Manifestations of copper excess

American Journal of Clinical Nutrition

Volumn 67, Issue 5 SUPPL., 1998, Pages

  Bremner, Ian ^a  

^a ROWETT RESEARCH INSTITUTE   (United Kingdom)

Author keywords

Copper; Copper excess; Copper toxicity; Hepatotoxicity; Humans; Lipid peroxidation; Pigs; Rats; Sheep; Wilson disease

Indexed keywords

COPPER;

CELLULAR DISTRIBUTION; CONFERENCE PAPER; DIETARY INTAKE; DNA DAMAGE; HUMAN; INTESTINE ABSORPTION; LIPID PEROXIDATION; LIVER TOXICITY; URINARY EXCRETION;

OVIS ARIES;

EID: 0031960482     PISSN: 00029165     EISSN: None     Source Type: Journal    
DOI: 10.1093/ajcn/67.5.1069S     Document Type: Conference Paper

References (38)

1. Chuttani HK, Gupta PS, Gulati S, et al. Acute copper sulfate poisoning. Am J Med 1965;39:849-54.
2. Bremner I. Copper toxicity studies using domestic and laboratory animals. In: Nriagu JO, ed. Copper in the environment. Part II: health effects. New York: John Wiley & Sons, 1979:285-306.
3. Tanner S. Role of copper in Indian childhood cirrhosis. Am J Clin Nutr 1997;67:1074S-81S.
4. Bull PC, Thomas GR, Rommens JM, Forbes JR, Cox DW. The Wilson disease gene is a putative copper transporting P-type ATPase similar to the Menkes gene. Nat Genet 1993;5:327-37.
5. Wu J, Forbes JR, Chen HS, Cox DW. The LEC rat has a deletion in the copper transporting ATPase gene homologous to the Wilson disease gene. Nat Genet 1994;7:541-5.
6. Woolliams JA, Suttle NF, Wiener G, Field AC, Woolliams C. The long-term accumulation and depletion of copper in the liver of different breeds of sheep fed diets of differing copper content. J Agric Sci Camb 1983;100:441-9.
7. Bull LB. The occurrence of chronic copper poisoning in grazing sheep in Australia. In: Plant and animal nutrition in relation to soil and climatic factors. London: Her Majesty's Stationery Office, 1951:300-10.
8. Sokol RJ, Devereaux M, Mierau GW, Hambidge KM, Shikes H. Oxidant injury to hepatic mitochondrial lipids in rats with dietary copper overload. Gastroenterology 1990;90:1061-71.
9. Bremner I. Involvement of metallothionein in the hepatic metabolism of copper. J Nutr 1987;117:19-29.
10. Allen MM, Harding JDJ. Experimental copper poisoning in pigs. Vet Rec 1962;74:173-9.
11. Fuentealba I, Hay wood S, Foster J. Cellular mechanisms of toxicity and tolerance in the copper-loaded rat. II. Pathogenesis of copper toxicity in the liver. Exp Mol Pathol 1989:50:26-37.
12. Fuentealba IC, Davis RW, Elmes ME, Jasani B, Haywood S. Mechanisms of tolerance in the copper-loaded rat liver. Exp Mol Pathol 1993;59:71-84.
13. Ishmael J, Gopinath C, Howell J. Experimental chronic toxicity in sheep: histological and histochemical changes during development of the changes in the liver. Res Vet Sci 1971;12:358-66.
14. Ishmael J. Gopinath C, Howell JM. Experimental chronic toxicity in sheep: biochemical and haematological studies during the development of changes in the liver. Res Vet Sci 1972;13:22-9.
15. King TP, Bremner I. Autophagy and apoptosis in liver during the prehaemolytic phase of chronic copper poisoning in sheep. J Comp Pathol 1979;89:515-29.
16. Goldfischer S, Bernstein J. Lipofuscin (aging) pigment granules of the newborn human liver. J Cell Biol 1969;42:253-61.
17. Johnson GF, Morell AG, Stocken RJ, Sternlieb I. Hepatic lysosomal copper protein in dogs with an inherited copper toxicosis. Hepatology 1981;l:243-8.
18. Goldfischer S. Demonstration of copper and acid phosphatase activity in hepatocyte lysosomes in experimental copper toxicity. Nature 1967;215:74-5.
19. Haywood S, Loughran ML, Batt RM. Copper toxicosis and tolerance in the rat. III. Intracellular localization of copper in the liver and kidney. Exp Mol Pathol 1985;43:209-19.
