Targeted and non-targeted effects from combinations of low doses of energetic protons and iron ions in human fibroblasts

International Journal of Radiation Biology

Volumn 87, Issue 3, 2011, Pages 311-319

  Yang, Hongying ^a   Magpayo, Nicole ^a   Held, Kathryn D ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

energetic protons; iron ions; non targeted effects; targeted effects

Indexed keywords

IRON; PROTEIN P53; PROTON;

ARTICLE; BYSTANDER EFFECT; CONTROLLED STUDY; DNA DAMAGE; HUMAN; HUMAN CELL; LOW ENERGY RADIATION; MICRONUCLEUS; PRIORITY JOURNAL; PROTON RADIATION; RADIATION FIELD; SKIN FIBROBLAST;

BYSTANDER EFFECT; CATALASE; CELL LINE; COCULTURE TECHNIQUES; DNA DAMAGE; FIBROBLASTS; HUMANS; HYDROGEN PEROXIDE; IONS; IRON; MICRONUCLEUS TESTS; PROTONS; REACTIVE OXYGEN SPECIES; SIGNAL TRANSDUCTION; SKIN;

EID: 79952141355     PISSN: 09553002     EISSN: 13623095     Source Type: Journal    
DOI: 10.3109/09553002.2010.537431     Document Type: Article

References (49)

