고    scopus 로고
    • Targeting of adenovirus vectors carrying a tumor cell-specific peptide: In vitro and in vivo studies
    • Rittner, K.; Schreiber, V.; Erbs, P.; Lusky, M. Targeting of adenovirus vectors carrying a tumor cell-specific peptide: in vitro and in vivo studies. Cancer Gene Ther. 2007, 14, 509-518.
    • (2007) Cancer Gene Ther , vol.14 , pp. 509-518
    • Rittner, K.1    Schreiber, V.2    Erbs, P.3    Lusky, M.4
  • 93
    • 0035043341 scopus 로고    scopus 로고
    • Genetic targeting of an adenovirus vector via replacement of the fiber protein with the phage T4 fibritin
    • Krasnykh, V.; Belousova, N.; Korokhov, N.; Mikheeva, G.; Curiel, D.T. Genetic targeting of an adenovirus vector via replacement of the fiber protein with the phage T4 fibritin. J. Virol. 2001, 75, 4176-4183.
    • (2001) J. Virol , vol.75 , pp. 4176-4183
    • Krasnykh, V.1    Belousova, N.2    Korokhov, N.3    Mikheeva, G.4    Curiel, D.T.5
  • 94
    • 1942437436 scopus 로고    scopus 로고
    • A chimeric adenovirus vector encoding reovirus attachment protein sigma1 targets cells expressing junctional adhesion molecule 1
    • Mercier, G.T.; Campbell, J.A.; Chappell, J.D.; Stehle, T.; Dermody, T.S.; Barry, M.A. A chimeric adenovirus vector encoding reovirus attachment protein sigma1 targets cells expressing junctional adhesion molecule 1. Proc. Natl. Acad. Sci. U. S. A. 2004, 101, 6188-6193.
    • (2004) Proc. Natl. Acad. Sci. U. S. A , vol.101 , pp. 6188-6193
    • Mercier, G.T.1    Campbell, J.A.2    Chappell, J.D.3    Stehle, T.4    Dermody, T.S.5    Barry, M.A.6
  • 95
    • 0032851439 scopus 로고    scopus 로고
    • Construction of a pseudoreceptor that mediates transduction by adenoviruses expressing a ligand in fiber or penton base
    • Einfeld, D.A.; Brough, D.E.; Roelvink, P.W.; Kovesdi, I.; Wickham, T.J. Construction of a pseudoreceptor that mediates transduction by adenoviruses expressing a ligand in fiber or penton base. J. Virol. 1999, 73, 9130-9136.
    • (1999) J. Virol , vol.73 , pp. 9130-9136
    • Einfeld, D.A.1    Brough, D.E.2    Roelvink, P.W.3    Kovesdi, I.4    Wickham, T.J.5
  • 100
    • 33947354213 scopus 로고    scopus 로고
    • Increased tumor localization and reduced immune response to adenoviral vector formulated with the liposome DDAB/DOPE
    • Steel, J.C.; Cavanagh, H.M.; Burton, M.A.; Abu-Asab, M.S.; Tsokos, M.; Morris, J.C.; Kalle, W.H. Increased tumor localization and reduced immune response to adenoviral vector formulated with the liposome DDAB/DOPE. Eur. J. Pharm. Sci. 2007, 30, 398-405.
    • (2007) Eur. J. Pharm. Sci , vol.30 , pp. 398-405
    • Steel, J.C.1    Cavanagh, H.M.2    Burton, M.A.3    Abu-Asab, M.S.4    Tsokos, M.5    Morris, J.C.6    Kalle, W.H.7
  • 101
    • 1642359484 scopus 로고    scopus 로고
    • Liposome-complexed adenoviral gene transfer in cancer cells expressing various levels of coxsackievirus and adenovirus receptor
    • Lee, E.M.; Hong, S.H.; Lee, Y.J.; Kang, Y.H.; Choi, K.C.; Choi, S.H.; Kim, I.H.; Lim, S.J. Liposome-complexed adenoviral gene transfer in cancer cells expressing various levels of coxsackievirus and adenovirus receptor. J. Cancer Res. Clin. Oncol. 2004, 130, 169-177.