20. Leighton M. The accumulation and subcellular localisation of copper in the liver of foetal deer. PhD thesis. University of London, 1987.
21. Bryan SE, Frieden E. Interaction of copper II with desoxyribonucleic acid below 30 °C. Biochemistry 1967;6:2728-34.
22. Novello F, Stirpe F. The effect of copper and other ions on the ribonucleic acid polymerase activity of isolated rat liver nuclei. Biochem J 1969;111:115-9.
23. Liu J, Kershaw WC, Klaassen CD. The protective effect of metallothionein on the toxicity of various metals in rat primary hepatocyte culture. Toxicol Appl Pharmacol 1991;107:27-34.
24. Freedman JH, Ciriolo MR, Peisach J. The role of glutathione in copper metabolism and toxicity. J Biol Chem 1989;264:5598-605.
25. Mehra RK, Bremner I. Species differences in the occurrence of copper-metallothionein in the paniculate fractions of the liver of copper-loaded animals. Biochem J 1984;219:539-46.
26. Bremner I, Mehra RK, Morrison JN, Wood AM. Effects of dietary copper supplementation of rats on the occurrence of metallothionein-I in liver and its secretion into blood, bile and urine. Biochem J 1986;235:735-9.
27. Evering WEND, Haywood S. Bremner I, Trafford J. The protective role of metallothionein in copper overload. I. Differential distribution of immunoreactive metallothionein in copper-loaded rat liver and kidney. Chem Biol Interact 1991;78:283-95.
28. Sugawara N, Sugawara C, Sato M, Takahashi H, Mon M. Excessive accumulation of hepatic copper in LEC rats aged 80 days without hepatitis and 130 days with hepatitis. Pharmacol Toxicol 1992;71:321-4.
29. Kadiiska MB, Hanna PM, Hernandez L, Mason RP. In vivo evidence of hydroxyl radical formation after acute copper and ascorbic acid intake: electron spin resonance spin-trapping investigation. Mol Pharmacol 1992;42:723-9.
30. Kadiiska MB, Hanna PM, Jordan SJ, Mason RP. Electron spin resonance evidence for free radical generation in copper-treated vitamin E- and selenium-deficient rats: in vivo spin-trapping investigation. Mol Pharmacol 1993;44:222-7.
31. Sokol RJ, Devereaux MW, O'Brien K, Khandwala RA, Loehr JP. Abnormal hepatic mitochondrial respiration and cytochrome c oxidase activity in rats with long-term copper overload. Gastroenterology 1993;105:178-87.
32. Myers BM, Prendergast FG, Holman R, Kuntz SM, Larusso NF. Alterations in hepatocyte lysosomes in experimental hepatic copper overload in rats. Gastroenterology 1993;105:1814-23.
33. Sagripanti J-L, Goering PL, Lamanna A. Interaction of copper with DNA and antagonism by other metals. Toxicol Appl Pharmacol 1991;110:477-85.
34. Milne L, Nicotera P, Orrenius S, Burkitt MJ. Effects of glutathione and chelating agents on copper-mediated DNA oxidation: pro-oxidant and antioxidant properties of glutathione. Arch Biochem Biophys 1993;304:102-9.
35. Cai L, Koropatnick J. Cherian MG. Metallothionein protects DNA from copper-induced but not iron-induced cleavage in vitro. Chem Biol Interact 1995;96:143-55.
36. Tsang SY, Tarn SC. Bremner I, Burkitt MJ. Copper-1,10-phenanthroline induces internucleosomal DNA fragmentation in HepG2 cells, resulting from direct oxidation by the hydroxyl radical. Biochem J 1996;317:13-6.
37. Burkitt MJ, Milne L. Nicotera P, Orrenius S. 1,10-Phenanthroline stimulates internucleosomal DNA fragmentation in isolated rat-liver nuclei by promoting the redox activity of endogenous copper ions. Biochem J 1996;313:163-9.
38. Toyokuni S, Sagripanti J-L. Increased 8-hydroxydeoxyguanosine in kidney and liver of rats continuously exposed to copper. Toxicol Appl Pharmacol 1994;126:91-7.