메뉴 건너뛰기




Volumn 86, Issue 1, 2007, Pages 8-16

Mesenchymal stem cells in cancer: Tumor-associated fibroblasts and cell-based delivery vehicles

Author keywords

Gene therapy; Mesenchymal stem cells; Stroma; Tumor microenvironment; Vascular network

Indexed keywords

ANTINEOPLASTIC AGENT; BETA INTERFERON; CHEMOKINE; CYTOKINE; GROWTH FACTOR;

EID: 34547619243     PISSN: 09255710     EISSN: None     Source Type: Journal    
DOI: 10.1532/IJH97.06230     Document Type: Review
Times cited : (156)

References (139)
  • 1
    • 0036113238 scopus 로고    scopus 로고
    • Tumor-associated fibroblasts (part I): Active stromal participants in tumor development and progression?
    • Kunz-Schughart LA, Knuechel R. Tumor-associated fibroblasts (part I): active stromal participants in tumor development and progression? Histol Histopathol. 2002;17:599-621.
    • (2002) Histol Histopathol , vol.17 , pp. 599-621
    • Kunz-Schughart, L.A.1    Knuechel, R.2
  • 2
    • 0036116860 scopus 로고    scopus 로고
    • Tumor-associated fibroblasts (part II): Functional impact on tumor tissue
    • Kunz-Schughart LA, Knuechel R. Tumor-associated fibroblasts (part II): functional impact on tumor tissue. Histol Histopathol. 2002;17:623-637.
    • (2002) Histol Histopathol , vol.17 , pp. 623-637
    • Kunz-Schughart, L.A.1    Knuechel, R.2
  • 3
    • 18844428327 scopus 로고    scopus 로고
    • Stromal fibroblasts present in invasive human breast carcinomas promote tumor growth and angiogenesis through elevated SDF-1/CXCL12 secretion
    • Orimo A, Gupta PB, Sgroi DC, et al. Stromal fibroblasts present in invasive human breast carcinomas promote tumor growth and angiogenesis through elevated SDF-1/CXCL12 secretion. Cell. 2005;121:335-348.
    • (2005) Cell , vol.121 , pp. 335-348
    • Orimo, A.1    Gupta, P.B.2    Sgroi, D.C.3
  • 4
    • 0032809359 scopus 로고    scopus 로고
    • What might a stromal response mean to prostate cancer progression?
    • Rowley DR. What might a stromal response mean to prostate cancer progression? Cancer Metastasis Rev. 1998;17:411-419.
    • (1998) Cancer Metastasis Rev , vol.17 , pp. 411-419
    • Rowley, D.R.1
  • 5
    • 0037899253 scopus 로고    scopus 로고
    • Role of tissue stroma in cancer cell invasion
    • De Wever O, Mareel M. Role of tissue stroma in cancer cell invasion. J Pathol. 2003;200:429-447.
    • (2003) J Pathol , vol.200 , pp. 429-447
    • De Wever, O.1    Mareel, M.2
  • 6
    • 0033947545 scopus 로고    scopus 로고
    • New prognostic histological parameter of invasive ductal carcinoma of the breast: Clinicopathological significance of fibrotic focus
    • Hasebe T, Mukai K, Tsuda H, Ochiai A. New prognostic histological parameter of invasive ductal carcinoma of the breast: clinicopathological significance of fibrotic focus. Pathol Int. 2000;50:263-272.
    • (2000) Pathol Int , vol.50 , pp. 263-272
    • Hasebe, T.1    Mukai, K.2    Tsuda, H.3    Ochiai, A.4
  • 7
    • 0242268883 scopus 로고    scopus 로고
    • Tumor reversion: Correction of malignant behavior by microenvironmental cues
    • Kenny PA, Bissell MJ. Tumor reversion: correction of malignant behavior by microenvironmental cues. Int J Cancer. 2003;107:688-695.
    • (2003) Int J Cancer , vol.107 , pp. 688-695
    • Kenny, P.A.1    Bissell, M.J.2
  • 8
    • 1542682338 scopus 로고    scopus 로고
    • Prognostic significance of scoring system based on histological heterogeneity of invasive ductal carcinoma for node-negative breast cancer patients
    • Kurosumi M, Tabei T, Inoue K, et al. Prognostic significance of scoring system based on histological heterogeneity of invasive ductal carcinoma for node-negative breast cancer patients. Oncol Rep. 2003;10:833-837.
    • (2003) Oncol Rep , vol.10 , pp. 833-837
    • Kurosumi, M.1    Tabei, T.2    Inoue, K.3
  • 9
    • 21844432918 scopus 로고    scopus 로고
    • Rac1b and reactive oxygen species mediate MMP-3-induced EMT and genomic instability
    • Radisky DC, Levy DD, Littlepage LE, et al. Rac1b and reactive oxygen species mediate MMP-3-induced EMT and genomic instability. Nature. 2005;436:123-127.
    • (2005) Nature , vol.436 , pp. 123-127
    • Radisky, D.C.1    Levy, D.D.2    Littlepage, L.E.3
  • 10
    • 0035445625 scopus 로고    scopus 로고
    • Genetic model of multi-step breast carcinogenesis involving the epithelium and stroma: Clues to tumour-microenvironment interactions
    • Kurose K, Hoshaw-Woodard S, Adeyinka A, Lemeshow S, Watson PH, Eng C. Genetic model of multi-step breast carcinogenesis involving the epithelium and stroma: clues to tumour-microenvironment interactions. Hum Mol Genet. 2001;10:1907-1913.
    • (2001) Hum Mol Genet , vol.10 , pp. 1907-1913
    • Kurose, K.1    Hoshaw-Woodard, S.2    Adeyinka, A.3    Lemeshow, S.4    Watson, P.H.5    Eng, C.6
  • 11
    • 0342264492 scopus 로고    scopus 로고
    • Concurrent and independent genetic alterations in the stromal and epithelial cells of mammary carcinoma: Implications for tumorigenesis
    • Moinfar F, Man YG, Arnould L, Bratthauer GL, Ratschek M, Tavassoli FA. Concurrent and independent genetic alterations in the stromal and epithelial cells of mammary carcinoma: implications for tumorigenesis. Cancer Res. 2000;60:2562-2566.
    • (2000) Cancer Res , vol.60 , pp. 2562-2566
    • Moinfar, F.1    Man, Y.G.2    Arnould, L.3    Bratthauer, G.L.4    Ratschek, M.5    Tavassoli, F.A.6
  • 12
    • 0242410394 scopus 로고    scopus 로고
    • Immunosuppressive effect of mesenchymal stem cells favors tumor growth in allogeneic animals
    • Djouad F, Plence P, Bony C, et al. Immunosuppressive effect of mesenchymal stem cells favors tumor growth in allogeneic animals. Blood. 2003;102:3837-3844.
    • (2003) Blood , vol.102 , pp. 3837-3844
    • Djouad, F.1    Plence, P.2    Bony, C.3
  • 15
    • 28944432805 scopus 로고    scopus 로고
    • Hill R, Song Y, Cardiff RD, Van Dyke T. Selective evolution of stromal mesenchyme with p53 loss in response to epithelial tumorigenesis. Cell. 2005;123:1001-1011.
    • Hill R, Song Y, Cardiff RD, Van Dyke T. Selective evolution of stromal mesenchyme with p53 loss in response to epithelial tumorigenesis. Cell. 2005;123:1001-1011.
  • 17
    • 0028890174 scopus 로고
    • The origin of the myofibroblasts in breast cancer: Recapitulation of tumor environment in culture unravels diversity and implicates converted fibroblasts and recruited smooth muscle cells
    • Ronnov-Jessen L, Petersen OW, Koteliansky VE, Bissell MJ. The origin of the myofibroblasts in breast cancer: recapitulation of tumor environment in culture unravels diversity and implicates converted fibroblasts and recruited smooth muscle cells. J Clin Invest. 1995;95:859-873.
    • (1995) J Clin Invest , vol.95 , pp. 859-873
    • Ronnov-Jessen, L.1    Petersen, O.W.2    Koteliansky, V.E.3    Bissell, M.J.4
  • 18
    • 0036644833 scopus 로고    scopus 로고
    • Bone marrow-derived mesenchymal stem cells as vehicles for interferon-β delivery into tumors
    • Studeny M, Marini FC, Champlin RE, Zompetta C, Fidler IJ, Andreeff M. Bone marrow-derived mesenchymal stem cells as vehicles for interferon-β delivery into tumors. Cancer Res. 2002;62: 3603-3608.