    • (2004) J. Cancer Res. Clin. Oncol , vol.130 , pp. 169-177
    • Lee, E.M.1    Hong, S.H.2    Lee, Y.J.3    Kang, Y.H.4    Choi, K.C.5    Choi, S.H.6    Kim, I.H.7    Lim, S.J.8
  • 102
    • 64849098821 scopus 로고    scopus 로고
    • Targeting of adenovirus serotype 5 pseudotyped with short fiber from serotype 41 to c-erbB2-positive cells using bispecific single-chain diabody
    • Kashentseva, E.A.; Douglas, J.T.; Zinn, K.R.; Curiel, D.T.; Dmitriev, I.P. Targeting of adenovirus serotype 5 pseudotyped with short fiber from serotype 41 to c-erbB2-positive cells using bispecific single-chain diabody. J. Mol. Biol. 2009, 388, 443-461.
    • (2009) J. Mol. Biol , vol.388 , pp. 443-461
    • Kashentseva, E.A.1    Douglas, J.T.2    Zinn, K.R.3    Curiel, D.T.4    Dmitriev, I.P.5
  • 103
  • 104
    • 37549008707 scopus 로고    scopus 로고
    • Modification of adenovirus gene transfer vectors with synthetic polymers: A scientific review and technical guide
    • Kreppel, F.; Kochanek, S. Modification of adenovirus gene transfer vectors with synthetic polymers: a scientific review and technical guide. Mol. Ther. 2008, 16, 16-29.
    • (2008) Mol. Ther , vol.16 , pp. 16-29
    • Kreppel, F.1    Kochanek, S.2
  • 105
    • 0035077806 scopus 로고    scopus 로고
    • Polymer-coated adenovirus permits efficient retargeting and evades neutralising antibodies
    • Fisher, K.D.; Stallwood, Y.; Green, N.K.; Ulbrich, K.; Mautner, V.; Seymour, L.W. Polymer-coated adenovirus permits efficient retargeting and evades neutralising antibodies. Gene Ther. 2001, 8, 341-348.
    • (2001) Gene Ther , vol.8 , pp. 341-348
    • Fisher, K.D.1    Stallwood, Y.2    Green, N.K.3    Ulbrich, K.4    Mautner, V.5    Seymour, L.W.6
  • 106
    • 45749157559 scopus 로고    scopus 로고
    • Modification of adenoviral vectors with polyethylene glycol modulates in vivo tissue tropism and gene expression
    • Hofherr, S.E.; Shashkova, E.V.; Weaver, E.A.; Khare, R.; Barry, M.A. Modification of adenoviral vectors with polyethylene glycol modulates in vivo tissue tropism and gene expression. Mol. Ther. 2008, 16, 1276-1282.
    • (2008) Mol. Ther , vol.16 , pp. 1276-1282
    • Hofherr, S.E.1    Shashkova, E.V.2    Weaver, E.A.3    Khare, R.4    Barry, M.A.5
  • 107
    • 68649104639 scopus 로고    scopus 로고
    • Chemical Modification with High Molecular Weight Polyethylene Glycol Reduces Transduction of Hepatocytes and Increases Efficacy of Intravenously Delivered Oncolytic Adenovirus
    • Doronin, K.; Shashkova, E.V.; May, S.M.; Hofherr, S.E.; Barry, M.A. Chemical Modification with High Molecular Weight Polyethylene Glycol Reduces Transduction of Hepatocytes and Increases Efficacy of Intravenously Delivered Oncolytic Adenovirus. Hum. Gene Ther. 2009, 20, 975-988.
    • (2009) Hum. Gene Ther , vol.20 , pp. 975-988
    • Doronin, K.1    Shashkova, E.V.2    May, S.M.3    Hofherr, S.E.4    Barry, M.A.5
  • 108
    • 84934439910 scopus 로고    scopus 로고
    • PEGylated adenovirus for targeted gene therapy
    • O'Riordan, C.R.; Song, A. PEGylated adenovirus for targeted gene therapy. Methods Mol. Biol. 2008, 434, 133-160.
