-
1
-
-
0344188096
-
An adenovirus mutant that replicates selectively in p53-deficient human tumor cells
-
Bischoff, J. R.; Kirn, D. H.; Williams, A.; Heise, C.; Horn, S.; Muna, M.; Ng, L.; Nye, J. A.; Sampson-Johannes, A.; Fattaey, A.; McCormick, F. An adenovirus mutant that replicates selectively in p53-deficient human tumor cells. Science 1996, 274, 373-376.
-
(1996)
Science
, vol.274
, pp. 373-376
-
-
Bischoff, J.R.1
Kirn, D.H.2
Williams, A.3
Heise, C.4
Horn, S.5
Muna, M.6
Ng, L.7
Nye, J.A.8
Sampson-Johannes, A.9
Fattaey, A.10
McCormick, F.11
-
2
-
-
0030917202
-
ONYX-015, an E1B gene-attenuated adenovirus, causes tumor-specific cytolysis and antitumoral efficacy that can be augmented by standard chemotherapeutic agents [see comments]
-
Heise, C.; Sampson, J. A.; Williams, A.; McCormick, F.; Von, H. D.; Kirn, D. H. ONYX-015, an E1B gene-attenuated adenovirus, causes tumor-specific cytolysis and antitumoral efficacy that can be augmented by standard chemotherapeutic agents [see comments]. Nat. Med. 1997, 3, 639-645.
-
(1997)
Nat. Med
, vol.3
, pp. 639-645
-
-
Heise, C.1
Sampson, J.A.2
Williams, A.3
McCormick, F.4
Von, H.D.5
Kirn, D.H.6
-
3
-
-
12944328660
-
A phase I study of ONYX-015, an E1B attenuated adenovirus, administered intratumorally to patients with recurrent head and neck cancer
-
Ganly, I.; Kirn, D.; Eckhardt, S.; Rodriguez, G.; Souter, D.; Von Hoff, D.; Kaye, S. A phase I study of ONYX-015, an E1B attenuated adenovirus, administered intratumorally to patients with recurrent head and neck cancer. Clin. Cancer Res. 2000, 6, 798-806.
-
(2000)
Clin. Cancer Res
, vol.6
, pp. 798-806
-
-
Ganly, I.1
Kirn, D.2
Eckhardt, S.3
Rodriguez, G.4
Souter, D.5
Von Hoff, D.6
Kaye, S.7
-
4
-
-
0033693231
-
Selective replication and oncolysis in p53 mutant tumors with ONYX-015, an E1B-55kD gene-deleted adenovirus, in patients with advanced head and neck cancer: A phase II trial
-
Nemunaitis, J.; Ganly, I.; Khuri, F.; Arsenau, J.; Kuhn, J.; McCarty, T.; Landers, S.; Maples, P.; Romel, L.; Randlev, B.; Reid, T.; Kaye, S.; Kirn, D. Selective replication and oncolysis in p53 mutant tumors with ONYX-015, an E1B-55kD gene-deleted adenovirus, in patients with advanced head and neck cancer: a phase II trial. Cancer Res. 2000, 60, 6359-6366.
-
(2000)
Cancer Res
, vol.60
, pp. 6359-6366
-
-
Nemunaitis, J.1
Ganly, I.2
Khuri, F.3
Arsenau, J.4
Kuhn, J.5
McCarty, T.6
Landers, S.7
Maples, P.8
Romel, L.9
Randlev, B.10
Reid, T.11
Kaye, S.12
Kirn, D.13
-
5
-
-
3042770838
-
The dl1520 virus is found preferentially in tumor tissue after direct intratumoral injection in oral carcinoma
-
Morley, S.; MacDonald, G.; Kirn, D.; Kaye, S.; Brown, R.; Soutar, D. The dl1520 virus is found preferentially in tumor tissue after direct intratumoral injection in oral carcinoma. Clin. Cancer Res. 2004, 10, 4357-4362.
-
(2004)
Clin. Cancer Res
, vol.10
, pp. 4357-4362
-
-
Morley, S.1
MacDonald, G.2
Kirn, D.3
Kaye, S.4
Brown, R.5
Soutar, D.6
-
6
-
-
0033831080
-
A controlled trial of ONYX-015, an E1B gene-deleted adenovirus, in combination with chemotherapy in patients with recurrent head and neck cancer
-
Khuri, F.; Nemunaitis, J.; Ganly, I.; Gore, M.; MacDougal, M.; Tannock, I.; Kaye, S.; Hong, W.; Kirn, D. A controlled trial of ONYX-015, an E1B gene-deleted adenovirus, in combination with chemotherapy in patients with recurrent head and neck cancer. Nat. Med. 2000, 6, 879-885.
