Involvement of the nonhomologous end joining DNA repair pathway in the bystander effect for chromosomal aberrations

Radiation Research

Volumn 159, Issue 2, 2003, Pages 262-267

  Little, John B ^a   Nagasawa, Hatsumi ^a   Li, Gloria C ^b   Chen, David J ^c  

^a HARVARD SCHOOL OF PUBLIC HEALTH   (United States)

^b MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

^c LAWRENCE BERKELEY NATIONAL LABORATORY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DOUBLE STRANDED DNA;

ALPHA RADIATION; ANIMAL CELL; ARTICLE; BYSTANDER EFFECT; CELL CYCLE G1 PHASE; CHROMOSOME ABERRATION; CONTROLLED STUDY; CULTURE MEDIUM; DNA REPAIR; DNA STRAND BREAKAGE; KNOCKOUT MOUSE; METAPHASE; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; RADIATION DOSE; RADIATION EXPOSURE;

NON-PROGRAMMATIC;

ALPHA PARTICLES; ANIMALS; BYSTANDER EFFECT; CELL LINE; CHROMOSOME ABERRATIONS; DEMECOLCINE; DNA DAMAGE; DNA REPAIR; DOSE-RESPONSE RELATIONSHIP, RADIATION; MICE; MICE, KNOCKOUT; RADIATION DOSAGE; RECOMBINATION, GENETIC;

EID: 0037316976     PISSN: 00337587     EISSN: None     Source Type: Journal    
DOI: 10.1667/0033-7587(2003)159[0262:IOTNEJ]2.0.CO;2     Document Type: Article

References (29)