    • (2008) Methods Mol. Biol , vol.434 , pp. 133-160
    • O'Riordan, C.R.1    Song, A.2
  • 109
    • 37549019328 scopus 로고    scopus 로고
    • Epidermal growth factor (EGF) receptor targeted delivery of PEGylated adenovirus
    • Park, J.W.; Mok, H.; Park, T.G. Epidermal growth factor (EGF) receptor targeted delivery of PEGylated adenovirus. Biochem. Biophys. Res. Commun. 2008, 366, 769-774.
    • (2008) Biochem. Biophys. Res. Commun , vol.366 , pp. 769-774
    • Park, J.W.1    Mok, H.2    Park, T.G.3
  • 110
    • 40849095967 scopus 로고    scopus 로고
    • Development of PEGylated adenovirus vector with targeting ligand
    • Eto, Y.; Yoshioka, Y.; Mukai, Y.; Okada, N.; Nakagawa, S. Development of PEGylated adenovirus vector with targeting ligand. Int. J. Pharm. 2008, 354, 3-8.
    • (2008) Int. J. Pharm , vol.354 , pp. 3-8
    • Eto, Y.1    Yoshioka, Y.2    Mukai, Y.3    Okada, N.4    Nakagawa, S.5
  • 111
    • 60049098649 scopus 로고    scopus 로고
    • Effect of preexisting immunity on oncolytic adenovirus vector INGN 007 antitumor efficacy in immunocompetent and immunosuppressed Syrian hamsters
    • Dhar, D.; Spencer, J.F.; Toth, K.; Wold, W.S.M. Effect of preexisting immunity on oncolytic adenovirus vector INGN 007 antitumor efficacy in immunocompetent and immunosuppressed Syrian hamsters. J. Virol. 2009, 83, 2130-2139.
    • (2009) J. Virol , vol.83 , pp. 2130-2139
    • Dhar, D.1    Spencer, J.F.2    Toth, K.3    Wold, W.S.M.4
  • 112
    • 34547434066 scopus 로고    scopus 로고
    • Use of the Syrian hamster as an animal model for oncolytic adenovirus vectors
    • Thomas, M.A.; Spencer, J.F.; Wold, W.S.M. Use of the Syrian hamster as an animal model for oncolytic adenovirus vectors. Met. Mol. Med. 2007, 130, 169-183.
    • (2007) Met. Mol. Med , vol.130 , pp. 169-183
    • Thomas, M.A.1    Spencer, J.F.2    Wold, W.S.M.3
  • 113
    • 28444474772 scopus 로고    scopus 로고
    • Identification of novel insertion sites in the Ad5 genome that utilize the Ad splicing machinery for therapeutic gene expression
    • Jin, F.; Kretschmer, P.J.; Hermiston, T.W. Identification of novel insertion sites in the Ad5 genome that utilize the Ad splicing machinery for therapeutic gene expression. Mol. Ther. 2005, 12, 1052-1063.
    • (2005) Mol. Ther , vol.12 , pp. 1052-1063
    • Jin, F.1    Kretschmer, P.J.2    Hermiston, T.W.3
  • 114
    • 30344477005 scopus 로고    scopus 로고
    • Second-generation replication-competent oncolytic adenovirus armed with improved suicide genes and ADP gene demonstrates greater efficacy without increased toxicity
    • Barton, K.N.; Paielli, D.; Zhang, Y.; Koul, S.; Brown, S.L.; Lu, M.; Seely, J.; Kim, J.H.; Freytag, S.O. Second-generation replication-competent oncolytic adenovirus armed with improved suicide genes and ADP gene demonstrates greater efficacy without increased toxicity. Mol. Ther. 2006, 13, 347-356.
    • Mol. Ther , vol.2006 , pp. 347-356
    • Barton, K.N.1    Paielli, D.2    Zhang, Y.3    Koul, S.4    Brown, S.L.5    Lu, M.6    Seely, J.7    Kim, J.H.8    Freytag, S.O.9
  • 116
    • 34249316871 scopus 로고    scopus 로고
    • Relaxin-expressing, fiber chimeric oncolytic adenovirus prolongs survival of tumor-bearing mice
    • erratum appears in Cancer Res. 2007 Jun 15;67(12):5998
    • Ganesh, S.; Gonzalez, E.M.; Idamakanti, N.; Abramova, M.; Vanroey, M.; Robinson, M.; Yun, C.O.; Jooss, K. Relaxin-expressing, fiber chimeric oncolytic adenovirus prolongs survival of tumor-bearing mice. [erratum appears in Cancer Res. 2007 Jun 15;67(12):5998]. Cancer Res. 2007, 67, 4399-4407.