1. Azzam EI, de Toledo SM, Little JB. 2001. Direct evidence for the participation of gap junction-mediated intercellular communication in the transmission of damage signals from alpha - particle irradiated to nonirradiated cells. Proceedings of the National Academy of Sciences of the USA 98:473-478. (Pubitemid 32105066)
2. Azzam EI, de Toledo SM, Spitz DR, Little JB. 2002. Oxidative metabolism modulates signal transduction and micronucleus formation in bystander cells from alpha-particle-irradiated normal human fibroblast cultures. Cancer Research 62: 5436-5442.
3. Ballarini F, Alloni D, Facoetti A, Mairani A, Nano R, Ottolenghi A. 2006. Modelling radiation-induced bystander effect and cellular communication. Radiation Protection Dosimetry 122:244-251. (Pubitemid 47090458)
4. Ballarini F, Biaggi M, Ottolenghi A, Sapora O. 2002. Cellular communication and bystander effects: A critical review for modelling low-dose radiation action. Mutation Research 501:1-12. (Pubitemid 34270645)
5. Belyakov OV, Malcolmson AM, Folkard M, Prise KM, Michael BD. 2001. Direct evidence for a bystander effect of ionizing radiation in primary human fibroblasts. British Journal of Cancer 84:674-679. (Pubitemid 32239002)
6. Bennett PV, Cutter NC, Sutherland BM. 2007. Split-dose exposures versus dual ion exposure in human cell neoplastic transformation. Radiation and Environmental Biophysics 46:119-123. (Pubitemid 46726005)
7. Blakely EA. 2000. Biological effects of cosmic radiation: Deterministic and stochastic. Health Physics 79:495-506.
8. Clutton SM, Townsend KM, Walker C, Ansell JD, Wright EG. 1996. Radiation-induced genomic instability and persisting oxidative stress in primary bone marrow cultures. Carcinogenesis 17:1633-1639. (Pubitemid 26280385)
9. Durante M, Kronenberg A. 2005. Ground-based research with heavy ions for space radiation protection. Advances in Space Research 35:180-184. (Pubitemid 40684050)
10. Fenech M. 2000. The in vitro micronucleus technique. Mutation Research 455:81-95.
11. Hada M, Meador JA, Cucinotta FA, Gonda SR, Wu H. 2007. Chromosome aberrations induced by dual exposure of protons and iron ions. Radiation and Environmental Biophysics 46:125-129. (Pubitemid 46725999)
12. Hall EJ, Giaccia AJ. 2006. Radiobiology for the radiologist. Philadelphia: Lippincott Williams & Wilkins.
13. Hamada N, Matsumoto H, Hara T, Kobayashi Y. 2007. Intercellular and intracellular signaling pathways mediating ionizing radiation-induced bystander effects. Journal of Radiation Research (Tokyo) 48:87-95. (Pubitemid 46535892)
14. Hei TK, Zhou H, Ivanov VN, Hong M, Lieberman HB, Brenner DJ, Amundson SA, Geard CR. 2008. Mechanism of radiationinduced bystander effects: A unifying model. Journal of Pharmacy and Pharmacology 60:943-950.
15. Ilnytskyy Y, Koturbash I, Kovalchuk O. 2009. Radiation-induced bystander effects in vivo are epigenetically regulated in a tissuespecific manner. Environmental and Molecular Mutagenesis 50:105-113.
16. Iyer R, Lehnert BE, Svensson R. 2000. Factors underlying the cell growth-related bystander responses to alpha particles. Cancer Research 60:1290-1298. (Pubitemid 30151997)
17. Iyer R, Lehnert BE. 2002a. Alpha-particle-induced increases in the radioresistance of normal human bystander cells. Radiation Research 157:3-7. (Pubitemid 34073381)
18. Iyer R, Lehnert BE. 2002b. Low dose, low-LET ionizing radiation-induced radioadaptation and associated early responses in unirradiated cells. Mutation Research 503:1-9. (Pubitemid 34607598)
19. Koturbash I, Boyko A, Rodriguez-Juarez R, McDonald RJ, Tryndyak VP, Kovalchuk I, Pogribny IP, Kovalchuk O. 2007. Role of epigenetic effectors in maintenance of the long-term persistent bystander effect in spleen in vivo. Carcinogenesis 28:1831-1838. (Pubitemid 47289047)
20. Kovalchuk O, Baulch JE. 2008. Epigenetic changes and nontargeted radiation effects - is there a link? Environmental and Molecular Mutagenesis 49:16-25. (Pubitemid 351293009)
21. Little JB, Nagasawa H, Li GC, Chen DJ. 2003. Involvement of the nonhomologous end joining DNA repair pathway in the bystander effect for chromosomal aberrations. Radiation Research 159:262-267. (Pubitemid 36182405)
22. Little JB. 2006. Cellular radiation effects and the bystander response. Mutation Research 597:113-118.
23. Lyng FM, Seymour CB, Mothersill CE. 2002. Initiation of apoptosis in cells exposed to medium from the progeny of irradiated cells: A possible mechanism for bystander-induced genomic instability? Radiation Research 157:365-370. (Pubitemid 34267248)
24. Matsumoto H, Hamada N, Takahashi A, Kobayashi Y, Ohnishi T. 2007. Vanguards of paradigm shift in radiation biology: Radiation-induced adaptive and bystander responses. Journal of Radiation Research (Tokyo) 48:97-106. (Pubitemid 46535893)
25. Matsumoto H, Hayashi S, Hatashita M, Ohnishi K, Shioura H, Ohtsubo T, Kitai R, Ohnishi T, Kano E. 2001. Induction of radioresistance by a nitric oxide-mediated bystander effect. Radiation Research 155:387-396. (Pubitemid 32204254)