    • (2002) Cancer Res , vol.62 , pp. 3603-3608
    • Studeny, M.1    Marini, F.C.2    Champlin, R.E.3    Zompetta, C.4    Fidler, I.J.5    Andreeff, M.6
  • 19
    • 7944220831 scopus 로고    scopus 로고
    • Mesenchymal stem cells: Potential precursors for tumor stroma and targeted-delivery vehicles for anticancer agents
    • Studeny M, Marini FC, Dembinski JL, et al. Mesenchymal stem cells: potential precursors for tumor stroma and targeted-delivery vehicles for anticancer agents. J Natl Cancer Inst. 2004;96: 1593-1603.
    • (2004) J Natl Cancer Inst , vol.96 , pp. 1593-1603
    • Studeny, M.1    Marini, F.C.2    Dembinski, J.L.3
  • 20
    • 9244236047 scopus 로고    scopus 로고
    • Bone marrow contribution to tumor-associated myofibroblasts and fibroblasts
    • Direkze NC, Hodivala-Dilke K, Jeffery R, et al. Bone marrow contribution to tumor-associated myofibroblasts and fibroblasts. Cancer Res. 2004;64:8492-8495.
    • (2004) Cancer Res , vol.64 , pp. 8492-8495
    • Direkze, N.C.1    Hodivala-Dilke, K.2    Jeffery, R.3
  • 21
    • 24944587964 scopus 로고    scopus 로고
    • Tie2 identifies a hematopoietic lineage of proangiogenic monocytes required for tumor vessel formation and a mesenchymal population of pericyte progenitors
    • De Palma M, Venneri MA, Galli R, et al. Tie2 identifies a hematopoietic lineage of proangiogenic monocytes required for tumor vessel formation and a mesenchymal population of pericyte progenitors. Cancer Cell. 2005;8:211-226.
    • (2005) Cancer Cell , vol.8 , pp. 211-226
    • De Palma, M.1    Venneri, M.A.2    Galli, R.3
  • 22
    • 28644432204 scopus 로고    scopus 로고
    • VEGFR1-positive haematopoietic bone marrow progenitors initiate the pre-metastatic niche
    • Kaplan RN, Riba RD, Zacharoulis S, et al. VEGFR1-positive haematopoietic bone marrow progenitors initiate the pre-metastatic niche. Nature. 2005;438:820-827.
    • (2005) Nature , vol.438 , pp. 820-827
    • Kaplan, R.N.1    Riba, R.D.2    Zacharoulis, S.3
  • 23
    • 20244374417 scopus 로고    scopus 로고
    • Human bone marrow-derived mesenchymal stem cells in the treatment of gliomas
    • Nakamizo A, Marini F, Amano T, et al. Human bone marrow-derived mesenchymal stem cells in the treatment of gliomas. Cancer Res. 2005;65:3307-3318.
    • (2005) Cancer Res , vol.65 , pp. 3307-3318
    • Nakamizo, A.1    Marini, F.2    Amano, T.3
  • 24
    • 17444410347 scopus 로고    scopus 로고
    • Mesenchymal stem cells: Progress toward promise
    • Le Blanc K, Pittenger M. Mesenchymal stem cells: progress toward promise. Cytotherapy. 2005;7:36-45.
    • (2005) Cytotherapy , vol.7 , pp. 36-45
    • Le Blanc, K.1    Pittenger, M.2
  • 26
    • 20444419744 scopus 로고    scopus 로고
    • Autologous mesenchymal stem cell transplantation in stroke patients
    • Bang OY, Lee JS, Lee PH, Lee G. Autologous mesenchymal stem cell transplantation in stroke patients. Ann Neurol. 2005;57: 874-882.
    • (2005) Ann Neurol , vol.57 , pp. 874-882
    • Bang, O.Y.1    Lee, J.S.2    Lee, P.H.3    Lee, G.4
  • 27
    • 20244389227 scopus 로고    scopus 로고
    • Cotransplantation of HLA-identical sibling culture-expanded mesenchymal stem cells and hematopoietic stem cells in hematologic malignancy patients
    • Lazarus HM, Koc ON, Devine SM, et al. Cotransplantation of HLA-identical sibling culture-expanded mesenchymal stem cells and hematopoietic stem cells in hematologic malignancy patients. Biol Blood Marrow Transplant. 2005;11:389-398.
    • (2005) Biol Blood Marrow Transplant , vol.11 , pp. 389-398
    • Lazarus, H.M.1    Koc, O.N.2    Devine, S.M.3
  • 28
    • 15444380614 scopus 로고    scopus 로고
    • Integral therapeutic potential of bone marrow mesenchymal stem cells
    • Kan I, Melamed E, Offen D. Integral therapeutic potential of bone marrow mesenchymal stem cells. Curr Drug Targets. 2005;6:31-41.
    • (2005) Curr Drug Targets , vol.6 , pp. 31-41
    • Kan, I.1    Melamed, E.2    Offen, D.3
  • 29
    • 0642280789 scopus 로고    scopus 로고
    • Plasticity of mesenchymal stem cells: Regenerative medicine for diseased hearts
    • Gojo S, Umezawa A. Plasticity of mesenchymal stem cells: regenerative medicine for diseased hearts. Hum Cell. 2003;16:23-30.
    • (2003) Hum Cell , vol.16 , pp. 23-30
    • Gojo, S.1    Umezawa, A.2
  • 30
    • 3042662157 scopus 로고    scopus 로고
    • Effect on left ventricular function of intracoronary transplantation of autologous bone marrow mesenchymal stem cell in patients with acute myocardial infarction
    • Chen SL, Fang WW, Ye F, et al. Effect on left ventricular function of intracoronary transplantation of autologous bone marrow mesenchymal stem cell in patients with acute myocardial infarction. Am J Cardiol. 2004;94:92-95.
    • (2004) Am J Cardiol , vol.94 , pp. 92-95
    • Chen, S.L.1    Fang, W.W.2    Ye, F.3
  • 31
    • 0032976690 scopus 로고    scopus 로고
    • Transplantability and therapeutic effects of bone marrow-derived mesenchymal cells in children with osteogenesis imperfecta
    • Horwitz EM, Prockop DJ, Fitzpatrick LA, et al. Transplantability and therapeutic effects of bone marrow-derived mesenchymal cells in children with osteogenesis imperfecta. Nat Med. 1999;5:309-313.
    • (1999) Nat Med , vol.5 , pp. 309-313
    • Horwitz, E.M.1    Prockop, D.J.2    Fitzpatrick, L.A.3
  • 32
    • 5444256371 scopus 로고    scopus 로고
    • Inflammation as a tumor promoter in cancer induction
    • Philip M, Rowley DA, Schreiber H. Inflammation as a tumor promoter in cancer induction. Semin Cancer Biol. 2004;14:433-439.
    • (2004) Semin Cancer Biol , vol.14 , pp. 433-439
    • Philip, M.1    Rowley, D.A.2    Schreiber, H.3
  • 33
    • 2342482526 scopus 로고    scopus 로고
    • Treatment of severe acute graft-versus-host disease with third party haploidentical mesenchymal stem cells
    • Le Blanc K, Rasmusson I, Sundberg B, et al. Treatment of severe acute graft-versus-host disease with third party haploidentical mesenchymal stem cells. Lancet. 2004;363:1439-1441.
    • (2004) Lancet , vol.363 , pp. 1439-1441
    • Le Blanc, K.1    Rasmusson, I.2    Sundberg, B.3
  • 34
    • 0035253742 scopus 로고    scopus 로고
    • Know thy neighbor: Stromal cells can contribute oncogenic signals
    • Tlsty TD, Hein PW. Know thy neighbor: stromal cells can contribute oncogenic signals. Curr Opin Genet Dev. 2001;11:54-59.
    • (2001) Curr Opin Genet Dev , vol.11 , pp. 54-59
    • Tlsty, T.D.1    Hein, P.W.2
  • 36
    • 0037180757 scopus 로고    scopus 로고
    • Inflammation and cancer
    • Coussens LM, Werb Z. Inflammation and cancer. Nature. 2002;420: 860-867.
    • (2002) Nature , vol.420 , pp. 860-867
    • Coussens, L.M.1    Werb, Z.2
  • 37
    • 8144228952 scopus 로고    scopus 로고
    • Friends or foes: Bipolar effects of the tumour stroma in cancer
    • Mueller MM, Fusenig NE. Friends or foes: bipolar effects of the tumour stroma in cancer. Nat Rev Cancer. 2004;4:839-849.
    • (2004) Nat Rev Cancer , vol.4 , pp. 839-849
    • Mueller, M.M.1    Fusenig, N.E.2
  • 38
    • 0141988568 scopus 로고    scopus 로고
    • Fundamental concepts of the angiogenic process
    • Folkman J. Fundamental concepts of the angiogenic process. Curr Mol Med. 2003;3:643-651.