    • (2007) Cancer Res , vol.67 , pp. 4399-4407
    • Ganesh, S.1    Gonzalez, E.M.2    Idamakanti, N.3    Abramova, M.4    Vanroey, M.5    Robinson, M.6    Yun, C.O.7    Jooss, K.8
  • 117
    • 33750207622 scopus 로고    scopus 로고
    • Relaxin expression from tumor-targeting adenoviruses and its intratumoral spread, apoptosis induction, and efficacy
    • Kim, J.H.; Lee, Y.S.; Kim, H.; Huang, J.H.; Yoon, A.R.; Yun, C.O. Relaxin expression from tumor-targeting adenoviruses and its intratumoral spread, apoptosis induction, and efficacy. J. Natl. Cancer Inst. 2006, 98, 1482-1493.
    • (2006) J. Natl. Cancer Inst , vol.98 , pp. 1482-1493
    • Kim, J.H.1    Lee, Y.S.2    Kim, H.3    Huang, J.H.4    Yoon, A.R.5    Yun, C.O.6
  • 118
    • 4243164553 scopus 로고    scopus 로고
    • Enhanced efficacy of Escherichia coli nitroreductase/CB1954 prodrug activation gene therapy using an E1B-55K-deleted oncolytic adenovirus vector
    • Chen, M.J.; Green, N.K.; Reynolds, G.M.; Flavell, J.R.; Mautner, V.; Kerr, D.J.; Young, L.S.; Searle, P.F. Enhanced efficacy of Escherichia coli nitroreductase/CB1954 prodrug activation gene therapy using an E1B-55K-deleted oncolytic adenovirus vector. Gene Ther. 2004, 11, 1126-1136.
    • (2004) Gene Ther , vol.11 , pp. 1126-1136
    • Chen, M.J.1    Green, N.K.2    Reynolds, G.M.3    Flavell, J.R.4    Mautner, V.5    Kerr, D.J.6    Young, L.S.7    Searle, P.F.8
  • 119
    • 0032503659 scopus 로고    scopus 로고
    • A novel three-pronged approach to kill cancer cells selectively: Concomitant viral, double suicide gene, and radiotherapy
    • Freytag, S.O.; Rogulski, K.R.; Paielli, D.L.; Gilbert, J.D.; Kim, J.H. A novel three-pronged approach to kill cancer cells selectively: concomitant viral, double suicide gene, and radiotherapy. Human Gene Ther. 1998, 9, 1323-1333.
    • (1998) Human Gene Ther , vol.9 , pp. 1323-1333
    • Freytag, S.O.1    Rogulski, K.R.2    Paielli, D.L.3    Gilbert, J.D.4    Kim, J.H.5
  • 121
    • 70350647412 scopus 로고    scopus 로고
    • Tumor immunosuppressive environment: Effects on tumor-specific and nontumor antigen immune responses
    • de Souza, A.P.; Bonorino, C. Tumor immunosuppressive environment: effects on tumor-specific and nontumor antigen immune responses. Expert. Rev. Anticancer Ther. 2009, 9, 1317-1332.
    • (2009) Expert. Rev. Anticancer Ther , vol.9 , pp. 1317-1332
    • de Souza, A.P.1    Bonorino, C.2
  • 122
    • 42049104455 scopus 로고    scopus 로고
    • Virus-mediated oncolysis induces danger signal and stimulates cytotoxic T-lymphocyte activity via proteasome activator upregulation
    • Endo, Y.; Sakai, R.; Ouchi, M.; Onimatsu, H.; Hioki, M.; Kagawa, S.; Uno, F.; Watanabe, Y.; Urata, Y.; Tanaka, N.; Fujiwara, T. Virus-mediated oncolysis induces danger signal and stimulates cytotoxic T-lymphocyte activity via proteasome activator upregulation. Oncogene 2008, 27, 2375-2381.