-
(2000)
Nat. Med
, vol.6
, pp. 879-885
-
-
Khuri, F.1
Nemunaitis, J.2
Ganly, I.3
Gore, M.4
MacDougal, M.5
Tannock, I.6
Kaye, S.7
Hong, W.8
Kirn, D.9
-
7
-
-
0035134629
-
Clinical research results with dl1520 (ONYX-015), a replication-selective adenovirus for the treatment of cancer: What have we learned?
-
Kirn, D. Clinical research results with dl1520 (ONYX-015), a replication-selective adenovirus for the treatment of cancer: what have we learned? Gene Ther. 2001, 8, 89-98.
-
(2001)
Gene Ther
, vol.8
, pp. 89-98
-
-
Kirn, D.1
-
8
-
-
0033929022
-
Complex interactions between the replicating oncolytic effect and the enzyme/prodrug effect of vaccinia-mediated tumor regression
-
McCart, J. A.; Puhlmann, M.; Lee, J.; Hu, Y.; Libutti, S. K.; Alexander, H. R.; Bartlett, D. L. Complex interactions between the replicating oncolytic effect and the enzyme/prodrug effect of vaccinia-mediated tumor regression. Gene Ther. 2000, 7, 1217-1223.
-
(2000)
Gene Ther
, vol.7
, pp. 1217-1223
-
-
McCart, J.A.1
Puhlmann, M.2
Lee, J.3
Hu, Y.4
Libutti, S.K.5
Alexander, H.R.6
Bartlett, D.L.7
-
9
-
-
30344448580
-
Effect of chemotherapy-induced DNA repair on oncolytic herpes simplex viral replication
-
Aghi, M.; Rabkin, S.; Martuza, R. L. Effect of chemotherapy-induced DNA repair on oncolytic herpes simplex viral replication. J. Natl. Cancer Inst. 2006, 98, 38-50.
-
(2006)
J. Natl. Cancer Inst
, vol.98
, pp. 38-50
-
-
Aghi, M.1
Rabkin, S.2
Martuza, R.L.3
-
10
-
-
0033140039
-
Replication-competent herpes simplex virus vector G207 and cisplatin combination therapy for head and neck squamous cell carcinoma
-
Chahlavi, A.; Todo, T.; Martuza, R. L.; Rabkin, S. D. Replication-competent herpes simplex virus vector G207 and cisplatin combination therapy for head and neck squamous cell carcinoma. Neoplasia 1999, 1, 162-169.
-
(1999)
Neoplasia
, vol.1
, pp. 162-169
-
-
Chahlavi, A.1
Todo, T.2
Martuza, R.L.3
Rabkin, S.D.4
-
11
-
-
27644575167
-
5-Fluorouracil and gemcitabine potentiate the efficacy of oncolytic herpes viral gene therapy in the treatment of pancreatic cancer
-
discussion 1077-1079
-
Eisenberg, D. P.; Adusumilli, P. S.; Hendershott, K. J.; Yu, Z.; Mullerad, M.; Chan, M. K.; Chou, T. C.; Fong, Y. 5-Fluorouracil and gemcitabine potentiate the efficacy of oncolytic herpes viral gene therapy in the treatment of pancreatic cancer. J. Gastrointest. Surg. 2005, 9, 1068-1077; discussion 1077-1079.
-
(2005)
J. Gastrointest. Surg
, vol.9
, pp. 1068-1077
-
-
Eisenberg, D.P.1
Adusumilli, P.S.2
Hendershott, K.J.3
Yu, Z.4
Mullerad, M.5
Chan, M.K.6
Chou, T.C.7
Fong, Y.8
-
12
-
-
10744227813
-
Phase I study of replication-competent adenovirus-mediated double-suicide gene therapy in combination with conventional-dose three-dimensional conformal radiation therapy for the treatment of newly diagnosed, intermediate- to high-risk prostate cancer
-
Freytag, S. O.; Stricker, H.; Pegg, J.; Paielli, D.; Pradhan, D. G.; Peabody, J.; DePeralta-Venturina, M.; Xia, X.; Brown, S.; Lu, M.; Kim, J. H. Phase I study of replication-competent adenovirus-mediated double-suicide gene therapy in combination with conventional-dose three-dimensional conformal radiation therapy for the treatment of newly diagnosed, intermediate- to high-risk prostate cancer. Cancer Res. 2003, 63, 7497-7506.