26. Matsumoto H, Hayashi S, Hatashita M, Shioura H, Ohtsubo T, Kitai R, Ohnishi T, Yukawa O, Furusawa Y, Kano E. 2000. Induction of radioresistance to accelerated carbon-ion beams in recipient cells by nitric oxide excreted from irradiated donor cells of human glioblastoma. International Journal of Radiation Biology 76:1649-1657.
27. Matsumoto H, Takahashi A, Ohnishi T. 2004. Radiation-induced adaptive responses and bystander effects. Biological Science in Space 18:247-254.
28. Matsumoto H, Tomita M, Otsuka K, Hatashita M. 2009. A new paradigm in radioadaptive response developing from microbeam research. Journal of Radiation Research (Tokyo) 50(Suppl. A):A67-79.
29. Morgan WF, Sowa MB. 2007. Non-targeted bystander effects induced by ionizing radiation. Mutation Research 616: 159-164. (Pubitemid 46206080)
30. Mothersill C, Seymour C. 1997. Medium from irradiated human epithelial cells but not human fibroblasts reduces the clonogenic survival of unirradiated cells. International Journal of Radiation Biology 71:421-427. (Pubitemid 27187398)
31. Mothersill C, Seymour C. 2006. Radiation-induced bystander effects and the DNA paradigm: An ''out of field'' perspective. Mutation Research 597:5-10.
32. Mothersill C, Seymour CB. 1998. Cell-cell contact during gamma irradiation is not required to induce a bystander effect in normal human keratinocytes: Evidence for release during irradiation of a signal controlling survival into the medium. Radiation Research 149:256-262. (Pubitemid 28104286)
33. Nagasawa H, Little JB. 1999. Unexpected sensitivity to the induction of mutations by very low doses of alpha-particle radiation: Evidence for a bystander effect. Radiation Research 152:552-557. (Pubitemid 29514159)
34. National Academy of Sciences. 2005. Health risks from exposure to low levels of ionizing radiation: BEIR VII Report. Washington, DC: National Academy Press.
35. Olivieri G. 1999. Adaptive response and its relationship to hormesis and low dose cancer risk estimation. Human & Experimental Toxicology 18:440-442. (Pubitemid 29354070)
36. Prise KM, Belyakov OV, Newman HC, Patel SSG, Folkard M, Michael BD. 2002. Non-targeted effects of radiation: Bystander responses in cell and tissue models. Radiation Protection Dosimetry 99:223-226.
37. Rugo RE, Secretan MB, Schiestl RH. 2002. X radiation causes a persistent induction of reactive oxygen species and a delayed reinduction of TP53 in normal human diploid fibroblasts. Radiation Research 158:210-219. (Pubitemid 34851817)
38. Sawant SG, Randers-Pehrson G, Geard CR, Brenner DJ, Hall EJ. 2001a. The bystander effect in radiation oncogenesis: I. Transformation in C3H 10T cells in vitro can be initiated in the unirradiated neighbors of irradiated cells. Radiation Research 155:397-401. (Pubitemid 32204255)
39. Sawant SG, Randers-Pehrson G, Metting NF, Hall EJ. 2001b. Adaptive response and the bystander effect induced by radiation in C3H 10T(1/2) cells in culture. Radiation Research 156:177-180. (Pubitemid 32701179)
40. Shao C, Folkard M, Prise KM. 2008a. Role of TGF-beta1 and nitric oxide in the bystander response of irradiated glioma cells. Oncogene 27:434-440.
41. Shao C, Prise KM, Folkard M. 2008b. Signaling factors for irradiated glioma cells induced bystander responses in fibroblasts. Mutation Research 638:139-145.
42. Shao C, Stewart V, Folkard M, Michael BD, PriseKM.2003. Nitric oxide-mediated signaling in the bystander response of individually targeted glioma cells. Cancer Research 63:8437-8442. (Pubitemid 37549500)
43. Simone NL, Soule BP, Ly D, Saleh AD, Savage JE, Degraff W, Cook J, Harris CC, Gius D, Mitchell JB. 2009. Ionizing radiation-induced oxidative stress alters miRNA expression. PLoS One 4:e6377.
44. Yang H, Asaad N, Held KD. 2005. Medium-mediated intercellular communication is involved in bystander responses of X-ray irradiated normal human fibroblasts. Oncogene 24:2096-2103. (Pubitemid 40516203)
45. Yang H, Anzenberg V, Held KD. 2007. The time dependence of bystander responses induced by iron-ion radiation in normal human skin fibroblasts. Radiation Research 168:292-298. (Pubitemid 351295131)
46. Zhang Y, Zhou J, Baldwin J, Held KD, Prise KM, Redmond RM, Liber HL. 2009. Ionizing radiation-induced bystander mutagenesis and adaptation: Quantitative and temporal aspects. Mutation Research 671:20-25
47. Zhou G, Bennett PV, Cutter NC, Sutherland BM. 2006. Proton-HZE-particle sequential dual-beam exposures increase anchorage-independent growth frequencies in primary human fibroblasts. Radiation Research 166: 488-494. (Pubitemid 44353432)
48. Zhou H, Randers-Pehrson G, Waldren CA, Vannais D, Hall EJ, Hei TK. 2000. Induction of a bystander mutagenic effect of alpha particles in mammalian cells. Proceedings of the National Academy of Sciences of the USA 97: 2099-2104. (Pubitemid 30134028)
49. Zhou H, Randers-Pehrson G, Geard CR, Brenner DJ, Hall EJ, Hei TK. 2003. Interaction between radiation-induced adaptive response and bystander mutagenesis in mammalian cells. Radiation Research 160:512-516. (Pubitemid 38055198)