    • (2008) Oncogene , vol.27 , pp. 2375-2381
    • Endo, Y.1    Sakai, R.2    Ouchi, M.3    Onimatsu, H.4    Hioki, M.5    Kagawa, S.6    Uno, F.7    Watanabe, Y.8    Urata, Y.9    Tanaka, N.10    Fujiwara, T.11
  • 123
    • 67650744372 scopus 로고    scopus 로고
    • Immune therapy for cancer
    • Dougan, M.; Dranoff, G. Immune therapy for cancer. Ann. Rev. Immunol. 2009, 27, 83-117.
    • (2009) Ann. Rev. Immunol , vol.27 , pp. 83-117
    • Dougan, M.1    Dranoff, G.2
  • 124
    • 57649125119 scopus 로고    scopus 로고
    • An oncolytic adenovirus expressing granulocyte macrophage colony-stimulating factor shows improved specificity and efficacy for treating human solid tumors
    • Lei, N.; Shen, F.B.; Chang, J.H.; Wang, L.; Li, H.; Yang, C.; Li, J.; Yu, D.C. An oncolytic adenovirus expressing granulocyte macrophage colony-stimulating factor shows improved specificity and efficacy for treating human solid tumors. Cancer Gene Ther. 2009, 16, 33-43.
    • (2009) Cancer Gene Ther , vol.16 , pp. 33-43
    • Lei, N.1    Shen, F.B.2    Chang, J.H.3    Wang, L.4    Li, H.5    Yang, C.6    Li, J.7    Yu, D.C.8
  • 125
    • 31544478298 scopus 로고    scopus 로고
    • CG0070, a conditionally replicating granulocyte macrophage colony-stimulating factor--armed oncolytic adenovirus for the treatment of bladder cancer
    • Ramesh, N.; Ge, Y.; Ennist, D.L.; Zhu, M.; Mina, M.; Ganesh, S.; Reddy, P.S.; Yu, D.C. CG0070, a conditionally replicating granulocyte macrophage colony-stimulating factor--armed oncolytic adenovirus for the treatment of bladder cancer. Clin. Cancer Res. 2006, 12, 305-313.
    • (2006) Clin. Cancer Res , vol.12 , pp. 305-313
    • Ramesh, N.1    Ge, Y.2    Ennist, D.L.3    Zhu, M.4    Mina, M.5    Ganesh, S.6    Reddy, P.S.7    Yu, D.C.8
  • 127
    • 52649152367 scopus 로고    scopus 로고
    • Significant antitumor activity of oncolytic adenovirus expressing human interferon-beta for hepatocellular carcinoma
    • He, L.F.; Gu, J.F.; Tang, W.H.; Fan, J.K.; Wei, N.; Zou, W.G.; Zhang, Y.H.; Zhao, L.L.; Liu, X.Y. Significant antitumor activity of oncolytic adenovirus expressing human interferon-beta for hepatocellular carcinoma. J. Gene Med. 2008, 10, 983-992.
    • (2008) J. Gene Med , vol.10 , pp. 983-992
    • He, L.F.1    Gu, J.F.2    Tang, W.H.3    Fan, J.K.4    Wei, N.5    Zou, W.G.6    Zhang, Y.H.7    Zhao, L.L.8    Liu, X.Y.9
  • 128
    • 33645840128 scopus 로고    scopus 로고
    • Immune gene-viral therapy with triplex efficacy mediated by oncolytic adenovirus carrying an interferon-gamma gene yields efficient antitumor activity in immunodeficient and immunocompetent mice
    • Su, C.; Peng, L.; Sham, J.; Wang, X.; Zhang, Q.; Chua, D.; Liu, C.; Cui, Z.; Xue, H.; Wu, H.; Yang, Q.; Zhang, B.; Liu, X.; Wu, M.; Qian, Q. Immune gene-viral therapy with triplex efficacy mediated by oncolytic adenovirus carrying an interferon-gamma gene yields efficient antitumor activity in immunodeficient and immunocompetent mice. Mol. Ther. 2006, 13, 918-927.