-
(2003)
Cancer Res
, vol.63
, pp. 7497-7506
-
-
Freytag, S.O.1
Stricker, H.2
Pegg, J.3
Paielli, D.4
Pradhan, D.G.5
Peabody, J.6
DePeralta-Venturina, M.7
Xia, X.8
Brown, S.9
Lu, M.10
Kim, J.H.11
-
13
-
-
0037087621
-
Phase I trial of intraperitoneal ONYX-015 adenovirus in patients with recurrent ovarian cancer
-
Vasey, P.; Seiden, M.; O'Neill, V.; Campo, S.; Johnston, S.; Davis, J.; Kirn, D.; Kaye, S.; Shulman, L. Phase I trial of intraperitoneal ONYX-015 adenovirus in patients with recurrent ovarian cancer. J. Clin. Oncol. 2002, 20(6), 1562-1569.
-
(2002)
J. Clin. Oncol
, vol.20
, Issue.6
, pp. 1562-1569
-
-
Vasey, P.1
Seiden, M.2
O'Neill, V.3
Campo, S.4
Johnston, S.5
Davis, J.6
Kirn, D.7
Kaye, S.8
Shulman, L.9
-
14
-
-
0036828125
-
Hepatic arterial infusion of a eplication-selective oncolytic adenovirus (dl1520): Phase II viral, immunologic, and clinical endpoints
-
Reid, T.; Galanis, E.; Abbruzzese, J.; Sze, D.; Wein, L. M.; Andrews, J.; Randlev, B.; Heise, C.; Uprichard, M.; Hatfield, M.; Rome, L.; Rubin, J.; Kirn, D. Hepatic arterial infusion of a eplication-selective oncolytic adenovirus (dl1520): phase II viral, immunologic, and clinical endpoints. Cancer Res. 2002, 62, 6070-6079.
-
(2002)
Cancer Res
, vol.62
, pp. 6070-6079
-
-
Reid, T.1
Galanis, E.2
Abbruzzese, J.3
Sze, D.4
Wein, L.M.5
Andrews, J.6
Randlev, B.7
Heise, C.8
Uprichard, M.9
Hatfield, M.10
Rome, L.11
Rubin, J.12
Kirn, D.13
-
15
-
-
0036904741
-
Intravascular adenoviral agents in cancer patients: Lessons from clinical trials
-
Reid, T.; Warren, R.; Kirn, D. Intravascular adenoviral agents in cancer patients: lessons from clinical trials. Cancer Gene Ther. 2002, 9, 979-986.
-
(2002)
Cancer Gene Ther
, vol.9
, pp. 979-986
-
-
Reid, T.1
Warren, R.2
Kirn, D.3
-
16
-
-
0034990761
-
Intravenous infusion of a replication-selective adenovirus (ONYX-015) in cancer patients: Safety, feasibility and biological activity
-
Nemunaitis, J.; Cunningham, C.; Buchanan, A.; Blackburn, A.; Edelman, G.; Maples, P.; Netto, G.; Tong, A.; Randlev, B.; Olson, S.; Kirn, D. Intravenous infusion of a replication-selective adenovirus (ONYX-015) in cancer patients: safety, feasibility and biological activity. Gene Ther. 2001, 8, 746-759.
-
(2001)
Gene Ther
, vol.8
, pp. 746-759
-
-
Nemunaitis, J.1
Cunningham, C.2
Buchanan, A.3
Blackburn, A.4
Edelman, G.5
Maples, P.6
Netto, G.7
Tong, A.8
Randlev, B.9
Olson, S.10
Kirn, D.11
-
17
-
-
0038518576
-
Phase II trial of intravenous CI-1042 in patients with metastatic colorectal cancer
-
Hamid, O.; Varteresian, M.; Wadler, S.; Benson, A.; Uprichard, M.; Galanis, E.; Omer, C.; Hackman, R.; Shields, A. Phase II trial of intravenous CI-1042 in patients with metastatic colorectal cancer. J. Clin. Oncol. 2003, 21, 1498-1504.
-
(2003)
J. Clin. Oncol
, vol.21
, pp. 1498-1504
-
-
Hamid, O.1
Varteresian, M.2
Wadler, S.3
Benson, A.4
Uprichard, M.5
Galanis, E.6
Omer, C.7
Hackman, R.8
Shields, A.9
-
18
-
-
3042684543
-
Analysis of a three-way race between tumor growth, a replication-competent virus and an immune response
-
Wu, J. T.; Kirn, D. H.; Wein, L. M. Analysis of a three-way race between tumor growth, a replication-competent virus and an immune response. Bull. Math. Biol. 2004, 66, 605-625.
-
(2004)
Bull. Math. Biol
, vol.66
, pp. 605-625
-
-
Wu, J.T.1
Kirn, D.H.2
Wein, L.M.3
-
19
-
-
0037444281
-
Validation and analysis of a mathematical model of a replication-competent oncolytic virus for cancer treatment: Implications for virus design and delivery
-
Wein, L. M.; Wu, J. T.; Kirn, D. H. Validation and analysis of a mathematical model of a replication-competent oncolytic virus for cancer treatment: implications for virus design and delivery. Cancer Res. 2003, 63, 1317-1324.