    • (2003) Curr Mol Med , vol.3 , pp. 643-651
    • Folkman, J.1
  • 39
    • 0021684729 scopus 로고
    • Induction of neovascularization in vivo and endothelial proliferation in vitro by tumor-associated macrophages
    • Polverini PJ, Leibovich SJ. Induction of neovascularization in vivo and endothelial proliferation in vitro by tumor-associated macrophages. Lab Invest. 1984;51:635-642.
    • (1984) Lab Invest , vol.51 , pp. 635-642
    • Polverini, P.J.1    Leibovich, S.J.2
  • 40
    • 0036839143 scopus 로고    scopus 로고
    • Macrophage polarization: Tumor-associated macrophages as a paradigm for polarized M2 mononuclear phagocytes
    • Mantovani A, Sozzani S, Locati M, Allavena P, Sica A. Macrophage polarization: tumor-associated macrophages as a paradigm for polarized M2 mononuclear phagocytes. Trends Immunol. 2002;23: 549-555.
    • (2002) Trends Immunol , vol.23 , pp. 549-555
    • Mantovani, A.1    Sozzani, S.2    Locati, M.3    Allavena, P.4    Sica, A.5
  • 41
    • 0348012943 scopus 로고    scopus 로고
    • The fibroblast: Sentinel cell and local immune modulator in tumor tissue
    • Silzle T, Randolph GJ, Kreutz M, Kunz-Schughart LA. The fibroblast: sentinel cell and local immune modulator in tumor tissue. Int J Cancer. 2004;108:173-180.
    • (2004) Int J Cancer , vol.108 , pp. 173-180
    • Silzle, T.1    Randolph, G.J.2    Kreutz, M.3    Kunz-Schughart, L.A.4
  • 42
    • 3543002277 scopus 로고    scopus 로고
    • VEGF-null cells require PDGFR α signaling-mediated stromal fibroblast recruitment for tumorigenesis
    • Dong J, Grunstein J, Tejada M, et al. VEGF-null cells require PDGFR α signaling-mediated stromal fibroblast recruitment for tumorigenesis. EMBO J. 2004;23:2800-2810.
    • (2004) EMBO J , vol.23 , pp. 2800-2810
    • Dong, J.1    Grunstein, J.2    Tejada, M.3
  • 43
    • 0027848681 scopus 로고
    • Interleukin 10 transfected into Chinese hamster ovary cells prevents tumor growth and macrophage infiltration
    • Richter G, Kruger-Krasagakes S, Hein G, et al. Interleukin 10 transfected into Chinese hamster ovary cells prevents tumor growth and macrophage infiltration. Cancer Res. 1993;53:4134-4137.
    • (1993) Cancer Res , vol.53 , pp. 4134-4137
    • Richter, G.1    Kruger-Krasagakes, S.2    Hein, G.3
  • 46
    • 26244432793 scopus 로고    scopus 로고
    • Proliferating fibroblasts at the invading tumour edge of colorectal adenocarcinomas are associated with endogenous markers of hypoxia, acidity, and oxidative stress
    • Sivridis E, Giatromanolaki A, Koukourakis MI. Proliferating fibroblasts at the invading tumour edge of colorectal adenocarcinomas are associated with endogenous markers of hypoxia, acidity, and oxidative stress. J Clin Pathol. 2005;58:1033-1038.
    • (2005) J Clin Pathol , vol.58 , pp. 1033-1038
    • Sivridis, E.1    Giatromanolaki, A.2    Koukourakis, M.I.3
  • 47
    • 25444506333 scopus 로고    scopus 로고
    • Stromal expression of connective tissue growth factor promotes angiogenesis and prostate cancer tumorigenesis
    • Yang F, Tuxhorn JA, Ressler SJ, McAlhany SJ, Dang TD, Rowley DR. Stromal expression of connective tissue growth factor promotes angiogenesis and prostate cancer tumorigenesis. Cancer Res. 2005;65:8887-8895.
    • (2005) Cancer Res , vol.65 , pp. 8887-8895
    • Yang, F.1    Tuxhorn, J.A.2    Ressler, S.J.3    McAlhany, S.J.4    Dang, T.D.5    Rowley, D.R.6
  • 48
    • 0030889354 scopus 로고    scopus 로고
    • Marrow stromal cells as stem cells for nonhematopoietic tissues
    • Prockop DJ. Marrow stromal cells as stem cells for nonhematopoietic tissues. Science. 1997;276:71-74.
    • (1997) Science , vol.276 , pp. 71-74
    • Prockop, D.J.1
  • 49
    • 0034050752 scopus 로고    scopus 로고
    • Development of myofibroblasts from human bone marrow mesenchymal stem cells cocultured with human colon carcinoma cells and TGF beta 1
    • Emura M, Ochiai A, Horino M, Arndt W, Kamino K, Hirohashi S. Development of myofibroblasts from human bone marrow mesenchymal stem cells cocultured with human colon carcinoma cells and TGF beta 1. In Vitro Cell Dev Biol Anim. 2000;36:77-80.
    • (2000) In Vitro Cell Dev Biol Anim , vol.36 , pp. 77-80
    • Emura, M.1    Ochiai, A.2    Horino, M.3    Arndt, W.4    Kamino, K.5    Hirohashi, S.6
  • 50
    • 0041441245 scopus 로고    scopus 로고
    • Bone-marrow-derived myofibroblasts contribute to the cancer-induced stromal reaction
    • Ishii G, Sangai T, Oda T, et al. Bone-marrow-derived myofibroblasts contribute to the cancer-induced stromal reaction. Biochem Biophys Res Commun. 2003;309:232-240.
    • (2003) Biochem Biophys Res Commun , vol.309 , pp. 232-240
    • Ishii, G.1    Sangai, T.2    Oda, T.3
  • 51
    • 10744228467 scopus 로고    scopus 로고
    • Multiple organ engraftment by bone-marrow-derived myofibroblasts and fibroblasts in bone-marrow-transplanted mice
    • Direkze NC, Forbes SJ, Brittan M, et al. Multiple organ engraftment by bone-marrow-derived myofibroblasts and fibroblasts in bone-marrow-transplanted mice. Stem Cells. 2003;21:514-520.
    • (2003) Stem Cells , vol.21 , pp. 514-520
    • Direkze, N.C.1    Forbes, S.J.2    Brittan, M.3
  • 52
    • 0034614637 scopus 로고    scopus 로고
    • The hallmarks of cancer
    • Hanahan D, Weinberg RA. The hallmarks of cancer. Cell. 2000; 100:57-70.
    • (2000) Cell , vol.100 , pp. 57-70
    • Hanahan, D.1    Weinberg, R.A.2
  • 53
    • 0030051051 scopus 로고    scopus 로고
    • Cellular changes involved in conversion of normal to malignant breast: Importance of the stromal reaction
    • Ronnov-Jessen L, Petersen OW, Bissell MJ. Cellular changes involved in conversion of normal to malignant breast: importance of the stromal reaction. Physiol Rev. 1996;76:69-125.
    • (1996) Physiol Rev , vol.76 , pp. 69-125
    • Ronnov-Jessen, L.1    Petersen, O.W.2    Bissell, M.J.3
  • 54
    • 10344220521 scopus 로고    scopus 로고
    • Endogenous angiogenesis inhibitors
    • Folkman J. Endogenous angiogenesis inhibitors. APMIS. 2004;112: 496-507.
    • (2004) APMIS , vol.112 , pp. 496-507
    • Folkman, J.1
  • 55
    • 0023089768 scopus 로고
    • Mesenchyme-dependent differentiation of epithelial progenitor cells in the gut
    • Haffen K, Kedinger M, Simon-Assmann P. Mesenchyme-dependent differentiation of epithelial progenitor cells in the gut. J Pediatr Gastroenterol Nutr. 1987;6:14-23.
    • (1987) J Pediatr Gastroenterol Nutr , vol.6 , pp. 14-23
    • Haffen, K.1    Kedinger, M.2    Simon-Assmann, P.3
  • 56
    • 0029677173 scopus 로고    scopus 로고
    • Role of mesenchymal-epithelial interactions in mammary gland development
    • Cunha GR, Hom YK. Role of mesenchymal-epithelial interactions in mammary gland development. J Mammary Gland Biol Neoplasia. 1996;1:21-35.