    • (2006) Mol. Ther , vol.13 , pp. 918-927
    • Su, C.1    Peng, L.2    Sham, J.3    Wang, X.4    Zhang, Q.5    Chua, D.6    Liu, C.7    Cui, Z.8    Xue, H.9    Wu, H.10    Yang, Q.11    Zhang, B.12    Liu, X.13    Wu, M.14    Qian, Q.15
  • 129
    • 33847210729 scopus 로고    scopus 로고
    • Targeting interferon-alpha increases antitumor efficacy and reduces hepatotoxicity of E1A-mutated spread-enhanced oncolytic adenovirus
    • Shashkova, E.V.; Spencer, J.F.; Wold, W.S.M.; Doronin, K. Targeting interferon-alpha increases antitumor efficacy and reduces hepatotoxicity of E1A-mutated spread-enhanced oncolytic adenovirus. Mol. Ther. 2007, 15, 598-607.
    • (2007) Mol. Ther , vol.15 , pp. 598-607
    • Shashkova, E.V.1    Spencer, J.F.2    Wold, W.S.M.3    Doronin, K.4
  • 130
    • 63649137545 scopus 로고    scopus 로고
    • Targeting the intratumoral dendritic cells by the oncolytic adenoviral vaccine expressing RANTES elicits potent antitumor immunity
    • Lapteva, N.; Aldrich, M.; Weksberg, D.; Rollins, L.; Goltsova, T.; Chen, S.Y.; Huang, X.F. Targeting the intratumoral dendritic cells by the oncolytic adenoviral vaccine expressing RANTES elicits potent antitumor immunity. J. Immunother. 2009, 32, 145-156.
    • (2009) J. Immunother , vol.32 , pp. 145-156
    • Lapteva, N.1    Aldrich, M.2    Weksberg, D.3    Rollins, L.4    Goltsova, T.5    Chen, S.Y.6    Huang, X.F.7
  • 131
    • 33750332951 scopus 로고    scopus 로고
    • Enhanced antitumor effect of oncolytic adenovirus expressing interleukin-12 and B7-1 in an immunocompetent murine model
    • Lee, Y.S.; Kim, J.H.; Choi, K.J.; Choi, I.K.; Kim, H.; Cho, S.; Cho, B.C.; Yun, C.O. Enhanced antitumor effect of oncolytic adenovirus expressing interleukin-12 and B7-1 in an immunocompetent murine model. Clin. Cancer Res. 2006, 12, 5859-5868.
    • (2006) Clin. Cancer Res , vol.12 , pp. 5859-5868
    • Lee, Y.S.1    Kim, J.H.2    Choi, K.J.3    Choi, I.K.4    Kim, H.5    Cho, S.6    Cho, B.C.7    Yun, C.O.8
  • 132
    • 0035576816 scopus 로고    scopus 로고
    • Heat shock and heat shock protein 70i enhance the oncolytic effect of replicative adenovirus
    • Haviv, Y.S.; Blackwell, J.L.; Li, H.; Wang, M.; Lei, X.; Curiel, D.T. Heat shock and heat shock protein 70i enhance the oncolytic effect of replicative adenovirus. Cancer Res. 2001, 61, 8361-8365.
    • (2001) Cancer Res , vol.61 , pp. 8361-8365
    • Haviv, Y.S.1    Blackwell, J.L.2    Li, H.3    Wang, M.4    Lei, X.5    Curiel, D.T.6
  • 133
    • 38349019847 scopus 로고    scopus 로고
    • Anticancer activity of oncolytic adenovirus vector armed with IFN-alpha and ADP is enhanced by pharmacologically controlled expression of TRAIL
    • Shashkova, E.V.; Kuppuswamy, M.N.; Wold, W.S.; Doronin, K. Anticancer activity of oncolytic adenovirus vector armed with IFN-alpha and ADP is enhanced by pharmacologically controlled expression of TRAIL. Cancer Gene Ther. 2008, 15, 72.
    • (2008) Cancer Gene Ther , vol.15 , pp. 72
    • Shashkova, E.V.1    Kuppuswamy, M.N.2    Wold, W.S.3    Doronin, K.4
  • 134
    • 0034893340 scopus 로고    scopus 로고
    • Gene delivery from the E3 region of replicating human adenovirus: Evaluation of the E3B region
    • Hawkins, L.K.; Hermiston, T.W. Gene delivery from the E3 region of replicating human adenovirus: evaluation of the E3B region. Gene Ther. 2001, 8, 1142-1148.
