Modelling radiation-induced bystander effect and cellular communication

Radiation Protection Dosimetry

Volumn 122, Issue 1-4, 2006, Pages 244-251

  Ballarini, Francesca ^a,b   Alloni, D ^a,b   Facoetti, A ^a,b   Mairani, A ^a,b   Nano, R ^a   Ottolenghi, A ^a,b  

^a UNIVERSITY OF PAVIA   (Italy)

^b INFN SEZIONE DI ROMA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM ION; CARRIER PROTEIN; CYCLIC AMP; INTERLEUKIN 2; INTERLEUKIN 8; REACTIVE OXYGEN METABOLITE; TRANSFORMING GROWTH FACTOR BETA; TUMOR NECROSIS FACTOR ALPHA;

ARTICLE; BYSTANDER EFFECT; CELL COMMUNICATION; CELL CYCLE; CELL DAMAGE; CELL DENSITY; CELL TYPE; GAP JUNCTION; HUMAN; ITALY; MATHEMATICAL MODEL; PROCESS MODEL; PROTEIN SECRETION; RADIATION DOSE; RADIATION EXPOSURE; RADIATION HAZARD; RADIATION INJURY; RADIATION PROTECTION; RADIOBIOLOGY; RADIOTHERAPY; THEORETICAL MODEL; TIME; ANIMAL; BIOLOGICAL MODEL; CELL SURVIVAL; COMPUTER SIMULATION; PHYSIOLOGY; RADIATION RESPONSE; REVIEW; SIGNAL TRANSDUCTION;

ANIMALS; BYSTANDER EFFECT; CELL SURVIVAL; COMPUTER SIMULATION; DOSE-RESPONSE RELATIONSHIP, RADIATION; HUMANS; MODELS, BIOLOGICAL; RADIATION DOSAGE; RADIATION TOLERANCE; SIGNAL TRANSDUCTION;

EID: 34347376973     PISSN: 01448420     EISSN: None     Source Type: Journal    
DOI: 10.1093/rpd/ncl446     Document Type: Article

References (27)