    • (1996) J Mammary Gland Biol Neoplasia , vol.1 , pp. 21-35
    • Cunha, G.R.1    Hom, Y.K.2
  • 57
    • 0035162210 scopus 로고    scopus 로고
    • Prolactin, growth hormone, and epidermal growth factor activate Stat5 in different compartments of mammary tissue and exert different and overlapping developmental effects
    • Gallego MI, Binart N, Robinson GW, et al. Prolactin, growth hormone, and epidermal growth factor activate Stat5 in different compartments of mammary tissue and exert different and overlapping developmental effects. Dev Biol. 2001;229:163-175.
    • (2001) Dev Biol , vol.229 , pp. 163-175
    • Gallego, M.I.1    Binart, N.2    Robinson, G.W.3
  • 58
    • 0017095517 scopus 로고
    • Mesenchyme-dependent morphogenesis and epithelium-specific cytodifferentiation in mouse mammary gland
    • Sakakura T, Nishizuka Y, Dawe CJ. Mesenchyme-dependent morphogenesis and epithelium-specific cytodifferentiation in mouse mammary gland. Science. 1976;194:1439-1441.
    • (1976) Science , vol.194 , pp. 1439-1441
    • Sakakura, T.1    Nishizuka, Y.2    Dawe, C.J.3
  • 59
    • 0032957973 scopus 로고    scopus 로고
    • Signaling through the stromal epidermal growth factor receptor is necessary for mammary ductal development
    • Wiesen JF, Young P, Werb Z, Cunha GR. Signaling through the stromal epidermal growth factor receptor is necessary for mammary ductal development, Development. 1999;126:335-344.
    • (1999) Development , vol.126 , pp. 335-344
    • Wiesen, J.F.1    Young, P.2    Werb, Z.3    Cunha, G.R.4
  • 60
    • 12344318372 scopus 로고    scopus 로고
    • Context, tissue plasticity, and cancer: Are tumor stem cells also regulated by the microenvironment?
    • Bissell MJ, Labarge MA. Context, tissue plasticity, and cancer: are tumor stem cells also regulated by the microenvironment? Cancer Cell. 2005;7:17-23.
    • (2005) Cancer Cell , vol.7 , pp. 17-23
    • Bissell, M.J.1    Labarge, M.A.2
  • 61
    • 0034161922 scopus 로고    scopus 로고
    • Irradiated mammary gland stroma promotes the expression of tumorigenic potential by unirradiated epithelial cells
    • Barcellos-Hoff MH, Ravani SA. Irradiated mammary gland stroma promotes the expression of tumorigenic potential by unirradiated epithelial cells. Cancer Res. 2000;60:1254-1260.
    • (2000) Cancer Res , vol.60 , pp. 1254-1260
    • Barcellos-Hoff, M.H.1    Ravani, S.A.2
  • 62
    • 0034696350 scopus 로고    scopus 로고
    • The matrix metalloproteinase stromelysin-1 acts as a natural mammary tumor promoter
    • Sternlicht MD, Bissell MJ, Werb Z. The matrix metalloproteinase stromelysin-1 acts as a natural mammary tumor promoter. Oncogene. 2000;19:1102-1113.
    • (2000) Oncogene , vol.19 , pp. 1102-1113
    • Sternlicht, M.D.1    Bissell, M.J.2    Werb, Z.3
  • 63
    • 0033597726 scopus 로고    scopus 로고
    • The stromal proteinase MMP3/stromelysin-1 promotes mammary carcinogenesis
    • Sternlicht MD, Lochter A, Sympson CJ, et al. The stromal proteinase MMP3/stromelysin-1 promotes mammary carcinogenesis. Cell. 1999;98:137-146.
    • (1999) Cell , vol.98 , pp. 137-146
    • Sternlicht, M.D.1    Lochter, A.2    Sympson, C.J.3
  • 64
    • 0036843937 scopus 로고    scopus 로고
    • Frequent somatic mutations in PTEN and TP53 are mutually exclusive in the stroma of breast carcinomas
    • Kurose K, Gilley K, Matsumoto S, Watson PH, Zhou XP, Eng C. Frequent somatic mutations in PTEN and TP53 are mutually exclusive in the stroma of breast carcinomas. Nat Genet. 2002;32: 355-357.
    • (2002) Nat Genet , vol.32 , pp. 355-357
    • Kurose, K.1    Gilley, K.2    Matsumoto, S.3    Watson, P.H.4    Zhou, X.P.5    Eng, C.6
  • 65
    • 0345366593 scopus 로고
    • Normal genetically mosaic mice produced from malignant teratocarcinoma cells
    • Mintz B, Illmensee K. Normal genetically mosaic mice produced from malignant teratocarcinoma cells. Proc Natl Acad Sci U S A. 1975;72:3585-3589.
    • (1975) Proc Natl Acad Sci U S A , vol.72 , pp. 3585-3589
    • Mintz, B.1    Illmensee, K.2
  • 66
    • 4143122292 scopus 로고    scopus 로고
    • Dynamic of distribution of human bone marrow-derived mesenchymal stem cells after transplantation into adult unconditioned mice
    • Allers C, Sierralta WD, Neubauer S, Rivera F, Minguell JJ, Conget PA. Dynamic of distribution of human bone marrow-derived mesenchymal stem cells after transplantation into adult unconditioned mice. Transplantation. 2004;78:503-508.
    • (2004) Transplantation , vol.78 , pp. 503-508
    • Allers, C.1    Sierralta, W.D.2    Neubauer, S.3    Rivera, F.4    Minguell, J.J.5    Conget, P.A.6
  • 67
    • 0842300402 scopus 로고    scopus 로고
    • Plasticity of human stem cells in the fetal sheep model of human stem cell transplantation
    • Almeida-Porada G, Porada C, Zanjani ED. Plasticity of human stem cells in the fetal sheep model of human stem cell transplantation. Int J Hematol. 2004;79:1-6.
    • (2004) Int J Hematol , vol.79 , pp. 1-6
    • Almeida-Porada, G.1    Porada, C.2    Zanjani, E.D.3
  • 68
    • 0037478581 scopus 로고    scopus 로고
    • Mesenchymal stem cell engraftment in lung is enhanced in response to bleomycin exposure and ameliorates its fibrotic effects
    • Ortiz LA, Gambelli F, McBride C, et al. Mesenchymal stem cell engraftment in lung is enhanced in response to bleomycin exposure and ameliorates its fibrotic effects. Proc Natl Acad Sci U S A. 2003;100:8407-8411.
    • (2003) Proc Natl Acad Sci U S A , vol.100 , pp. 8407-8411
    • Ortiz, L.A.1    Gambelli, F.2    McBride, C.3
  • 69
    • 0141564860 scopus 로고    scopus 로고
    • Human cord blood-derived mesenchymal stem cells home and survive in the marrow of immunodeficient mice after systemic infusion
    • Erices AA, Allers CI, Conget PA, Rojas CV, Minguell JJ. Human cord blood-derived mesenchymal stem cells home and survive in the marrow of immunodeficient mice after systemic infusion. Cell Transplant. 2003;12:555-561.
    • (2003) Cell Transplant , vol.12 , pp. 555-561
    • Erices, A.A.1    Allers, C.I.2    Conget, P.A.3    Rojas, C.V.4    Minguell, J.J.5
  • 70
    • 0033824164 scopus 로고    scopus 로고
    • Mesenchymal stem cells: Biology and potential clinical uses
    • Deans RJ, Moseley AB. Mesenchymal stem cells: biology and potential clinical uses. Exp Hematol. 2000;28:875-884.
    • (2000) Exp Hematol , vol.28 , pp. 875-884
    • Deans, R.J.1    Moseley, A.B.2
  • 71
    • 31644450990 scopus 로고    scopus 로고
    • Administered mesenchymal stem cells enhance recovery from ischemia/reperfusion-induced acute renal failure in rats
    • Lange C, Togel F, Ittrich H, et al. Administered mesenchymal stem cells enhance recovery from ischemia/reperfusion-induced acute renal failure in rats. Kidney Int. 2005;68:1613-1617.
    • (2005) Kidney Int , vol.68 , pp. 1613-1617
    • Lange, C.1    Togel, F.2    Ittrich, H.3
  • 72
    • 24344448730 scopus 로고    scopus 로고
    • Bone marrow-derived mesenchymal stem cells in repair of the injured lung
    • Rojas M, Xu J, Woods CR, et al. Bone marrow-derived mesenchymal stem cells in repair of the injured lung. Am J Respir Cell Mol Biol. 2005;33:145-152.
    • (2005) Am J Respir Cell Mol Biol , vol.33 , pp. 145-152
    • Rojas, M.1    Xu, J.2    Woods, C.R.3
  • 73
    • 16244408979 scopus 로고    scopus 로고
    • Plasticity and therapeutic potential of mesenchymal stem cells in the nervous system
    • Phinney DG, Isakova I. Plasticity and therapeutic potential of mesenchymal stem cells in the nervous system. Curr Pharm Des. 2005; 11:1255-1265.