-
(2003)
Cancer Res
, vol.63
, pp. 1317-1324
-
-
Wein, L.M.1
Wu, J.T.2
Kirn, D.H.3
-
20
-
-
33745161873
-
A phase I trial of intravenous CG7870, a replication-selective, prostate-specific antigen-targeted oncolytic adenovirus, for the treatment of hormone-refractory, metastatic prostate cancer
-
Small, E. J.; Carducci, M. A.; Burke, J. M.; Rodriguez, R.; Fong, L.; van Ummersen, L.; Yu, D. C.; Aimi, J.; Ando, D.; Working, P.; Kirn, D.; Wilding, G. A phase I trial of intravenous CG7870, a replication-selective, prostate-specific antigen-targeted oncolytic adenovirus, for the treatment of hormone-refractory, metastatic prostate cancer. Mol. Ther. 2006, 14, 107-117.
-
(2006)
Mol. Ther
, vol.14
, pp. 107-117
-
-
Small, E.J.1
Carducci, M.A.2
Burke, J.M.3
Rodriguez, R.4
Fong, L.5
van Ummersen, L.6
Yu, D.C.7
Aimi, J.8
Ando, D.9
Working, P.10
Kirn, D.11
Wilding, G.12
-
21
-
-
0033193127
-
Intratumoral recombinant GM-CSF-encoding virus as gene therapy in patients with cutaneous melanoma
-
Mastrangelo, M. J.; Maguire, H. C., Jr.; Eisenlohr, L. C.; Laughlin, C. E.; Monken, C. E.; McCue, P. A.; Kovatich, A. J.; Lattime, E. C. Intratumoral recombinant GM-CSF-encoding virus as gene therapy in patients with cutaneous melanoma. Cancer Gene Ther. 1999, 6, 409-422.
-
(1999)
Cancer Gene Ther
, vol.6
, pp. 409-422
-
-
Mastrangelo, M.J.1
Maguire Jr., H.C.2
Eisenlohr, L.C.3
Laughlin, C.E.4
Monken, C.E.5
McCue, P.A.6
Kovatich, A.J.7
Lattime, E.C.8
-
22
-
-
12944315014
-
Conditionally replicating herpes simplex virus mutant, G207 for the treatment of malignant glioma: Results of a phase I trial
-
Markert, J. M.; Medlock, M. D.; Rabkin, S. D.; Gillespie, G. Y.; Todo, T.; Hunter, W. D.; Palmer, C. A.; Feigenbaum, F.; Tornatore, C.; Tufaro, F.; Martuza, R. L. Conditionally replicating herpes simplex virus mutant, G207 for the treatment of malignant glioma: results of a phase I trial. Gene Ther. 2000, 7, 867-874.
-
(2000)
Gene Ther
, vol.7
, pp. 867-874
-
-
Markert, J.M.1
Medlock, M.D.2
Rabkin, S.D.3
Gillespie, G.Y.4
Todo, T.5
Hunter, W.D.6
Palmer, C.A.7
Feigenbaum, F.8
Tornatore, C.9
Tufaro, F.10
Martuza, R.L.11
-
23
-
-
0036569510
-
Phase I trial of intravenous administration of PV701, an oncolytic virus, in patients with advanced solid cancers
-
Pecora, A. L.; Rizvi, N.; Cohen, G. I.; Meropol, N. J.; Sterman, D.; Marshall, J. L.; Goldberg, S.; Gross, P.; O'Neil, J. D.; Groene, W. S.; Roberts, M. S.; Rabin, H.; Bamat, M. K.; Lorence, R. M. Phase I trial of intravenous administration of PV701, an oncolytic virus, in patients with advanced solid cancers. J. Clin. Oncol. 2002, 20, 2251-2266.
-
(2002)
J. Clin. Oncol
, vol.20
, pp. 2251-2266
-
-
Pecora, A.L.1
Rizvi, N.2
Cohen, G.I.3
Meropol, N.J.4
Sterman, D.5
Marshall, J.L.6
Goldberg, S.7
Gross, P.8
O'Neil, J.D.9
Groene, W.S.10
Roberts, M.S.11
Rabin, H.12
Bamat, M.K.13
Lorence, R.M.14
-
24
-
-
28844496639
-
Oncolytic Virotherapy: Approaches to tumor targeting and enhancing antitumor effects
-
Thorne, S. H.; Hermiston, T.; Kirn, D. Oncolytic Virotherapy: Approaches to tumor targeting and enhancing antitumor effects. Semin. Oncol. 2005, 32, 537-548.