1. J. B. Little, Radiation carcinogenesis. Carcinogenesis 21, 397-404 (2000).
2. C. Mothersill and C. Seymour, Radiation-induced bystander effects: Past history and future directions. Radiat. Res. 155, 759-767 (2001).
3. H. Nagasawa and J. B. Little, Induction of sister chromatid exchanges by extremely low doses of alpha-particles. Cancer Res. 52, 6394-6396 (1992).
4. A. Deshpande, E. H. Goodwin, S. M. Bailey, B. L. Marrone and B. E. Lehnert, Alpha-particle-induced sister chromatid exchange in normal human lung fibroblasts: Evidence for an extranuclear target. Radiat. Res. 145, 260-267 (1996).
5. H. Nagasawa and J. B. Little, Unexpected sensitivity to the induction of mutations by very low doses of alpha-particle radiation: Evidence for a bystander effect. Radiat. Res. 152, 552-557 (1999).
6. H. Zhou, G. Randers-Pehrson, C. A. Waldren, D. Vannais, E. J. Hall and T. K. Hei, Induction of a bystander mutagenic effect of alpha particles in mammalian cells. Proc. Natl. Acad. Sci. USA 97, 2099-2104 (2000).
7. S. G. Sawant, G. Randers-Pehrson, C. R. Geard, D. J. Brenner and E. J. Hall, The bystander effect in radiation oncogenesis: I. Transformation in C3H 10T1/2 cells in vitro can be initiated in the unirradiated neighbors of irradiated cells. Radiat. Res. 155, 397-401 (2001).
8. E. I. Azzam, S. M. de Toledo, T Gooding and J. B. Little, Intercellular communication is involved in the bystander regulation of gene expression in human cells exposed to very low fluences of alpha particles. Radiat. Res. 150, 497-504 (1998).
9. E. I. Azzam, S. M. de Toledo and J. B. Little, Direct evidence for the participation of gap junction-mediated intercellular communication in the transmission of damage signals from alpha-particle irradiated to nonirradiated cells. Proc. Natl. Acad. Sci. USA 98, 473-478 (2001).
10. B. E. Lehnert and E. H. Goodwin, A new mechanism for DNA alterations induced by alpha particles such as those emitted by radon and radon progeny. Environ. Health Perspect. 105 (Suppl.), 1095-1101 (1997).
11. C. Mothersill and C. Seymour, Medium from irradiated human epithelial cells but not human fibroblasts reduces the clonogenic survival of unirradiated cells. Int. J. Radiat. Biol. 71, 421-417 (1997).
12. P. K. Narayanan, E. H. Goodwin and B. E. Lehnert, Alpha particles initiate biological production of superoxide anions and hydrogen peroxide in human cells. Cancer Res. 57, 3963-3971 (1997).
13. E. Azzam, S. M. de Toledo and J. B. Little, Oxidative metabolism modulates signal transduction and micronucleus formation in bystander cells from alpha-particle-irradiated normal human fibroblast cultures. Cancer Res. 62, 5436-5442 (2002).
14. L. Huo, H. Nagasawa and J. B. Little, HPRT mutants induced in bystander cells by very low fluences of alpha particles result primarily from point mutations. Radiat. Res. 156, 521-525 (2001).
15. H. Nagasawa, L. Huo and J. B. Little, Increased bystander mutagenic effect in DNA double strand break repair deficient mammalian cells. Int. J. Radiat. Biol., in press.
16. J. M. de Murcia, C. Niedergang, C. Trucco, M. Ricoul, B. Dutrillaux, M. Mark, F. J. Oliver, M. Masson, A. Dierich and G. de Murcia, Requirement of poly(ADP-ribose) polymerase in recovery from DNA damage in mice and in cells. Proc. Natl. Acad. Sci. USA 94, 7303-7307 (1997).
17. R. Araki, R. Fukumura, A. Fujimori, Y. Taya, Y. Shiloh, A. Kurimasa, S. Burma, G. C. Li, D. J. Chen and M. Abe, Enhanced phosphorylation of p53 serine 18 following DNA damage in DNA-dependent protein kinase catalytic subunit-deficient cells. Cancer Res. 59, 3543-3546 (1999).
18. N. F. Metting, A. M. Koehler, H. Nagasawa, J. M. Nelson and J. B. Little, Design of a benchtop alpha particle irradiator. Health Phys. 68, 710-715 (1995).
19. M. R. Raju, Y. Eisen, S. Carpenter and W. C. Inkret, Radiobiology of alpha particles. III. Cell inactivation by alpha-particle traversals of the cell nucleus. Radiat. Res. 128, 204-209 (1991).
20. A. J. Fornace, Jr., H. Nagasawa and J. B. Little, Relationship of DNA repair to chromosome aberrations, sister-chromatid exchanges and survival during liquid-holding recovery in X-irradiated mammalian cells. Mutat. Res. 70, 323-336 (1980).
21. A. Bishayee, H. Z. Hill, D. Stein, D. V. Rao and R. W. Howell, Free radical-initiated and gap junction-mediated bystander effect due to nonuniform distribution of incorporated radioactivity in a three-dimensional tissue culture model. Radiat. Res. 155, 335-344 (2001).
22. R. Iyer and B. E. Lehnert, Factors underlying the cell growth-related bystander responses to alpha particles. Cancer Res. 60, 1290-1298 (2000).
23. B. M. Sutherland, P. V. Bennett, O. Sidorkina and J. Laval, Clustered DNA damages induced in isolated DNA and in human cells by low doses of ionizing radiation. Proc. Natl. Acad. Sci. USA 97, 103-108 (2000).
24. M. Frankenberg-Schwager and D. Frankenberg, DNA double-strand breaks: Their repair and relationship to cell killing in yeast. Int. J. Radiat. Biol. 58, 569-575 (1990).
25. D. O. Ferguson and F. W. Alt, DNA double strand break repair and chromosomal translocation: Lessons from animal models. Oncogene 20, 5572-5579 (2001).
26. Y. Gao, Y. Sun, K. M. Frank, P. Dikkes, Y. Fujiwara, K. J. Seidl, J. M. Sekiguchi, G. A. Rathbun, W. Swat and F. W. Alt, A critical role for DNA end-joining proteins in both lymphogenesis and neurogenesis. Cell 95, 891-902 (1998).
27. M. Hashimoto, C. D. Donald, S. M. Yannone, D. J. Chen, R. Roy and Y. W. Kow, A possible role of Ku in mediating sequential repair of closely opposed lesions. J. Biol. Chem. 276, 12827-12831 (2001).
28. P. Decker and S. Muller, Modulating poly(ADP-ribose) polymerase activity: Potential for the prevention and therapy of pathogenic situations involving DNA damage and oxidative stress. Curr. Pharm. Biotechnol. 3, 275-283 (2002).
29. V. Rudat, N. Bachmann, J. H. Kupper and K. J. Weber, Overexpression of the DNA-binding domain of poly(ADP-ribose) polymerase inhibits rejoining of ionizing radiation-induced DNA double-strand breaks. Int. J. Radiat. Biol. 77, 303-307 (2001).