    • (2001) Gene Ther , vol.8 , pp. 1142-1148
    • Hawkins, L.K.1    Hermiston, T.W.2
  • 135
    • 2342453303 scopus 로고    scopus 로고
    • A tumor-targeted and conditionally replicating oncolytic adenovirus vector expressing TRAIL for treatment of liver metastases
    • Sova, P.; Ren, X.W.; Ni, S.; Bernt, K.M.; Mi, J.; Kiviat, N.; Lieber, A. A tumor-targeted and conditionally replicating oncolytic adenovirus vector expressing TRAIL for treatment of liver metastases. Mol. Ther. 2004, 9, 496-509.
    • (2004) Mol. Ther , vol.9 , pp. 496-509
    • Sova, P.1    Ren, X.W.2    Ni, S.3    Bernt, K.M.4    Mi, J.5    Kiviat, N.6    Lieber, A.7
  • 136
    • 57549092526 scopus 로고    scopus 로고
    • The tumour microenvironment: A novel target for cancer therapy
    • Hanna, E.; Quick, J.; Libutti, S.K. The tumour microenvironment: a novel target for cancer therapy. Oral Dis. 2009, 15, 8-17.
    • (2009) Oral Dis , vol.15 , pp. 8-17
    • Hanna, E.1    Quick, J.2    Libutti, S.K.3
  • 138
    • 19944384542 scopus 로고    scopus 로고
    • Potent antitumor efficacy of an E1B 55kDa-deficient adenovirus carrying murine endostatin in hepatocellular carcinoma
    • Li, G.; Sham, J.; Yang, J.; Su, C.; Xue, H.; Chua, D.; Sun, L.; Zhang, Q.; Cui, Z.; Wu, M.; Qian, Q. Potent antitumor efficacy of an E1B 55kDa-deficient adenovirus carrying murine endostatin in hepatocellular carcinoma. Int. J. Cancer 2005, 113, 640-648.
    • (2005) Int. J. Cancer , vol.113 , pp. 640-648
    • Li, G.1    Sham, J.2    Yang, J.3    Su, C.4    Xue, H.5    Chua, D.6    Sun, L.7    Zhang, Q.8    Cui, Z.9    Wu, M.10    Qian, Q.11
  • 139
    • 20144373435 scopus 로고    scopus 로고
    • Suppression of tumor growth by oncolytic adenovirus-mediated delivery of an antiangiogenic gene, soluble FLT-1
    • Zhang, Z.; Zou, W.; Wang, J.; Gu, J.; Dang, Y.; Li, B.; Zhao, L.; Qian, C.; Qian, Q.; Liu, X. Suppression of tumor growth by oncolytic adenovirus-mediated delivery of an antiangiogenic gene, soluble FLT-1. Mol. Ther. 2004, 11, 553-562.
    • (2004) Mol. Ther , vol.11 , pp. 553-562
    • Zhang, Z.1    Zou, W.2    Wang, J.3    Gu, J.4    Dang, Y.5    Li, B.6    Zhao, L.7    Qian, C.8    Qian, Q.9    Liu, X.10
  • 140
    • 33846334835 scopus 로고    scopus 로고
    • VEGF-specific short hairpin RNA-expressing oncolytic adenovirus elicits potent inhibition of angiogenesis and tumor growth.[see comment]
    • Yoo, J.Y.; Kim, J.H.; Kwon, Y.G.; Kim, E.C.; Kim, N.K.; Choi, H.J.; Yun, C.O. VEGF-specific short hairpin RNA-expressing oncolytic adenovirus elicits potent inhibition of angiogenesis and tumor growth.[see comment]. Mol. Ther. 2007, 15, 295-302.
    • (2007) Mol. Ther , vol.15 , pp. 295-302
    • Yoo, J.Y.1    Kim, J.H.2    Kwon, Y.G.3    Kim, E.C.4    Kim, N.K.5    Choi, H.J.6    Yun, C.O.7


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