    • (2005) Curr Pharm Des , vol.11 , pp. 1255-1265
    • Phinney, D.G.1    Isakova, I.2
  • 74
    • 22144460191 scopus 로고    scopus 로고
    • Human mesenchymal stem cells xenografted directly to rat liver are differentiated into human hepatocytes without fusion
    • Sato Y, Araki H, Kato J, et al. Human mesenchymal stem cells xenografted directly to rat liver are differentiated into human hepatocytes without fusion. Blood. 2005;106:756-763.
    • (2005) Blood , vol.106 , pp. 756-763
    • Sato, Y.1    Araki, H.2    Kato, J.3
  • 75
    • 4544303726 scopus 로고    scopus 로고
    • Allogeneic bone marrow-derived mesenchymal stromal cells promote the regeneration of injured skeletal muscle without differentiation into myofibers
    • Natsu K, Ochi M, Mochizuki Y, Hachisuka H, Yanada S, Yasunaga Y. Allogeneic bone marrow-derived mesenchymal stromal cells promote the regeneration of injured skeletal muscle without differentiation into myofibers. Tissue Eng. 2004;10:1093-1112.
    • (2004) Tissue Eng , vol.10 , pp. 1093-1112
    • Natsu, K.1    Ochi, M.2    Mochizuki, Y.3    Hachisuka, H.4    Yanada, S.5    Yasunaga, Y.6
  • 76
    • 19944432052 scopus 로고    scopus 로고
    • Mesenchymal stem cells differentiate into an endothelial phenotype, enhance vascular density, and improve heart function in a canine chronic ischemia model
    • Silva GV, Litovsky S, Assad JA, et al. Mesenchymal stem cells differentiate into an endothelial phenotype, enhance vascular density, and improve heart function in a canine chronic ischemia model. Circulation. 2005;111:150-156.
    • (2005) Circulation , vol.111 , pp. 150-156
    • Silva, G.V.1    Litovsky, S.2    Assad, J.A.3
  • 77
    • 10744229598 scopus 로고    scopus 로고
    • BDNF gene-modified mesenchymal stem cells promote functional recovery and reduce infarct size in the rat middle cerebral artery occlusion model
    • Kurozumi K, Nakamura K, Tamiya T, et al. BDNF gene-modified mesenchymal stem cells promote functional recovery and reduce infarct size in the rat middle cerebral artery occlusion model. Mol Ther. 2004;9:189-197.
    • (2004) Mol Ther , vol.9 , pp. 189-197
    • Kurozumi, K.1    Nakamura, K.2    Tamiya, T.3
  • 78
    • 22144475112 scopus 로고    scopus 로고
    • Allogeneic mesenchymal stem cell transplantation in postinfarcted rat myocardium: Short- and long-term effects
    • Dai W, Hale SL, Martin BJ, et al. Allogeneic mesenchymal stem cell transplantation in postinfarcted rat myocardium: short- and long-term effects. Circulation. 2005;112:214-223.
    • (2005) Circulation , vol.112 , pp. 214-223
    • Dai, W.1    Hale, S.L.2    Martin, B.J.3
  • 79
    • 20144389388 scopus 로고    scopus 로고
    • Human mesenchymal stem cells are tolerized by mice and improve skin and spinal cord injuries
    • Mansilla E, Marin GH, Sturla F, et al. Human mesenchymal stem cells are tolerized by mice and improve skin and spinal cord injuries. Transplant Proc. 2005;37:292-294.
    • (2005) Transplant Proc , vol.37 , pp. 292-294
    • Mansilla, E.1    Marin, G.H.2    Sturla, F.3
  • 80
    • 4444318026 scopus 로고    scopus 로고
    • Transplanted mesenchymal stem cells are effective for skin regeneration in acute cutaneous wounds
    • Satoh H, Kishi K, Tanaka T, et al. Transplanted mesenchymal stem cells are effective for skin regeneration in acute cutaneous wounds. Cell Transplant. 2004;13:405-412.
    • (2004) Cell Transplant , vol.13 , pp. 405-412
    • Satoh, H.1    Kishi, K.2    Tanaka, T.3
  • 81
    • 0022891340 scopus 로고
    • Tumors: Wounds that do not heal. Similarities between tumor stroma generation and wound healing
    • Dvorak HF. Tumors: wounds that do not heal. Similarities between tumor stroma generation and wound healing. N Engl J Med. 1986; 315:1650-1659.
    • (1986) N Engl J Med , vol.315 , pp. 1650-1659
    • Dvorak, H.F.1
  • 83
    • 0033515827 scopus 로고    scopus 로고
    • Multilineage potential of adult human mesenchymal stem cells
    • Pittenger MF, Mackay AM, Beck SC, et al. Multilineage potential of adult human mesenchymal stem cells. Science. 1999;284: 143-147.
    • (1999) Science , vol.284 , pp. 143-147
    • Pittenger, M.F.1    Mackay, A.M.2    Beck, S.C.3
  • 84
    • 0038664242 scopus 로고    scopus 로고
    • Molecular and cellular characterisation of highly purified stromal stem cells derived from human bone marrow
    • Gronthos S, Zannettino AC, Hay SJ, et al. Molecular and cellular characterisation of highly purified stromal stem cells derived from human bone marrow. J Cell Sci. 2003;116:1827-1835.
    • (2003) J Cell Sci , vol.116 , pp. 1827-1835
    • Gronthos, S.1    Zannettino, A.C.2    Hay, S.J.3
  • 85
    • 0035525779 scopus 로고    scopus 로고
    • Purification and ex vivo expansion of postnatal human marrow mesodermal progenitor cells
    • Reyes M, Lund T, Lenvik T, Aguiar D, Koodie L, Verfaillie CM. Purification and ex vivo expansion of postnatal human marrow mesodermal progenitor cells. Blood. 2001;98:2615-2625.
    • (2001) Blood , vol.98 , pp. 2615-2625
    • Reyes, M.1    Lund, T.2    Lenvik, T.3    Aguiar, D.4    Koodie, L.5    Verfaillie, C.M.6
  • 86
    • 20444429578 scopus 로고    scopus 로고
    • Adult mesenchymal stem cells: Characterization, differentiation, and application in cell and gene therapy
    • Baksh D, Song L, Tuan RS. Adult mesenchymal stem cells: characterization, differentiation, and application in cell and gene therapy. J Cell Mol Med. 2004;8:301-316.
    • (2004) J Cell Mol Med , vol.8 , pp. 301-316
    • Baksh, D.1    Song, L.2    Tuan, R.S.3
  • 87
    • 0038281370 scopus 로고    scopus 로고
    • Mesenchymal stem cells distribute to a wide range of tissues following systemic infusion into nonhuman primates
    • Devine SM, Cobbs C, Jennings M, Bartholomew A, Hoffman R. Mesenchymal stem cells distribute to a wide range of tissues following systemic infusion into nonhuman primates. Blood. 2003; 101:2999-3001.
    • (2003) Blood , vol.101 , pp. 2999-3001
    • Devine, S.M.1    Cobbs, C.2    Jennings, M.3    Bartholomew, A.4    Hoffman, R.5
  • 88
    • 0042913484 scopus 로고    scopus 로고
    • Use of adult marrow mesenchymal stem cells for regeneration of cardiomyocytes
    • Fukuda K. Use of adult marrow mesenchymal stem cells for regeneration of cardiomyocytes. Bone Marrow Transplant. 2003;32 (suppl 1):S25-S27.
    • (2003) Bone Marrow Transplant , vol.32 , Issue.SUPPL. 1
    • Fukuda, K.1
  • 89
    • 0036676009 scopus 로고    scopus 로고
    • Allogeneic mesenchymal stem cell infusion for treatment of metachromatic leukodystrophy (MLD) and Hurler syndrome (MPS-IH)
    • Koc ON, Day J, Nieder M, Gerson SL, Lazarus HM, Krivit W. Allogeneic mesenchymal stem cell infusion for treatment of metachromatic leukodystrophy (MLD) and Hurler syndrome (MPS-IH). Bone Marrow Transplant. 2002;30:215-222.
    • (2002) Bone Marrow Transplant , vol.30 , pp. 215-222
    • Koc, O.N.1    Day, J.2    Nieder, M.3    Gerson, S.L.4    Lazarus, H.M.5    Krivit, W.6
  • 90
    • 37649026269 scopus 로고    scopus 로고
    • Adult bone marrow stem cells for cell and gene therapies: Implications for greater use
    • Ballas CB, Zielske SP, Gerson SL. Adult bone marrow stem cells for cell and gene therapies: implications for greater use. J Cell Biochem Suppl. 2002;38:20-28.
