Functional roles of an ERG current isolated in cerebellar Purkinje neurons

Journal of Neurophysiology

Volumn 90, Issue 3, 2003, Pages 1817-1828

  Sacco, Tiziana ^a   Bruno, Alessandro ^a   Wanke, Enzo ^b   Tempia, Filippo ^a  

^a Section of Human Physiology   (Italy)

^b UNIVERSITY OF MILANO BICOCCA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM ION; MEMBRANE PROTEIN; N METHYL N [2 [METHYL(1 METHYL 1H BENZIMIDAZOL 2 YL)AMINO]ETHYL] 4 [(METHYLSULFONYL)AMINO]BENZENESULFONAMIDE; POTASSIUM CHANNEL; POTASSIUM ION;

ADAPTATION; ANIMAL TISSUE; ARTICLE; BRAIN SLICE; CHANNEL GATING; CLIMBING FIBER; CONCENTRATION RESPONSE; FEMALE; MALE; MOUSE; NERVE CELL MEMBRANE STEADY POTENTIAL; NERVE POTENTIAL; NONHUMAN; PATCH CLAMP; POTASSIUM CHANNEL ERG; PRIORITY JOURNAL; PURKINJE CELL;

ACTION POTENTIALS; ANIMALS; CEREBELLUM; ETHER-A-GO-GO POTASSIUM CHANNELS; FEMALE; MALE; MICE; POTASSIUM CHANNEL BLOCKERS; POTASSIUM CHANNELS; POTASSIUM CHANNELS, VOLTAGE-GATED; PURKINJE CELLS;

EID: 0141856608     PISSN: 00223077     EISSN: None     Source Type: Journal    
DOI: 10.1152/jn.00104.2003     Document Type: Article

References (46)