1. Mothersill, C. and Seymour, C. B. Medium from irradiated human epithelial cells but not human fibroblasts reduces the clonogenic survival of unirradiated cells. Int. J. Radiat. Biol. 71, 421-427 (1997).
2. Prise, K., Belyakov, O.V., Folkard,M. and Michael B.D. Studies of bystander effects in human fibroblasts using a charged particle microbeam. Int. J. Radiat. Biol. 74, 793-798 (1998).
3. Nagasawa, H. and Little, J. B. Unexpected sensitivity to the induction of mutations by very low doses of alpha-particle radiation: evidence for a bystander effect. Radiat. Res. 152, 552-557 (1999).
4. Zhou, H., Randers-Pehrson, G., Waldren, C. A., Vannais, D., Hall, E. J. and Hei, T. K. Induction of a bystander mutagenic effect of alpha particles in mammalian cells. Proc. Natl Acad. Sci. USA 97, 2099-2104 (2000).
5. Miller, R. C., Randers-Pehrson, G., Geard, C. R., Hall, E. J. and Brenner, D. J. The oncogenic transformation potential of the passage of single alpha particles through mammalian cell nuclei. Proc. Natl Acad. Sci. USA 96 19-22 (1999).
6. Sawant, S. G., Randers-Pehrson, G., Geard, C. R., Brenner, D. J. and Hall, E. J. The bystander effect in radiation oncogenesis: I. Transformation in C3H 10T1/2 cells in vitro can be initiated in the unirradiated neighbours of irradiated cells. Radiat. Res. 155, 397-401 (2001).
7. Nagasawa, H. and Little, J. B. Induction of sister chromatid exchanges by extremely low doses of alpha particles. Cancer Res. 52, 6394-6396 (1992).
8. Deshpande, A., Goodwin, E. H., Bailey, S. M., Marrone, B. L. and Lehnert, B. E. Alpha-particle induced sister chromatid exchange in normal human lung fibroblast: Evidence for an extracellular target. Radiat. Res. 145, 260-267 (1996).
9. Azzam, E. I., de Toledo, S. M., Little, J. B. Direct evidence for the participation of gap-junction mediated intercellular communication in the transmission of damage signals from alpha-particle irradiated to non-irradiated cells. Proc. Natl Acad. Sci. USA 98: 473-478 (2001).
10. Yang, H., Asaad, N. and Held, K. D. Medium-mediated intercellular communication is involved in bystander responses of X-ray-irradiated normal human fibroblasts. Oncogene 24, 2096-2103 (2005).
11. Ballarini, F., Biaggi, M., Ottolenghi, A. and Sapora, O. Cellular communication and bystander effects: A critical review for modeling low-dose radiation action. Mutat. Res. 501, 1-12 (2002).
12. Goldberg, Z. and Lehnert, B. E. Radiation-induced effects in unirradiated cells: A review and implications in cancer. Int. J. Oncol. 21, 337-349 (2002).
13. Morgan, W. F. Non-targeted and delayed effects of exposure to ionizing radiation: I. Radiation-induced genomic instability and bystander effects in vitro. Radiat. Res. 159, 567-580 (2003).
14. Morgan, W. F. Non-targeted and delayed effects of exposure to ionizing radiation: II. Radiation-induced genomic instability and bystander effects in vivo, clastogenic factors and transgenerational effects. Radiat. Res. 159, 581-596 (2003).
15. Hei, T. K., Persaud, R., Zhou, H. and Suzuki, M. Genotoxicity in the eyes of bystnder cells. Mutat. Res. 568, 111-120 (2004).
16. Coates, P. J., Lorimore, S. A. and Wright, E. G. Damaging and protective cell signaling in the untargeted effects of ionizing radiation. Mutat. Res. 568, 5-20 (2004).
17. Shao, C., Folkard, M., Michael, B. D. and Prise, K. Bystander signaling between glioma cells and fibroblasts targeted with counted particles. Int. J. Cancer 116, 45-51 (2005).
18. Narayanan, P. K., LaRue, R. E. A., Goodwin, E. H. and Lehnert, B. E. Alpha particles initiate biological production of interleukin-8 in human cells. Radiat. Res. 152, 57-63 (1999).
19. Facoetti, A., Ballarini, F., Cherubini, R., Gerardi, S., Nano, R., Ottolenghi, A., Prise, K. M., Trott, K. R. and Zilio, C. Gamma ray-induced bystander effect in tumour glioblastoma cells: A specific study on cell survival cytokine release and cytokine receptors, Radiat. Prot. Dosim. 122, 271-274 (2006).
20. Lehnert, B. E. and Iyer, R. Cell-growth related bystander responses to alpha particles and gamma rays. Proc. Eleventh Int. Congress of Radiat. Res. 2, 488-491 (1999).
21. Barcellos-Hoff, M. H. and Brooks, A. L. Extracellular signaling through the microenvironment: A hypothesis relating carcinogenesis, bystander effects and genomic instability. Radiat. Res. 156, 618-627 (2001).
22. Brenner, D. J., Little, J. B. and Sachs, R. K. The bystander effect in radiation oncogenesis: II. A quantitative model. Radiat. Res. 155, 402-408 (2001).
23. Nikjoo, H. and Khvostunov, I. K. Biophysical model of the radiation-induced bystander effect. Int. J. Radiat. Biol. 79, 43-52 (2003).
24. Little, M. P., Filipe, J. A. N., Prise, K. M., Folkard, M. and Belyakov, O. V. A model for radiation-induced bystander effects, with allowance for spatial position and the effects of cell turnover. J. Theor. Biol. 232, 329-338 (2005).
25. Belyakov, O. V., Malcolmson, A. M., Folkard, M., Prise, K. M. and Michael, B. D. Direct evidence for a bystander effect of ionizing radiation in primary human fibroblasts. Br. J. Cancer 84, 674-679 (2001).
26. Belyakov, O. V., Folkard, M., Mothersill, C., Prise, K. M. and Michael, B. D. Bystander induced apoptosis and premature differentiation in primary urothelial explants after charged particle microbeam irradiation Radiat. Prot. Dosim. 99, 249-251 (2002).
27. Belyakov, O. V., Mitchell, S. A., Parikh, D., Randers-Pehrson, G., Marino, S. A., Amundson, S. A., Geard, C. R. and Brenner, D. J. Biological effects in unirradiated human tissue induced by radiation damage up to 1 mm away. Proc. Natl Acad. Sci USA 102, 14203-14208 (2005).