Colonic availability of polyphenols and D-(-)-quinic acid after apple smoothie consumption

Molecular Nutrition and Food Research

Volumn 55, Issue 3, 2011, Pages 368-377

  Hagl, Stephanie ^a   Deusser, Hannah ^a   Soyalan, Buelent ^a   Janzowski, Christine ^a   Will, Frank ^b   Dietrich, Helmut ^b   Albert, Franz Werner ^c   Rohner, Simone ^a   Richling, Elke ^a  

^a Rheinland Pfälzische Technische Universität Kaiserslautern Landau   (Germany)

^b Forschungsanstalt Geisenheim   (Germany)

^c Westpfalz Klinikum GmbH   (Germany)

Author keywords

Apple smoothie; Chlorogenic acid; D ( ) Quinic acid; Ileostomy; Phloretin

Indexed keywords

CAFFEOYLQUINIC ACID; DRUG DERIVATIVE; FLAVONOID; PHENOL DERIVATIVE; PHLORETIN; POLYPHENOLS; PROANTHOCYANIDIN; QUINIC ACID;

ADULT; AGED; APPLE; ARTICLE; BEVERAGE; BIOAVAILABILITY; CHEMISTRY; FEMALE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; ILEOSTOMY; MALE; MIDDLE AGED;

ADULT; AGED; BEVERAGES; BIOLOGICAL AVAILABILITY; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; FEMALE; FLAVONOIDS; HUMANS; ILEOSTOMY; MALE; MALUS; MIDDLE AGED; PHENOLS; PHLORETIN; PROANTHOCYANIDINS; QUINIC ACID;

MALUS X DOMESTICA;

EID: 79952129517     PISSN: 16134125     EISSN: 16134133     Source Type: Journal    
DOI: 10.1002/mnfr.201000252     Document Type: Article

References (28)

1. Koch, T. C., Briviba, K., Watzl, B., Fahndrich, C. et al., Prevention of colon carcinogenesis by apple juice in vivo: impact of juice constituents and obesity. Mol. Nutr. Food Res. 2009, 53, 1289-1302.
2. Gallus, S., Talamini, R., Giacosa, A., Montella, M. et al., Does an apple a day keep the oncologist away? Ann. Oncol. 2005, 16, 1841-1844.
3. Vrhovsek, U., Rigo, A., Tonon, D., Mattivi, F., Quantitation of polyphenols in different apple varieties. J. Agric. Food Chem. 2004, 52, 6532-6538.
4. Souci, S., Fachmann, W., Kraut, H., Food Composition and Nutrition Tables, med-pharm GmbH Scientific Publishers, Stuttgart 2005.
5. Landolfi, R., Mower, R. L., Steiner, M., Modification of platelet function and arachidonic acid metabolism by bioflavonoids. Structure-activity relations. Biochem. Pharmacol. 1984, 33, 1525-1530.
6. Pietta, P. G., Flavonoids as antioxidants. J. Nat. Prod. 2000, 63, 1035-1042.
7. Robak, J., Gryglewski, R. J., Flavonoids are scavengers of superoxide anions. Biochem. Pharmacol. 1988, 37, 837-841.
8. Gerhauser, C., Cancer chemopreventive potential of apples, apple juice, and apple components. Planta Med. 2008, 74, 1608-1624.
9. Kahle, K., Kraus, M., Scheppach, W., Richling, E., Colonic availability of apple polyphenols - a study in ileostomy subjects. Mol. Nutr. Food Res. 2005, 49, 1143-1150.
10. Tsao, R., Yang, R., Young, J. C., Zhu, H., Polyphenolic profiles in eight apple cultivars using high-performance liquid chromatography (HPLC). J. Agric. Food Chem. 2003, 51, 6347-6353.
11. Scalbert, A., Williamson, G., Dietary intake and bioavailability of polyphenols. J. Nutr. 2000, 130, 2073S-2085S.
12. Kahle, K., Huemmer, W., Kempf, M., Scheppach, W. et al., Polyphenols are intensively metabolized in the human gastrointestinal tract after apple juice consumption. J. Agric. Food Chem. 2007, 55, 10605-10614.
13. Marks, S. C., Mullen, W., Borges, G., Crozier, A., Absorption, metabolism, and excretion of cider dihydrochalcones in healthy humans and subjects with an ileostomy. J. Agric. Food Chem. 2009, 57, 2009-2015.
14. Kahle, K., Kraus, M., Richling, E., Polyphenol profiles of apple juices. Mol. Nutr. Food Res. 2005, 49, 797-806.
15. Will, F., Zessner, H., Becker, H., Dietrich, H., Semi-preparative isolation and physico-chemical characterization of 4-coumaroylquinic acid and phloretin-2'-O-xyloglucoside from laccase-oxidized apple juice. LWT-Food Science and Technology 2007, 40, 1344-1351.
16. Sefkow, M., First efficient synthesis of chlorogenic acid. Eur. J. Org. Chem. 2001, 14, 1137-1141.
17. Sefkow, M., Kelling, A., Schilde, U., First efficient synthesis of 1-, 4- and 5-caffeoylquinic acid. Eur. J. Org. Chem. 2001, 2735-2742.
18. Trugo, L. C., Macrae, R., Chlorogenic acid composition of instant coffees. Analyst 1984, 109, 263-266.
19. Erk, T., Bergmann, H., Richling, E., A novel method for the quantification of quinic acid in food using stable isotope dilution analysis. J. AOAC Int. 2009, 92, 730-733.
20. Stalmach, A., Troufflard, S., Serafini, M., Crozier, A., Absorption, metabolism and excretion of Choladi green tea flavan-3-ols by humans with an ileostomy. Mol. Nutr. Food Res. 2009, 53, S44-S53.
21. Will, F., Roth, M., Olk, M., Ludwig, M., Dietrich, H., Processing and analytical characterisation of pulp-enriched apple juices. LWT-Food Science and Technology 2008, 41, 2057-2063.
22. Mateos, R., Goya, L., Bravo, L., Uptake and metabolism of hydroxycinnamic acids (chlorogenic, caffeic, and ferulic acids) by HepG2 cells as a model of the human liver. J. Agric. Food Chem. 2006, 54, 8724-8732.
23. Olthof, M. R., Hollman, P. C., Katan, M. B., Chlorogenic acid and caffeic acid are absorbed in humans. J. Nutr. 2001, 131, 66-71.
24. Kern, S. M., Bennett, R. N., Needs, P. W., Mellon, F. A. et al., Characterization of metabolites of hydroxycinnamates in the in vitro model of human small intestinal epithelium caco-2 cells. J. Agric. Food Chem. 2003, 51, 7884-7891.
25. Spencer, J. P., Metabolism of tea flavonoids in the gastrointestinal tract. J. Nutr. 2003, 133, 3255S-3261S.
26. Deprez, S., Mila, I., Huneau, J. F., Tome, D., Scalbert, A., Transport of proanthocyanidin dimer, trimer, and polymer across monolayers of human intestinal epithelial Caco-2 cells. Antioxid. Redox Signal 2001, 3, 957-967.
27. Gosse, F., Guyot, S., Roussi, S., Lobstein, A. et al., Chemopreventive properties of apple procyanidins on human colon cancer-derived metastatic SW620 cells and in a rat model of colon carcinogenesis. Carcinogenesis 2005, 26, 1291-1295.
28. Barth, S. W., Fähndrich, C., Bub, A., Dietrich, H. et al., Cloudy apple juice decrease DNA damage, hyperproliferation and aberrant crypt foci development in the distal colon of DMH-initiated rats. Carcinogenesis 2005, 26, 1414-1421.