-
(2005)
Semin. Oncol
, vol.32
, pp. 537-548
-
-
Thorne, S.H.1
Hermiston, T.2
Kirn, D.3
-
25
-
-
0034820992
-
Phase I study of intravesical vaccinia virus as a vector for gene therapy of bladder cancer
-
Gomella, L. G.; Mastrangelo, M. J.; McCue, P. A.; Maguire, H. C. J.; Mulholland, S. G.; Lattime, E. C. Phase I study of intravesical vaccinia virus as a vector for gene therapy of bladder cancer. J. Urol. 2001, 166, 1291-1295.
-
(2001)
J. Urol
, vol.166
, pp. 1291-1295
-
-
Gomella, L.G.1
Mastrangelo, M.J.2
McCue, P.A.3
Maguire, H.C.J.4
Mulholland, S.G.5
Lattime, E.C.6
-
26
-
-
0014967848
-
Use of vaccinia virus in the treatment of metastatic malignant melanoma
-
Hunter-Craig, I.; Newton, K.; Westbury, G.; Lacey, B. Use of vaccinia virus in the treatment of metastatic malignant melanoma. Br. Med. J. 1970, 2, 512-515.
-
(1970)
Br. Med. J
, vol.2
, pp. 512-515
-
-
Hunter-Craig, I.1
Newton, K.2
Westbury, G.3
Lacey, B.4
-
27
-
-
0016066489
-
Immunotherapy of malignant melanoma with vaccinia virus
-
Roenigk, H.; Deodhar, S.; Jacques, R.; Burdick, K. Immunotherapy of malignant melanoma with vaccinia virus. Arch. Dermatol. 1974, 109, 668-673.
-
(1974)
Arch. Dermatol
, vol.109
, pp. 668-673
-
-
Roenigk, H.1
Deodhar, S.2
Jacques, R.3
Burdick, K.4
-
28
-
-
0023145269
-
Clinical trial of attenuated vaccinia virus as strain in the treatment of advanced adenocarcinoma. Report on two cases
-
Arakawa, S. J.; Hamami, G.; Umezu, K.; Kamidono, S.; Ishigami, J.; Arakawa, S. Clinical trial of attenuated vaccinia virus as strain in the treatment of advanced adenocarcinoma. Report on two cases. J. Cancer Res. Clin. 1987, 113, 95-98.
-
(1987)
J. Cancer Res. Clin
, vol.113
, pp. 95-98
-
-
Arakawa, S.J.1
Hamami, G.2
Umezu, K.3
Kamidono, S.4
Ishigami, J.5
Arakawa, S.6
-
29
-
-
0013084069
-
Vitiligo in a case of vaccinia virus-treated melanoma
-
Burdick, K.; Hawk, W. Vitiligo in a case of vaccinia virus-treated melanoma. Cancer 1964, 17, 708-712.
-
(1964)
Cancer
, vol.17
, pp. 708-712
-
-
Burdick, K.1
Hawk, W.2
-
30
-
-
0018203346
-
Remission of chronic lymphocytic leukemia after smallpox vaccination
-
Hansen, R. M.; Libnoch, J. A. Remission of chronic lymphocytic leukemia after smallpox vaccination. Arch. Intern. Med. 1978, 138, 1137-1138.
-
(1978)
Arch. Intern. Med
, vol.138
, pp. 1137-1138
-
-
Hansen, R.M.1
Libnoch, J.A.2
-
31
-
-
0023227802
-
The effect of attenuated vaccinia virus AS strain on multiple myeloma; a case report
-
Kawa, A.; Arakawa, S. The effect of attenuated vaccinia virus AS strain on multiple myeloma; a case report. Jpn. J. Exp. Med. 1987, 57, 79-81.
-
(1987)
Jpn. J. Exp. Med
, vol.57
, pp. 79-81
-
-
Kawa, A.1
Arakawa, S.2
-
32
-
-
0035077806
-
Polymer-coated adenovirus permits efficient retargeting and evades neutralising antibodies
-
Fisher, K. D.; Stallwood, Y.; Green, N. K.; Ulbrich, K.; Mautner, V.; Seymour, L. W. Polymer-coated adenovirus permits efficient retargeting and evades neutralising antibodies. Gene Ther. 2001, 8, 341-348.
-
(2001)
Gene Ther
, vol.8
, pp. 341-348
-
-
Fisher, K.D.1
Stallwood, Y.2
Green, N.K.3
Ulbrich, K.4
Mautner, V.5
Seymour, L.W.6
-
33
-
-
12444295422
-
Replication of an integrin targeted conditionally replicating adenovirus on primary ovarian cancer spheroids
-
Lam, J. T.; Bauerschmitz, G. J.; Kanerva, A.; Barker, S. D.; Straughn, J. M.; Wang, M.; Barnes, M. N.; Blackwell, J. L.; Siegal, G. P.; Alvarez, R. D.; Curiel, D. T.; Hemminki, A. Replication of an integrin targeted conditionally replicating adenovirus on primary ovarian cancer spheroids. Cancer Gene Ther. 2003, 10, 377-387.