    • (2002) J Cell Biochem Suppl , vol.38 , pp. 20-28
    • Ballas, C.B.1    Zielske, S.P.2    Gerson, S.L.3
  • 91
    • 4544271598 scopus 로고    scopus 로고
    • Ex vivo expansion of cord blood mononuclear cells on mesenchymal stem cells
    • McNiece I, Harrington J, Turney J, Kellner J, Shpall EJ. Ex vivo expansion of cord blood mononuclear cells on mesenchymal stem cells. Cytotherapy. 2004;6:311-317.
    • (2004) Cytotherapy , vol.6 , pp. 311-317
    • McNiece, I.1    Harrington, J.2    Turney, J.3    Kellner, J.4    Shpall, E.J.5
  • 92
    • 33646502840 scopus 로고    scopus 로고
    • Mesenchymal stem cells derived from bone marrow favor tumor cell growth in vivo
    • Zhu W, Xu W, Jiang R, et al. Mesenchymal stem cells derived from bone marrow favor tumor cell growth in vivo. Exp Mol Pathol. 2006;80:267-274.
    • (2006) Exp Mol Pathol , vol.80 , pp. 267-274
    • Zhu, W.1    Xu, W.2    Jiang, R.3
  • 93
    • 9444265320 scopus 로고    scopus 로고
    • Gastric cancer originating from bone marrow-derived cells
    • Houghton J, Stoicov C, Nomura S, et al. Gastric cancer originating from bone marrow-derived cells. Science. 2004;306:1568-1571.
    • (2004) Science , vol.306 , pp. 1568-1571
    • Houghton, J.1    Stoicov, C.2    Nomura, S.3
  • 94
    • 1842527031 scopus 로고    scopus 로고
    • Environmental guidance of normal and tumor cell plasticity: Epithelial mesenchymal transitions as a paradigm
    • Prindull G, Zipori D. Environmental guidance of normal and tumor cell plasticity: epithelial mesenchymal transitions as a paradigm. Blood. 2004;103:2892-2899.
    • (2004) Blood , vol.103 , pp. 2892-2899
    • Prindull, G.1    Zipori, D.2
  • 95
    • 0034018741 scopus 로고    scopus 로고
    • Selective interactions between epithelial tumour cells and bone marrow mesenchymal stem cells
    • Hombauer H, Minguell JJ. Selective interactions between epithelial tumour cells and bone marrow mesenchymal stem cells. Br J Cancer. 2000;82:1290-1296.
    • (2000) Br J Cancer , vol.82 , pp. 1290-1296
    • Hombauer, H.1    Minguell, J.J.2
  • 96
    • 24944587964 scopus 로고    scopus 로고
    • Tie2 identifies a hematopoietic lineage of proangiogenic monocytes required for tumor vessel formation and a mesenchymal population of pericyte progenitors
    • De Palma M, Venneri MA, Galli R, et al. Tie2 identifies a hematopoietic lineage of proangiogenic monocytes required for tumor vessel formation and a mesenchymal population of pericyte progenitors. Cancer Cell. 2005;8:211-226.
    • (2005) Cancer Cell , vol.8 , pp. 211-226
    • De Palma, M.1    Venneri, M.A.2    Galli, R.3
  • 97
    • 0038644403 scopus 로고    scopus 로고
    • Targeting exogenous genes to tumor angiogenesis by transplantation of genetically modified hematopoietic stem cells
    • De Palma M, Venneri MA, Roca C, Naldini L. Targeting exogenous genes to tumor angiogenesis by transplantation of genetically modified hematopoietic stem cells. Nat Med. 2003;9:789-795.
    • (2003) Nat Med , vol.9 , pp. 789-795
    • De Palma, M.1    Venneri, M.A.2    Roca, C.3    Naldini, L.4
  • 98
    • 0141679073 scopus 로고    scopus 로고
    • Transforming growth factor-β1 down-regulates expression of chemokine stromal cell-derived factor-1: Functional consequences in cell migration and adhesion
    • Wright N, de Lera TL, Garcia-Moruja C, et al. Transforming growth factor-β1 down-regulates expression of chemokine stromal cell-derived factor-1: functional consequences in cell migration and adhesion. Blood. 2003;102:1978-1984.
    • (2003) Blood , vol.102 , pp. 1978-1984
    • Wright, N.1    de Lera, T.L.2    Garcia-Moruja, C.3
  • 99
    • 1842531265 scopus 로고    scopus 로고
    • A significant proportion of myofibroblasts are of bone marrow origin in human liver fibrosis
    • Forbes SJ, Russo FP, Rey V, et al. A significant proportion of myofibroblasts are of bone marrow origin in human liver fibrosis. Gastroenterology. 2004;126:955-963.
    • (2004) Gastroenterology , vol.126 , pp. 955-963
    • Forbes, S.J.1    Russo, F.P.2    Rey, V.3
  • 100
    • 25444510172 scopus 로고    scopus 로고
    • In vivo and in vitro characterization of human fibroblasts recruited selectively into human cancer stroma
    • Ishii G, Sangai T, Ito T, et al. In vivo and in vitro characterization of human fibroblasts recruited selectively into human cancer stroma. Int J Cancer. 2005;117:212-220.
    • (2005) Int J Cancer , vol.117 , pp. 212-220
    • Ishii, G.1    Sangai, T.2    Ito, T.3
  • 101
    • 20344400608 scopus 로고    scopus 로고
    • Effect of differences in cancer cells and tumor growth sites on recruiting bone marrow-derived endothelial cells and myofibroblasts in cancer-induced stroma
    • Sangai T, Ishii G, Kodama K, et al. Effect of differences in cancer cells and tumor growth sites on recruiting bone marrow-derived endothelial cells and myofibroblasts in cancer-induced stroma. Int J Cancer. 2005;115:885-892.
    • (2005) Int J Cancer , vol.115 , pp. 885-892
    • Sangai, T.1    Ishii, G.2    Kodama, K.3
  • 102
    • 33644829464 scopus 로고    scopus 로고
    • Growth factor-mediated interaction between tumor cells and stromal fibroblasts in an experimental model of human small-cell lung cancer
    • Sugimoto T, Takiguchi Y, Kurosu K, et al. Growth factor-mediated interaction between tumor cells and stromal fibroblasts in an experimental model of human small-cell lung cancer. Oncol Rep. 2005;14:823-830.
    • (2005) Oncol Rep , vol.14 , pp. 823-830
    • Sugimoto, T.1    Takiguchi, Y.2    Kurosu, K.3
  • 103
    • 0037530144 scopus 로고    scopus 로고
    • Recruitment of human umbilical vein endothelial cells and human primary fibroblasts into experimental tumors growing in SCID mice
    • Roni V, Habeler W, Parenti A, et al. Recruitment of human umbilical vein endothelial cells and human primary fibroblasts into experimental tumors growing in SCID mice. Exp Cell Res. 2003;287:28-38.
    • (2003) Exp Cell Res , vol.287 , pp. 28-38
    • Roni, V.1    Habeler, W.2    Parenti, A.3
  • 104
    • 10744231064 scopus 로고    scopus 로고
    • Both hepatocyte growth factor (HGF) and stromal-derived factor-1 regulate the metastatic behavior of human rhabdomyosarcoma cells, but only HGF enhances their resistance to radiochemotherapy
    • Jankowski K, Kucia M, Wysoczynski M, et al. Both hepatocyte growth factor (HGF) and stromal-derived factor-1 regulate the metastatic behavior of human rhabdomyosarcoma cells, but only HGF enhances their resistance to radiochemotherapy. Cancer Res. 2003;63:7926-7935.
    • (2003) Cancer Res , vol.63 , pp. 7926-7935
    • Jankowski, K.1    Kucia, M.2    Wysoczynski, M.3
  • 105
    • 13444306377 scopus 로고    scopus 로고
    • Crosstalk between cancer cells and bone microenvironment in bone metastasis
    • Yoneda T, Hiraga T. Crosstalk between cancer cells and bone microenvironment in bone metastasis. Biochem Biophys Res Commun. 2005;328:679-687.
    • (2005) Biochem Biophys Res Commun , vol.328 , pp. 679-687
    • Yoneda, T.1    Hiraga, T.2
  • 106
    • 3142696364 scopus 로고    scopus 로고
    • Targeted therapy of brain tumors utilizing neural stem and progenitor cells
    • Burns MJ, Weiss W. Targeted therapy of brain tumors utilizing neural stem and progenitor cells. Front Biosci. 2003;8:e228-e234.