1. Abbott GW, Sesti F, Splawski I, Buck ME, Lehmann MH, Timothy KW, Keating MT, and Goldstein SA. MiRP1 forms IKr potassium channels with HERG and is associated with cardiac arrhythmia. Cell 97: 175-187, 1999.
2. + currents in opossum esophageal circular smooth muscle. Am J Physiol Cell Physiol 277: C1284-C1290, 1999.
3. 3 rat anterior pituitary cells. Pfluegers Arch 435: 119-129, 1997.
4. + current in clonal rat pituitary cells and its modulation by thyrotrophin-releasing hormone. J Physiol 429: 169-189, 1990.
5. + current in prolactin secretion from rat lactotrophs. Mol Cell Endocrinol 148: 37-45, 1999.
6. + channel. Eur J Neurosci 16: 415-428, 2002.
7. + current highly conserved in tumors of different histogenesis: a selective advantage for cancer cells? Cancer Res 58: 815-822, 1998.
8. + channels: spike frequency adaptation. J Physiol 501: 313-318, 1997.
9. Crepel F. Maturation of the cerebellar Purkinje cells. I. Postnatal evolution of the Purkinje cell spontaneous firing in the rat. Exp Brain Res 14: 463-471, 1972.
10. Crepel F and Penit-Soria J. Inward rectification and low threshold calcium conductance in rat cerebellar Purkinje cells. An in vitro study. J Physiol 372: 1-23, 1986.
11. + channel by dual pathways. Curr Biol 10: 671-674, 2000.
12. Curran ME, Splawski I, Timothy KW, Vincent GM, Green ED, and Keating MT. A molecular basis for cardiac arrhythmia: HERG mutations cause long QT syndrome. Cell 80: 795-803, 1995.
13. Faravelli L, Arcangeli A, Olivotto M, and Wanke E. A HERG-like channel in rat F-11 DRG cell line: pharmacological identification and biophysical characterisation. J Physiol 496: 13-23, 1996.
14. Ganetzky B and Wu CF. Neurogenetic analysis of potassium currents in Drosophila: synergistic effects on neuromuscular transmission in double mutants. J Neurogenet 1: 17-28, 1983.
15. Harris NC and Constanti A. Mechanism of block by ZD 7288 of the hyperpolarization-activated inward rectifying current in guinea pig substantia nigra neurons in vitro. J Neurophysiol 74: 2366-2378, 1995.
16. Heath BM and Terrar DA. Protein kinase C enhances the rapidly activating delayed rectifier potassium current, IKr, through a reduction in C-type inactivation in guinea-pig ventricular myocytes. J Physiol 522: 391-402, 2000.
17. Hounsgaard J and Midtgaard J. Intrinsic determinants of firing pattern in Purkinje neurons of the turtle cerebellum in vitro. J Physiol 402: 731-749, 1988.
18. Ito M. The Cerebellum and Motor Control. New York: Raven, 1984.
19. Ito M. Cerebellar long-term depression: characterization, signal transduction, and functional roles. Physiol Rev 81: 1143-1195, 2001.
20. Johnson JP Jr, Balser JR, and Bennett PB. A novel extracellular calcium sensing mechanism in voltage-gated potassium ion channels. J Neurosci 21: 4143-4153, 2001.
21. + current in MMQ lactotrophs and its accommodating role during slow firing and prolactin release. J Neurosci 22: 3414-3425, 2002.
22. Llinas R and Sugimori M. Electrophysiological properties of in vitro Purkinje neuron somata in mammalian cerebellar slices. J Physiol 305: 171-195, 1980.
23. + channel subunits encoded by the ether-a-go-go related (ERG) genes ERG1, ERG2 and ERG3 in the rat brain. Soc Neurosci Abstr 26: 1910, 2000.
24. Ohya S, Horowitz B, and Greenwood IA. Functional and molecular identification of ERG channels in murine portal vein myocytes. Am J Physiol Cell Physiol 283: C866-C778, 2002.
25. Overholt JL, Ficker E, Yang T, Shams H, Bright GR, and Prabhakar NR. HERG-like potassium current regulates the resting membrane potential in glomus cells of the rabbit carotid body. J Neurophysiol 83: 1150-1157, 2000.
26. + channels in firing and release. FASEB J 14: 2601-2610, 2000.
27. Sacco T and Tempia F. A-type potassium currents active at subthreshold potentials in mouse cerebellar Purkinje cells. J Physiol 543: 505-520, 2002.
28. Sacco T, Wanke E, and Tempia F. Expression of ERG potassium current in cerebellar Purkinje neurons (Abstract). Pfluegers Arch 442: R63, 2001a.
29. Sacco T, Wanke E, and Tempia F. ERG potassium current in mouse cerebellar Purkinje neurons. Soc Neurosci Abstr 27: 4190, 2001b.
30. + channels in brain. J Neurosci 21: 4609-4624, 2001.
31. + current. Differential sensitivity to block by class III antiarrhythmic agents. J Gen Physiol 96: 195-215, 1990.
32. Kr potassium channel. Cell 81: 299-307, 1995.
33. + currents by thyrotropin-releasing hormone in anterior pituitary cells via the native signal cascade. J Physiol 532: 143-163, 2001.
34. + channels. Eur J Neurosci 11: 753-760, 1999.
35. + channel subunit, Erg1 and KCNQ2/3, contribute to the M-like current in a mammalian neuronal cell. J Neurosci 19: 7742-7756, 1999.
36. Shi W, Wymore RS, Wang HS, Pan Z, Cohen IS, McKinnon D, and Dixon JE. Identification of two nervous system-specific members of the erg potassium channel gene family. J Neurosci 17: 9423-9432, 1997.
37. Shibasaki T. Conductance and kinetics of delayed rectifier potassium channels in nodal cells of the rabbit heart. J Physiol 387: 227-250, 1987.
38. + channel. J Biol Chem 278: 2503-2514, 2003.
39. Smith PL, Baukrowitz T, and Yellen G. The inward rectification mechanism of the HERG cardiac potassium channel. Nature 379: 833-836, 1996.
40. K block and lack of reverse use dependence in cat ventricular myocytes. Cardiovasc Res 27: 1580-1591, 1993.
41. Suessbrich H, Schonherr R, Heinemann SH, Attali B, Lang F, and Busch AE. The inhibitory effect of the antipsychotic drug haloperidol on HERG potassium channels expressed in Xenopus oocytes. Br J Pharmacol 120: 968-974, 1997.
42. Warmke JW and Ganetzky B. A family of potassium channel genes related to eag in Drosophila and mammals. Proc Natl Acad Sci USA 91: 3438-3442, 1994.
43. Welsh JP, Lang EJ, Sugihara I, and Llinas R. Dynamic organization of motor control within the olivocerebellar system. Nature 374: 453-457, 1995.
44. Woodward DJ, Hoffer BJ, and Lapham LW. Postnatal development of electrical and enzyme histochemical activity in Purkinje cells. Exp Neurol 23: 120-139, 1969.
45. Witchel HJ and Hancox JC. Familial and acquired long qt syndrome and the cardiac rapid delayed rectifier potassium current. Clin Exp Pharmacol Physiol 27: 753-766, 2000.
46. + channel, erg. Circ Res 80: 261-268, 1997.