-
(2003)
Cancer Gene Ther
, vol.10
, pp. 377-387
-
-
Lam, J.T.1
Bauerschmitz, G.J.2
Kanerva, A.3
Barker, S.D.4
Straughn, J.M.5
Wang, M.6
Barnes, M.N.7
Blackwell, J.L.8
Siegal, G.P.9
Alvarez, R.D.10
Curiel, D.T.11
Hemminki, A.12
-
34
-
-
0033589344
-
Tumor-specific gene delivery using recombinant vaccinia virus in a rabbit model of liver metastases
-
Gnant, M. F.; Noll, L. A.; Irvine, K. R.; Puhlmann, M.; Terrill, R. E.; Alexander, H. R., Jr.; Bartlett, D. L. Tumor-specific gene delivery using recombinant vaccinia virus in a rabbit model of liver metastases. J. Natl. Cancer Inst. 1999, 91, 1744-1750.
-
(1999)
J. Natl. Cancer Inst
, vol.91
, pp. 1744-1750
-
-
Gnant, M.F.1
Noll, L.A.2
Irvine, K.R.3
Puhlmann, M.4
Terrill, R.E.5
Alexander Jr., H.R.6
Bartlett, D.L.7
-
35
-
-
0035893770
-
Systemic cancer therapy with a tumor-selective vaccinia virus mutant lacking thymidine kinase and vaccinia growth factor genes
-
McCart, J. A.; Ward, J. M.; Lee, J.; Hu, Y.; Alexander, H. R.; Libutti, S. K.; Moss, B.; Bartlett, D. L. Systemic cancer therapy with a tumor-selective vaccinia virus mutant lacking thymidine kinase and vaccinia growth factor genes. Cancer Res. 2001, 61, 8751-8757.
-
(2001)
Cancer Res
, vol.61
, pp. 8751-8757
-
-
McCart, J.A.1
Ward, J.M.2
Lee, J.3
Hu, Y.4
Alexander, H.R.5
Libutti, S.K.6
Moss, B.7
Bartlett, D.L.8
-
36
-
-
0034927057
-
Replication-selective virotherapy for cancer: Biological principles, risk management and future directions
-
Kirn, D.; Martuza, R. L.; Zwiebel, J. Replication-selective virotherapy for cancer: Biological principles, risk management and future directions. Nat. Med. 2001, 7, 781-787.
-
(2001)
Nat. Med
, vol.7
, pp. 781-787
-
-
Kirn, D.1
Martuza, R.L.2
Zwiebel, J.3
-
37
-
-
0035863458
-
Phase II trial of intratumoral administration of ONYX-015, a replication-selective adenovirus, in patients with refractory head and neck cancer
-
Nemunaitis, J.; Khuri, F.; Ganly, I.; Arseneau, J.; Posner, M.; Vokes, E.; Kuhn, J.; McCarty, T.; Landers, S.; Blackburn, A.; Romel, L.; Randlev, B.; Kaye, S.; Kirn, D. Phase II trial of intratumoral administration of ONYX-015, a replication-selective adenovirus, in patients with refractory head and neck cancer. J. Clin. Oncol. 2001, 19, 289-298.
-
(2001)
J. Clin. Oncol
, vol.19
, pp. 289-298
-
-
Nemunaitis, J.1
Khuri, F.2
Ganly, I.3
Arseneau, J.4
Posner, M.5
Vokes, E.6
Kuhn, J.7
McCarty, T.8
Landers, S.9
Blackburn, A.10
Romel, L.11
Randlev, B.12
Kaye, S.13
Kirn, D.14
-
38
-
-
0344188096
-
An adenovirus mutant that replicates selectively in p53-deficient human tumor cells [see comments]
-
Bischoff, J. R.; Kirn, D. H.; Williams, A.; Heise, C.; Horn, S.; Muna, M.; Ng, L.; Nye, J. A.; Sampson-Johannes, A.; Fattaey, A.; McCormick, F. An adenovirus mutant that replicates selectively in p53-deficient human tumor cells [see comments]. Science 1996, 274, 373-376.
-
(1996)
Science
, vol.274
, pp. 373-376
-
-
Bischoff, J.R.1
Kirn, D.H.2
Williams, A.3
Heise, C.4
Horn, S.5
Muna, M.6
Ng, L.7
Nye, J.A.8
Sampson-Johannes, A.9
Fattaey, A.10
McCormick, F.11
-
39
-
-
0034161976
-
In vivo antitumor activity of ONYX-015 is influenced by p53 status and is augmented by radiotherapy
-
Rogulski, K.; Freytag, S.; Zhang, K.; Gilbert, J.; Paielli, D.; Kim, J.; Heise, C.; Kirn, D. H. In vivo antitumor activity of ONYX-015 is influenced by p53 status and is augmented by radiotherapy. Cancer Res. 2000, 60, 1193-1196.