    • (2003) Front Biosci , vol.8
    • Burns, M.J.1    Weiss, W.2
  • 107
    • 2942596445 scopus 로고    scopus 로고
    • Targeted delivery of progenitor cells for cartilage repair
    • Dennis JE, Cohen N, Goldberg VM, Caplan AI. Targeted delivery of progenitor cells for cartilage repair. J Orthop Res. 2004;22:735-741.
    • (2004) J Orthop Res , vol.22 , pp. 735-741
    • Dennis, J.E.1    Cohen, N.2    Goldberg, V.M.3    Caplan, A.I.4
  • 108
    • 11144252801 scopus 로고    scopus 로고
    • Mesenchymal stem cells: Biological characteristics and potential clinical applications
    • Kassem M. Mesenchymal stem cells: biological characteristics and potential clinical applications. Cloning Stem Cells. 2004;6:369-374.
    • (2004) Cloning Stem Cells , vol.6 , pp. 369-374
    • Kassem, M.1
  • 109
    • 16844377227 scopus 로고    scopus 로고
    • Tissue-specific engraftment after in utero transplantation of allogeneic mesenchymal stem cells into sheep fetuses
    • Schoeberlein A, Holzgreve W, Dudler L, Hahn S, Surbek DV. Tissue-specific engraftment after in utero transplantation of allogeneic mesenchymal stem cells into sheep fetuses. Am J Obstet Gynecol. 2005;192:1044-1052.
    • (2005) Am J Obstet Gynecol , vol.192 , pp. 1044-1052
    • Schoeberlein, A.1    Holzgreve, W.2    Dudler, L.3    Hahn, S.4    Surbek, D.V.5
  • 110
    • 33645759735 scopus 로고    scopus 로고
    • Mesenchymal stem cell transplantation in a rabbit corneal alkali burn model: Engraftment and involvement in wound healing
    • Ye J, Yao K, Kim JC. Mesenchymal stem cell transplantation in a rabbit corneal alkali burn model: engraftment and involvement in wound healing. Eye. 2006;20:482-490.
    • (2006) Eye , vol.20 , pp. 482-490
    • Ye, J.1    Yao, K.2    Kim, J.C.3
  • 111
    • 12144270060 scopus 로고    scopus 로고
    • Human fetal mesenchymal stem cells as vehicles for gene delivery
    • Chan J, O'Donoghue K, de la Fuente J, et al. Human fetal mesenchymal stem cells as vehicles for gene delivery. Stem Cells. 2005;23:93-102.
    • (2005) Stem Cells , vol.23 , pp. 93-102
    • Chan, J.1    O'Donoghue, K.2    de la Fuente, J.3
  • 112
    • 10444275247 scopus 로고    scopus 로고
    • Isolation of mesenchymal stem cells of fetal or maternal origin from human placenta
    • In 't Anker PS, Scherjon SA, Kleijburg-van der Keur C, et al. Isolation of mesenchymal stem cells of fetal or maternal origin from human placenta. Stem Cells. 2004;22:1338-1345.
    • (2004) Stem Cells , vol.22 , pp. 1338-1345
    • In 't Anker, P.S.1    Scherjon, S.A.2    Kleijburg-van der Keur, C.3
  • 113
    • 16944363593 scopus 로고    scopus 로고
    • Systemic delivery of human growth hormone or human factor IX in dogs by reintroduced genetically modified autologous bone marrow stromal cells
    • Hurwitz DR, Kirchgesser M, Merrill W, et al. Systemic delivery of human growth hormone or human factor IX in dogs by reintroduced genetically modified autologous bone marrow stromal cells. Hum Gene Ther. 1997;8:137-156.
    • (1997) Hum Gene Ther , vol.8 , pp. 137-156
    • Hurwitz, D.R.1    Kirchgesser, M.2    Merrill, W.3
  • 114
    • 20844432900 scopus 로고    scopus 로고
    • Gene transfer to human joints: Progress toward a gene therapy of arthritis
    • Evans CH, Robbins PD, Ghivizzani SC, et al. Gene transfer to human joints: progress toward a gene therapy of arthritis. Proc Natl Acad Sci U S A. 2005;102:8698-8703.
    • (2005) Proc Natl Acad Sci U S A , vol.102 , pp. 8698-8703
    • Evans, C.H.1    Robbins, P.D.2    Ghivizzani, S.C.3
  • 115
    • 19944406772 scopus 로고    scopus 로고
    • Mesenchymal stem cells that produce neurotrophic factors reduce ischemic damage in the rat middle cerebral artery occlusion model
    • Kurozumi K, Nakamura K, Tamiya T, et al. Mesenchymal stem cells that produce neurotrophic factors reduce ischemic damage in the rat middle cerebral artery occlusion model. Mol Ther. 2005;11:96-104.
    • (2005) Mol Ther , vol.11 , pp. 96-104
    • Kurozumi, K.1    Nakamura, K.2    Tamiya, T.3
  • 116
    • 33745187411 scopus 로고    scopus 로고
    • Intravenous infusion of immortalized human mesenchymal stem cells protects against injury in a cerebral ischemia model in adult rat
    • Honma T, Honmou O, Iihoshi S, et al. Intravenous infusion of immortalized human mesenchymal stem cells protects against injury in a cerebral ischemia model in adult rat. Exp Neurol. 2006;199:56-66.
    • (2006) Exp Neurol , vol.199 , pp. 56-66
    • Honma, T.1    Honmou, O.2    Iihoshi, S.3
  • 117
    • 17744394087 scopus 로고    scopus 로고
    • Mesenchymal stem cells (MSC) as therapeutic cytoreagents for gene therapy
    • Hamada H, Kobune M, Nakamura K, et al. Mesenchymal stem cells (MSC) as therapeutic cytoreagents for gene therapy. Cancer Sci. 2005;96:149-156.
    • (2005) Cancer Sci , vol.96 , pp. 149-156
    • Hamada, H.1    Kobune, M.2    Nakamura, K.3
  • 118
    • 0034975453 scopus 로고    scopus 로고
    • Mesenchymal stem cells: Building blocks for molecular medicine in the 21st century
    • Caplan AI, Bruder SP. Mesenchymal stem cells: building blocks for molecular medicine in the 21st century. Trends Mol Med. 2001;7: 259-264.
    • (2001) Trends Mol Med , vol.7 , pp. 259-264
    • Caplan, A.I.1    Bruder, S.P.2
  • 119
    • 23144450870 scopus 로고    scopus 로고
    • Stem cell proteomes: A profile of human mesenchymal stem cells derived from umbilical cord blood
    • Feldmann RE Jr, Bieback K, Maurer MH, et al. Stem cell proteomes: a profile of human mesenchymal stem cells derived from umbilical cord blood. Electrophoresis. 2005;26:2749-2758.
    • (2005) Electrophoresis , vol.26 , pp. 2749-2758
    • Feldmann Jr, R.E.1    Bieback, K.2    Maurer, M.H.3
  • 120
    • 0035031713 scopus 로고    scopus 로고
    • Pathologic classification of rhabdomyosarcomas and correlations with molecular studies
    • Parham DM. Pathologic classification of rhabdomyosarcomas and correlations with molecular studies. Mod Pathol. 2001;14:506-514.
    • (2001) Mod Pathol , vol.14 , pp. 506-514
    • Parham, D.M.1
  • 121
    • 0037105788 scopus 로고    scopus 로고
    • The desmoplastic response to infiltrating breast carcinoma: Gene expression at the site of primary invasion and implications for comparisons between tumor types
    • Iacobuzio-Donahue CA, Argani P, Hempen PM, Jones J, Kern SE. The desmoplastic response to infiltrating breast carcinoma: gene expression at the site of primary invasion and implications for comparisons between tumor types. Cancer Res. 2002;62:5351-5357.
    • (2002) Cancer Res , vol.62 , pp. 5351-5357
    • Iacobuzio-Donahue, C.A.1    Argani, P.2    Hempen, P.M.3    Jones, J.4    Kern, S.E.5
  • 122
    • 19844373824 scopus 로고    scopus 로고
    • Soluble mediators of inflammation during tumor development
    • Robinson SC, Coussens LM. Soluble mediators of inflammation during tumor development. Adv Cancer Res. 2005;93:159-187.
    • (2005) Adv Cancer Res , vol.93 , pp. 159-187
    • Robinson, S.C.1    Coussens, L.M.2
  • 123
    • 3042699460 scopus 로고    scopus 로고
    • Adult human mesenchymal stem cell as a target for neoplastic transformation
    • Serakinci N, Guldberg P, Burns JS, et al. Adult human mesenchymal stem cell as a target for neoplastic transformation. Oncogene. 2004;23:5095-5098.