-
(2000)
Cancer Res
, vol.60
, pp. 1193-1196
-
-
Rogulski, K.1
Freytag, S.2
Zhang, K.3
Gilbert, J.4
Paielli, D.5
Kim, J.6
Heise, C.7
Kirn, D.H.8
-
40
-
-
0031743945
-
Replication of ONYX-015, a potential anticancer adenovirus, is independent of p53 status in tumor cells
-
Rothmann, T.; Hengstermann, A.; Whitaker, N. J.; Scheffner, M.; zur Hausen, H. Replication of ONYX-015, a potential anticancer adenovirus, is independent of p53 status in tumor cells. J. Virol. 1998, 72, 9470-9478.
-
(1998)
J. Virol
, vol.72
, pp. 9470-9478
-
-
Rothmann, T.1
Hengstermann, A.2
Whitaker, N.J.3
Scheffner, M.4
zur Hausen, H.5
-
41
-
-
0033623250
-
Loss of p14ARF in tumor cells facilitates replication of the adenovirus mutant dl1520 (ONYX-015)
-
Ries, S. J.; Brandts, C. H.; Chung, A. S.; Biederer, C. H.; Hann, B. C.; Lipner, E. M.; McCormick, F.; Korn, M. Loss of p14ARF in tumor cells facilitates replication of the adenovirus mutant dl1520 (ONYX-015). Nat. Med. 2000, 6, 1128-1133.
-
(2000)
Nat. Med
, vol.6
, pp. 1128-1133
-
-
Ries, S.J.1
Brandts, C.H.2
Chung, A.S.3
Biederer, C.H.4
Hann, B.C.5
Lipner, E.M.6
McCormick, F.7
Korn, M.8
-
42
-
-
0033022039
-
p53-Independent and -dependent requirements for E1B-55K in adenovirus type 5 replication
-
Harada, J.; Berk, A. p53-Independent and -dependent requirements for E1B-55K in adenovirus type 5 replication. J. Virol. 1999, 73, 5333-5344.
-
(1999)
J. Virol
, vol.73
, pp. 5333-5344
-
-
Harada, J.1
Berk, A.2
-
43
-
-
19944363519
-
Late viral RNA export, rather than p53 inactivation, determines ONYX-015 tumor selectivity
-
O'Shea, C. C.; Johnson, L.; Bagus, B.; Choi, S.; Nicholas, C.; Shen, A.; Boyle, L.; Pandey, K.; Soria, C.; Kunich, J.; Shen, Y.; Habets, G.; Ginzinger, D.; McCormick, F. Late viral RNA export, rather than p53 inactivation, determines ONYX-015 tumor selectivity. Cancer Cell 2004, 6, 611-623.
-
(2004)
Cancer Cell
, vol.6
, pp. 611-623
-
-
O'Shea, C.C.1
Johnson, L.2
Bagus, B.3
Choi, S.4
Nicholas, C.5
Shen, A.6
Boyle, L.7
Pandey, K.8
Soria, C.9
Kunich, J.10
Shen, Y.11
Habets, G.12
Ginzinger, D.13
McCormick, F.14
-
44
-
-
22244479672
-
Heat shock phenocopies E1B-55K late functions and selectively sensitizes refractory tumor cells to ONYX-015 oncolytic viral therapy
-
O'Shea, C. C.; Soria, C.; Bagus, B.; McCormick, F. Heat shock phenocopies E1B-55K late functions and selectively sensitizes refractory tumor cells to ONYX-015 oncolytic viral therapy. Cancer Cell 2005, 8, 61-74.
-
(2005)
Cancer Cell
, vol.8
, pp. 61-74
-
-
O'Shea, C.C.1
Soria, C.2
Bagus, B.3
McCormick, F.4
-
45
-
-
0035893770
-
Systemic cancer therapy with a tumor-selective vaccinia virus mutant lacking thymidine kinase and vaccinia growth factor genes
-
McCart, A.; Ward, J.; Lee, J.; Hu, Y.; Alexander, H.; Libutti, S.; Moss, B.; Bartlett, D. Systemic cancer therapy with a tumor-selective vaccinia virus mutant lacking thymidine kinase and vaccinia growth factor genes. Cancer Res. 2001, 61, 8751-8757.