    • (2004) Oncogene , vol.23 , pp. 5095-5098
    • Serakinci, N.1    Guldberg, P.2    Burns, J.S.3
  • 124
    • 17144363265 scopus 로고    scopus 로고
    • Spontaneous human adult stem cell transformation
    • Rubio D, Garcia-Castro J, Martin MC, et al. Spontaneous human adult stem cell transformation. Cancer Res. 2005;65:3035-3039.
    • (2005) Cancer Res , vol.65 , pp. 3035-3039
    • Rubio, D.1    Garcia-Castro, J.2    Martin, M.C.3
  • 125
    • 17144384449 scopus 로고    scopus 로고
    • Tumorigenic heterogeneity in cancer stem cells evolved from long-term cultures of telomerase-immortalized human mesenchymal stem cells
    • Burns JS, Abdallah BM, Guldberg P, Rygaard J, Schroder HD, Kassem M. Tumorigenic heterogeneity in cancer stem cells evolved from long-term cultures of telomerase-immortalized human mesenchymal stem cells. Cancer Res. 2005;65:3126-3135.
    • (2005) Cancer Res , vol.65 , pp. 3126-3135
    • Burns, J.S.1    Abdallah, B.M.2    Guldberg, P.3    Rygaard, J.4    Schroder, H.D.5    Kassem, M.6
  • 126
    • 7244221734 scopus 로고    scopus 로고
    • Marrow-derived mesenchymal stem cells: Role in epithelial tumor cell determination
    • Fierro FA, Sierralta WD, Epunan MJ, Minguell JJ. Marrow-derived mesenchymal stem cells: role in epithelial tumor cell determination. Clin Exp Metastasis. 2004;21:313-319.
    • (2004) Clin Exp Metastasis , vol.21 , pp. 313-319
    • Fierro, F.A.1    Sierralta, W.D.2    Epunan, M.J.3    Minguell, J.J.4
  • 127
    • 0042415425 scopus 로고    scopus 로고
    • Role of the stromal microenvironment in carcinogenesis of the prostate
    • Cunha GR, Hayward SW, Wang YZ, Ricke WA. Role of the stromal microenvironment in carcinogenesis of the prostate. Int J Cancer. 2003;107:1-10.
    • (2003) Int J Cancer , vol.107 , pp. 1-10
    • Cunha, G.R.1    Hayward, S.W.2    Wang, Y.Z.3    Ricke, W.A.4
  • 128
    • 10344234761 scopus 로고    scopus 로고
    • Molecular insights into prostate cancer progression: The missing link of tumor microenvironment
    • Chung LW, Baseman A, Assikis V, Zhau HE. Molecular insights into prostate cancer progression: the missing link of tumor microenvironment. J Urol. 2005;173:10-20.
    • (2005) J Urol , vol.173 , pp. 10-20
    • Chung, L.W.1    Baseman, A.2    Assikis, V.3    Zhau, H.E.4
  • 129
    • 0242509783 scopus 로고    scopus 로고
    • Mesenchymal progenitor cell-mediated inhibition of tumor growth in vivo and in vitro in gelatin matrix
    • Ohlsson LB, Varas L, Kjellman C, Edvardsen K, Lindvall M. Mesenchymal progenitor cell-mediated inhibition of tumor growth in vivo and in vitro in gelatin matrix. Exp Mol Pathol. 2003;75: 248-255.
    • (2003) Exp Mol Pathol , vol.75 , pp. 248-255
    • Ohlsson, L.B.1    Varas, L.2    Kjellman, C.3    Edvardsen, K.4    Lindvall, M.5
  • 130
    • 8444238622 scopus 로고    scopus 로고
    • Macrophagic response to human mesenchymal stem cell and poly(ε-caprolactone) implantation in nonobese diabetic/severe combined immunodeficient mice
    • Xia Z, Ye H, Choong C, et al. Macrophagic response to human mesenchymal stem cell and poly(ε-caprolactone) implantation in nonobese diabetic/severe combined immunodeficient mice. J Biomed Mater Res A. 2004;71:538-548.
    • (2004) J Biomed Mater Res A , vol.71 , pp. 538-548
    • Xia, Z.1    Ye, H.2    Choong, C.3
  • 131
    • 25444520289 scopus 로고    scopus 로고
    • Evaluation of mesenchymal stem cells following implantation in alveolar sockets: A canine safety study
    • De Kok IJ, Drapeau SJ, Young R, Cooper LF. Evaluation of mesenchymal stem cells following implantation in alveolar sockets: a canine safety study. Int J Oral Maxillofac Implants. 2005;20:511-518.
    • (2005) Int J Oral Maxillofac Implants , vol.20 , pp. 511-518
    • De Kok, I.J.1    Drapeau, S.J.2    Young, R.3    Cooper, L.F.4
  • 132
    • 20144365245 scopus 로고    scopus 로고
    • In vivo chondrogenesis of adult bone-marrow-derived autologous mesenchymal stem cells
    • Chen J, Wang C, Lu S, et al. In vivo chondrogenesis of adult bone-marrow-derived autologous mesenchymal stem cells. Cell Tissue Res. 2005;319:429-438.
    • (2005) Cell Tissue Res , vol.319 , pp. 429-438
    • Chen, J.1    Wang, C.2    Lu, S.3
  • 133
    • 0036376654 scopus 로고    scopus 로고
    • Cells as vehicles for cancer gene therapy: The missing link between targeted vectors and systemic delivery?
    • Harrington K, Alvarez-Vallina L, Crittenden M, et al. Cells as vehicles for cancer gene therapy: the missing link between targeted vectors and systemic delivery? Hum Gene Ther. 2002;13:1263-1280.
    • (2002) Hum Gene Ther , vol.13 , pp. 1263-1280
    • Harrington, K.1    Alvarez-Vallina, L.2    Crittenden, M.3
  • 134
    • 0035527591 scopus 로고    scopus 로고
    • Isolation and characterization of rapidly self-renewing stem cells from cultures of human marrow stromal cells
    • Prockop DJ, Sekiya I, Colter DC. Isolation and characterization of rapidly self-renewing stem cells from cultures of human marrow stromal cells. Cytotherapy. 2001;3:393-396.
    • (2001) Cytotherapy , vol.3 , pp. 393-396
    • Prockop, D.J.1    Sekiya, I.2    Colter, D.C.3
  • 135
    • 0036456669 scopus 로고    scopus 로고
    • Expansion of human adult stem cells from bone marrow stroma: Conditions that maximize the yields of early progenitors and evaluate their quality
    • Sekiya I, Larson BL, Smith JR, Pochampally R, Cui JG, Prockop DJ. Expansion of human adult stem cells from bone marrow stroma: conditions that maximize the yields of early progenitors and evaluate their quality. Stem Cells. 2002;20:530-541.
    • (2002) Stem Cells , vol.20 , pp. 530-541
    • Sekiya, I.1    Larson, B.L.2    Smith, J.R.3    Pochampally, R.4    Cui, J.G.5    Prockop, D.J.6
  • 136
    • 22144485628 scopus 로고    scopus 로고
    • To go or not to go: Migration of human mesenchymal progenitor cells stimulated by isoforms of PDGF
    • Fiedler J, Etzel N, Brenner RE. To go or not to go: migration of human mesenchymal progenitor cells stimulated by isoforms of PDGF. J Cell Biochem. 2004;93:990-998.
    • (2004) J Cell Biochem , vol.93 , pp. 990-998
    • Fiedler, J.1    Etzel, N.2    Brenner, R.E.3
  • 137
    • 24744434734 scopus 로고    scopus 로고
    • Dynamic imaging of allogeneic mesenchymal stem cells trafficking to myocardial infarction
    • Kraitchman DL, Tatsumi M, Gilson WD, et al. Dynamic imaging of allogeneic mesenchymal stem cells trafficking to myocardial infarction. Circulation. 2005;112:1451-1461.
    • (2005) Circulation , vol.112 , pp. 1451-1461
    • Kraitchman, D.L.1    Tatsumi, M.2    Gilson, W.D.3
  • 138
    • 33645506693 scopus 로고    scopus 로고
    • Hepatocyte growth factor effects on mesenchymal stem cells: Proliferation, migration, and differentiation
    • Forte G, Minieri M, Cossa P, et al. Hepatocyte growth factor effects on mesenchymal stem cells: proliferation, migration, and differentiation. Stem Cells. 2006;24:23-33.
    • (2006) Stem Cells , vol.24 , pp. 23-33
    • Forte, G.1    Minieri, M.2    Cossa, P.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.