-
(2001)
Cancer Res
, vol.61
, pp. 8751-8757
-
-
McCart, A.1
Ward, J.2
Lee, J.3
Hu, Y.4
Alexander, H.5
Libutti, S.6
Moss, B.7
Bartlett, D.8
-
46
-
-
0033950819
-
Vaccinia as a vector for tumor-directed gene therapy: Biodistribution of a thymidine kinase-deleted mutant
-
Puhlmann, M.; Brown, C. K.; Gnant, M.; Huang, J.; Libutti, S. K.; Alexander, H. R.; Bartlett, D. L. Vaccinia as a vector for tumor-directed gene therapy: biodistribution of a thymidine kinase-deleted mutant. Cancer Gene Ther. 2000, 7, 66-73.
-
(2000)
Cancer Gene Ther
, vol.7
, pp. 66-73
-
-
Puhlmann, M.1
Brown, C.K.2
Gnant, M.3
Huang, J.4
Libutti, S.K.5
Alexander, H.R.6
Bartlett, D.L.7
-
47
-
-
0032526693
-
The molecular basis of viral oncolysis: Usurpation of the Ras signaling pathway by reovirus
-
Strong, J.; Coffey, M.; Tang, D.; Sabinin, P.; Lee, P. The molecular basis of viral oncolysis: usurpation of the Ras signaling pathway by reovirus. EMBO J. 1998, 17, 3351-3362.
-
(1998)
EMBO J
, vol.17
, pp. 3351-3362
-
-
Strong, J.1
Coffey, M.2
Tang, D.3
Sabinin, P.4
Lee, P.5
-
48
-
-
0033929057
-
Exploiting tumor-specific defects in the interferon pathway with a previously unknown oncolytic virus
-
Stojdl, D. F.; Lichty, B.; Knowles, S.; Marius, R.; Atkins, H.; Sonenberg, N.; Bell, J. C. Exploiting tumor-specific defects in the interferon pathway with a previously unknown oncolytic virus. Nat. Med. 2000, 6, 821-825.
-
(2000)
Nat. Med
, vol.6
, pp. 821-825
-
-
Stojdl, D.F.1
Lichty, B.2
Knowles, S.3
Marius, R.4
Atkins, H.5
Sonenberg, N.6
Bell, J.C.7
-
49
-
-
0026751242
-
Newcastle disease virus selectively kills human tumor cells
-
Reichard, K. W.; Lorence, R. M.; Cascino, C. J.; Peeples, M. E.; Walter, R. J.; Fernando, M. B.; Reyes, H. M.; Greager, J. A. Newcastle disease virus selectively kills human tumor cells. J. Surg. Res. 1992, 52, 448-453.
-
(1992)
J. Surg. Res
, vol.52
, pp. 448-453
-
-
Reichard, K.W.1
Lorence, R.M.2
Cascino, C.J.3
Peeples, M.E.4
Walter, R.J.5
Fernando, M.B.6
Reyes, H.M.7
Greager, J.A.8
-
50
-
-
0035890773
-
-
Bergmann, M.; Romirer, I.; Sachet, M.; Fleischhacker, R.; Garcia-Sastre, A.; Palese, P.; Wolff, K.; Pehamberger, H.; Jakesz, R.; Muster, T. A genetically engineered influenza A virus with Ras-dependent oncolytic properties. Cancer Res. 2001, 61, 8188-8193.
-
Bergmann, M.; Romirer, I.; Sachet, M.; Fleischhacker, R.; Garcia-Sastre, A.; Palese, P.; Wolff, K.; Pehamberger, H.; Jakesz, R.; Muster, T. A genetically engineered influenza A virus with Ras-dependent oncolytic properties. Cancer Res. 2001, 61, 8188-8193.
-
-
-
-
51
-
-
10744223476
-
VSV strains with defects in their ability to shutdown innate immunity are potent systemic anti-cancer agents
-
Stojdl, D. F.; Lichty, B. D.; tenOever, B. R.; Paterson, J. M.; Power, A. T.; Knowles, S.; Marius, R.; Reynard, J.; Poliquin, L.; Atkins, H.; Brown, E. G.; Durbin, R. K.; Durbin, J. E.; Hiscott, J.; Bell, J. C. VSV strains with defects in their ability to shutdown innate immunity are potent systemic anti-cancer agents. Cancer Cell 2003, 4, 263-275.
-
(2003)
Cancer Cell
, vol.4
, pp. 263-275
-
-
Stojdl, D.F.1
Lichty, B.D.2
tenOever, B.R.3
Paterson, J.M.4
Power, A.T.5
Knowles, S.6
Marius, R.7
Reynard, J.8
Poliquin, L.9
Atkins, H.10
Brown, E.G.11
Durbin, R.K.12
Durbin, J.E.13
Hiscott, J.14
Bell, J.C.15
|